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Company Overview
BioVaxys Technology Corp. is a clinical-stage biopharmaceutical company registered in British Columbia, Canada, that focuses on advanced immunotherapies using its proprietary DPX™ immune-educating platform and HapTenix© 'neoantigen' tumor cell construct technology. These innovative platforms are designed to orchestrate targeted, robust, and persistent antigen-specific immune responses, addressing complex challenges in oncology, infectious diseases, and antigen desensitization.
Core Technology and Platforms
The cornerstone of BioVaxys’ approach is the DPX™ platform, a non-aqueous, lipid-in-oil delivery system that facilitates the steady recruitment of antigen presenting cells (APCs) to the injection site. This ensures that antigens—whether peptides, proteins, mRNA, or small molecules—are retained in a manner that promotes prolonged immune stimulation. The unique, 'no release' mechanism of DPX™ contrasts with conventional aqueous or emulsion-based formulations by delivering antigens in a concentrated, targeted fashion.
Complementing DPX™ is the HapTenix© platform, which enables the design of personalized immunotherapeutic vaccines targeting tumor-specific neoantigens. Through these integrated systems, BioVaxys is able to package multiple antigens, supporting research and clinical development across a wide array of therapeutic areas.
Clinical Pipeline and Therapeutic Areas
BioVaxys is currently involved in pioneering clinical studies with its immunotherapeutic candidates. Its portfolio spans several indications including:
- Oncology: Development of vaccine formulations for cancers such as advanced Relapsed-Refractory Diffuse Large B Cell Lymphoma (DLBCL), platinum resistant ovarian cancer, and other tumor types, leveraging both the DPX™ and HapTenix© platforms.
- Infectious Diseases: Utilization of the DPX™ platform in developing vaccines that drive both T cell and B cell responses to combat viral infections, including respiratory pathogens.
- Antigen Desensitization: Addressing immunological disorders through novel approaches that modulate immune responses, with potential applications for food allergies and other conditions.
Market Position and Competitive Landscape
Within the competitive biopharmaceutical landscape, BioVaxys distinguishes itself by integrating a flexible antigen delivery system with targeted immune activation. The company's reliance on robust intellectual property, including patents for low dose volume delivery of B-cell epitopes and innovative formulations, underpins its strategy for partnering and co-development. While challenges such as regulatory approvals and clinical validation are inherent in the biopharmaceutical sector, BioVaxys’ strategic focus on technology-driven immunotherapies positions it as a significant contributor to the evolving field of vaccine technology.
Operational and Business Model Insights
BioVaxys generates value not solely through its clinical programs but also by leveraging its extensive IP portfolio and establishing strategic partnerships. This includes collaborations that extend the application of its proprietary platforms to diverse areas, from animal health (via licensed technologies) to human therapeutic applications. The company operates with a clear emphasis on scientific innovation, rigorous clinical development, and the safeguarding of its intellectual properties, which collectively enhance industry trust and credibility.
Scientific and Technological Credibility
Through numerous preclinical studies and early clinical trials, BioVaxys has demonstrated its capacity to induce sustained immune responses across multiple therapeutic modalities. The depth of their research is supported by detailed immunogenicity assessments and comparative studies illustrating the advantages of the DPX™ platform over traditional delivery methods. This scientific rigor serves as the foundation for future research collaborations and validates their standing as experts in the field of immune-educating technologies.
Conclusion
BioVaxys Technology Corp. offers a comprehensive, technology-driven approach to immunotherapy development, underpinned by its innovative DPX™ and HapTenix© platforms. By addressing key limitations of traditional delivery systems and fostering strategic collaborations, the company continues to contribute valuable insights and solutions within the biopharmaceutical industry. Its emphasis on robust intellectual property, scientific excellence, and methodical clinical development makes it a noteworthy entity for those seeking detailed, unbiased information on cutting-edge immunotherapeutics.
BioVaxys Technology Corp (BVAXF) is developing its DPX™ platform as an alternative to lipid nanoparticles (LNPs) for delivering mRNA vaccines. The DPX technology is a patented delivery platform that can incorporate various bioactive molecules to produce targeted, long-lasting immune responses.
Proof-of-concept studies conducted with Etherna and PCI Biotech showed that DPX provides enhanced stability of packaged mRNA, attracts specific Antigen Presenting Cells to the injection site, and induces specific immune responses. Unlike LNPs, which can cause adverse reactions and stability issues, DPX remains localized at the injection site and demonstrated stability for up to 14 days in vivo.
The company is pursuing collaborations with organizations having promising tumor and virus-specific polynucleotide antigens, positioning DPX as a potential solution in the mRNA vaccine market, which is projected to reach $48 billion by 2030.
BioVaxys Technology Corp. (CSE: BIOV, OTCQB: BVAXF) has announced its upcoming presentation at the Emerging Growth Conference on Thursday, January 16, 2025, from 3:25 PM to 3:35 PM Eastern Time. The clinical-stage company, which develops vaccines using its DPX™ immune educating platform for cancers, infectious diseases, and immune disorders, will host an interactive online session.
CEO James Passin and President & COO Kenneth Kovan will lead the presentation, offering shareholders and investors a real-time interaction opportunity. The event includes a Q&A session, with questions accepted both in advance via Questions@EmergingGrowth.com and during the live presentation. Participants who cannot attend live can access an archived webcast through EmergingGrowth.com and their YouTube channel.
BioVaxys Technology Corp (CSE: BIOV, OTCQB: BVAXF) has secured a 48-kilogram supply of GMP-grade lipid for its DPX antigen packaging delivery platform. The lipids, previously owned by IMV Inc., will be used to restart clinical studies and initiate new preclinical studies. The company acquired IMV's intellectual property and programs in February 2024.
The DPX technology is a patented delivery platform capable of packaging various bioactive molecules, including mRNA, peptides, proteins, and small molecules. This non-aqueous and non-systemic platform enables immune cell recruitment and antigen uptake at injection sites, delivering to regional lymph nodes via Antigen Presenting Cells to stimulate durable immune responses.
BioVaxys Technology Corp. and SpayVac for Wildlife announce that SpayVac's Madison facility is now fully operational to produce two contraceptive vaccines: the pZP vaccine (SpayVac®) and a new GnRH vaccine for aquaculture. The scaled-up production capacity will support field trials, market studies, and new antigen formulations. Recent large-scale shipments were made for a feral horse project in Europe and an immunocontraception project in Southeast Asia. The company is conducting trials with the U.S. government, EU, and an aquaculture genetics company, exploring alternatives to induced triploidy. SpayVac's technology, licensed from BioVaxys, uses a patented liposome-based antigen delivery platform.
BioVaxys Technology Corp (OTCQB: BVAXF) has joined the Rapid Response Partnership Vehicle (RRPV), a consortium supporting the US Government's Biomedical Advanced Research and Development Authority (BARDA). The RRPV aims to accelerate medical countermeasure development for pandemic influenza, emerging infectious diseases, and biological threats. The consortium includes major organizations like AstraZeneca, Novavax, and Genentech. BioVaxys believes its DPX platform can significantly contribute to BARDA's vaccine programs. The company's clinical pipeline includes maveropepimut-S, currently in Phase II trials for lymphoma and ovarian cancer treatment.
BioVaxys Technology Corp (OTCQB: BVAXF) has announced significant study results for its DPX™ immune-educating delivery platform. The research, conducted with Dalhousie University, demonstrates that DPX outperforms traditional aqueous and emulsion-based antigen delivery systems in immune system activation. Key findings show that DPX maintains antigens at the injection site and drives active APC uptake over time. The platform demonstrated superior lymphocyte retention and significant immune cell infiltration within 2 days of injection. Notably, DPX showed activation of more critical T cell subset markers than oil emulsion systems and exhibited inherent immune-activating properties even without antigen cargo.
BioVaxys Technology Corp (CSE: BIOV, OTCQB: BVAXF) announces its participation in the upcoming Emerging Growth Conference on October 30th, 2024, at 9:40 AM EST. CEO James Passin will deliver a live, interactive presentation, providing an opportunity for shareholders and investors to engage directly with the company leadership.
The clinical-stage company, which develops immune-educating therapies using its DPX™ platform for cancers, infectious diseases, and immune disorders, welcomes questions from participants either in advance via Questions@EmergingGrowth.com or during the live event. For those unable to attend, an archived webcast will be available on EmergingGrowth.com and their YouTube channel.
BioVaxys Technology Corp. (CSE: BIOV, OTCQB: BVAXF) has engaged Dr. Rajkannan Rajagopalan as Advisor for developing and producing the Company's DPX™ formulations. Dr. Rajagopalan, with over 20 years of experience in nanoparticles formulation development, will assist with:
- Development of DPX formulations for the peanut allergy vaccine program with McMaster University
- Planned preclinical studies of DPX/mRNA vaccines
- Continued Phase 1 studies in oncology and infectious disease
- Expansion into new opportunities with DPX
- Support for current licensees using liposomes-based vaccine technology
- Establishing BioVaxys' non-GLP clinical supply facility for DPX formulations production
Additionally, Brittany Davison, a Chartered Professional Accountant, joins as an Advisor from the former IMV, Inc., where she served as Chief Accounting Officer and Acting Chief Financial Officer.
BioVaxys Technology Corp. (CSE: BIOV, OTCQB: BVAXF) announces CEO James Passin's upcoming presentation at the Life Sciences Investor Forum on September 19th, 2024. The live, interactive online event allows investors to engage directly with the company.
Recent highlights include:
- Acquisition of DPX™ immune educating platform technology assets
- Collaboration with AP Visionaries to develop food allergy treatments
- Potential product registrations from licensees Zoetis and SpayVac-for-Wildlife
- Advancement of DPX™ platform for infectious diseases
BioVaxys is developing novel immunotherapies for cancers, infectious diseases, and other immunological conditions using its DPX™ and HapTenix© platforms. The company's lead candidate, maveropepimut-S, is in Phase II trials for DLBCL and ovarian cancer.
BioVaxys Technology Corp. (BVAXF) has been invited to present at The Personalized Cancer Vaccine Summit in Boston, MA, from December 3-5, 2024. The presentation, titled "A Novel Delivery System for Personalized Peptide & mRNA Vaccines for More Targeted Therapies," will showcase new data on the company's DPX Immune Educating Platform.
Chief Medical Officer David Berd, MD, will present findings from recent in vivo studies conducted by researchers at UConn Health and The Ohio State University Comprehensive Cancer Center. The data suggests that DPX has a significant role in delivering tumor neoepitope vaccines that induce tumor rejection and may possess anti-tumor capacity on its own.
BioVaxys is continuing additional studies on DPX's potential in delivering tumor neoepitope vaccines and its anti-tumor capabilities.
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