CalciMedica Announces Appointment of Dr. Alan Glicklich to Board of Directors

Rhea-AI Summary

CalciMedica (Nasdaq: CALC) announced the appointment of Dr. Alan Glicklich to its Board of Directors, effective January 15, 2025. Dr. Glicklich, currently Chief Medical Officer of Nuvig Therapeutics, brings over 20 years of biotechnology industry experience. He will contribute to CalciMedica's development of Auxora, their CRAC channel inhibition therapy, as it progresses toward Phase 3 trials in acute pancreatitis and awaits data from the KOURAGE trial in acute kidney injury.

Dr. Glicklich's experience includes leadership roles at Chinook Therapeutics, Bird Rock Bio, and Arena Pharmaceuticals, where he successfully led clinical development programs. At Nuvig Therapeutics, he is currently preparing multiple Phase 2 trials for inflammatory autoimmune diseases. His appointment strengthens CalciMedica's expertise in inflammatory and immunologic disease spaces.

Positive

• Auxora shows promising Phase 2 clinical trial results in reducing organ failure
• Company advancing toward Phase 3 trial for acute pancreatitis
• Addition of experienced board member with relevant clinical development expertise

Negative

• No currently approved disease-modifying therapies in target indications
• KOURAGE trial results still pending

LA JOLLA, Calif., Jan. 14, 2025 /PRNewswire/ -- CalciMedica Inc. ("CalciMedica" or the "Company") (Nasdaq: CALC), a clinical-stage biopharmaceutical company focused on developing novel calcium release-activated calcium (CRAC) channel inhibition therapies for acute and chronic inflammatory and immunologic illnesses, today announced the appointment of Alan Glicklich, M.D. to the Company's Board of Directors effective on January 15, 2025. Dr. Glicklich has more than 20 years of experience in the biotechnology industry and currently serves as Chief Medical Officer of Nuvig Therapeutics.

"We are very pleased to welcome Alan to our Board and excited to benefit from his extensive clinical development experience and impressive track record working with biotech and pharma companies, specifically in the inflammatory and immunologic disease spaces," said Rachel Leheny, Ph.D., Chief Executive Officer of CalciMedica. "As we progress Auxora towards a Phase 3 trial in acute pancreatitis and look ahead to data from our KOURAGE trial in acute kidney injury, Alan's perspective will be extremely valuable to CalciMedica."

In his position at Nuvig Therapeutics, a company pursuing multiple inflammatory autoimmune diseases, Dr. Glicklich is currently leading a clinical team planning to initiate multiple Phase 2 trials. Prior to Nuvig, Dr. Glicklich was Chief Medical Officer of Chinook Therapeutics, where he was responsible for the clinical development, clinical operations, medical affairs, biometrics, regulatory, and pharmacovigilance teams. While at Chinook, he designed and operationalized a successful Phase 3 registrational study for atrasentan in IgA nephropathy as well as multiple earlier phase studies across rare chronic kidney disease indications. Before that, Dr. Glicklich was Chief Medical Officer at Bird Rock Bio, where he focused on monoclonal antibody development for inflammatory and fibrotic diseases. Prior to Bird Rock, he was Vice President of Clinical Development at Arena Pharmaceuticals, where he designed and operationalized two Phase 2 programs in pulmonary arterial hypertension and ulcerative colitis. Dr. Glicklich has also held positions at BMS, Sanofi-Aventis, and Regeneron. Dr. Glicklich holds an M.D. from the University of Wisconsin and an M.B.A. from the Emory University-Goizueta School of Business, as well as a B.A. in Biology from the University of Chicago.

"I am impressed by the data from the multiple Phase 2 clinical trials with CalciMedica's drug, Auxora, which has shown a variety of benefits, including a substantial reduction in organ failure, in acute inflammatory diseases. These benefits are important to patients in CalciMedica's lead indications of acute pancreatitis and acute kidney injury, in which organ failure is a significant cause of mortality and morbidity, no disease-modifying therapies are available, and the standard of care is inadequate. I look forward to working with the team at CalciMedica to bring these much-needed therapies to patients," said Dr. Glicklich.

About CalciMedica
CalciMedica is a clinical-stage biopharmaceutical company focused on developing novel CRAC channel inhibition therapies for inflammatory and immunologic diseases. CalciMedica's proprietary technology targets the inhibition of CRAC channels to modulate the immune response and protect against tissue cell injury, with the potential to provide therapeutic benefits in life-threatening inflammatory and immunologic diseases for which there are currently no approved therapies. CalciMedica's lead product candidate Auxora™ has demonstrated positive and consistent clinical results in multiple completed efficacy clinical trials. CalciMedica has announced data for a Phase 2b trial (called CARPO – NCT04681066) in patients with acute pancreatitis (AP) and accompanying systemic inflammatory response syndrome (SIRS). The Company has also completed a Phase 2 trial (called CARDEA – NCT04345614) in patients with COVID pneumonia. The Company is currently conducting a Phase 2 trial (called KOURAGE – NCT06374797) in patients with acute kidney disease (AKI) with associated acute hypoxemic respiratory failure (AHRF) with data expected in 2025 and continuing to support the ongoing Phase 1/2 trial (called CRSPA – NCT04195347) in pediatric patients with asparaginase-induced pancreatic toxicity (AIPT) with data expected in 2025. CalciMedica was founded by scientists from Torrey Pines Therapeutics and the Harvard CBR Institute for Biomedical Research, and is headquartered in La Jolla, CA. For more information, please visit www.calcimedica.com.

Forward-Looking Statements
This communication contains forward-looking statements which include, but are not limited to,  CalciMedica's ongoing and planned clinical trials and the timing and design thereof, including its plans to progress a Phase 3 trial of Auxora in AP, and the expected timing for the release of data from those trials, including its ongoing Phase 1/2 CRSPA trial of Auxora in pediatric patients with AIPT and its ongoing Phase 2 KOURAGE trial of Auxora in AKI with associated AHRF; the potential benefits of Auxora for the treatment of AP, AKI and AIPT; and the potential of CalciMedica's proprietary technology to provide therapeutic benefits in life-threatening inflammatory and immunologic diseases. These forward-looking statements are subject to the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. CalciMedica's expectations and beliefs regarding these matters may not materialize. Actual outcomes and results may differ materially from those contemplated by these forward-looking statements as a result of uncertainties, risks, and changes in circumstances. Risks and uncertainties that could cause actual outcomes and results to differ materially from those contemplated by the forward-looking statements are included under the caption "Risk Factors" in CalciMedica's Quarterly Report on Form 10-Q for the quarter ended September 30, 2024, filed with the U.S. Securities and Exchange Commission (SEC) on November 13, 2024, and elsewhere in CalciMedica's subsequent reports on Form 10-K, Form 10-Q or Form 8-K filed with the SEC from time to time and available at www.sec.gov. These documents can be accessed on CalciMedica's web page at ir.calcimedica.com/financials-filings/sec-filings. The forward-looking statements contained herein are made as of the date hereof, and CalciMedica undertakes no obligation to update them after this date, except as required by law.

CalciMedica Contact:

Investors and Media
Argot Partners
Sarah Sutton/Kevin Murphy
calcimedica@argotpartners.com
(212) 600-1902

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SOURCE CalciMedica, Inc.

FAQ

What is the significance of Dr. Glicklich joining CalciMedica's (CALC) board in January 2025?

Dr. Glicklich brings over 20 years of biotechnology experience and expertise in inflammatory and immunologic diseases, which is valuable for CalciMedica's development of Auxora and upcoming Phase 3 trials.

What are the main indications for CalciMedica's (CALC) drug Auxora?

Auxora is being developed for acute pancreatitis (moving to Phase 3) and acute kidney injury (KOURAGE trial), conditions where organ failure is a significant cause of mortality and morbidity.

What clinical stage is CalciMedica's (CALC) Auxora in for acute pancreatitis?

Auxora has completed Phase 2 trials and is progressing toward Phase 3 trials for acute pancreatitis.

What results has CalciMedica's (CALC) Auxora shown in clinical trials?

Auxora has demonstrated benefits in Phase 2 clinical trials, including a substantial reduction in organ failure in acute inflammatory diseases.