Welcome to our dedicated page for Cabaletta Bio news (Ticker: CABA), a resource for investors and traders seeking the latest updates and insights on Cabaletta Bio stock.
Cabaletta Bio, Inc. (symbol: CABA) is a clinical-stage biotechnology company dedicated to the discovery and development of engineered T cell therapies for patients suffering from B cell-mediated autoimmune diseases. Utilizing its proprietary Chimeric AutoAntibody Receptor (CAAR) and Chimeric Antigen Receptor T cells for autoimmunity (CARTA) technologies, Cabaletta aims to provide targeted, effective, and potentially curative treatments.
The company's flagship product candidate, DSG3-CAART, is in Phase I clinical trials for treating mucosal pemphigus vulgaris, an autoimmune blistering skin disease. Other promising candidates include MuSK-CAART for myasthenia gravis and FVIII-CAART for a subset of patients with hemophilia A. Cabaletta is also actively developing DSG3/1-CAART for mucocutaneous pemphigus vulgaris, with several products in various stages of preclinical and discovery phases.
In recent developments, Cabaletta Bio received approval from the U.S. FDA for its Investigational New Drug (IND) application for CABA-201, a fully human CD19-CAR T cell investigational therapy for generalized myasthenia gravis (gMG). This expands their portfolio into neurology, complementing prior clearances for lupus, myositis, and systemic sclerosis. The upcoming Phase 1/2 clinical trial for CABA-201 aims to test its efficacy in treating gMG patients, potentially offering a groundbreaking one-time dose treatment.
Furthermore, Cabaletta has secured multiple Fast Track Designations from the FDA for CABA-201 in conditions like dermatomyositis and systemic sclerosis, facilitating expedited development and review. These designations highlight the critical unmet needs in these patient populations and amplify Cabaletta’s commitment to pioneering advanced therapies.
Based in Philadelphia, PA, Cabaletta Bio continues to advance its innovative pipeline, guided by robust scientific research and strategic collaborations. The company is well-positioned financially, with adequate resources to fund its operations into the first half of 2026. Cabaletta's mission is to harness the power of engineered T cells to unlock transformative therapies, offering patients durable, drug-free remissions and improved quality of life.
Cabaletta Bio has received Fast Track Designation from the FDA for its MuSK-CAART therapy, aimed at improving daily living and muscle strength in patients with MuSK antibody-positive myasthenia gravis (MG). The IND application was cleared, enabling a first-in-human clinical trial set to start in 2022 with approximately 20 patients. The trial will include dose escalation and cohort expansion. The therapy targets autoantibodies specifically, addressing a critical unmet need as current treatments have significant limitations.
Cabaletta Bio, a clinical-stage biotechnology company focused on targeted cell therapies for autoimmune diseases, announced that CEO Steven Nichtberger will join the Neuromuscular corporate panel at the Cowen Virtual 42nd Annual Health Care Conference on March 7, 2022, at 9:10 a.m. ET.
A live webcast will be accessible on the company's website, with replays available for 30 days. Cabaletta Bio's innovative CABA platform aims to develop therapies for conditions like pemphigus vulgaris and myasthenia gravis, positioning the company at the forefront of biotechnological advancements in autoimmune treatment.
Cabaletta Bio, a clinical-stage biotechnology company, has announced the promotions of Gwendolyn Binder, Ph.D. to President of Science and Technology and Arun Das, M.D. to Chief Business Officer. Dr. Binder, previously Executive Vice President, has a strong background in engineered T cell therapy, while Dr. Das, formerly Executive Director of New Product Planning, has significant experience in business development. Both leaders will report to CEO Steven Nichtberger, emphasizing strategic contributions to enhance the company's mission to develop treatments for B cell-mediated autoimmune diseases.
Cabaletta Bio, a clinical-stage biotechnology company (Nasdaq: CABA), announced that CEO Steven Nichtberger, M.D. will present at the 40th Annual J.P. Morgan Healthcare Conference on January 12, 2022, at 9:00 a.m. ET. A live webcast will be available on their website, with a replay accessible for 90 days.
The company focuses on engineered T cell therapies for B cell-mediated autoimmune diseases. Their lead candidate, DSG3-CAART, is in the DesCAARTes™ Phase 1 clinical trial for pemphigus vulgaris and has received Fast Track Designation from the FDA.
Cabaletta Bio, a clinical-stage biotechnology company focused on engineered T cell therapies, announced that CEO Steven Nichtberger will present a pre-recorded company presentation at the H.C. Wainwright BioConnect Conference. This presentation will be available for on-demand viewing starting January 10, 2022, at 7:00 a.m. ET. The replay will be accessible on the company's website for 90 days. The company is developing therapies targeting B cell-mediated autoimmune diseases, including its lead candidate DSG3-CAART for mucosal pemphigus vulgaris, which has received Fast Track Designation from the FDA.
Cabaletta Bio (Nasdaq: CABA) reported top-line results from the DesCAARTes™ Phase 1 trial evaluating DSG3-CAART for mucosal Pemphigus Vulgaris. As of December 12, 2021, six patients from the two lowest dose cohorts have completed follow-ups. Notable findings revealed that in cohort A1, two of three participants exhibited worsened disease activity, while one participant showed improvement. In cohort A2, two of three patients maintained stable conditions. The trial aims to expand dosage and optimize treatment efficacy, with future results expected in early 2022.
On November 9, 2021, Cabaletta Bio, a clinical-stage biotechnology company focused on engineered T cell therapies for B cell-mediated autoimmune diseases, announced its participation in two investor conferences. The events include the Guggenheim Securities 3rd Annual Neuro/Immunology Conference on November 16 and the Evercore ISI 4th Annual HealthCONx Conference on November 30, featuring fireside chats by CEO Steven Nichtberger. The company’s proprietary CABA™ platform targets specific autoantibody-producing B cells and is evaluating its lead candidate, DSG3-CAART, in a Phase 1 trial.
Cabaletta Bio, Inc. (Nasdaq: CABA) has appointed Samik Basu, M.D. as Chief Scientific Officer and Heather Harte-Hall as Chief Compliance Officer. Both executives have extensive experience and will report to Gwendolyn Binder, Ph.D., Executive Vice President of Science & Technology. Dr. Basu, previously Vice President of Preclinical Research, has a background in T-cell immunotherapy, while Ms. Harte-Hall has led compliance at Adaptimmune Therapeutics. These appointments aim to strengthen leadership as the company advances its DSG3-CAART product candidate for mucosal pemphigus vulgaris.
Cabaletta Bio reported promising updates from the DesCAARTes™ Phase 1 trial, highlighting a dose-dependent increase in DSG3-CAART persistence in the third patient cohort. No dose-limiting toxicities or significant adverse events were recorded as of October 31, 2021. The company ended Q3 2021 with $119.3M in cash and expects funding to last through 1Q23. Upcoming milestones include the top-line biologic activity data from the first two low-dose cohorts and an IND submission for MuSK-CAART.
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