Perspective Therapeutics Presents Positive Preclinical Alpha Particle Therapy Data at the World Molecular Imaging Congress 2023 and the 36th Annual Congress of the European Association of Nuclear Medicine

Rhea-AI Summary

[212Pb]VMT-α-NET shows promise in treating neuroendocrine tumors

Positive

• Three fractionated doses of [212Pb]VMT-α-NET resulted in a 70% complete response rate and an 80% survival rate at 120 days
• A tumor dose of 32 grays (Gy) of radiation from 212Pb brought a high probability of a complete response
• Three fractionated doses of 740 kBq of [212Pb]VMT-α-NET produced 100% overall survival at 90-days

Negative

• None.

 

• [²¹²Pb]VMT-α-NET shows promise in effectively treating neuroendocrine tumors
  
  
• Administration of fractionated doses of [²¹²Pb]VMT-α-NET shows 100% survival in a robust model of metastatic neuroblastoma
  
  

SEATTLE, WA, Sept. 11, 2023 (GLOBE NEWSWIRE) -- Perspective Therapeutics, Inc. (“Perspective” or “the Company”) (NYSE AMERICAN: CATX), today announced the presentation of preclinical data from two independent studies at the World Molecular Imaging Congress (WMIC) 2023, held on September 5-9, 2023, in Prague, Czech Republic, and the 36^th Annual Congress of the European Association of Nuclear Medicine (EANM) in Vienna, Austria, from September 9-13, 2023.

Dr. Michael K. Schultz, Chief Scientific Officer at Perspective Therapeutics, presented research at the WWIC on the potential of lead-based targeted alpha particle therapy using [²¹²Pb]VMT-α-NET for the treatment of neuroendocrine tumors (NETs). The study was carried out by Dr. Dongyoul Lee, an assistant professor at the Korea Military Academy. The activity of [²¹²Pb]VMT-α-NET was studied in a tumor xenograft mouse model, both as a single dose (3.7 MBq) and three fractionated doses (3 × 1.2 MBq).

The dose depositions in tumor and normal organs were estimated based on ²⁰³Pb biodistribution data. In addition, tumor progression, survival rates, and body weight changes over a 120-day period were assessed, and favorable radiochemical characteristics were observed. Highlights of the presentation titled “Targeted Alpha Therapy for Neuroendocrine Tumors: Therapeutic Efficacy and Dosimetry Analysis of [²¹²Pb]VMT-α-NET in Preclinical Models”, include:

• Administrations of the three fractionated doses of [²¹²Pb]VMT-α-NET resulted in a 70% complete response rate and an 80% survival rate at 120 days.
• Under experimental conditions, a tumor dose of 32 grays (Gy) of radiation from ²¹²Pb brought a high probability of a complete response.
• A renal dose of 12 Gy from ²¹²Pb showed no significant toxicity indication.
  
  

“The results of our dosimetry analysis demonstrate how Perspective’s image guided approach followed by ²¹²Pb-based alpha particle therapy may represent a promising form of therapy for NETs,” said Dr. Lee. “Favorable deposition was observed in the target tumor over normal organs following the administration of ²¹²Pb-VMT-α-NET in a tumor xenograft mouse model. This indicates precision and efficacy in the treatment against NETS with the potential to outperform current standard of care therapies.”

The second study was presented by Perspective’s Principal Research Scientist Dijie Liu at the EANM Congress and looked at the establishment of a novel metastatic neuroblastoma model and the subsequent therapeutic effect of [²¹²Pb]VMT-α-NET administrations. Intracardiac injection of IMR32-luc cells led to wide-spread metastatic disease within two weeks as observed via bioluminescence imaging. Uptake in tumors was shown using sequential SPECT imaging using [²⁰³Pb]VMT-α-NET. Efficacy was demonstrated in subsequent therapeutic administrations of [²¹²Pb]VMT-α-NET. Highlights of the presentation titled “Preclinical Evaluation of [²¹²Pb]VMT-α-NET Targeted Alpha Therapy for High-Risk Metastatic Neuroblastoma”, include:

• A maximum tolerated dose (MTD) of [²¹²Pb]VMT-α-NET in severe combined immunodeficient (SCID) mice was determined as 2.22 MBq without acute toxicity.
• For the 90-day efficacy study, median survival days for vehicle control, single and 2 fractionated dose groups were 37, 66.5 and 84, respectively.
• Three fractionated doses of 740 kBq of [²¹²Pb]VMT-α-NET produced 100% overall survival at 90-days, with all having either a partial response or stable disease.
  
  

Perspective Therapeutics’ Chief Scientific Officer, Dr. Michael K. Schultz, said “This additional preclinical work further demonstrates our team’s capabilities to advance Perspective’s [²¹²Pb]VMT-α-NET program into indications beyond neuroendocrine tumors. Pediatric neuroblastoma is an indication with a very high unmet need and with this preclinical research we have demonstrated the potential of our product in this setting."

About Perspective Therapeutics, Inc.
Perspective Therapeutics, Inc., is a diversified medical technology and radiopharmaceutical company that is pioneering advanced treatment applications for cancers throughout the body. The Company has a proprietary technology that utilizes the alpha emitting isotope Lead-212 to deliver powerful radiation specifically to cancer cells via specialized targeting peptides. The Company is also developing complementary imaging diagnostics that incorporate the same targeting peptides which provide the opportunity to personalize treatment and optimize patient outcomes. This “theranostic” approach enables the ability to see the specific tumor and then treat it to potentially improve efficacy and minimize toxicity associated with many other types of cancer treatments.

The Company’s melanoma (VMT01) and neuroendocrine tumor (VMT-α-NET) programs have entered Phase 1/2a imaging and therapy trials for the treatment of metastatic melanoma and neuroendocrine tumors at several leading academic institutions. The Company has also developed a proprietary Lead-212 generator to secure key isotopes for clinical trial and commercial operations.

In addition to its targeted alpha therapy programs, Perspective is the sole producer of Cesium-131 brachytherapy seeds which are commercially available in the United States for the treatment of prostate cancer and other solid tumors.

For more information, please visit the Company’s website at www.perspectivetherapeutics.com .
  
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