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Carisma Therapeutics to Present New Data at the American Society of Gene and Cell Therapy (ASGCT) Annual Meeting

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Carisma Therapeutics Inc. (Nasdaq: CARM) announced the acceptance of two abstracts at the ASGCT 2024 Annual Meeting. The preclinical data showcases the potential of engineered macrophage cell therapy for liver and lung fibrosis treatment. The Redirected Soluble Modulator technology aims to enhance immune receptor signaling. The company looks to expand its macrophage engineering platform beyond oncology.
Carisma Therapeutics Inc. (Nasdaq: CARM) ha annunciato l'accettazione di due abstract per il Meeting Annuale ASGCT 2024. I dati preclinici mostrano il potenziale della terapia cellulare macrofagica ingegnerizzata per il trattamento della fibrosi epatica e polmonare. La tecnologia del Modulatore Solubile Riorientato mira a potenziare il segnale dei recettori immunitari. L'azienda mira ad espandere la sua piattaforma di ingegneria macrofagica oltre l'oncologia.
Carisma Therapeutics Inc. (Nasdaq: CARM) anunció la aceptación de dos resúmenes en la Reunión Anual de ASGCT 2024. Los datos preclínicos destacan el potencial de la terapia celular de macrófagos ingenierizados para el tratamiento de la fibrosis hepática y pulmonar. La tecnología de Modulador Soluble Redirigido busca mejorar la señalización del receptor inmunitario. La compañía busca expandir su plataforma de ingeniería de macrófagos más allá de la oncología.
Carisma Therapeutics Inc. (Nasdaq: CARM)가 ASGCT 2024 연례 회의에서 두 개의 초록이 수락되었다고 발표했습니다. 전임상 데이터는 간 및 폐 섬유화 치료를 위한 공학적으로 설계된 대식세포 치료제의 잠재력을 보여줍니다. 전환 가능 용해성 조절기 기술은 면역 수용체 신호를 강화하는 것을 목표로 합니다. 이 회사는 종양학을 넘어 대식세포 공학 플랫폼을 확장하고자 합니다.
Carisma Therapeutics Inc. (Nasdaq: CARM) a annoncé l'acceptation de deux résumés à la Réunion Annuelle ASGCT 2024. Les données précliniques mettent en évidence le potentiel de la thérapie cellulaire macrophage conçue pour le traitement de la fibrose du foie et des poumons. La technologie du Modulateur Soluble Redirigé vise à améliorer la signalisation des récepteurs immunitaires. L'entreprise cherche à étendre sa plateforme d'ingénierie des macrophages au-delà de l'oncologie.
Carisma Therapeutics Inc. (Nasdaq: CARM) hat die Annahme von zwei Abstracts bei der ASGCT 2024 Jahreskonferenz bekannt gegeben. Die präklinischen Daten verdeutlichen das Potenzial der entwickelten Makrophagen-Zelltherapie für die Behandlung von Leber- und Lungenfibrose. Die Technologie des umgeleiteten löslichen Modulators zielt darauf ab, die Signalgebung der Immunrezeptoren zu verbessern. Das Unternehmen strebt an, seine Plattform für Makrophagen-Engineering über die Onkologie hinaus zu erweitern.
Positive
  • The acceptance of abstracts at ASGCT 2024 signifies recognition in the gene and cell therapy field.
  • The preclinical data indicates promising results for the treatment of liver and lung fibrosis.
  • The novel Redirected Soluble Modulator technology shows potential in boosting immune receptor signaling.
  • Carisma's focus on innovative immunotherapies highlights its commitment to addressing unmet medical needs.
  • The expansion of the macrophage engineering platform into new therapeutic areas demonstrates strategic growth.
  • The availability of posters online enhances transparency and accessibility of research findings.
Negative
  • None.

Preclinical data highlights the potential of engineered macrophage cell therapy as a treatment for liver and lung fibrosis

Novel Redirected Soluble Modulator technology has demonstrated the potential to enhance immune receptor signaling

PHILADELPHIA, April 22, 2024 /PRNewswire/ -- Carisma Therapeutics Inc. (Nasdaq: CARM) ("Carisma" or the "Company"), a clinical-stage biopharmaceutical company focused on discovering and developing innovative immunotherapies, today announced the acceptance of two abstracts at the American Society of Gene and Cell Therapy (ASGCT) 2024 Annual Meeting being held May 7-11, 2024, in Baltimore, MD.

"We are excited to present new preclinical data highlighting the potential of our engineered macrophage cell therapies for the treatment of liver and lung fibrosis, both of which represent significant unmet medical needs with limited available therapies for patients," said Michael Klichinsky, PharmD, PhD, Co-founder and Chief Scientific Officer of Carisma. "We look forward to presenting these data and are excited to expand our macrophage engineering platform beyond oncology."

Poster Presentation Details:

Title: Genetically Engineered Macrophage Cell Therapy Reverses Liver and Lung Fibrosis in Preclinical Models 
Abstract #: 852
Session: Other Cellular and Regenerative Therapies
Date & Time: Wednesday, May 8, 2024; 12:00 PM ET
Location: Exhibit Hall

Title: Redirected Soluble Modulators (RSM) – A Novel Engineering Strategy to Enhance Immune Receptor Signaling
Abstract #: 812
Session: Immune Targeting and Approaches with Genetically-Modified Cells and Cell Therapies
Date & Time: Wednesday, May 8, 2024; 12:00 PM ET
Location: Exhibit Hall

The posters presented at ASGCT 2024 will be available online in the "Publications" section of Carisma's website at https://carismatx.com/technology/publications/ following the start of the respective poster sessions.

About Carisma

Carisma Therapeutics Inc. is a clinical stage biopharmaceutical company focused on utilizing our proprietary macrophage and monocyte cell engineering platform to develop transformative immunotherapies to treat cancer and other serious diseases. We have created a comprehensive, differentiated proprietary cell therapy platform focused on engineered macrophages and monocytes, cells that play a crucial role in both the innate and adaptive immune response. Carisma is headquartered in Philadelphia, PA. For more information, please visit www.carismatx.com.

Cautionary Note on Forward-Looking Statements
Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements" within the meaning of The Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements relating to Carisma's business, strategy, future operations, cash runway, the advancement of Carisma's product candidates and product pipeline, and clinical development of Carisma's product candidates, including expectations regarding timing of initiation and results of clinical trials. The words "anticipate," "believe," "contemplate," "continue," "could," "estimate," "expect," "goals," "intend," "may," "might," "outlook," "plan," "project," "potential," "predict," "target," "possible," "will," "would," "could," "should," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words.

Any forward-looking statements are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. These risks and uncertainties include, but are not limited to, (i) Carisma's ability to obtain, maintain and protect its intellectual property rights related to its product candidates; (ii) Carisma's ability to advance the development of its product candidates under the timelines it anticipates in planned and future clinical trials and with its current financial and human resources; (iii) Carisma's ability to replicate in later clinical trials positive results found in preclinical studies and early-stage clinical trials of its product candidates; (iv) Carisma's ability to realize the anticipated benefits of its research and development programs, strategic partnerships, research and licensing programs and academic and other collaborations; (v) regulatory requirements or developments and Carisma's ability to obtain and maintain necessary approvals from the U.S. Food and Drug Administration and other regulatory authorities related to its product candidates; (vi) changes to clinical trial designs and regulatory pathways; (vii) risks associated with Carisma's ability to manage expenses; (viii) changes in capital resource requirements; (ix) risks related to the inability of Carisma to obtain sufficient additional capital to continue to advance its product candidates and its preclinical programs; and (x) legislative, regulatory, political and economic developments.

For a discussion of these risks and uncertainties, and other important factors, any of which could cause Carisma's actual results to differ from those contained in the forward-looking statements, see the "Risk Factors" set forth in the Company's Annual Report on Form 10-K for the year ended December 31, 2023, as well as discussions of potential risks, uncertainties, and other important factors in Carisma's other recent filings with the Securities and Exchange Commission. Any forward-looking statements that are made in this press release speak as of the date of this press release. Carisma undertakes no obligation to revise the forward-looking statements or to update them to reflect events or circumstances occurring after the date of this press release, whether as a result of new information, future developments or otherwise, except as required by the federal securities laws.

Investors:
Shveta Dighe
Head of Investor Relations
investors@carismatx.com

Media Contact:
Julia Stern
(763) 350-5223
jstern@realchemistry.com

Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/carisma-therapeutics-to-present-new-data-at-the-american-society-of-gene-and-cell-therapy-asgct-annual-meeting-302123620.html

SOURCE Carisma Therapeutics Inc.

FAQ

What did Carisma Therapeutics announce regarding the ASGCT 2024 Annual Meeting?

Carisma Therapeutics announced the acceptance of two abstracts at the ASGCT 2024 Annual Meeting.

What is the focus of the preclinical data presented by Carisma Therapeutics?

The preclinical data highlights the potential of engineered macrophage cell therapy for liver and lung fibrosis treatment.

What technology did Carisma Therapeutics showcase to enhance immune receptor signaling?

Carisma Therapeutics presented the Redirected Soluble Modulator technology to enhance immune receptor signaling.

When and where will Carisma Therapeutics present the abstracts at the ASGCT 2024 Annual Meeting?

Carisma Therapeutics will present the abstracts on Wednesday, May 8, 2024, at 12:00 PM ET in the Exhibit Hall.

Where can the posters presented at ASGCT 2024 be accessed online?

The posters will be available online in the 'Publications' section of Carisma's website at https://carismatx.com/technology/publications/

Carisma Therapeutics, Inc.

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