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Barinthus Biotherapeutics plc (NASDAQ: BRNS) is a clinical-stage biopharmaceutical leader advancing T cell immunotherapies for chronic infections, autoimmune disorders, and cancer. This news hub provides investors and researchers with essential updates on the company’s clinical trials, regulatory milestones, and scientific advancements.
Discover timely updates about BRNS’s proprietary platforms including ChAdOx, MVA, and SNAP-Tolerance Immunotherapy. Our curated news collection covers critical developments in vaccine candidates, partnership announcements, and progress across three core therapeutic areas: infectious disease management, autoimmune treatment innovation, and oncology breakthroughs.
Key updates include phase trial results, FDA communications, intellectual property developments, and strategic collaborations. The resource is designed to help stakeholders track the company’s progress in addressing hepatitis B, celiac disease, and resistant cancers through novel immune modulation approaches.
Bookmark this page for streamlined access to verified updates about Barinthus Bio’s pipeline candidates and corporate developments. Check regularly for new insights into how the company’s T cell-focused strategies may shape future treatment paradigms.
Barinthus Bio (NASDAQ: BRNS) has reported its full year 2024 financial results and corporate updates, highlighting its strategic transformation into an immunology and inflammatory disease-focused company. The company's lead asset, VTP-1000, a potentially curative immunotherapy for celiac disease, is progressing with first data expected in Q3 2025.
Key financial highlights include:
- Cash position of $112.4 million as of December 31, 2024
- Revenue of $15.0 million in 2024, up from $0.8 million in 2023
- Net loss of $61.1 million ($1.55 per share)
- Research and development expenses of $42.2 million
The company's SNAP-TI platform shows promise in promoting antigen-specific immune tolerance. In chronic hepatitis B trials, VTP-300 demonstrated encouraging results with eight participants achieving undetectable HBsAg levels. The company's cash runway is expected to extend into 2027.
Barinthus Biotherapeutics has announced its participation in the upcoming Investor Summit Virtual event scheduled for March 11, 2025. The company will be represented by CEO Bill Enright and CFO Gemma Brown at this significant investor conference.
Barinthus Bio announced a strategic shift to focus on Immunology and Inflammation (I&I) with a priority on developing VTP-1000 for celiac disease, expecting Phase 1 data by mid-2025. The company will halt further development of VTP-300 for chronic hepatitis B (CHB) until a partner is found. To extend its cash runway to early 2027, Barinthus will cut costs by reducing its workforce by 65% and closing its U.K. site, focusing future operations in Germantown, Maryland.
Financially, the company reported $112 million in cash and equivalents as of December 31, 2024. This restructuring aims to streamline operations and align resources with its new strategic focus. Key 2025 milestones include:
- Mid-2025: Phase 1 data for VTP-1000 in celiac disease.
- Q3 2025: Start of multiple ascending dose Phase 1 trial for VTP-1000.
- Q2 2025: Results from Phase 2b HBV003 and Phase 2a IM-PROVE II trials for VTP-300 in CHB.
- Q2 2025: Results from Phase 1 PCA001 trial for VTP-850 in prostate cancer.
CEO Bill Enright emphasized the company's commitment to leveraging its SNAP-TI platform for autoimmune diseases and expressed gratitude to departing executives and staff.
Barinthus Biotherapeutics (NASDAQ: BRNS) has promoted Geoffrey Lynn, M.D., Ph.D. to Chief Scientific Officer (CSO), effective December 1, 2024. Dr. Lynn, co-inventor of the SNAP-TI technology, succeeds Nadège Pelletier, Ph.D., who served as CSO since early 2023. The company has achieved notable progress with VTP-300 in chronic hepatitis B treatment and recently initiated a Phase 1 trial for VTP-1000 in celiac disease. Dr. Lynn previously led Avidea Technologies from 2017 until its acquisition by Barinthus Bio in 2021.
Barinthus Biotherapeutics announced significant results from its ongoing Phase 2b HBV003 clinical trial for chronic hepatitis B treatment. The study, involving 121 participants, evaluated VTP-300 combined with low-dose nivolumab. Key findings include: eight participants achieved complete HBsAg loss, two met functional cure criteria, and two participants who discontinued NUC therapy developed HBsAb positivity. Among 40 participants assessed for NUC discontinuation, 24 were eligible, and nine chose to discontinue. Six remained off NUC therapy, with five maintaining this status for over six months. The treatment was generally well-tolerated with no treatment-related SAEs reported.
Arbutus Biopharma and Barinthus Bio announced new preliminary data from Phase 2a IM-PROVE II trial showing enhanced results when combining imdusiran, VTP-300, and low-dose nivolumab in treating chronic hepatitis B virus. 23% of participants receiving this combination achieved HBsAg loss by Week 48, with significantly greater mean declines in HBsAg levels (p<0.017) compared to other cohorts. The trial included 22 non-cirrhotic participants in Group C, with 13 eligible for nivolumab treatment. The combination therapy was generally well tolerated with no immune-related adverse events reported.
Barinthus Bio (NASDAQ: BRNS) reported Q3 2024 financial results and corporate updates. The company completed enrollment in the HBV003 trial of VTP-300 for chronic hepatitis B with 121 participants, and initiated the Phase 1 AVALON trial of VTP-1000 for celiac disease. Financial highlights include $106.1M in cash as of September 30, 2024, $15M in revenue from Vaxzevria® royalties, and a net loss of $8.1M ($0.21 per share). R&D expenses were $11.1M, down from $11.7M in Q2. The company expects current resources to fund operations into Q2 2026.
Barinthus Biotherapeutics (NASDAQ: BRNS) announced that updated clinical data from its chronic hepatitis B program will be presented at The Liver Meeting® 2024 in San Diego. The late-breaking presentation will focus on VTP-300 combined with low-dose nivolumab and its association with HBsAg loss in specific chronic hepatitis B patients. The company will also participate in several medical congresses including the International Workshop on HBV Cure 2024 and the BSI Immune Therapies Summit. Additionally, management will attend investor conferences including Guggenheim's Healthcare Innovation Conference and Jefferies London Healthcare Conference for presentations and one-to-one meetings.
Barinthus Biotherapeutics plc (NASDAQ: BRNS) has announced the completion of enrollment for two clinical trials: HBV003, a Phase 2b trial of VTP-300 in chronic hepatitis B (CHB), and PCA001, a Phase 1 trial of VTP-850 in prostate cancer. The HBV003 trial enrolled 121 participants to evaluate VTP-300 and low-dose nivolumab as a potential functional cure for CHB. Interim data showed the treatment was generally well-tolerated and led to sustained declines in HBsAg levels, with 76% of participants meeting NUC therapy discontinuation criteria.
The PCA001 trial enrolled 22 participants to determine the recommended Phase 2 dosing regimen of VTP-850 for prostate cancer. Data updates are anticipated in Q4 2024 for HBV003 and H1 2025 for PCA001. CEO Bill Enright highlighted the company's execution of its strategy and the significance of completing enrollment in these challenging recruitment areas.
Barinthus Biotherapeutics plc (NASDAQ: BRNS) has initiated a Phase 1 clinical trial of VTP-1000, an investigational immunotherapy for celiac disease. The AVALON trial (NCT06310291) aims to enroll 42 adults with celiac disease to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of VTP-1000.
The trial consists of two parts: a single ascending dose (SAD) and a multiple ascending dose part with a controlled gluten challenge. VTP-1000 utilizes Barinthus Bio's proprietary SNAP-TI platform to deliver gluten-derived peptide antigens and rapamycin in nanoparticles, aiming to promote immune tolerance to gluten.
Celiac disease affects an estimated 1 in 100 people globally and currently has no approved treatments. VTP-1000 seeks to restore immune system tolerance to gluten, potentially reducing inflammation in the small intestine following gluten exposure.
