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About Context Therapeutics Inc.
Context Therapeutics Inc. (Nasdaq: CNTX) is a clinical-stage biopharmaceutical company dedicated to advancing innovative therapies for solid tumors. Headquartered in Philadelphia, the company focuses on developing T cell engaging (TCE) bispecific antibodies, a cutting-edge immunotherapy approach that redirects the body's immune system to target and destroy cancer cells. With a robust pipeline of clinical-stage assets, Context is at the forefront of addressing unmet medical needs in oncology, particularly in hormone-dependent and underserved cancers.
Core Focus: T Cell Engaging Bispecific Antibodies
Context Therapeutics specializes in TCE bispecific antibodies, which are engineered to bind simultaneously to tumor-specific antigens and T cells, facilitating targeted immune responses against cancer cells. Their lead program, CTIM-76, targets Claudin 6 (CLDN6), a protein highly expressed in multiple solid tumors but absent in most healthy tissues, ensuring specificity and minimizing off-target effects. Additionally, their pipeline includes CT-95, a Mesothelin (MSLN) x CD3 bispecific antibody, and CT-202, a Nectin-4 x CD3 bispecific antibody, both of which are being developed to treat advanced cancers with limited therapeutic options.
Innovative Pipeline and Development Strategy
Context's pipeline reflects a strategic emphasis on addressing solid tumors with high unmet needs. The company's therapies are designed for scalability and low immunogenicity, ensuring broader accessibility and reduced adverse effects. CTIM-76 is currently in Phase 1 clinical trials, targeting gynecologic and testicular cancers, while CT-95 and CT-202 are advancing toward clinical development. Context's acquisition of promising assets like CT-95 and CT-202 underscores their commitment to building a diverse and innovative portfolio of TCE therapeutics.
Market Position and Competitive Landscape
Operating in the highly competitive oncology sector, Context Therapeutics differentiates itself through its focus on bispecific antibody technology and its ability to address limitations of first-generation therapies. By targeting tumor-specific proteins like CLDN6, MSLN, and Nectin-4, the company positions itself as a leader in developing next-generation immunotherapies. Their approach to scalable manufacturing and robust preclinical data further strengthens their competitive edge. Key competitors include other biotech firms specializing in immuno-oncology, but Context's emphasis on underserved cancer types and differentiated product profiles sets them apart.
Commitment to Addressing Unmet Medical Needs
Context Therapeutics is driven by a mission to transform the treatment landscape for solid tumors. By leveraging advanced TCE technology and focusing on cancers with limited therapeutic options, the company aims to provide hope to patients and families affected by these challenging diseases. Their strategic acquisitions, robust pipeline, and focus on innovation highlight their dedication to improving patient outcomes and advancing the field of oncology.
Context Therapeutics (Nasdaq: CNTX), a clinical-stage biopharmaceutical company focused on T cell engaging bispecific antibodies for solid tumors, has announced its participation in multiple upcoming investor conferences in April and May 2025.
The company will participate in four major events:
- Stifel Virtual Targeted Oncology Forum (April 8-9) featuring a presentation on April 8 at 10:00 AM ET
- Jones Healthcare and Technology Innovation Conference in Las Vegas (April 8-9)
- 24th Annual Needham Virtual Healthcare Conference (April 7-10)
- Citizens Life Sciences Conference in New York City (May 7-8) with a presentation on May 8 at 2:30 PM ET
The company will conduct one-on-one meetings during all conferences.
Context Therapeutics (Nasdaq: CNTX), a clinical-stage biopharmaceutical company focused on T cell engaging bispecific antibodies for solid tumors, has announced an upcoming poster presentation at the AACR Annual Meeting 2025 in Chicago (April 25-30, 2025).
The presentation will feature data on CT-95, the company's clinical asset targeting mesothelin x CD3 TCE. The poster will specifically detail the selection methodology for the first-in-human dose of CT-95, utilizing the minimal anticipated biological effect level (MABEL) approach. The research supports a proposed clinical starting dose of 0.1 μg/kg for CT-95.
Context Therapeutics (CNTX) reported its full year 2024 financial results and business highlights. The company ended 2024 with $94.4 million in cash, expected to fund operations into 2027. Key developments include the first patient dosed with CTIM-76 in January 2025 for CLDN6-positive cancers, acquisition of CT-95, and in-licensing of CT-202.
Financial results show R&D expenses increased to $22.7 million in 2024 from $17.8 million in 2023, primarily due to $14.75 million in research charges related to CT-95 acquisition and CT-202 licensing. The company reported a net loss of $26.7 million for 2024, compared to $24.0 million in 2023.
Upcoming milestones include first patient dosing for CT-95 in Q2 2025, initial CTIM-76 clinical data in H1 2026, and CT-95 trial data in mid-2026.
Context Therapeutics (Nasdaq: CNTX), a biopharmaceutical company focused on solid tumor treatments, has granted stock options to two new employees as employment inducements. The grants total 46,000 shares of common stock, awarded outside the company's 2021 Long-Term Performance Incentive Plan, complying with Nasdaq Rule 5635(c)(4).
The options were granted on February 18 and 24, 2025, with exercise prices of $0.83 and $0.8314 per share respectively, matching Context's closing stock prices on those dates. These 10-year options follow a four-year vesting schedule: 25% vests after one year, with the remaining 75% vesting in 36 monthly installments. Vesting is contingent on continued employment with Context.
Context Therapeutics (Nasdaq: CNTX), a biopharmaceutical company focused on T cell engagers for solid tumors, has announced its participation in three major upcoming investor conferences in February and March 2025:
• B. Riley Securities Precision Oncology & Radiopharma Conference: Two panel discussions scheduled for February 28, 2025, at 8:00 a.m. and 10:00 a.m. ET in New York
• TD Cowen 45th Annual Healthcare Conference: Presentation scheduled for March 3, 2025, at 11:10 a.m. ET in Boston
• Leerink Partners Global Healthcare Conference: Fireside chat scheduled for March 10, 2025, at 10:00 a.m. ET in Miami
The company will also conduct one-on-one meetings with investors at each conference.
Context Therapeutics (CNTX) has initiated its Phase 1 clinical trial for CTIM-76, a Claudin 6 x CD3 T cell engaging bispecific antibody, with the first patient now dosed. The trial focuses on patients with CLDN6-positive gynecologic and testicular cancers.
The open-label study will evaluate safety and efficacy in subjects with CLDN6-positive advanced or metastatic ovarian, endometrial, and testicular cancer. The trial aims to assess safety, tolerability, pharmacokinetics, and anti-tumor activity through metrics including overall response rate, duration of response, and disease control rate. Expected to enroll up to 70 patients, the company anticipates sharing initial data in the first half of 2026.
Context Therapeutics (Nasdaq: CNTX) has appointed Andy Pasternak as Chairman of its Board of Directors, effective January 13, 2025, succeeding Richard Berman. Pasternak brings over 25 years of biopharmaceutical experience and currently serves as an Advisory Partner at Bain & Company.
Most recently, Pasternak was Executive Vice President and Chief Strategy Officer at Horizon Therapeutics, where he played a key role in the company's $28 billion acquisition by Amgen in 2023. His responsibilities included corporate strategy, M&A, business development, commercial development, and portfolio management.
Prior to Horizon, he served as Head of Healthcare Practice in the Americas at Bain & Company. He currently serves on the Board of Directors of Endo and is an adjunct lecturer at Northwestern University's Kellogg School of Management.
Context Therapeutics (CNTX) reported Q3 2024 financial results and business updates. The company expanded its pipeline through acquisitions of CT-95 and CT-202, two T cell engaging bispecific antibodies. Cash position stood at $84.8 million as of September 30, 2024. Q3 net loss increased to $17.5 million from $5.9 million year-over-year, primarily due to R&D expenses of $16.8 million. The company expects current cash to fund operations into 2027, including Phase 1 trials for CTIM-76 and CT-95, and IND filing for CT-202.
Context Therapeutics (Nasdaq: CNTX), a biopharmaceutical company focused on T cell engagers for solid tumors, has announced its participation in three major investor conferences this November. The company will present at the Guggenheim Global Healthcare Conference (November 11), UBS Global Healthcare Conference (November 13), and Stifel 2024 Healthcare Conference (November 19).
The presentations will include fireside chats and one-on-one meetings with investors. All sessions will be webcast live and available for replay for 90 days on the company's investor relations website.
Context Therapeutics Inc. (Nasdaq: CNTX), a biopharmaceutical company focused on T cell engagers for solid tumors, has announced a poster presentation at the Society for Immunotherapy of Cancer's (SITC) 39th Annual Meeting. The presentation will feature their clinical asset CTIM-76, a Claudin 6 x CD3 bispecific antibody.
The poster, titled 'Determination of first in human dose of the T cell-redirecting bispecific antibody CTIM-76 targeting Claudin 6,' will be presented on Saturday, November 9, 2024, at 9:00 a.m. CDT in Exhibit Halls AB of the George R. Brown Convention Center in Houston, TX. The authors of the presentation are Kelly Byrnes-Blake, Ed Calamai, Stanley Roberts, and Eric Butz.
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