Welcome to our dedicated page for Celldex Therapeutics news (Ticker: CLDX), a resource for investors and traders seeking the latest updates and insights on Celldex Therapeutics stock.
Celldex Therapeutics, Inc. (NASDAQ: CLDX) is a cutting-edge biopharmaceutical company focused on developing targeted therapeutics for devastating diseases with inadequate treatment options. The company leverages a proprietary portfolio of antibodies and immunomodulators to create novel, disease-specific therapies that modify the body's immune response. Founded with the belief that harnessing the immune system's power could overcome significant barriers in drug development, Celldex has built a robust pipeline of therapeutic antibodies, antibody-drug conjugates, immune system modulators, and vaccines.
Celldex is actively engaged in clinical trials for its promising pipeline products, including Varlilumab, CDX-301, CDX-1140, CDX-0159/Anti-KIT Program (barzolvolimab), and CDX-527. These therapies target conditions like breast cancer, metastatic melanoma, lung cancer, solid tumors, and ovarian cancer, focusing on specific patient populations with high unmet medical needs.
Recently, Celldex reported positive results from its Phase 2 clinical trial of barzolvolimab in patients with chronic spontaneous urticaria (CSU), a condition unresponsive to standard antihistamines and biologics. The study demonstrated significant improvements in patient symptoms, paving the way for Phase 3 trials. Additional clinical studies are underway for barzolvolimab in chronic inducible urticaria (CIndU), prurigo nodularis (PN), and eosinophilic esophagitis (EOE).
Celldex's financial health is robust, with substantial capital to support ongoing research and development. The company's recent public offering raised significant funds, ensuring the continuation of its innovative programs through 2027. Strategic partnerships, including collaborations with renowned institutions like Rockefeller University, further bolster Celldex's research endeavors.
Celldex Therapeutics is at the forefront of biotech innovation, striving to deliver transformative treatments for severe inflammatory, allergic, autoimmune, and other debilitating diseases. Stay updated with the latest developments and news by visiting www.celldex.com.
Celldex Therapeutics (NASDAQ: CLDX) reported its 2021 financial results, highlighting a 95% complete response rate in its Phase 1b study for chronic inducible urticaria with CDX-0159. The firm holds $408.3 million in cash, sufficient to fund operations through 2025. Phase 2 studies for chronic spontaneous urticaria and eosinophilic esophagitis are set to begin in Q2 2022 and Q4 2022, respectively. However, total revenues dropped to $0.3 million in Q4 2021 compared to $3.8 million in Q4 2020, and the net loss for the year was $70.5 million.
Celldex Therapeutics (NASDAQ:CLDX) will host a conference call on February 28, 2022, at 4:30 p.m. ET to discuss its Q4 and full year 2021 financial results and corporate updates. Interested parties can access the live or recorded webcast on the company's website. Celldex focuses on developing monoclonal and bispecific antibodies targeting serious diseases with inadequate treatments. Their pipeline aims to enhance patient outcomes in cancer and inflammatory diseases.
Celldex Therapeutics (NASDAQ:CLDX) announced its participation in a virtual fireside chat at the 11th Annual SVB Leerink Global Healthcare Conference on February 16, 2022, at 1:00 p.m. ET. Senior management will represent the company during this event. Interested parties can access a webcast of the presentation via the company's 'Events & Presentations' page, with a replay available for 30 days afterward. Celldex focuses on developing monoclonal and bispecific antibodies aimed at treating severe diseases, including various cancers and inflammatory diseases.
Celldex Therapeutics (NASDAQ:CLDX) announced the first patient has been dosed in a Phase 1 study of CDX-0159 for prurigo nodularis (PN), a debilitating skin disease. This monoclonal antibody targets the KIT receptor to aid in reducing chronic itch linked to PN. The study will enroll about 40 patients divided into four groups, assessing safety and clinical effects over 8 weeks. The Chief Medical Officer highlighted the milestone's potential impact on patients suffering from PN, as there are currently no approved treatments.
Celldex Therapeutics (NASDAQ:CLDX) announced promising preclinical results for CDX-585, a bispecific antibody targeting ILT4 and PD-1 pathways, at the SITC 2021 meeting. The data indicate that CDX-585 successfully merges blockade of these checkpoints, enhancing T cell activation and demonstrating anti-tumor effects in humanized melanoma models. This marks the first advancement from a collaboration with Biosion, Inc. and supports the initiation of manufacturing and IND-enabling studies, with significant implications for immune response in cancer therapy.
Celldex Therapeutics (NASDAQ:CLDX) will participate in several virtual investor conferences in November 2021. Notable events include the Guggenheim 3rd Annual Healthcare Talks Neuro/Immunology Conference on November 16 at 10:20 a.m. ET, the Jefferies London Healthcare Conference available on-demand starting November 18 at 3:00 a.m. ET, and the Evercore ISI 4th Annual HealthCONx Conference on November 30 at 8:25 a.m. ET. Webcasts of these presentations will be accessible on the Celldex website for 30 days post-event.
Celldex Therapeutics (NASDAQ:CLDX) announced its Q3 2021 financial results, reporting a net loss of $20.5 million, or ($0.45) per share. Revenue for the quarter was $0.2 million, reflecting growth from contract manufacturing but a decline in licensing revenue. Cash remains strong at $423.1 million, supported by a $287.5 million public offering in July. The company reported positive outcomes in its Phase 1b study of CDX-0159, achieving a 95% complete response rate in chronic inducible urticaria patients, alongside promising data from multiple clinical trials across its pipeline.
Celldex Therapeutics has announced promising results from its Phase 1b trial of CDX-0159, a monoclonal antibody for treating antihistamine-refractory chronic inducible urticaria. A single dose of CDX-0159 led to rapid and sustained improvement in urticaria control and significantly enhanced quality of life for patients. Notably, 95% of patients achieved a complete response to provocation tests, with over 80% reaching a 'well controlled' status within four weeks. The data supports the potential of CDX-0159 to transform treatment for these debilitating conditions.
Celldex Therapeutics (NASDAQ:CLDX) announced participation in the 2021 Cantor Virtual Global Healthcare Conference on September 29, 2021, at 1:20 p.m. ET. Senior management will engage in a fireside chat during the event.
A webcast of the presentation will be accessible on the company's Events & Presentations page.
Celldex Therapeutics (NASDAQ:CLDX) announced that an abstract on CDX-0159's efficacy in managing symptoms of cold contact urticaria and symptomatic dermographism will be presented at the European Academy of Dermatology and Venereology 30th Congress from September 29 to October 2, 2021. The presentation highlights the antibody's rapid clinical response and quality of life improvements. Interim data available at submission in May will be updated at the event. CDX-0159 targets the KIT receptor, essential for mast cell function in chronic urticaria.
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