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BELLUS Health Inc. (BLU) is an innovative biopharmaceutical development company dedicated to creating novel therapeutics for conditions with high unmet medical needs. Based in Canada, the company’s flagship project is BLU-5937, a groundbreaking drug candidate designed to treat chronic cough. Chronic cough, persisting for over eight weeks, significantly impacts the quality of life of more than 2.7 million patients in the United States alone. By targeting the P2X3 receptor, BLU-5937 offers a promising solution for patients who do not respond to existing treatments.

The drug candidate is a potent, highly selective, orally bioavailable small molecule antagonist of the P2X3 receptor, making it a potential best-in-class treatment option. The rights to BLU-5937 were acquired through a license agreement with the Neomed Institute in February 2017.

Beyond its lead project, BELLUS Health has vested interests in various partnered drug development initiatives, showcasing its broad commitment to addressing diverse medical challenges. The company's strategic partnerships and cutting-edge research underscore its pivotal role in the biopharmaceutical industry.

With continuous advancements and strong economic interests in multiple projects, BELLUS Health is positioned as a key player in developing revolutionary therapies that could significantly improve patients' lives. Investors and stakeholders remain keenly interested in the company's progress and future potential.

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BELLUS Health Inc. (NASDAQ:BLU) has announced participation in the Jefferies Healthcare Conference from June 8-10, 2022, in New York City. CEO Roberto Bellini will engage in a fireside chat on June 8 at 11:00 a.m. ET. The company focuses on innovative therapies for refractory chronic cough, with its candidate BLU-5937 completing a Phase 2b trial and a Phase 3 program expected to start in H2 2022. Chronic cough affects around 9 million patients in the U.S., highlighting a significant market opportunity for BELLUS Health's therapeutics.

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BELLUS Health (NASDAQ: BLU) announced significant updates in its recent press release. The company has scheduled an End-of-Phase 2 meeting with the FDA for June 2022, focusing on the Phase 3 program for BLU-5937, a potential treatment for refractory chronic cough (RCC). BELLUS ended Q1 2022 with US$234 million in cash and reported a net loss of US$14.4 million, a slight improvement from US$15.8 million in the previous year. The company will present at the ATS 2022 International Conference, showcasing data from the Phase 2b SOOTHE trial.

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BELLUS Health (NASDAQ: BLU) announced the presentation of three late-breaking abstracts from its Phase 2b SOOTHE trial at the ATS 2022 International Conference in San Francisco from May 13-18, 2022. The abstracts will cover safety, efficacy, and responder analyses related to BLU-5937 for refractory chronic cough (RCC). BELLUS plans to initiate a Phase 3 program in the second half of 2022, addressing a significant unmet need for the estimated 9 million RCC patients in the U.S. Currently, no specific therapy is approved for this condition.

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BELLUS Health, a clinical-stage biopharmaceutical company focused on novel therapeutics for refractory chronic cough (RCC), announced its participation in multiple investor conferences in May 2022. Events include the Bloom Burton & Co. Healthcare Investor Conference on May 2, the I&I Event by LifeSci Capital on May 10, the RBC Capital Markets Global Healthcare Conference on May 18, and the H.C. Wainwright Global Investment Conference on May 25. BELLUS’s product candidate, BLU-5937, has shown promise in a Phase 2b trial and a Phase 3 program is set to start in late 2022.

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BELLUS Health Inc. (Nasdaq: BLU), a clinical-stage biopharmaceutical company, will participate in the Cowen & Co. 42nd Annual Health Care Conference. CEO Roberto Bellini will be on the Respiratory/Infections Panel on March 8, 2022, at 2:10 p.m. ET. The panel discussion will address the company's advancements in treating refractory chronic cough (RCC) and other cough hypersensitivity conditions. Following the event, a recorded webcast will be available on BELLUS Health's website. This aligns with their goal to initiate a Phase 3 program for their product candidate BLU-5937 in late 2022.

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BELLUS Health announced positive topline results from its Phase 2b SOOTHE trial for BLU-5937, a potential best-in-class P2X3 antagonist for refractory chronic cough (RCC). The trial demonstrated a 34% placebo-adjusted reduction in cough frequency at day 28. The company plans to seek an End-of-Phase 2 meeting with the FDA in Q2 2022 and initiate Phase 3 studies in the latter half of 2022. As of December 31, 2021, BELLUS had $248.8 million in cash compared to <$98.3 million> in 2020 but reported a net loss of $71.2 million for 2021 due to increased R&D expenses.

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BELLUS Health Inc. (NASDAQ: BLU) has successfully completed a public offering of 25 million common shares at US$8.00 each, generating total gross proceeds of US$200 million. The offering includes an underwriters' option for an additional 3.75 million shares. The funds will be used for research and development, general administrative expenses, and working capital. The offering adheres to regulations in Canada and the United States, having been reported under a prospectus supplement dated December 14, 2021.

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BELLUS Health is set to conduct a public offering of 25 million common shares at a price of US$8.00 per share, expected to close on December 17, 2021. The offering will be underwritten by a syndicate including Jefferies, Evercore ISI, and RBC Capital Markets. Funds raised will primarily support research and development, along with general corporate needs. Additionally, underwriters have a 30-day option to purchase an extra 3.75 million shares.

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BELLUS Health (BLU) announced a proposed public offering of common shares totaling US$175 million. This follows a preliminary prospectus supplement filed with Canadian securities authorities and the SEC. The net proceeds are intended for research and development, administrative expenses, and working capital. Underwriters will have a 30-day option to purchase an additional 15% of shares offered. The offering's pricing will be determined based on market conditions, with customary closing conditions, including TSX approval.

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BELLUS Health announced significant results from its Phase 2b SOOTHE trial of BLU-5937 for treating refractory chronic cough (RCC). The trial revealed a 34% placebo-adjusted reduction in 24-hour cough frequency at both 50 mg and 200 mg BID doses (p ≤ 0.005). BLU-5937 showed favorable tolerability with a low rate of taste-related adverse events (<6.5%). The company plans to discuss the Phase 3 program with the FDA in 2Q 2022. However, the Phase 2a BLUEPRINT trial for chronic pruritus did not achieve statistical significance.

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FAQ

What is the market cap of BLU (BLU)?

The market cap of BLU (BLU) is approximately 1.9B.

What is BELLUS Health Inc.?

BELLUS Health Inc. is a biopharmaceutical development company focused on developing novel therapeutics for high unmet medical needs.

What is BLU-5937?

BLU-5937 is BELLUS Health's lead drug candidate, designed to treat chronic cough. It targets the P2X3 receptor and is considered a potential best-in-class treatment.

How does BLU-5937 work?

BLU-5937 works by antagonizing the P2X3 receptor, which is clinically validated for treating chronic cough, especially in patients who do not respond to current therapies.

What is chronic cough?

Chronic cough is a cough that lasts more than eight weeks and can have significant adverse social, psychosocial, and physical effects on quality of life.

When did BELLUS Health acquire the rights to BLU-5937?

BELLUS Health acquired the rights to BLU-5937 in February 2017 through a license agreement with the Neomed Institute.

Who are the potential beneficiaries of BLU-5937?

Patients suffering from chronic cough, particularly those who do not respond to existing therapies, are the primary beneficiaries of BLU-5937.

What other projects is BELLUS Health involved in?

BELLUS Health has economic interests in various partnered drug development projects, reflecting its commitment to addressing diverse medical challenges.

Where is BELLUS Health headquartered?

BELLUS Health is headquartered in Canada.

Why is BLU-5937 considered a potential best-in-class drug?

BLU-5937 is considered a potential best-in-class drug due to its highly selective and potent antagonism of the P2X3 receptor, offering significant promise for chronic cough treatment.

How does BELLUS Health contribute to the biopharmaceutical industry?

BELLUS Health contributes to the biopharmaceutical industry through its innovative research, strategic partnerships, and development of novel therapeutics for conditions with high unmet medical needs.

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