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Black Diamond Therapeutics, Inc. (Nasdaq: BDTX) is a leading precision oncology medicine company headquartered in Cambridge, Massachusetts. Founded in 2014, the company focuses on the discovery and development of small molecule, tumor-agnostic therapies designed to target families of oncogenic mutations across various cancers.
The core of Black Diamond’s innovative approach lies in its proprietary Mutation-Allostery-Pharmacology (MAP) platform. This platform enables the identification and targeting of allosteric mutations in key cancer-related kinases, offering new therapeutic options for patients with limited treatments available.
The company’s lead product candidate, BDTX-189, is a potent inhibitor targeting non-canonical and oncogenic mutations of ERBB kinases, including the epidermal growth factor receptor (EGFR) and tyrosine-protein kinase. The development pipeline also includes BDTX-1535, an advanced fourth-generation EGFR inhibitor, and BDTX-4933, targeting KRAS, NRAS, and BRAF mutations in solid tumors.
Recent clinical updates highlight the potential of BDTX-1535 in treating non-small cell lung cancer (NSCLC) and glioblastoma (GBM), demonstrating efficacy against over 50 clinically relevant non-classical EGFR mutations and resistance mutations like C797S. This candidate is currently advancing through Phase 2 trials, with promising results expected in 2024.
Black Diamond Therapeutics has also established significant collaborations and partnerships to bolster its research and development efforts. These collaborations aim to enhance the understanding of mutation landscapes and accelerate the delivery of new therapies to patients.
For more information, visit Black Diamond Therapeutics.
Black Diamond Therapeutics (Nasdaq: BDTX) has announced the ongoing Phase 1 dose escalation study of BDTX-1535 targeting non-small cell lung cancer (NSCLC) with EGFR mutations and recurrent glioblastoma multiforme (GBM). Additionally, preclinical data for BDTX-4933 shows it effectively inhibits aberrant RAF signaling in models with BRAF and RAS mutations. The company presented findings at the 2023 AACR Annual Meeting, highlighting its MasterKey approach to oncology, which aims to address unmet needs in cancer treatment.
The Phase 1 study of BDTX-1535, initiated in 2022, is set to expand cohorts in 2023, while a Phase 1 trial for BDTX-4933 is scheduled for Q2 2023. The upcoming clinical updates are anticipated in the second half of this year.
Black Diamond Therapeutics (BDTX) reported its 2022 financial results, showing significant developments in its MasterKey pipeline. The company received FDA clearance for BDTX-4933 and is on track to provide a clinical update on BDTX-1535 in the second half of 2023. As of December 31, 2022, BDTX had $122.8 million in cash, enough to fund operations through Q3 2024. The company plans to initiate a Phase 1 clinical trial for BDTX-4933 in early 2023. R&D expenses decreased to $64.4 million, while net loss for 2022 was $91.2 million, improved from $125.6 million in 2021, indicating potential operational efficiencies.
Black Diamond Therapeutics (Nasdaq: BDTX) announced that its CEO, David M. Epstein, Ph.D., will present an update on the company’s advancements at the Cowen 43rd Annual Health Care Conference on March 6, 2023, at 12:50 p.m. ET in Boston, MA. The presentation will be accessible via a live webcast on the company’s investor relations page, with a replay available for 90 days post-event.
Black Diamond specializes in precision oncology, focusing on MasterKey therapies targeting oncogenic driver mutations in genetically-defined cancers, including its lead programs BDTX-1535 for EGFR mutant-positive non-small cell lung cancer and glioblastoma, and BDTX-4933 targeting RAF mutations.
Black Diamond Therapeutics, Inc. (Nasdaq: BDTX) will present an update on its progress at the 41st Annual J.P. Morgan Healthcare Conference on January 12, 2023, at 9:00 a.m. PT in San Francisco. CEO David M. Epstein will lead the presentation, focusing on the company’s advancements in precision oncology therapies targeting oncogenic driver mutations in genetically defined cancers. Black Diamond's pipeline includes clinical-stage programs BDTX-1535 and BDTX-4933, aiming to address significant unmet medical needs.
Black Diamond Therapeutics (Nasdaq: BDTX) announced the resignation of Chairman Robert A. Ingram for personal reasons. Mark Velleca, an existing Board member, has been appointed as the new Chairman. Ingram expressed confidence in the company's future, highlighting its robust pipeline and MAP drug discovery engine. Velleca shared enthusiasm for advancing Black Diamond's precision oncology mission, especially regarding ongoing clinical programs like BDTX-1535. Both leaders acknowledged the company's commitment to addressing significant unmet needs in oncology.
Black Diamond Therapeutics (Nasdaq: BDTX) announced the formation of Launchpad Therapeutics, an antibody-focused precision oncology company, through a $30 million Series A investment led by Versant Ventures and NEA. Black Diamond contributed early-stage antibody programs and licensed its MAP Drug Discovery Engine to Launchpad, receiving a minority equity stake in return. This strategic move enables Black Diamond to concentrate on its existing drug pipeline while Launchpad aims to leverage advanced computational tools for novel antibody therapies, addressing genetically defined cancers.
Black Diamond Therapeutics, a precision oncology company (Nasdaq: BDTX), will participate in three investor conferences in November and December 2022. The events include the H.C. Wainwright 3rd Annual Precision Oncology Virtual Conference on November 14, the Stifel 2022 Healthcare Conference on November 15, and the Piper Sandler 34th Annual Healthcare Conference on December 1. Each presentation will be available via webcast on the company’s investor relations website for 90 days post-event.
Black Diamond Therapeutics (Nasdaq: BDTX) reported significant preclinical progress in its MasterKey therapies, BDTX-1535 and BDTX-4933, showcasing promising anti-tumor activity at the EORTC-NCI-AACR Symposium. The company is on track to update clinical data for BDTX-1535 in 2023 and plans to file an IND for BDTX-4933 in the first half of 2023. Financially, BDTX reported approximately $144.2 million in cash as of September 30, 2022, with a net loss of $21.7 million for Q3 2022. The company anticipates sufficient funding for operations into Q3 2024.
Black Diamond Therapeutics (BDTX) presented new preclinical data on BDTX-1535 and BDTX-4933 at the EORTC-NCI-AACR Symposium in Barcelona. BDTX-1535 is an irreversible EGFR inhibitor showing significant anti-tumor activity in multiple models of glioblastoma multiforme (GBM) and non-small cell lung cancer (NSCLC), while sparing wild-type EGFR. BDTX-4933 targets oncogenic BRAF mutations, achieving tumor regression in preclinical studies. Both therapies leverage Black Diamond's MAP Drug Discovery Engine and are currently in development, with updates expected in 2023.
Black Diamond Therapeutics (Nasdaq: BDTX) announced that CEO David M. Epstein, Ph.D., will present an update on the company’s progress at the H.C. Wainwright 24th Annual Global Investment Conference. The presentation will be available on-demand starting September 12, 2022, at 7:00 AM ET. Additionally, Black Diamond's management will participate in investor meetings at the Morgan Stanley 20th Annual Global Healthcare Conference from September 12-14, 2022, in New York, NY. For access to the webcast and further details, visit blackdiamondtherapeutics.com.
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