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Bristol-Myers Squibb Co. (BMY) is a renowned American multinational pharmaceutical company headquartered in New York City. As one of the largest pharmaceutical companies globally, Bristol-Myers Squibb (BMS) consistently ranks on the Fortune 500 list. In fiscal 2022, the company achieved total revenue of $46.2 billion.
Bristol-Myers Squibb focuses on discovering, developing, and marketing drugs across various therapeutic areas, including cardiovascular, cancer, and immune disorders. A significant area of focus for BMS is immuno-oncology, where it has established itself as a leader in drug development. Approximately 70% of BMS's total sales are derived from the U.S. market, reflecting its higher dependence on this region compared to its peers.
Recent achievements and collaborations highlight BMS's commitment to innovation and partnerships. On May 22, 2024, BMS joined NeoPhore Limited's oversubscribed Series B extension round. This additional investment will enable NeoPhore to explore novel biology associated with the DNA mismatch repair (MMR) pathway in cancer, and further advance its pre-clinical studies. NeoPhore aims to generate next-generation immuno-oncology therapeutics to improve clinical outcomes for cancer patients.
Another noteworthy collaboration was announced on June 5, 2024, with I-Mab, a U.S.-based global biotech company. This partnership will evaluate the combination of givastomig, an investigational Claudin 18.2 x 4-1BB bispecific antibody, with BMS's immune checkpoint inhibitor, nivolumab, and chemotherapy. The study, a multi-national Phase 1, will focus on advanced Claudin 18.2-positive gastric and esophageal cancers. BMS will supply nivolumab, which is designed to enhance T-cell function and improve anti-tumor responses.
Additionally, on June 5, 2024, Envisagenics, an AI-driven biotechnology company, announced a Series B fundraising round with participation from BMS. This funding will be utilized to further develop Envisagenics' pipeline of novel preclinical oncology assets using their cloud-based AI drug discovery platform, SpliceCore®. This collaboration underscores BMS's continued investment in innovative technologies and therapeutics.
Bristol-Myers Squibb's mission is to discover, develop, and deliver innovative medicines that help patients prevail over serious diseases. Through strategic partnerships, cutting-edge research, and a commitment to therapeutic advancements, BMS continues to make significant strides in the biopharmaceutical industry.
Bristol Myers Squibb (NYSE: BMY) has received approval from the European Commission for Opdivo (nivolumab) in combination with Cabometyx (cabozantinib) as a first-line treatment for adults with advanced renal cell carcinoma (RCC). This decision follows the successful Phase 3 CheckMate -9ER trial, highlighting superior efficacy in key endpoints such as progression-free survival and overall survival compared to sunitinib. The combination treatment demonstrated manageable safety with low treatment-related discontinuations, broadening options for RCC patients in Europe.
Bristol Myers Squibb (NYSE: BMY) reported significant results from the CheckMate -816 study, demonstrating that neoadjuvant treatment with Opdivo (nivolumab) plus chemotherapy resulted in a pathologic complete response (pCR) of 24% compared to 2.2% for chemotherapy alone (p<0.0001). This trial is the first Phase 3 study showing improved pCR in resectable stage Ib to IIIa non-small cell lung cancer (NSCLC). Additionally, Opdivo plus chemotherapy was well tolerated, with no new safety signals detected. The findings suggest potential benefits for long-term survival in NSCLC patients.
Bristol Myers Squibb (NYSE: BMY) announced positive topline results from the Phase 3 CheckMate -648 trial, which evaluated the combination of Opdivo (nivolumab) with chemotherapy or Yervoy (ipilimumab) in patients with unresectable advanced or metastatic esophageal squamous cell carcinoma (ESCC). Results showed significant improvements in overall survival (OS) and progression-free survival (PFS) for both combinations in patients expressing PD-L1. The safety profiles were consistent with previous reports. Upcoming data will be shared at a medical conference and with health authorities.
HUYABIO International has announced a clinical collaboration with Bristol-Myers Squibb to conduct a Phase 3 trial evaluating the combination of HBI-8000 and Opdivo® (nivolumab) for treating unresectable or metastatic melanoma. Following a successful Phase 2 study that reported an overall response rate above 70%, this trial aims to further assess safety and efficacy. HBI-8000 is an epigenetic immunomodulator already approved for lymphoma and metastatic breast cancer in China.
Bristol Myers Squibb (NYSE:BMY) will host a virtual Investor Event on April 23, 2021, at 10:30 a.m. ET. The event will discuss data from the Phase 3 trials POETYK PSO-1 and PSO-2 of deucravacitinib, focused on treating moderate-to-severe psoriasis. The findings will be presented during the American Academy of Dermatology Virtual Meeting Experience (AAD VMX). Investors and the public can access the live webcast and materials at investor.bms.com, with an archived version available later the same day.
Bristol Myers Squibb (BMY) announced the validation of its type II variation application by the European Medicines Agency for Opdivo (nivolumab) to treat high-risk muscle-invasive urothelial carcinoma post-surgery. This validation confirms a complete submission, initiating the EMA’s centralized review. Opdivo showed significant potential in reducing cancer recurrence risk in the CheckMate -274 trial, with a strong safety profile. The application marks a step towards providing a first adjuvant immunotherapy option for this patient demographic in the EU.
Bristol Myers Squibb (NYSE: BMY) announced positive primary results from the Phase 2/3 RELATIVITY-047 trial, demonstrating that the fixed-dose combination of relatlimab and Opdivo significantly improved progression-free survival (PFS) in patients with untreated metastatic or unresectable melanoma compared to Opdivo alone. This marks the first Phase 3 data involving an anti-LAG-3 antibody. The combination therapy was well-tolerated, with no new safety signals. Follow-up on overall survival is ongoing. These findings could enhance treatment options for melanoma patients.
Bristol Myers Squibb (NYSE: BMY) announced the FDA's acceptance of its New Drug Application (NDA) for mavacamten, an oral allosteric modulator aimed at treating symptomatic obstructive hypertrophic cardiomyopathy (oHCM). The FDA set a PDUFA goal date for January 28, 2022. Clinical results from the Phase 3 EXPLORER-HCM trial indicated that mavacamten met primary and secondary endpoints, showcasing significant symptom relief and improved quality of life for patients. This first-in-class therapy addresses the underlying molecular defect of oHCM, a condition affecting approximately 160,000 to 200,000 people in the U.S. and EU.
Bristol Myers Squibb (NYSE:BMY) will release its first-quarter results on April 29, 2021, at 9 a.m. ET. Company executives will discuss financial performance and respond to investor inquiries during a conference call. Interested parties can access the live webcast at investor.bms.com or by dialing 800-458-4121 (U.S.) or +1 313-209-6672 (international) with confirmation code 3705525. A replay will be available from April 29 at 12:30 p.m. ET until May 13, 2021. For more information, visit BMS.com.
Bristol Myers Squibb (NYSE: BMY) will participate in a fireside chat at Barclays’ Virtual Global Healthcare Conference on March 9, 2021, at 3 p.m. ET. David Elkins, Executive Vice President and Chief Financial Officer, will address investor questions during the session. Investors and the public can access the live webcast at investor.bms.com, with materials available at the beginning of the event and an archived version posted later that day. The company focuses on developing innovative medicines for serious diseases.
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