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Candel Therapeutics, Inc. (NASDAQ: CADL) is a clinical-stage biopharmaceutical company at the forefront of developing innovative viral-based immunotherapies to combat cancer. Headquartered in Massachusetts, the company leverages its proprietary multimodal platforms to deliver off-the-shelf therapies that elicit a robust and individualized systemic anti-tumor immune response. Operating within the competitive and rapidly evolving immuno-oncology space, Candel Therapeutics addresses significant unmet medical needs by targeting solid tumors with precision and innovation.
Core Technologies and Platforms
Candel Therapeutics has established two proprietary viral-based immunotherapy platforms designed to revolutionize cancer treatment:
- Gene Mediated Cytotoxic Immunotherapy (GMCI™) Platform: This platform utilizes genetically modified adenoviruses to deliver a localized, tumor-targeted immune response. As an "off-the-shelf" solution, GMCI™ activates the patient’s immune system to generate a personalized and precise response against cancer cells without requiring extensive customization.
- enLIGHTEN™ Discovery Platform: A systematic, iterative platform leveraging herpes simplex virus (HSV) constructs and advanced analytics to create novel viral immunotherapies. This platform is designed to accelerate the discovery and development of therapies for solid tumors, utilizing human biology insights to optimize therapeutic outcomes.
Pipeline and Key Product Candidates
Candel’s product pipeline is anchored by two lead candidates:
- CAN-2409: Developed from the adenovirus platform, this candidate is undergoing clinical trials for multiple indications, including non-small cell lung cancer (NSCLC), borderline resectable pancreatic ductal adenocarcinoma (PDAC), and localized prostate cancer. CAN-2409 aims to address patients who are non-responsive to traditional immune checkpoint inhibitors, providing a novel therapeutic option.
- CAN-3110: Originating from the HSV platform, this candidate is being evaluated in phase 1b trials for recurrent high-grade glioma (rHGG). Designed to treat difficult-to-treat cancers, CAN-3110 demonstrates the potential of HSV-based therapies in addressing aggressive tumor types.
Market Position and Competitive Landscape
Operating within the immuno-oncology sector, Candel Therapeutics competes against established biopharmaceutical giants and emerging innovators. The company differentiates itself through its multimodal approach, combining the benefits of viral-based platforms with advanced analytics and human biology insights. This unique positioning allows Candel to address complex cancers with tailored, systemic solutions that complement existing therapies.
Significance and Industry Impact
Candel Therapeutics’ commitment to developing off-the-shelf, multimodal immunotherapies positions it as a key player in the fight against cancer. By focusing on systemic, individualized immune responses, the company addresses critical gaps in current treatment paradigms. Its innovative platforms and promising clinical results underscore its potential to transform cancer care, making it a noteworthy entity in the biopharmaceutical industry.
Candel Therapeutics, Inc. (Nasdaq: CADL) announced participation in two investor conferences. CEO Paul Peter Tak will attend Citi's 17th Annual BioPharma Conference in Boston on September 7. Candel will also present at the H.C. Wainwright 24th Annual Global Investment Conference via webcast on September 12 at 7:00 AM ET. The company focuses on oncolytic viral immunotherapies for cancer treatment, with lead products CAN-2409 and CAN-3110. A webcast of the latter presentation will be archived for up to 90 days. Visit Candel's website for more details.
Candel Therapeutics, Inc. (Nasdaq: CADL) reported its Q2 2022 financial results, revealing a net loss of $4.1 million, a significant decrease from $17.1 million in Q2 2021. The company maintains a strong cash position of $86.8 million, sufficient to fund operations into Q1 2024. Candel announced a promising 87.5% disease control rate from its phase 2 clinical trial of CAN-2409 in NSCLC at ASCO 2022. Upcoming milestones include phase 3 trials for high-grade glioma and updates on their enLIGHTEN™ Discovery Platform.
Candel Therapeutics, Inc. (Nasdaq: CADL) announced the appointment of three new board members, Gary Nabel, Joseph C. Papa, and Renee Gaeta, effective August 8, 2022. Their extensive experience in biopharmaceuticals and finance is expected to bolster Candel's strategies in oncolytic viral immunotherapies for cancer treatment. The new directors replace outgoing members, maintaining the board's nine-member structure. Candel aims to leverage this leadership change to enhance its growth and innovation in the cancer treatment space.
Candel Therapeutics reported promising findings from its Phase 2 clinical trial of CAN-2409 in patients with advanced non-small cell lung cancer (NSCLC) at the ASCO Annual Meeting.
The trial demonstrated a 87.5% disease control rate in patients previously progressing on anti-PD-1 therapy, with 62.5% showing durable stabilization. A 15% partial response rate was observed, along with tumor regression in both injected and uninjected lesions. The treatment was well tolerated, highlighting CAN-2409's potential as a viable option for NSCLC patients lacking effective alternatives.
Candel Therapeutics, a late clinical-stage biopharmaceutical company focused on oncolytic viral immunotherapies, announced that CEO Paul Peter Tak will present at H.C. Wainwright’s Annual Global Investment Conference.
Date: May 24, 2022, Time: 7:00 am ET for on-demand viewing. Candel's leading candidates include CAN-2409 and CAN-3110, designed to induce immune responses against cancer. For more details, visit Candel Therapeutics’ website.
Candel Therapeutics (Nasdaq: CADL) reported its Q1 2022 financial results and outlined key advancements in oncolytic viral immunotherapy for cancer. The company strengthened its cash position with a $20 million debt financing and reported cash equivalents of $94.3 million as of March 31, 2022. Research and development expenses rose to $5.4 million, reflecting increased clinical trial activities. Notably, the net loss decreased to $874,000 compared to $4.5 million in Q1 2021. Candel is set to present pivotal clinical data at the upcoming ASCO Annual Meeting in June 2022.
Candel Therapeutics, Inc. (Nasdaq: CADL) announced the acceptance of an abstract for presentation at the ASCO Annual Meeting 2022, scheduled for June 3-7 at McCormick Place, Chicago. The abstract will present data from a phase 2 clinical trial on CAN-2409 and valacyclovir in combination with anti-PD-1/PD-L1 agents for treating stage III/IV NSCLC patients. Key details include:
- Abstract Title: First report of safety/tolerability and preliminary antitumor activity of CAN-2409
- Presenter: Charu Aggarwal
- Date: June 6, 2022
- Abstract Number: 9037
Candel Therapeutics (CADL) reported a strong cash position of $82.6 million as of December 31, 2021, up from $35.1 million in 2020, bolstered by a successful IPO. Despite a net loss of $36.1 million for the year, the company plans to present key clinical trial data in 2022, seeking to advance its oncolytic viral immunotherapies for various cancers. Operating expenses increased to $25.9 million, driven by R&D and administrative costs linked to its growth strategy. Candel is positioned for critical milestones with upcoming data readouts expected in mid-2022.
Candel Therapeutics (Nasdaq: CADL) has appointed Dr. Seshu Tyagarajan as the Chief Technical and Development Officer. Tyagarajan brings over 20 years of experience from Novartis, where she led CGT manufacturing strategies, including the BLA submission for Kymriah, the first FDA-approved CAR-T therapy. Her expertise in biologics manufacturing is expected to enhance Candel’s development efforts for oncolytic viral immunotherapy, which targets solid tumors. The company aims to leverage her insights to elevate its technical operations.
Candel Therapeutics, Inc. (Nasdaq: CADL) has secured a $25 million loan from Silicon Valley Bank, with $20 million available immediately and up to $5 million contingent on specific milestones. This financing extends the company's cash runway into Q4 2023, providing operational flexibility ahead of key clinical trials, including CAN-2409 and CAN-3110. CEO Paul Peter Tak highlights the attractive, non-dilutive terms of the loan as beneficial for upcoming data release and trial initiation, crucial for the company's oncolytic viral immunotherapy programs.
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