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EQRx and CM Life Sciences III Inc. announced that the SEC has declared effective the registration statement for their previously announced business combination. A virtual special meeting for CM Life Sciences III’s stockholders will take place on December 16, 2021, to approve the agreement. The merger is expected to close shortly thereafter, resulting in CM Life Sciences III being renamed EQRx, Inc., with stock trading under the ticker symbols EQRX and EQRXW.
EQRx has announced its participation in a fireside chat at the 4th Annual Evercore ISI HealthCONx Conference, scheduled for Thursday, December 2, at 4:45 p.m. ET. The event can be accessed via webcast on the company's Investor Relations page. Founded in January 2020, EQRx aims to provide innovative medicines at lower prices and is in the process of merging with CM Life Sciences III (CMLTU), expected to complete in Q4 2021.
EQRx has entered into a strategic collaboration with Abdul Latif Jameel Health to enhance commercial access to its oncology drugs, aumolertinib and sugemalimab, in select Middle Eastern markets, Turkey, and Africa. Aumolertinib targets advanced non-small cell lung cancer, while sugemalimab is an investigational PD-L1 antibody. Both drugs have shown promising clinical trial results. This partnership aims to provide affordable cancer treatment options globally. EQRx's development of cost-effective medicines continues as it aligns with its mission to disrupt traditional healthcare models.
EQRx has partnered with Evotec to leverage its data-driven drug discovery platform to enhance EQRx's pipeline focused on oncology and immunology. This collaboration aims to accelerate the development of innovative, affordable medicines. EQRx will focus on clinical development while Evotec will lead drug discovery and pre-clinical development. Additionally, Evotec will gain from potential profits through a profit-sharing mechanism. This partnership aligns with EQRx's mission to provide cost-effective therapies and follows its proposed merger with CM Life Sciences III, expected to complete in Q4 2021.
EQRx has launched a corporate video series titled 'Remaking Medicine: On The Record' aimed at providing insights into its innovative approach to pharmaceutical development. Moderated by CFO Jami Rubin, the series includes discussions on EQRx's product pipeline, commercial strategies, and its mission for affordable medicine. The series is available online and concludes with a Q&A session set for December 2021. EQRx, established in January 2020, aims to disrupt high-cost drug markets and is in the process of merging with CM Life Sciences III to accelerate its growth.
EQRx has signed a memorandum of understanding with NHS England to establish a long-term partnership focusing on patient access to affordable cancer medicines. This collaboration is contingent on regulatory approval from the UK Medicines and Healthcare products Regulatory Agency (MHRA) and a favorable health technology assessment from NICE. EQRx's lead cancer drugs, aumolertinib and sugemalimab, have received Innovation Passport designations, allowing for accelerated regulatory processes in the UK. The agreement aims to provide innovative treatments for advanced lung cancer, addressing a significant public health need.
EQRx and Absci Corporation (ABSI) have entered a discovery collaboration to develop affordable, innovative therapeutics utilizing Absci's Drug Creation™ technology. This partnership aims to produce several clinical candidates, particularly in oncology and immunology. The collaboration is designed to enhance EQRx's portfolio with cost-effective treatment options while Absci may invest further at various development stages for a larger share of sales. This aligns with EQRx's mission to provide new medicines at lower prices.
EQRx has appointed Kathy Giusti to its board of directors, bringing her expertise in precision medicine and patient advocacy. Giusti, the founder of the Multiple Myeloma Research Foundation, has significantly contributed to the approval of 15 drugs for multiple myeloma. With a strong background in leadership within the pharmaceutical industry, she highlights EQRx's mission to make lifesaving treatments accessible and affordable. This strategic move aims to enhance EQRx's efforts to disrupt the pharmaceutical industry with innovative, lower-cost medicines.
EQRx has announced positive results from the Phase 3 GEMSTONE-301 study of sugemalimab, a PD-L1 monoclonal antibody, showing improved progression-free survival (PFS) in patients with Stage III NSCLC. The study met its primary endpoint, with a median PFS of 9.0 months compared to 5.8 months for placebo (HR=0.64). Sugemalimab demonstrated benefits for patients treated with both concurrent and sequential chemoradiotherapy, with promising trends in overall survival (OS). The presentation will occur at the ESMO Congress 2021 on September 18, 2021.
EQRx announced updated data from CStone Pharmaceuticals’ Phase 3 GEMSTONE-302 study at the IASLC 2021 World Conference on Lung Cancer. This trial evaluates the anti-PD-L1 antibody sugemalimab with chemotherapy for Stage IV non-small cell lung cancer (NSCLC). The study reported a progression-free survival (PFS) of 9.0 months for the combination therapy versus 4.9 months for chemotherapy alone (HR=0.48, P<0.0001). Preliminary overall survival (OS) was 22.8 months for the combination versus 17.7 months for placebo. No new safety signals emerged.
