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Cardiol Therapeu - CRDL STOCK NEWS

Welcome to our dedicated page for Cardiol Therapeu news (Ticker: CRDL), a resource for investors and traders seeking the latest updates and insights on Cardiol Therapeu stock.

Overview of Cardiol Therapeutics Inc.

Cardiol Therapeutics Inc. is a clinical-stage life sciences company dedicated to researching and developing innovative anti-inflammatory and anti-fibrotic therapies for treating heart diseases. The company focuses on conditions that have long challenged the medical community, such as recurrent pericarditis, acute myocarditis, and various forms of heart failure. By harnessing the potential of nanoscale drug delivery and proprietary cannabidiol formulations, Cardiol Therapeutics aims to provide novel non-immunosuppressive treatment options that address inflammatory and fibrotic mechanisms at the cellular level.

Core Business and Therapeutic Approach

The company is at the forefront of clinical research with its lead candidate, an oral cannabidiol formulation known as CardiolRx. This molecule is designed to inhibit the activation of the inflammasome pathway, thereby reducing the cascade of inflammatory responses and mitigating fibrotic cardiac remodeling. Through its rigorous clinical development programs, Cardiol Therapeutics is pioneering approaches that could change the way heart diseases are managed, particularly for patients who have limited options due to the lack of approved therapies.

Clinical Programs and Research Emphasis

Cardiol Therapeutics has structured its clinical trials with a dual focus: evaluating efficacy in reducing symptoms such as chest pain, inflammation, and adverse cardiac remodeling, while also emphasizing safety and tolerability. Its leading clinical trials, executed in multiple prominent clinical centers, are designed to fulfill critical endpoints through well-defined patient study protocols. The strategic incorporation of advanced imaging techniques and biomarker measurements in these trials underscores the company’s dedication to scientific accuracy and innovation.

Scientific Rationale and Innovation

At the heart of Cardiol Therapeutics™ approach is its commitment to addressing unmet needs in cardiovascular health. The company leverages proprietary nanoformulations to enhance drug delivery and bioavailability, ensuring that therapeutic agents like CardiolRx are effective in modulating cellular pathways that drive inflammation and fibrosis. This approach not only represents an evolution in cardiology treatment but also highlights the company's emphasis on translating molecular research into practical, effective therapies.

Market Position and Competitive Landscape

Operating within the competitive realm of biotechnology and pharmaceutical research, Cardiol Therapeutics distinguishes itself by focusing on chronic inflammatory heart diseases—a critical and underserved area in current medical practice. Its strategic pipeline, regulatory milestones such as Investigational New Drug (IND) authorization, and ongoing multi-center trials collectively contribute to positioning the company as an expert in leveraging anti-inflammatory mechanisms to improve cardiac outcomes. The integration of clinical data, rigorous research, and adherence to high regulatory standards reinforces the company's reputation for experience, expertise, authoritativeness, and trustworthiness.

Technology and Methodological Excellence

Using advanced nanotherapeutic techniques, Cardiol Therapeutics is at the cutting edge of drug formulation technology. Its research centers around optimizing the delivery of cannabidiol to targeted cardiac tissues, thereby ensuring that the drug can effectively reduce inflammation and fibrosis while minimizing potential systemic side effects. This methodological rigor, combined with its comprehensive clinical trial design, exemplifies how the company bridges pre-clinical research with actionable clinical innovations.

Commitment to Patient-Centric Innovation

Cardiol Therapeutics remains dedicated to improving the quality of life for patients suffering from debilitating heart conditions. By developing therapies that offer a non-immunosuppressive alternative to existing treatments, the company aims to provide options that are both accessible and effective. The patient-centric focus is clearly evidenced by its clinical trial designs, which prioritize measurable improvements in symptomatic relief and overall cardiac function.

This comprehensive overview underscores Cardiol Therapeutics' significant role in addressing a substantial unmet medical need within the cardiovascular space. With its scientifically driven approach and commitment to innovation, the company continues to advance therapeutic options that may reshape clinical treatment pathways for heart disease.

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Cardiol Therapeutics Inc. (CRDL) exceeds 50% patient enrollment for ARCHER, a Phase II trial investigating CardiolRx™ for acute myocarditis treatment.
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Cardiol Therapeutics Inc. (NASDAQ: CRDL) (TSX: CRDL) is conducting MAvERIC-Pilot, a Phase II open-label pilot study investigating the safety, tolerability, and efficacy of CardiolRx™ in patients with recurrent pericarditis. The study, which has enrolled 50% of its 25-patient objective, is anticipated to complete patient recruitment during Q1 2024. The primary efficacy endpoint is the change in patient-reported pericarditis pain using an 11-point numeric rating scale, with secondary endpoints including the NRS score after 26 weeks of treatment and changes in circulating levels of C-reactive protein.
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Cardiol Therapeutics Inc. (NASDAQ: CRDL) (TSX: CRDL) announced that study results demonstrated that cannabidiol treatment inhibits the mesothelial to mesenchymal transition in an experimental model of pericarditis. The results were presented at the 2023 Annual Meeting of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. This research suggests a potential broader therapeutic benefit of CardiolRx™ in preventing pericarditis complications.
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Cardiol Therapeutics Inc. has achieved over 50% patient enrollment in its Phase II open-label pilot study investigating the safety and efficacy of CardiolRx in patients with recurrent pericarditis. The study aims to evaluate improvement in objective measures of the disease and the feasibility of reducing background therapy. The company expressed gratitude to clinical collaborators and patients for their contribution. Recurrent pericarditis is a debilitating inflammatory heart disease that affects quality of life and physical activity. The study will inform the design of a pivotal Phase III trial for potential regulatory approval of CardiolRx.
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Cardiol Therapeutics receives notice of non-compliance with minimum bid price requirement on Nasdaq
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Results demonstrate that Cardiol's novel CRD-38 formulation attenuates harmful fat distribution and key markers of cardiac inflammation and remodelling. The study shows that subcutaneously administered cannabidiol slows increases in body weight and heart weight, and prevents increases in key cardiac inflammatory and remodelling markers in a model of heart failure with preserved ejection fraction.
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Cardiol Therapeutics Inc. announces CEO presentation at Cantor Fitzgerald 2023 Global Healthcare Conference.
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Cardiol Therapeutics announces initiation of all collaborating research centers for ARCHER trial
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Cardiol Therapeutics Inc. will be presenting a company overview at the Canaccord Genuity 43rd Annual Growth Conference on August 10, 2023. The presentation will be given by Cardiol's President and CEO, David Elsley, and will focus on the research and clinical development of anti-inflammatory and anti-fibrotic therapies for heart disease.
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Cardiol Therapeutics Inc. (NASDAQ: CRDL) (TSX: CRDL) has regained compliance with the minimum bid price requirement under Nasdaq Listing Rule 5550(a)(2) for continued listing on The Nasdaq Capital Market. The company is in compliance with all applicable listing standards and looks forward to reporting on important milestones associated with its ongoing Phase 2 clinical programs in recurrent pericarditis and acute myocarditis.
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FAQ

What is the current stock price of Cardiol Therapeu (CRDL)?

The current stock price of Cardiol Therapeu (CRDL) is $0.81 as of April 4, 2025.

What is the market cap of Cardiol Therapeu (CRDL)?

The market cap of Cardiol Therapeu (CRDL) is approximately 70.2M.

What is the core business of Cardiol Therapeutics Inc.?

Cardiol Therapeutics Inc. is focused on the research and clinical development of anti-inflammatory and anti-fibrotic therapies for treating heart diseases. The company utilizes advanced cannabidiol-based formulations to address conditions like recurrent pericarditis, acute myocarditis, and heart failure.

How does Cardiol Therapeutics approach drug development?

The company leverages proprietary nanotherapeutic techniques to optimize drug delivery and enhance bioavailability in target tissues. Its approach centers on inhibiting the inflammasome pathway to reduce inflammation and fibrosis, ensuring a scientifically rigorous pathway from pre-clinical research to clinical application.

What are the primary clinical programs of the company?

Cardiol Therapeutics conducts multiple clinical trials that include studies on its lead oral cannabidiol formulation, CardiolRx, and other novel drug candidates. These studies are designed to evaluate safety, efficacy, and potential benefits in reducing cardiac inflammation and remodeling.

Which heart conditions is Cardiol Therapeutics targeting?

The company is primarily targeting conditions such as recurrent pericarditis, acute myocarditis, and heart failure, particularly focusing on patients who lack effective non-immunosuppressive treatment options.

What distinguishes Cardiol Therapeutics from its competitors?

Cardiol Therapeutics stands out due to its emphasis on innovative nanotherapeutics and a deep scientific understanding of the inflammatory mechanisms in heart disease. Its commitment to robust clinical trial design and regulatory compliance reinforces its authoritativeness in the field.

How does the company ensure the safety and efficacy of its therapies?

Safety and efficacy are ensured through carefully structured multi-center clinical trials that incorporate advanced imaging, biomarker assessments, and rigorous monitoring. This scientific approach helps validate the benefits of their innovative therapies while prioritizing patient safety.

What role does cannabidiol play in Cardiol Therapeutics' treatments?

Cannabidiol is utilized in Cardiol Therapeutics' formulations to inhibit key inflammatory pathways, particularly the activation of the inflammasome. This action helps reduce inflammation and fibrosis in cardiac tissues, offering potential therapeutic benefits in managing heart diseases.
Cardiol Therapeu

Nasdaq:CRDL

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70.24M
78.77M
4%
12.19%
2.29%
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