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Channel Therapeutics Corporation - CHRO STOCK NEWS

Welcome to our dedicated page for Channel Therapeutics Corporation news (Ticker: CHRO), a resource for investors and traders seeking the latest updates and insights on Channel Therapeutics Corporation stock.

Overview

Channel Therapeutics Corporation is a clinical-stage biotechnology company dedicated to the development and commercialization of non-opioid pain management therapies. The company leverages innovative science to specifically target the NaV1.7 sodium channel – a validated mechanism in the modulation of pain – making it a significant player in the clinical-stage biotechnology space. By focusing on non-addictive therapeutic approaches, the company addresses a critical unmet need within chronic pain and ocular pain indications, offering potential alternatives to traditional opioid treatments.

Core Therapeutic Programs

The company’s development pipeline is strategically structured around two primary programs:

  • CC8464: This program targets neuropathic pain conditions, including manifestations such as idiopathic small fiber neuropathy and erythromelalgia. The therapy focuses on the selective inhibition of the NaV1.7 channel to alleviate chronic pain without invoking the central nervous system effects associated with opioids. Early clinical studies have underscored its potential for effective pain relief with minimal adverse effects.
  • CT2000: Designed for the treatment of acute and chronic eye pain, CT2000 represents a novel approach as traditional ophthalmic pain therapies often involve corticosteroids or NSAIDs that carry risks of sight-threatening complications. By addressing pain at its molecular source, this program aims to fill a significant gap in the treatment of ocular pain conditions.

Research and Development Approach

Channel Therapeutics Corporation adopts a rigorous research methodology emphasizing scientific precision and safety. Preclinical studies, followed by methodical Phase I trials, form the backbone of its development strategy. The company conducts comprehensive animal model testing to validate the efficacy of NaV1.7 inhibition, ensuring that its treatments not only alleviate pain but also maintain a strong safety profile. This systematic approach underscores the firm commitment to reducing adverse effects such as systemic side effects typically associated with other pain therapeutics.

Scientific and Strategic Rigor

The company is guided by a commitment to scientific excellence and fiscal responsibility. Its strategy includes:

  • Precision Targeting: By focusing on the NaV1.7 channel and related receptors within the NaV family, Channel Therapeutics provides a targeted approach to pain management that minimizes the potential for abuse or addictive outcomes.
  • Innovative Clinical Design: Utilizing dose escalation strategies, the company is actively engaged in optimizing the balance between efficacy and minimization of side effects, thereby enhancing patient safety throughout clinical assessments.
  • Enhanced Market Differentiation: The company’s strategic exploration of orphan indications and expanding portfolio in ocular pain treatment not only positions it favorably within niche markets but also establishes distinct competitive advantages over conventional opioid-based treatments.

Competitive Landscape and Market Position

Within the competitive biotech sphere, Channel Therapeutics Corporation differentiates itself by focusing exclusively on non-opioid pain therapies. The emphasis on a mechanism-based approach via NaV1.7 inhibition, coupled with an extensive pipeline addressing both neuropathic and ocular pain, places the company at an intersection of innovation and clear market demand. This methodical approach to clinical development, combined with a commitment to addressing significant unmet medical needs, provides the foundation for a robust and enduring market presence.

Expertise and Industry Credibility

The company’s operations exemplify a balance between advanced scientific methodologies and prudent business practices. By aligning its clinical programs with recognized scientific principles and ensuring transparency in its research initiatives, Channel Therapeutics builds substantial credibility among clinicians, investors, and regulatory bodies. Its ongoing engagement with regulatory authorities and utilization of strategic initiatives – such as non-dilutive capital and potential licensing opportunities – further reinforce its standing as an entity committed to excellence and innovation in pain management.

Conclusion

Channel Therapeutics Corporation emerges as a noteworthy contributor to the field of non-opioid pain therapeutics. Its focused approach on targeting the NaV1.7 channel, robust preclinical and early clinical validations, and strategic positioning within challenging pain indications all contribute to its distinct identity in the biotechnology industry. Investors and industry observers can appreciate the company’s meticulous execution in addressing critical aspects of pain management, all while adhering to the highest standards of scientific and operational rigor.

Rhea-AI Summary

Channel Therapeutics (NYSE: CHRO) has provided insights on the differences between NaV1.7 and NaV1.8 pain signal inhibitors, following Vertex Pharmaceutical's Phase 2 data announcement for Suzetrigine. The company emphasizes that while both are voltage-gated sodium channels in sensory neurons, NaV1.7 overexpression leads to more severe pain compared to NaV1.8's moderate pain effects.

Channel is pursuing a three-pronged approach with their NaV1.7 inhibitor: an oral treatment for neuropathic pain, an eye drop formulation for eye pain, and a slow-release depot formulation for post-surgical nerve blocks. The company expects critical data readouts in 2025 to validate their clinical development strategy.

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Channel Therapeutics (NYSE: CHRO) announced positive results from preclinical trials of its NaV1.7 inhibitor nerve block formulations for acute pain. The study demonstrated superior efficacy and duration compared to bupivacaine, the current standard of care. Three out of four formulations showed better efficacy than bupivacaine, with one formulation remaining effective for over four days.

The trials included thermal hyperalgesia and mechanical allodynia tests in rodents, with multiple test arms including placebo, bupivacaine, and four Company formulations. Unlike current nerve block therapies that cause temporary paralysis, the NaV1.7 approach doesn't impact mobility, potentially offering better post-surgical physical therapy options.

The Company is targeting the post-operative global pain market, valued at $2.6 billion in 2023. Results for additional studies on eye drops for various types of eye pain are expected in late January 2025.

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Channel Therapeutics (NYSE American: CHRO), formerly Chromocell, announced its name change and reincorporation in Nevada. The company focuses on developing non-opioid pain treatments through sodium channel modulation, specifically targeting NaV1.7. The company provided updates on three therapeutic programs: Depot Program for postoperative nerve blocks showing 96-hour sustained release in animals with pending efficacy results; Eye Pain Program with well-tolerated animal studies and expected Phase II human trials in Q2 2025; and a Chronic Pain program planned for Q1 2025 pending program-specific financing.

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Chromocell Therapeutics (NYSE American: CHRO) has unveiled an injectable depot program using peripheral nerve blocks for post-operative pain treatment. The program leverages the company's NaV1.7 molecule, targeting a market of approximately 700,000 total knee replacements and 500,000 shoulder arthroplasties performed annually in the US. The company's drug has shown no addictive properties in four Phase I trials and demonstrated strong efficacy in preclinical models. The program aims to reduce opioid usage and could benefit from NOPAIN Act provisions upon FDA approval.

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Chromocell Therapeutics (NYSE American: CHRO), a non-opioid pain treatment developer, has announced its participation in two upcoming investor conferences. CEO Frank Knuettel II will present at the LDMicro Main Event XVII on October 29, 2024, from 10:00-10:25 AM PT in Los Angeles, and at the Spartan Capital Investor Conference on November 4, 2024, from 9:45-10:00 AM ET in NYC.

Both events offer opportunities for one-on-one meetings and networking with institutional investors, industry leaders, and capital market representatives. The LDMicro event focuses on showcasing emerging micro-cap companies, while the Spartan conference brings together public company executives and institutional investors for strategic discussions.

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Chromocell Therapeutics (NYSE American: CHRO) has announced an amendment to its stock repurchase plan, increasing the total value of shares available for repurchase by an additional $500,000 to $750,000. The amendment also extends the plan's termination date from December 31, 2024, to June 30, 2025. The company's CEO Frank Knuettel stated this decision reflects their belief that the common stock is undervalued and represents an attractive investment at current prices. The repurchases may be conducted through open market or private transactions, subject to Rule 10b-18 regulations and trading plans under Rule 10b5-1.

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Chromocell Therapeutics (NYSE American: CHRO), a leader in non-opioid pain treatment development, will present at the H.C. Wainwright 26th Annual Global Investment Conference. CEO Frank Knuettel will provide a company overview, with the virtual presentation available from September 9th at 7:00 A.M. (ET).

Institutional investors can register at www.hcwevents.com/annualconference. The presentation will be accessible through Chromocell's Investor section website, with an archived replay available for at least 30 days. This event allows Chromocell to highlight its progress in developing innovative non-opioid pain treatments, focusing on modulating NaV1.7 receptors in the peripheral nervous system.

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Chromocell Therapeutics (NYSE American: CHRO), a pioneer in non-opioid pain treatment development, has announced a stock repurchase plan of up to $250,000 of its common stock. This represents approximately 23% of the non-affiliate float based on the August 6, 2024 closing price. The plan, which is discretionary and can be modified or terminated at any time, aims to enhance stockholder value.

CEO Frank Knuettel stated that while the company remains focused on allocating capital to clinical and pre-clinical programs, they believe the current stock price doesn't reflect their progress in developing drugs for neuropathic and chronic pain. The company views its stock as an attractive investment opportunity and expects to make announcements in the coming months supporting their drug development efforts.

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Chromocell Therapeutics (NYSE American: CHRO), a leader in non-opioid pain treatment development, has announced its participation in the Virtual Investor Lunch Break Series. The event, titled 'The Chromocell Opportunity,' is scheduled for Thursday, July 18, 2024, at 12:00 PM ET.

Frank Knuettel II, serving as both CEO and CFO, will present a corporate overview and business outlook. The session will include a live Q&A segment, allowing attendees to submit questions. A live video webcast will be available on the company's website, with a replay accessible for 90 days following the event.

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Chromocell Therapeutics , listed as CHRO on NYSE American, will have its CEO present at Alliance Global Partners Healthcare Company Showcase on May 21, 2024. The conference will feature top healthcare companies discussing industry catalysts and future trends. Investors can attend the 20-minute 'fireside chat' style presentations online.

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FAQ

What is the current stock price of Channel Therapeutics Corporation (CHRO)?

The current stock price of Channel Therapeutics Corporation (CHRO) is $1.3638 as of April 4, 2025.

What is the market cap of Channel Therapeutics Corporation (CHRO)?

The market cap of Channel Therapeutics Corporation (CHRO) is approximately 8.5M.

What is the primary focus of Channel Therapeutics Corporation?

The company is dedicated to developing non-opioid, non-addictive pain therapeutics by targeting the NaV1.7 sodium channel to treat chronic and ocular pain conditions.

How does the company approach pain management differently than traditional therapies?

Channel Therapeutics focuses on precision targeting of molecular pain pathways, avoiding opioids and their associated side effects by using non-addictive mechanisms such as NaV1.7 inhibition.

What therapeutic programs are included in the company’s pipeline?

The pipeline features programs such as CC8464, aimed at neuropathic pain conditions, and CT2000, developed for addressing acute and chronic ocular pain.

How does Channel Therapeutics ensure the safety of its treatments?

The company employs rigorous preclinical and Phase I trials to validate the efficacy and safety of its compounds, carefully monitoring for side effects and optimizing dosage strategies.

What mechanisms does the company target to alleviate pain?

Their research focuses on the targeted inhibition of the NaV1.7 sodium channel, a critical mediator in pain signaling, ensuring an approach that minimizes central nervous system side effects.

How is the company positioned in the competitive landscape of biotechnology?

By concentrating on non-opioid pain management and leveraging a focused pipeline of novel therapies, the company differentiates itself in markets with significant unmet needs and stringent safety profiles.

What are the potential market applications of the company's therapies?

Their therapies are aimed at treating various types of chronic pain, including neuropathic and ocular pain, which represent significant market opportunities due to limited effective alternatives in these areas.
Channel Therapeutics Corporation

NYSE:CHRO

CHRO Rankings

CHRO Stock Data

8.46M
872.63k
86.78%
12.8%
0.46%
Biotechnology
Biological Products, (no Disgnostic Substances)
Link
United States
NORTH BRUNSWICK