Can-Fite BioPharma Ltd. American Depositary Shares, each representing three hundred (300) Ordinary Shares - CANF STOCK NEWS

Can-Fite BioPharma (NYSE American: CANF) announced positive results from the Phase III COMFORT study for its drug Piclidenoson, targeting psoriasis. The study showed significant efficacy, surpassing placebo and demonstrating a safety profile comparable to that of placebo and better tolerated than Otezla®. CEO Dr. Pnina Fishman will present the findings at the 6th Annual Dermatology Drug Development Summit in Boston on November 2, 2022. With over 400 adults assessed, the promising outcomes set the stage for an upcoming pivotal Phase III registration trial.

Can-Fite BioPharma has announced the initiation of a global pivotal Phase III study for Namodenoson, a treatment for advanced liver cancer, also known as hepatocellular carcinoma (HCC). A case report presented at the AASLD’s The Liver Meeting highlights a patient who achieved a complete response after five years of treatment. The pivotal study is open for patient enrollment in various countries, including Israel and the U.S. Namodenoson holds Orphan Drug and Fast Track Status in both the U.S. and Europe.

Can-Fite BioPharma is advancing its Namodenoson liver drug candidate in a Phase IIb NASH study after a successful Phase IIa trial. CEO Dr. Pnina Fishman will present at the H.C. Wainwright 6th Annual NASH Investor Conference on October 17, 2022. NASH represents a significant market opportunity, expected to reach $35-$40 billion by 2025. The ongoing Phase IIb trial will evaluate Namodenoson’s efficacy against placebo in 140 subjects. Namodenoson has shown promise as a treatment for NASH and hepatocellular carcinoma, achieving Orphan Drug and Fast Track Designations.

Can-Fite BioPharma Ltd. (NYSE American: CANF) will be featured in an interview on The RedChip Money Report airing on Bloomberg TV on September 24, 2022, at 7 p.m. ET. CEO Dr. Pnina Fishman will discuss key topics including the Company's Phase 3 trials for Psoriasis and Liver Cancer, and potential $100 million in milestone payments. Can-Fite is advancing therapies in inflammatory, cancer, and liver diseases, with drugs like Namodenoson and Piclidenoson showing promising results in clinical trials. The interview can be accessed in full on Can-Fite’s website.

Can-Fite BioPharma (NYSE American: CANF) announced positive results from the Phase III COMFORT™ study of its psoriasis treatment, Piclidenoson, presented by Dr. Kim Papp at the EADV Congress. The study met its primary endpoint, showing a statistically significant improvement over placebo (p=0.037) at 16 weeks. Piclidenoson demonstrated a safety profile comparable to placebo and better tolerability than Otezla®. The drug is set to progress into a pivotal Phase III registration trial for moderate to severe psoriasis and has shown promise for long-term treatment.

Can-Fite BioPharma Ltd. (NYSE American: CANF) reported financial results for the quarter ending June 30, 2022, showcasing a strong balance sheet with $12.72 million in cash. Key developments include the approval of Namodenoson for compassionate use in Romania and the initiation of a pivotal Phase III study for liver cancer. The Phase III COMFORT trial for psoriasis successfully met its primary endpoint with Piclidenoson. Revenues reached $0.40 million, up 2.7%, while net loss declined to $4.62 million. The company plans to submit registration for Piclidenoson to FDA and EMA.

Can-Fite BioPharma announced that its liver cancer drug Namodenoson has been approved for compassionate use in Romania, showing complete response in at least one patient. The Phase III pivotal study for advanced liver cancer is now open for patient enrollment in multiple countries, including Israel and the U.S. The FDA and EMA have provided regulatory support, and Namodenoson has Orphan Drug and Fast Track status. The liver cancer market is projected to reach $3.8 billion by 2027, reflecting a significant opportunity for Can-Fite.

Can-Fite BioPharma (NYSE: CANF) announced that Dr. Kim A. Papp will present findings from the Phase III COMFORT study at the 31st EADV Congress in Milan on September 10, 2022. The study showed that Piclidenoson significantly improved psoriasis symptoms compared to placebo. Dr. Papp, a leading expert with over 150 studies, is also designing a pivotal Phase III trial for FDA and EMA submission. Can-Fite's drug candidate is positioned to address severe psoriasis, leveraging its unique mechanism of action to inhibit inflammatory cytokines.

Can-Fite BioPharma (NYSE American: CANF) announced the completion of a safety study for Piclidenoson, a treatment for canine osteoarthritis. The efficacy trial will be financed by Vetbiolix, which holds exclusive rights to Piclidenoson for two years. The global market for canine osteoarthritis is anticipated to reach $3 billion by 2028. If successful, Vetbiolix will pay Can-Fite milestone and royalty fees upon regulatory approval. Piclidenoson aims to provide a safer alternative to current NSAID treatments.