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Cognition Therapeutics Releases New Episode of “Conversations” Podcast: Executing Clinical Research in Dementia with Lewy Bodies (DLB)

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Cognition Therapeutics (NASDAQ: CGTX) has released a new episode of its "Conversations" video podcast titled "Executing Clinical Research in Dementia with Lewy Bodies (DLB)" during DLB Awareness Month. The episode features a panel of experts discussing:

  • Similarities and differences between DLB and Alzheimer's disease
  • Unique symptoms experienced by DLB patients
  • Design of the SHIMMER study of CT1812 in mild-to-moderate DLB
  • Importance of identifying clinical and functional benefit signals in DLB, which currently lacks approved disease-modifying therapies

The podcast is moderated by Cognition's CMO, Dr. Anthony Caggiano, and includes three leading experts in the field. It is available on the Cognition website under the Conversations tab, presented in three chapters covering comparisons between Alzheimer's and DLB, SHIMMER study design, and metrics for success in signal-finding studies.

Cognition Therapeutics (NASDAQ: CGTX) ha rilasciato un nuovo episodio del suo podcast video "Conversations" intitolato "Esecuzione della Ricerca Clinica nella Demenza con Corpi di Lewy (DLB)" durante il Mese di Sensibilizzazione sulla DLB. L'episodio presenta un panel di esperti che discutono:

  • Somiglianze e differenze tra DLB e la malattia di Alzheimer
  • Sintomi unici sperimentati dai pazienti con DLB
  • Progettazione dello studio SHIMMER di CT1812 nei pazienti con DLB da lieve a moderata
  • Importanza di identificare segnali di beneficio clinico e funzionale nella DLB, che attualmente manca di terapie modificanti la malattia approvate

Il podcast è moderato dal CMO di Cognition, il Dr. Anthony Caggiano, e include tre esperti di spicco nel campo. È disponibile sul sito web di Cognition nella sezione Conversations, presentato in tre capitoli che coprono i confronti tra Alzheimer e DLB, la progettazione dello studio SHIMMER e metriche per il successo negli studi di ricerca di segnali.

Cognition Therapeutics (NASDAQ: CGTX) ha lanzado un nuevo episodio de su podcast de video "Conversations" titulado "Ejecutando la Investigación Clínica en Demencia con Cuerpos de Lewy (DLB)" durante el Mes de Concienciación sobre DLB. El episodio presenta un panel de expertos que discuten:

  • Semejanzas y diferencias entre DLB y la enfermedad de Alzheimer
  • Síntomas únicos experimentados por los pacientes con DLB
  • Diseño del estudio SHIMMER de CT1812 en DLB leve a moderada
  • Importancia de identificar señales de beneficio clínico y funcional en DLB, que actualmente carece de terapias modificadoras de la enfermedad aprobadas

El podcast está moderado por el CMO de Cognition, el Dr. Anthony Caggiano, e incluye a tres expertos líderes en el campo. Está disponible en el sitio web de Cognition en la pestaña de Conversations, presentado en tres capítulos que cubren comparaciones entre Alzheimer y DLB, diseño del estudio SHIMMER y métricas para el éxito en estudios de búsqueda de señales.

Cognition Therapeutics (NASDAQ: CGTX)은 DLB 인식의 달 동안 "루이몸 치매의 임상 연구 수행"라는 제목의 새로운 "Conversations" 비디오 팟캐스트 에피소드를 출시했습니다. 이 에피소드는 전문가 패널이 다음 사항을 논의합니다:

  • DLB와 알츠하이머병 사이의 유사점과 차이점
  • DLB 환자들이 경험하는 독특한 증상
  • 경증에서 중등도 DLB 환자를 위한 CT1812의 SHIMMER 연구 디자인
  • 현재 승인된 질병 수정 치료법이 없는 DLB에서 임상적 및 기능적 이점 신호를 식별하는 것의 중요성

이 팟캐스트는 Cognition의 CMO인 Anthony Caggiano 박사가 진행하며, 이 분야의 선도적인 세 명의 전문가가 포함되어 있습니다. Cognition 웹사이트의 Conversations 탭에서 확인할 수 있으며, 알츠하이머와 DLB 간의 비교, SHIMMER 연구 디자인 및 신호 탐지 연구의 성공 메트릭을 다루는 세 개의 챕터로 구성되어 있습니다.

Cognition Therapeutics (NASDAQ: CGTX) a publié un nouvel épisode de son podcast vidéo "Conversations" intitulé "Exécution de la recherche clinique dans la démence à corps de Lewy (DLB)" pendant le mois de sensibilisation à la DLB. Cet épisode présente un panel d'experts discutant des thèmes suivants:

  • Similarités et différences entre la DLB et la maladie d'Alzheimer
  • Symptômes uniques rencontrés par les patients atteints de DLB
  • Conception de l'étude SHIMMER de CT1812 chez des patients atteints de DLB léger à modéré
  • Importance d'identifier les signaux de bénéfice clinique et fonctionnel dans la DLB, qui ne dispose actuellement d'aucune thérapie modifiant la maladie approuvée

Le podcast est modéré par le CMO de Cognition, Dr. Anthony Caggiano, et inclut trois experts de premier plan dans ce domaine. Il est disponible sur le site Web de Cognition dans l'onglet Conversations, présenté en trois chapitres couvrant les comparaisons entre la maladie d'Alzheimer et la DLB, le design de l'étude SHIMMER et les métriques de succès dans les études de recherche de signaux.

Cognition Therapeutics (NASDAQ: CGTX) hat eine neue Episode seines Video-Podcasts "Conversations" mit dem Titel "Durchführung klinischer Forschung bei Demenz mit Lewy-Körperchen (DLB)" während des DLB Awareness Month veröffentlicht. Die Episode umfasst ein Expertenteam, das folgende Themen diskutiert:

  • Ähnlichkeiten und Unterschiede zwischen DLB und Alzheimer
  • Einzigartige Symptome, die bei DLB-Patienten auftreten
  • Entwurf der SHIMMER-Studie zu CT1812 bei mildem bis moderatem DLB
  • Die Bedeutung der Identifizierung klinischer und funktionaler Nutzen-Signale bei DLB, das derzeit keine genehmigten krankheitsmodifizierenden Therapien hat

Der Podcast wird von Cognitions CMO, Dr. Anthony Caggiano, moderiert und umfasst drei führende Experten auf diesem Gebiet. Er ist auf der Website von Cognition unter dem Tab Conversations verfügbar, dargestellt in drei Kapiteln, die Vergleiche zwischen Alzheimer und DLB, den Design der SHIMMER-Studie und Erfolgsmessungen in Signal-finding-Studien abdecken.

Positive
  • Cognition Therapeutics is conducting the SHIMMER study of CT1812 in mild-to-moderate DLB
  • The company is actively engaging with leading experts in the field of DLB research
  • Cognition is raising awareness about DLB through educational content during DLB Awareness Month
Negative
  • There are currently no approved disease-modifying therapies for DLB

PURCHASE, N.Y., Oct. 22, 2024 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (the “Company” or “Cognition”) (NASDAQ: CGTX), a clinical-stage company developing drugs that treat neurodegenerative disorders, has released a new Conversations video podcast episode. The new episode, which has been launched during DLB Awareness Month, is titled “Executing Clinical Research in Dementia with Lewy Bodies (DLB).”

This conversation features a panel of experts who discuss the similarities and differences between DLB and Alzheimer’s disease, as well as the unique constellation of symptoms experienced by DLB patients. Panelists also discuss the design of the SHIMMER study of CT1812 in mild-to-moderate DLB, and the value of identifying signals of clinical and functional benefit in a condition for which there are currently no approved disease-modifying therapies.

Anthony Caggiano, M.D., Ph.D. CMO and head of R&D for Cognition Therapeutics moderates the discussion with three leading experts:

  • James E. Galvin, MD, MPH, director of the Comprehensive Center for Brain Health at the University of Miami Miller School of Medicine;
  • Lawrence S. Honig, MD, PhD, FAAN, professor of neurology at Columbia University Irving Medical Center; and
  • David Shprecher, D.O., movement disorder director at Banner Sun Health Research Institute and a clinical associate professor at the University of Arizona.

Listen to episode nine, “Executing Clinical Research in Dementia with Lewy Bodies (DLB)” on the Conversations tab of the Cognition website. This conversation is presented in 3 Chapters: 1) Comparing Alzheimer’s disease and DLB; 2) SHIMMER Design and Outcomes; and 3) Metrics for Success in a Signal-finding Study.

Health Care Disclaimer
Our podcast series does not constitute the practice of medical advice, diagnosis or treatment. Always talk to your health care provider for diagnosis and treatment, including your specific medical needs. If you have or suspect that you have a medical problem or condition, please contact a qualified health care professional immediately.

About Cognition Therapeutics, Inc.
Cognition Therapeutics, Inc., is a clinical-stage biopharmaceutical company discovering and developing innovative, small molecule therapeutics targeting age-related degenerative disorders of the central nervous system and retina. We currently are investigating our lead candidate CT1812 in clinical programs in Alzheimer’s disease, dementia with Lewy bodies (DLB) and dry age-related macular degeneration (dry AMD). We believe CT1812 and our pipeline of σ-2 receptor modulators can regulate pathways that are impaired in these degenerative diseases, with an approach that is functionally distinct from other treatments. More about Cognition Therapeutics and our pipeline can be found at https://cogrx.com.

About the SHIMMER Study
The SHIMMER study (NCT05225415) is a double-blind, placebo-controlled Phase 2 clinical trial that enrolled 130 adults with mild-to-moderate DLB. Participants were evenly randomized to receive either placebo or one of two oral once-daily doses of CT1812 (100 mg or 300 mg) for six months. Participants are assessed throughout the study using the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE), which track cognitive performance; the Clinician Assessment of Fluctuation (CAF) to measure the frequency and duration of cognitive fluctuations; and the MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, an objective assessment of parkinsonism.

The SHIMMER study is supported by a grant award from the National Institute on Aging of the National Institutes of Health (NIH) totaling approximately $30 million and is being conducted in collaboration with James E. Galvin, MD, MPH, director of the Comprehensive Center for Brain Health at the University of Miami Miller School of Medicine and the Lewy Body Dementia Association (LBDA). The SHIMMER study is being conducted at over 30 sites in the United States, many of which are LBDA centers of excellence.

Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. All statements contained in this press release or made during the conference, other than statements of historical facts or statements that relate to present facts or current conditions, including but not limited to, statements regarding our product candidates, including CT1812, and any expected or implied benefits or results, including that initial clinical results observed with respect to CT1812 will be replicated in later trials and our clinical development plans, including statements regarding our clinical studies of CT1812 and any analyses of the results therefrom, are forward-looking statements. These statements, including statements relating to the timing and expected results of our clinical trials involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. In some cases, you can identify forward-looking statements by terms such as “may,” “might,” “will,” “should,” “expect,” “plan,” “aim,” “seek,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “forecast,” “potential” or “continue” or the negative of these terms or other similar expressions. We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our business, financial condition, and results of operations. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified and some of which are beyond our control. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: competition; our ability to secure new (and retain existing) grant funding; our ability to grow and manage growth, maintain relationships with suppliers and retain our management and key employees; our ability to successfully advance our current and future product candidates through development activities, preclinical studies and clinical trials and costs related thereto; uncertainties inherent in the results of preliminary data, pre-clinical studies and earlier-stage clinical trials being predictive of the results of early or later-stage clinical trials; the timing, scope and likelihood of regulatory filings and approvals, including regulatory approval of our product candidates; changes in applicable laws or regulations; the possibility that the we may be adversely affected by other economic, business or competitive factors, including ongoing economic uncertainty; our estimates of expenses and profitability; the evolution of the markets in which we compete; our ability to implement our strategic initiatives and continue to innovate our existing products; our ability to defend our intellectual property; the impacts of ongoing global and regional conflicts on our business, supply chain and labor force; and the risks and uncertainties described more fully in the “Risk Factors” section of our annual and quarterly reports filed with the Securities & Exchange Commission and are available at www.sec.gov. These risks are not exhaustive and we face both known and unknown risks. You should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in our forward-looking statements may not be achieved or occur, and actual results could differ materially from those projected in the forward-looking statements. Moreover, we operate in a dynamic industry and economy. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties that we may face. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.

Contact Information:
Cognition Therapeutics, Inc.
info@cogrx.com
Casey McDonald (media) 
Tiberend Strategic Advisors, Inc.
cmcdonald@tiberend.com
Mike Moyer (investors)
LifeSci Advisors 
mmoyer@lifesciadvisors.com
   

This press release was published by a CLEAR® Verified individual.


FAQ

What is the SHIMMER study by Cognition Therapeutics (CGTX) investigating?

The SHIMMER study is investigating CT1812, Cognition Therapeutics' drug candidate, for the treatment of mild-to-moderate Dementia with Lewy Bodies (DLB).

What experts are featured in Cognition Therapeutics' (CGTX) new podcast episode on DLB research?

The podcast features Dr. James E. Galvin from the University of Miami, Dr. Lawrence S. Honig from Columbia University, and Dr. David Shprecher from Banner Sun Health Research Institute and the University of Arizona.

What are the main topics discussed in Cognition Therapeutics' (CGTX) podcast on DLB research?

The podcast discusses comparisons between Alzheimer's disease and DLB, the design of the SHIMMER study, and metrics for success in signal-finding studies for DLB treatments.

When was the new episode of Cognition Therapeutics' (CGTX) podcast on DLB research released?

The new episode was released on October 22, 2024, during DLB Awareness Month.

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