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On May 14, 2024, Codexis (NASDAQ: CDXS) announced a significant milestone in enzymatic synthesis at the TIDES USA annual meeting. The company successfully synthesized a full-length oligonucleotide via its ECO Synthesis™ platform, offering an alternative method for RNA-based therapeutics production. This platform demonstrated coupling efficiency greater than 98% and minimized impurities compared to conventional methods. Codexis also launched RNA Ligase Screening and Optimization Services, aimed at improving RNA synthesis efficiency and scalability. This development could potentially lower manufacturing costs and enhance the quality and yield of RNA therapeutics.
Codexis, Inc. (NASDAQ: CDXS) reported a 32% increase in total revenue for Q1 2024, with product revenue up 14%. The company secured its first substantial order for dsRNA Ligase from a large pharma customer. Codexis also received a $40 million loan facility agreement with Innovatus, strengthening its cash position. Additionally, the company entered into an exclusive global license agreement with Roche Sequencing Solutions, Inc. Codexis expects to achieve significant milestones in enzymatic synthesis and ECO Synthesis™ platform development, with a focus on DNA ligation. Financially, the company saw positive growth in total and product revenues, improved product gross margin, and reduced R&D and SG&A expenses. The net loss decreased compared to Q1 2023, with cash reserves to support operations until positive cash flow is expected in 2026. Codexis reaffirmed its 2024 financial guidance, anticipating growth across product and R&D revenues.