Bolt Biotherapeutics, Inc. Provides Update on Global Cancer Immunotherapy Co-Development with Toray Industries, Inc.
Bolt Biotherapeutics (BOLT) announced that Caprin-1 is the target of their worldwide co-development collaboration with Toray Industries. The partners are developing a Boltbody™ Immune-Stimulating Antibody Conjugate (ISAC) targeting Caprin-1, which is applicable to multiple solid tumor types.
Under the agreement, Toray provides proprietary antibodies targeting Caprin-1, including TRK-950, while Bolt contributes proprietary linker-payloads from its Boltbody™ ISAC platform. Caprin-1 is a tumor-specific antigen highly expressed on solid tumors with minimal presence in normal tissues, and contributes to tumor growth and metastases. Toray's TRK-950 antibody is currently in Phase 2 development for Gastric cancer.
Bolt Biotherapeutics (BOLT) ha annunciato che Caprin-1 è il target della loro collaborazione globale di co-sviluppo con Toray Industries. I partner stanno sviluppando un Anticorpo Coniugato Immunostimolante Boltbody™ (ISAC) che targetizza il Caprin-1, applicabile a più tipologie di tumori solidi.
Secondo l'accordo, Toray fornisce anticorpi proprietari targeting Caprin-1, incluso il TRK-950, mentre Bolt contribuisce con coniugati linker-payload proprietari dalla sua piattaforma Boltbody™ ISAC. Il Caprin-1 è un antigene specifico per il tumore altamente espresso nei tumori solidi con una presenza minima nei tessuti normali e contribuisce alla crescita e alle metastasi del tumore. L'anticorpo TRK-950 di Toray è attualmente in fase di sviluppo di Fase 2 per il cancro gastrico.
Bolt Biotherapeutics (BOLT) anunció que Caprin-1 es el objetivo de su colaboración de co-desarrollo a nivel mundial con Toray Industries. Los socios están desarrollando un Conjugado de Anticuerpo Inmunoestimulante Boltbody™ (ISAC) que dirige al Caprin-1, aplicable a múltiples tipos de tumores sólidos.
Según el acuerdo, Toray proporciona anticuerpos propietarios que atacan el Caprin-1, incluyendo el TRK-950, mientras que Bolt contribuye con enlaces y cargas útiles propietarios de su plataforma Boltbody™ ISAC. El Caprin-1 es un antígeno específico para tumores que se expresa altamente en tumores sólidos con una presencia mínima en tejidos normales y contribuye al crecimiento y las metástasis del tumor. El anticuerpo TRK-950 de Toray está actualmente en desarrollo de Fase 2 para el cáncer gástrico.
볼트 바이오테라퓨틱스(BOLT)가 카프린-1을 토라야 산업과의 전 세계 공동 개발 협력의 목표라고 발표했습니다. 파트너들은 여러 고형 종양 유형에 적용 가능한 볼바디™ 면역 자극 항체 접합체(ISAC)를 개발하고 있습니다.
계약에 따라 토라이는 카프린-1을 목표로 하는 독점 항체, 즉 TRK-950을 제공하고, 볼트는 자사의 볼바디™ ISAC 플랫폼에서 독점적인 링커-페이로드를 기여합니다. 카프린-1은 고형 종양에서 높은 발현을 보이며 정상 조직에서는 최소한의 존재를 가진 종양 특이적 항원으로 종양 성장과 전이 기여합니다. 토라이의 TRK-950 항체는 현재 위암에 대해 2상 개발 중입니다.
Bolt Biotherapeutics (BOLT) a annoncé que Caprin-1 est la cible de leur collaboration mondiale de co-développement avec Toray Industries. Les partenaires développent un Anticorps Conjugué Immunostimulant Boltbody™ (ISAC) ciblant Caprin-1, applicable à plusieurs types de tumeurs solides.
Selon l'accord, Toray fournit des anticorps propriétaires ciblant Caprin-1, y compris le TRK-950, tandis que Bolt contribue avec des charges utiles et des liens propriétaires issus de sa plateforme Boltbody™ ISAC. Caprin-1 est un antigène spécifique aux tumeurs, hautement exprimé dans les tumeurs solides avec une présence minimale dans les tissus normaux, et contribue à la croissance des tumeurs et aux métastases. L'anticorps TRK-950 de Toray est actuellement en développement de phase 2 pour le cancer de l'estomac.
Bolt Biotherapeutics (BOLT) hat bekannt gegeben, dass Caprin-1 das Ziel ihrer weltweiten Co-Entwicklungspartnerschaft mit Toray Industries ist. Die Partner entwickeln einen Boltbody™ Immunstimulierenden Antikörper-Konjugat (ISAC), der auf Caprin-1 abzielt und auf mehrere feste Tumorarten anwendbar ist.
Im Rahmen der Vereinbarung stellt Toray proprietäre Antikörper zur Verfügung, die auf Caprin-1 abzielen, einschließlich TRK-950, während Bolt proprietäre Linker-Payloads von seiner Boltbody™ ISAC-Plattform bereitstellt. Caprin-1 ist ein tumorspezifisches Antigen, das hochgradig in soliden Tumoren exprimiert wird, mit minimaler Präsenz in normalen Geweben, und trägt zum Tumorwachstum und zur Metastasierung bei. Der TRK-950-Antikörper von Toray befindet sich derzeit in der Phase 2 der Entwicklung für Magenkrebs.
- Development of novel cancer therapy targeting Caprin-1, expressed in multiple solid tumor types
- TRK-950 antibody already in Phase 2 development, validating the target
- Caprin-1 shows minimal expression in normal tissues, suggesting potential for better safety profile
- Strategic collaboration combines Toray's antibodies with Bolt's ISAC technology platform
- None.
Insights
This strategic collaboration marks a pivotal development for Bolt Biotherapeutics, particularly given the significant market opportunity in solid tumor treatments. The targeting of Caprin-1, which is highly expressed across multiple solid tumor types while showing minimal expression in normal tissues, represents a potentially valuable therapeutic approach with broad applications.
The collaboration's strength lies in its complementary technology integration: Toray's validated antibody TRK-950, currently in Phase 2 trials for gastric cancer, combined with Bolt's proprietary Boltbody™ ISAC platform. This validation through clinical development significantly de-risks the program and provides a clear pathway for expansion into multiple cancer indications.
From a market perspective, the solid tumor therapeutic landscape represents a multi-billion dollar opportunity. The specificity of Caprin-1 expression in tumor cells, coupled with its role in tumor growth and metastases, positions this program favorably against competing approaches. The joint commercialization agreement suggests balanced risk-sharing and aligned interests in bringing this potential therapy to market.
The collaboration's foundation in Stanford research, coupled with Toray's commitment to life innovation and established presence in oncology, provides both scientific credibility and commercial validation. For investors, this partnership represents a significant value driver for Bolt, potentially accelerating their path to market while sharing development costs and risks.
-- Targeting Unmet Needs for Treating Solid Tumors--
REDWOOD CITY, Calif., Feb. 11, 2025 (GLOBE NEWSWIRE) -- Bolt Biotherapeutics, Inc., announced today that the target of their worldwide co-development collaboration with Toray Industries, Inc. is Caprin-1, a novel cancer target discovered by Toray. The collaborators are developing a Boltbody™ Immune-Stimulating Antibody Conjugate (ISAC) targeting Caprin-1, which is applicable to multiple solid tumor types. Under the existing Joint Development and License Agreement, Toray supplies its proprietary antibodies targeting Caprin-1, such as the antibody TRK-950, and Bolt contributes proprietary linker-payloads from its Boltbody™ ISAC platform technology. Bolt plans to co-develop and jointly commercialize the resulting ISAC product candidate with Toray.
Caprin-1 is a tumor-specific antigen that is strongly expressed on the cell membrane surface of most solid tumors, with minimal expression on the surface of normal tissues. Caprin-1 has also been shown to contribute to tumor growth and metastases. Toray’s asset TRK-950 is a monoclonal antibody targeting Caprin-1 that is in Phase 2 development for Gastric cancer, providing validation for this antigen as a promising ISAC target.
The connection between Toray and Bolt relationship dates back to 2002, when Dr. Fumiyoshi Okano, Senior Director of Toray, worked to enhance cancer immunotherapy techniques in Professor Ed Engleman’s lab at Stanford University. After returning to Japan, Dr. Okano discovered the novel cancer therapeutic target Caprin-1 and created an anti Caprin-1 monoclonal antibody TRK-950. Toray later decided to collaborate with Bolt in order to maximize the potential of TRK-950 with the Boltbody™ ISAC technology.
“On a personal note, it is gratifying to see a collaboration that has roots in my Stanford lab. I’ve been exchanging ideas with Dr. Okano for over 20 years and we have tremendous respect for each other. Bolt’s technology also came from my lab, and we are excited to combine Bolt’s technology with Toray’s proprietary antibodies such as TRK-950, which targets a novel tumor-specific antigen expressed on a high percentage of solid tumors,” stated Ed Engleman, M.D., Bolt co-founder and co-director of the Immunology and Immunotherapy Research Program at the Stanford Cancer Institute. “Toray’s commitment to research and technology development is inspiring, and the combination of these two technologies has great potential to provide significant benefit for patients with many different types of cancer who are not adequately managed with current therapies.”
“Working with my mentor Professor Engleman on this collaboration is a career highlight for me,” said Dr. Okano. “Bolt is taking the lead in ISAC development with their Boltbody™ ISAC technology platform. We are excited about our collaboration with Bolt exploring the complementary combination of our technologies. In recent years Toray has increasingly focused on “life innovation”, hastening improvements in medical technology and disease prevention. Our goal is to reduce the burden on medical professionals while helping people live longer, healthier lives. We have prioritized oncology as one of the important areas for Toray and are working to create industry-leading therapies that have the potential to significantly improve outcomes for patients. This collaboration is consistent with Toray’s mission to achieve a healthy society through development of innovative drugs.”
About the Boltbody™ Immune-Stimulating Antibody Conjugate (ISAC) Platform
Bolt Biotherapeutics’ Boltbody™ ISAC platform harnesses the precision of antibodies with the power of the innate and adaptive immune system to reprogram the tumor microenvironment to generate a productive anti-cancer response. Each Boltbody™ ISAC candidate comprises a tumor-targeting antibody, a non-cleavable linker, and a proprietary immune stimulant. The antibody is designed to target one or more markers on the surface of a tumor cell and the immune stimulant is designed to recruit and activate myeloid cells. Activated myeloid cells initiate a positive feedback loop by releasing cytokines and chemokines, chemical signals that attract other immune cells and lower the activation threshold for an immune response. This increases the population of activated immune system cells in the tumor microenvironment and promotes a robust immune response with the goal of generating durable therapeutic responses for patients with cancer.
About Toray’s Multi-cancer Antibody TRK-950
TRK-950 is a monoclonal antibody that binds to and attacks cancer cells by targeting Caprin-1, a novel cancer therapeutic target discovered by Toray. Caprin-1 is strongly expressed on the cell membrane surfaces of gastric cancer and most other solid tumors and far less so on the cell membrane surfaces of normal tissues. It is also highly expressed on the cell membrane surfaces of metastatic cancer cells and cancer stem cells, which cause cancers to metastasize and recur. Toray has worked on TRK-950 development to inhibit cancer cell growths and metastases and cancer recurrences while minimizing side effects for many solid tumors. TRK-950 began Phase 1 studies in the United States and France in 2017 and in Japan in 2022, and has been administered to more than 155 cancer patients. It has been observed that the combination of TRK-950 with anticancer drugs is more effective. The clinical trials were expanded to include South Korea in 2023, and a Phase 2 clinical trial in patients with gastric cancer is currently ongoing.
About Toray Industries, Inc.
Toray is a leading global company in innovative technologies and advanced materials. Since its foundation in 1926, the Company has contributed to society through the creation of new value and addressed global challenges by delivering high value-added products including fibers and textiles, resins and films, and carbon fiber composite materials. It operates in 26 countries and regions with about 48,000 employees worldwide.
For more information, please visit www.toray.com.
About Bolt Biotherapeutics, Inc.
Bolt Biotherapeutics is a clinical-stage biopharmaceutical company developing novel immunotherapies for the treatment of cancer. Bolt Biotherapeutics’ pipeline candidates are built on the Company’s deep expertise in myeloid biology and cancer drug development. The Company’s pipeline includes BDC-3042, a first-in-class agonist antibody that activates macrophages by targeting Dectin-2, and BDC-4182, a next-generation Boltbody™ Immune-Stimulating Antibody Conjugate (ISAC) clinical candidate targeting claudin 18.2. BDC-3042 is currently in a Phase 1 dose escalation trial that includes patients with any of seven different solid tumor types. BDC-4182 is supported by strong in vitro and in vivo data demonstrating potent anti-tumor activity, and activities are underway to support the initiation of clinical trials in 2025. Bolt Biotherapeutics is also developing multiple Boltbody™ ISACs in strategic collaborations with leading biopharmaceutical companies. For more information, please visit https://www.boltbio.com/.
Investor Relations and Media Contact:
Matthew DeYoung
Argot Partners
(212) 600-1902
boltbio@argotpartners.com
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