Can-Fite BioPharma Ltd. American Depositary Shares, each representing three hundred (300) Ordinary Shares - CANF STOCK NEWS

Can-Fite BioPharma (NYSE American: CANF) announced the initiation of preclinical studies for its drug candidates Piclidenoson and Namodenoson, in preparation for future NDA and MAA submissions to the FDA and EMA. Piclidenoson is currently in the COMFORT Phase III study for psoriasis, while Namodenoson, which has Orphan Drug and Fast Track Status, will begin a Phase III study for hepatocellular cancer by Q4 2021. The company aims to obtain marketing approvals for both drugs, addressing significant market needs.

Can-Fite BioPharma Ltd (NYSE American: CANF) announced successful pre-clinical studies showing that a CBD-rich T3/C15 cannabis fraction inhibits liver cancer cell growth. This mechanism targets the A3 adenosine receptor (A3AR), crucial in liver cancer treatment. The company’s drug candidate Namodenoson is set to enter a Phase III study for advanced liver cancer in Q4 2021. The global medical cannabis market is projected to grow to $56.7 billion by 2026, highlighting significant market opportunities for Can-Fite’s cannabinoid-based therapies.

Can-Fite BioPharma Ltd. (NYSE American: CANF) has announced that its six distribution agreements for drug candidates Piclidenoson and Namodenoson could yield up to $130 million in milestone payments, alongside double-digit royalties on net sales. The company has already secured over $20 million in non-dilutive upfront and milestone payments. Territories covered include Canada, Spain, Switzerland, and more, with further discussions targeting larger markets like the U.S. and Japan. CEO Dr. Pnina Fishman emphasized the strategic growth potential in untapped markets.

Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI) reported a net loss of $14.44 million for the year ended December 31, 2020, an increase from $12.62 million in 2019. Revenues decreased to $0.76 million, down 63% from $2.03 million. Their cash position improved to $8.26 million from $2.69 million due to $17.68 million in financing activities. Can-Fite announced a $42.7 million out-licensing deal with Ewopharma and is progressing with clinical trials for drugs targeting COVID-19, psoriasis, and liver cancer.

Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI) announced an upcoming interview with CEO Dr. Pnina Fishman on The RedChip Money Report®, airing on March 20th at 7 p.m. ET. In the interview, Dr. Fishman will discuss significant milestones and the company’s proprietary drug pipeline targeting inflammatory, cancer, and liver diseases. Notably, Can-Fite's lead candidates include Piclidenoson and Namodenoson, both in advanced clinical studies. This interview aims to reach a large audience, potentially impacting investor interest.

Can-Fite BioPharma Ltd (NYSE American: CANF, TASE: CFBI) announced positive results from a preclinical study on its drug candidate CF602 for treating erectile dysfunction (ED) in diabetic rats. The study showed that CF602, particularly at a 500 nM dose, led to significant improvements in ED compared to placebo groups (p<0.001). The market for ED therapies is projected to reach $3.2 billion by 2022, and the company sees CF602 as a valuable candidate due to its safety profile as a topical treatment. Can-Fite also has other drugs in development targeting common and severe conditions.

Can-Fite BioPharma Ltd. (NYSE American: CANF) has signed an exclusive distribution agreement with Ewopharma for its drugs Piclidenoson and Namodenoson. The agreement includes an upfront payment of $2.25 million and potential milestone payments of up to $40.45 million, along with 17.5% royalties on net sales. Piclidenoson is aimed at treating psoriasis, while Namodenoson targets liver diseases like hepatocellular carcinoma (HCC) and NASH. This partnership offers Can-Fite immediate access to Central Eastern European markets and non-dilutive funding.

Can-Fite BioPharma Ltd. (NYSE American: CANF) has commenced a Phase II COVID-19 study, enrolling the first of 40 patients. The study, randomized and double-blind, evaluates Piclidenoson combined with standard supportive care versus placebo in hospitalized patients with moderate to severe COVID-19. Efficacy assessments will occur at Day 29, focusing on clinical status and safety data. Piclidenoson is a first-in-class treatment with proven anti-inflammatory effects, also being tested in psoriasis trials. The company's lead drug is positioned in multi-billion dollar markets addressing cancer and liver diseases.

Can-Fite BioPharma Ltd. (NYSE: CANF) (TASE: CFBI) announced promising results from its Phase II study of Namodenoson for advanced liver cancer, showcasing nearly 4 years of overall survival in two patients, with notable improvements in ascites and liver function. The FDA and EMA approved the pivotal Phase III trial design, which plans to enroll 450 patients. Namodenoson holds Orphan Drug Designation and Fast Track Status in the U.S. This development marks a significant step towards a New Drug Application for hepatocellular carcinoma treatment.