Welcome to our dedicated page for Cabaletta Bio news (Ticker: CABA), a resource for investors and traders seeking the latest updates and insights on Cabaletta Bio stock.
Cabaletta Bio, Inc. (symbol: CABA) is a clinical-stage biotechnology company dedicated to the discovery and development of engineered T cell therapies for patients suffering from B cell-mediated autoimmune diseases. Utilizing its proprietary Chimeric AutoAntibody Receptor (CAAR) and Chimeric Antigen Receptor T cells for autoimmunity (CARTA) technologies, Cabaletta aims to provide targeted, effective, and potentially curative treatments.
The company's flagship product candidate, DSG3-CAART, is in Phase I clinical trials for treating mucosal pemphigus vulgaris, an autoimmune blistering skin disease. Other promising candidates include MuSK-CAART for myasthenia gravis and FVIII-CAART for a subset of patients with hemophilia A. Cabaletta is also actively developing DSG3/1-CAART for mucocutaneous pemphigus vulgaris, with several products in various stages of preclinical and discovery phases.
In recent developments, Cabaletta Bio received approval from the U.S. FDA for its Investigational New Drug (IND) application for CABA-201, a fully human CD19-CAR T cell investigational therapy for generalized myasthenia gravis (gMG). This expands their portfolio into neurology, complementing prior clearances for lupus, myositis, and systemic sclerosis. The upcoming Phase 1/2 clinical trial for CABA-201 aims to test its efficacy in treating gMG patients, potentially offering a groundbreaking one-time dose treatment.
Furthermore, Cabaletta has secured multiple Fast Track Designations from the FDA for CABA-201 in conditions like dermatomyositis and systemic sclerosis, facilitating expedited development and review. These designations highlight the critical unmet needs in these patient populations and amplify Cabaletta’s commitment to pioneering advanced therapies.
Based in Philadelphia, PA, Cabaletta Bio continues to advance its innovative pipeline, guided by robust scientific research and strategic collaborations. The company is well-positioned financially, with adequate resources to fund its operations into the first half of 2026. Cabaletta's mission is to harness the power of engineered T cells to unlock transformative therapies, offering patients durable, drug-free remissions and improved quality of life.
Cabaletta Bio, a clinical-stage biotechnology company focused on targeted cell therapies for autoimmune diseases, has announced an underwritten public offering of pre-funded warrants and common stock. The offering aims to sell 6,213,776 pre-funded warrants at $5.51999 each and 126,815 shares of common stock at $5.52, totaling expected gross proceeds of approximately $35 million. The offering, which is oversubscribed and backed by prominent investors, is set to close on December 12, 2022. Proceeds will fund the clinical development of CABA-201 and other ongoing studies.
Cabaletta Bio (Nasdaq: CABA) announced that Dr. Steven Nichtberger will join a virtual fireside chat at the 5th Annual Evercore ISI HealthCONx Conference on November 30, 2022, at 9:40 a.m. ET. The event will provide insights into the company's efforts in developing curative targeted cell therapies for autoimmune diseases, including engineered T cell therapies. A live webcast will be accessible on the company's website, with replays available for 30 days afterward. Cabaletta Bio is headquartered in Philadelphia, PA.
Cabaletta Bio, Inc. (Nasdaq: CABA) reported its third-quarter financial results for 2022, highlighting progress in its clinical development of innovative cell therapies for autoimmune diseases. The company plans to submit an IND for CABA-201 in the first half of 2023, with initial data expected by early 2024. Financials show R&D expenses of $8.2 million, unchanged year-over-year, and G&A costs at $3.6 million, up slightly. Cash reserves decreased to $85.9 million from $122.2 million, projecting funds through mid-2024. Regulatory incentives were noted for MuSK-CAART, enhancing future growth prospects.
Cabaletta Bio has announced a global license for a fully human CD19 binder for autoimmune disease treatment. The CABA-201 Investigational New Drug (IND) application is expected in the first half of 2023, with initial clinical data anticipated by mid-2024, subject to IND approval. This development is informed by a partnership with Dr. Georg Schett, a leader in CD19-targeting therapies. The collaboration aims to enhance understanding of immunologic responses in autoimmune conditions. CABA-201 has the potential to address diseases like systemic lupus erythematosus and rheumatoid arthritis.
Cabaletta Bio, focused on developing targeted cell therapies for autoimmune diseases, will present data from the DesCAARTes™ trial of DSG3-CAART for mucosal-dominant pemphigus vulgaris at the 29th Annual Congress of the European Society of Gene & Cell Therapy in Edinburgh from October 11-14, 2022.
The poster, titled 'Characterization of DSG3-CAART cells prior to & following adoptive transfer in mucosal Pemphigus Vulgaris,' will be presented on October 13, 2022, by Dr. Samik Basu. More information will be available on the ESGCT website and Cabaletta’s own site post-presentation.
Cabaletta Bio (Nasdaq: CABA), a clinical-stage biotechnology firm, announced that CEO Steven Nichtberger, M.D., will participate in a fireside chat at the Chardan 6th Annual Genetic Medicines Conference on October 3, 2022, at 4:00 p.m. ET in New York. The event will be webcast live, and a replay will be available for 30 days on their website. Cabaletta Bio specializes in engineered T cell therapies aimed at treating autoimmune diseases, with a pipeline focusing on conditions like pemphigus vulgaris and myasthenia gravis.
Cabaletta Bio, Inc. (Nasdaq: CABA) presented new clinical data from its DesCAARTes™ trial at the EADV Congress, highlighting safety and persistence of DSG3-CAART therapy. The trial showed no dose-limiting toxicities, with one instance of grade 1 cytokine release syndrome. Importantly, while no consistent trends in antibody or disease activity reductions were noted, one patient showed significant improvement, including decreased steroid use. The company aims to prioritize a combination study using cyclophosphamide and intravenous immunoglobulin to enhance treatment efficacy.
Cabaletta Bio, a clinical-stage biotechnology company focused on targeted cell therapies for autoimmune diseases, announced its participation in two investor conferences in September 2022. CEO Steven Nichtberger will engage in fireside chats at the Morgan Stanley 20th Annual Global Healthcare Conference on September 12 and the H.C. Wainwright 24th Annual Global Investment Conference on September 14, both in New York. Live webcasts will be available on the company's website, with replays accessible for 30 days.
Cabaletta Bio, Inc. (Nasdaq: CABA) announced a late-breaking presentation at the 31st EADV Congress, scheduled from September 7-10, 2022, in Milan, Italy. The presentation will focus on new clinical data from cohorts A4 and A5 of the DesCAARTes™ trial, which investigates DSG3-CAART therapy for mucosal-dominant pemphigus vulgaris. Dr. David J. Chang will present preliminary findings on September 10, 2022. Additionally, Dr. Aimee Payne will discuss CAAR T cell advancements on September 9, 2022. The trial aims to determine the maximum tolerated dose and evaluate safety and efficacy of DSG3-CAART.
Cabaletta Bio (CABA) reported its financial results for Q2 2022, revealing R&D expenses of $9.5 million, up from $7.9 million in Q2 2021. General and administrative expenses increased slightly to $3.5 million from $3.3 million. As of June 30, 2022, the company held $96.8 million in cash, down from $122.2 million at year-end 2021, but still sufficient to support operations through Q1 2024. The company is advancing its DesCAARTes™ trial and expects to present significant clinical data at the upcoming EADV Congress in September 2022.
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