BWXT Medical and Laurentis Complete Key Tc-99m Generator Program Milestone
Ontario Power Generation's Darlington Nuclear Generating Station has successfully installed a new isotope system, enabling the production of life-saving Molybdenum-99 (Mo-99) isotopes, a first for a commercial reactor. This innovative production will help alleviate the long-standing shortages of Mo-99, crucial for generating Technetium-99m, a primary diagnostic imaging agent in nuclear medicine. The project, a collaboration between Laurentis Energy Partners and BWXT Medical Ltd., awaits final regulatory approvals from the FDA and Health Canada before commercial production begins. The facility can produce enough Mo-99 to meet a significant portion of North America's demand.
- First commercial production of Mo-99 at Darlington Nuclear Generating Station.
- Will help resolve long-standing shortages of Mo-99 in North America.
- Potential to produce multiple medical isotopes in the future.
- Dependence on FDA and Health Canada approvals for commercial production.
- Historical instability in domestic supply since October 2016 could affect future operations.
The production of Mo-99 at
With the necessary equipment now installed, the team will continue with planned commissioning and preparation activities for commercial production of Mo-99, pending completion of validation runs and approval from the
Mo-99 is used to produce Technetium-99 metastable (Tc-99m), one of the most prevalently used diagnostic imaging agents in nuclear medicine, which helps detect illnesses like cancer and heart disease.
Tc-99m is delivered to radiopharmacies and hospitals across
Quick Facts:
- Because of the unique design of Darlington’s CANDU reactors, medical isotopes can be produced without interrupting the generation of clean energy.
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North America has not had a stable domestic supply of Mo-99 since Canada’s National Research Universal reactor ceased production inOctober 2016 . Hospitals have had to rely on imports fromEurope ,Africa , andAustralia . - Once operational, the arrangement between Laurentis and BWXT Medical will be capable of producing enough Mo-99 to supply a significant portion of the current and future North American demand.
- Historically, Mo-99 has been produced within research reactors using uranium as a starting material. Alternatively, BWXT Medical’s Tc-99m generator will be produced using natural molybdenum targets irradiated at Darlington Nuclear, greatly reducing waste by-products.
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In the future, the newly-installed Target Delivery System (TDS) at
Darlington may be used to produce other medical isotopes. -
With the addition of Mo-99, multiple isotopes are now produced at
Darlington : Helium-3, Mo-99, and Tritium, with plans underway to produce Cobalt-60 – currently also extracted from reactors at Pickering.
Quotes:
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“Tc-99m is the workhorse isotope for nuclear medicine,” said Dr.
David Laidley , Nuclear Medicine Physician atLondon Health Sciences Centre . “Used in over 80 percent of all nuclear medicine procedures, the availability of this critical isotope will save countless lives.” -
“Ontario is leading the way on the production of medical isotopes, leveraging our world-class nuclear generation stations and supply chain,” said
Todd Smith , Ontario’s Minister of Energy. “Production of Molybdenum-99 atOntario's Darlington Nuclear Generating Station , a world-first for a commercial power reactor, will create a steady global supply of radiopharmaceuticals which help our healthcare system detect illnesses like cancer and heart disease." -
“This is an exciting milestone for all companies involved, but most importantly, for patients in need,” said
Ken Hartwick , President and CEO of OPG. “Ontario’s nuclear generating stations have demonstrated for decades their value extends beyond producing reliable, affordable, clean energy. I’m proud of the role our employees and stations play in providing life-saving medical isotopes to the world.” -
“Completing the installation of the TDS at
Darlington is a significant milestone for the Laurentis and BWXT team,” said Dr.Jonathan Cirtain ,BWXT Medical Ltd. President and Chief Executive Officer. “This partnership leverages Darlington’s industry-leading operational reliability, the expertise of Laurentis and OPG to provide irradiation services, and BWXT’s proprietary neutron capture process and innovative production technology. It has been a collaborative and industry-leading effort.” -
“The installation of the TDS is the result of many years and countless hours of support from everyone involved at Laurentis, BWXT, OPG, and our other project partners,” said
Jason Van Wart , President of Laurentis. “The entire team was tireless in their efforts to install this ground-breaking isotope irradiation system to secure a reliable, large-scale supply of a crucial diagnostic isotope that hospitals and patients so desperately need. As we continue to innovate and aspire to be a global leader in isotope production, I look forward to what our team and the industry will accomplish next.”
Watch a video on how
To learn more about nuclear medicine capabilities and, specifically Tc-99m (2:44), click here: https://www.bwxt.com/bwxt-medical/nuclear-medicine-capabilities-1
About
About OPG
As one of North America’s largest, most diverse electricity generators, OPG invests millions in local economies and employs thousands of people across
About
Forward Looking Statements
BWXT cautions that this release contains forward-looking statements, including statements relating to the production, performance, timing, impact and value of Tc-99m and changes in demand, benefit and applicability of Tc-99m. These forward-looking statements involve a number of risks and uncertainties, including, among other things, changes in market demand for, delays in and commercialization of our Tc-99m production; our ability to obtain the necessary regulatory approvals, licenses and permits in a timely manner; the ability to commercialize this product; competition in an environment of rapid technological change; and the enforcement and protection of our intellectual property rights. If one or more of these or other risks materialize, actual results may vary materially from those expressed. For a more complete discussion of these and other risk factors, please see BWXT’s annual report on Form 10-K for the year ended
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