Bioasis Announces Positive Results From an Efficacy Study of xB3™-IL-1RA in a Model of Multiple Sclerosis

Rhea-AI Summary

Bioasis Technologies (TSXV:BTI; OTCQB:BIOAF) announced positive results from a preclinical study of its xB³™ platform, showing efficacy in delivering an interleukin-1 receptor inhibitor across the blood-brain barrier in a rodent model of multiple sclerosis. Treatment with xB³™-IL-1RA led to delayed onset and reduced clinical symptoms compared to control groups. Dr. Deborah Rathjen emphasized the technology's potential to treat neuroinflammatory disorders. These findings support the ongoing development of xB³™ as a solution for CNS conditions with high unmet medical needs.

Positive

• Demonstrated efficacy of xB³™-IL-1RA in preclinical models for CNS disorders.
• Delayed onset and reduced symptoms of multiple sclerosis in treated rodents compared to controls.
• Further validation of the xB³™ platform for large molecule biologic delivery.

Negative

• None.

NEW HAVEN, Conn., July 07, 2021 (GLOBE NEWSWIRE) -- BIOASIS TECHNOLOGIES INC. (TSXV:BTI; OTCQB:BIOAF), (the “Company” or “Bioasis”), a pre-clinical, research-stage biopharmaceutical company developing its proprietary xB³™ platform technology to enhance the delivery of biologics across the blood-brain barrier (“BBB”) for the treatment of central nervous system (“CNS”) disorders in areas of high unmet medical need, including brain cancers and neurodegenerative diseases, today announced positive results from an efficacy study of a blood-brain barrier penetrant interleukin-1 receptor inhibitor in a preclinical rodent model of multiple sclerosis.

In previously published work¹, a recombinant fusion protein of Bioasis’ proprietary xB³™ peptide with an interleukin-1 receptor antagonist (xB³™-IL-1RA) demonstrated efficient delivery of effective concentrations of IL-1RA to the brain eliciting analgesia in a neuropathic pain animal model. Systemic administration of IL-1RA alone did not elicit analgesia.

Since IL-1 cytokines have been implicated in many autoimmune and neuroinflammatory diseases, xB³™-IL-1RA was investigated disease in the rodent experimental allergic encephalomyelitis (EAE) model of multiple sclerosis. Multiple doses of xB³™-IL-1RA were administered during the disease induction phase, resulting in both delayed onset and overall reduced clinical symptom score in animals treated with xB³™-IL-1RA compared to control animals (p<0.016 repeated measures ANOVA).

The data from this study provides further evidence for the utility of xB³™ peptide as a platform technology for delivery of large molecule biologics across the BBB. Furthermore, this study confirms the potential applicability of xB³™-IL-1RA to the treatment of neuroinflammatory diseases such as multiple sclerosis.

“These data further confirm the ability of the xB³™ delivery platform to enhance the delivery of large molecule therapeutics into CNS compartments with demonstrated disease-relevant efficacy. We are progressing these data and believe that xB³™-IL-1RA holds promise for the treatment of a broad range of neuroinflammatory diseases,” said Dr. Deborah Rathjen, Executive Chair of the Board of Bioasis.

¹ Thom G, Tian MM, Hatcher JP, et al. A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model. J Cereb Blood Flow Metab. 2019;39(10):2074-2088. doi:10.1177/0271678X18772998

On behalf of the Board of Directors of Bioasis Technologies Inc.
Deborah Rathjen, Ph.D., Executive Chair of the Board

Follow on:
Facebook
Instagram
LinkedIn
Twitter

BTI-CRP

About Bioasis

Bioasis Technologies Inc. is a biopharmaceutical company developing the xB³™ platform, a proprietary technology for the delivery of therapeutics across the blood brain barrier and the treatment of CNS disorders in areas of high unmet medical need, including brain cancers and neurodegenerative diseases. The delivery of therapeutics across the blood brain barrier represents the final frontier in treating neurological disorders. The in-house development programs at Bioasis are designed to develop symptomatic and disease-modifying treatments for brain-related diseases and disorders. For more information about the Company, please visit www.bioasis.us.

Forward Looking Statements

Certain statements in this press release contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 or forward-looking information under applicable Canadian securities legislation that may not be based on historical fact along with other statements containing the words “believe,” “may,” “plan,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect” and similar expressions. Such forward-looking statements or information involve known and unknown risks, uncertainties and other factors that may cause our actual results, events or developments, or industry results, to be materially different from any future results, events or developments express or implied by such forward-looking statements or information. Such factors include, among others, our stage of development, lack of any product revenues, additional capital requirements, risk associated with the completion of clinical trials and obtaining regulatory approval to market our products, the ability to protect our intellectual property, dependence on collaborative partners and the prospects for negotiating additional corporate collaborations or licensing arrangements and their timing. Specifically, certain risks and uncertainties that could cause such actual events or results expressed or implied by such forward-looking statements and information to differ materially from any future events or results expressed or implied by such statements and information include, but are not limited to, the risks and uncertainties that: products that we develop may not succeed in preclinical or clinical trials, or future products in our targeted corporate objectives; our future operating results are uncertain and likely to fluctuate; we may not be able to raise additional capital; we may not be successful in establishing additional corporate collaborations or licensing arrangements; we may not be able to establish marketing and the costs of launching our products may be greater than anticipated; we have no experience in commercial manufacturing; we may face unknown risks related to intellectual property matters; we face increased competition from pharmaceutical and biotechnology companies; and other factors as described in detail in our filings with the Canadian securities regulatory authorities at www.sedar.com. Given these risks and uncertainties, you are cautioned not to place undue reliance on such forward-looking statements and information, which are qualified in their entirety by this cautionary statement. All forward-looking statements and information made herein are based on our current expectations and we undertake no obligation to revise or update such forward-looking statements and information to reflect subsequent events or circumstances, except as required by law.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release

Contacts:

Deborah Rathjen, Ph.D., Executive Chair of the Board and CEO
deborah@bioasis.us
203-533-7082

Investor Contact:
Graeme Dick
Colwell Capital Corp.
graeme@colwellcapital.com
403-561-8989 

FAQ

What are the recent results from Bioasis Technologies related to multiple sclerosis?

Bioasis Technologies announced positive results from a study showing the efficacy of its xB³™ platform in delivering an interleukin-1 receptor inhibitor, resulting in delayed onset and reduced symptoms in a rodent model of multiple sclerosis.

How does the xB³™ platform enhance drug delivery?

The xB³™ platform enhances the delivery of biologics across the blood-brain barrier, targeting CNS disorders with high unmet medical needs.

What is the significance of the xB³™-IL-1RA findings for Bioasis Technologies?

The findings support the potential of xB³™-IL-1RA as a treatment for neuroinflammatory diseases, validating the xB³™ platform's capability to deliver therapeutics effectively.

When was Bioasis Technologies' positive study result announced?

The positive study results were announced on July 7, 2021.