Bicycle Therapeutics to Present Five Posters Highlighting Preclinical Data from its Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) Programs at the SITC 37th Annual Meeting

Rhea-AI Summary

Bicycle Therapeutics (NASDAQ: BCYC) announced the presentation of preclinical data for BT7480 and BT7455 at the 37th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) in Boston, from November 8-12, 2022. Five posters will be presented, highlighting innovative findings related to tumor-targeted immune cell agonists. Notable topics include the efficacy of Bicycle NK-TICA and the evaluation of humanized animal models. This event underscores Bicycle's commitment to advancing their proprietary bicyclic peptide technology in cancer therapy.

Positive

• Presentation of preclinical data at a prestigious conference indicates strong research activity.
• BT7480 and BT7455 are innovative Bicycle tumor-targeted immune cell agonists with promising applications.

Negative

• None.

CAMBRIDGE, England, & BOSTON--(BUSINESS WIRE)-- Bicycle Therapeutics plc (NASDAQ:BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle®) technology, today announced that preclinical data for BT7480, a novel Bicycle tumor-targeted immune cell agonist (Bicycle TICA), and BT7455, an EphA2/CD137 Bicycle TICA, will be presented in five poster presentations at the Society for Immunotherapy of Cancer’s (SITC) 37^th Annual Meeting, being held in Boston, M.A. and virtually on November 8-12, 2022. Details on Bicycle’s poster presentations at SITC are as follows:

Poster Title: NKp46 engaging Bicycle NK-TICA® drives tumor targeted cytotoxicity
Presenter: Alexandra Rezvaya, Bicycle Therapeutics
Session Title: Immuno-conjugates and chimeric molecules
Poster #: 1207
Date and Time: Thursday, November 10 at 9 a.m. ET

Poster Title: Utility of humanized animal models for in vivo evaluation of NK-TICA®, novel Bicycle tumor-targeted immune cell agonist® (Bicycle TICA®) designed to engage NK cells
Presenter: Lukas Stanczuk, Bicycle Therapeutics
Session Title: Novel single-agent immunotherapies
Poster #: 1388
Date and Time: Friday, November 11 at 9 a.m. ET

Poster Title: Transcriptional profiling of Bicycle® tumor-targeted CD137 agonist-treated mouse tumors revealed an early and rapid activation of myeloid cells followed by infiltration of cytotoxic T cells into the tumor
Presenter: Johanna Lahdenranta, Bicycle Therapeutics
Session Title: Novel single-agent immunotherapies
Poster #: 1356
Date and Time: Friday, November 11 at 9 a.m. ET

Poster Title: BT7455, a fully synthetic Bicycle tumor-targeted immune cell agonist®, leads to potent EphA2-dependent CD137 agonism and robust anti-tumor efficacy
Presenters: Kristin Hurov and Lia Luus, Bicycle Therapeutics
Session Title: Novel single-agent immunotherapies
Poster #: 1340
Date and Time: Friday, November 11 at 9 a.m. ET

Poster Title: In-depth characterization of cDC1 ex vivo and in vitro models: development and comparison of conventional dendritic cell culture systems for industry
Presenter: Anna Licht, Bicycle Therapeutics
Session Title: Immune cell types and biology
Poster #: 980
Date and Time: Friday, November 11 at 9 a.m. ET

The poster presentations are available on the Publications section of bicycletherapeutics.com.

About Bicycle Therapeutics

Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycles, for diseases that are underserved by existing therapeutics. Bicycles are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycles attractive candidates for drug development. Bicycle is evaluating BT5528, a second-generation Bicycle Toxin Conjugate (BTC®) targeting EphA2; BT8009, a second-generation BTC targeting Nectin-4, a well-validated tumor antigen; and BT7480, a Bicycle TICA® targeting Nectin-4 and agonizing CD137, in company-sponsored Phase I/II trials. In addition, BT1718, a BTC that targets MT1-MMP, is being investigated in an ongoing Phase I/IIa clinical trial sponsored by the Cancer Research UK Centre for Drug Development. Bicycle is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, MA. For more information, visit bicycletherapeutics.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20221110005380/en/

Investors:

David Borah, CFA

VP, Capital Markets & Investor Relations

david.borah@bicycletx.com

617-203-8300

Media:

Argot Partners

Sarah Sutton

bicycle@argotpartners.com

212-600-1902

Source: Bicycle Therapeutics

FAQ

What is the significance of Bicycle Therapeutics' presentations at SITC 2022?

The presentations highlight innovative findings and advancements in their tumor-targeted therapies, showcasing their research capabilities.

What are BT7480 and BT7455?

BT7480 and BT7455 are novel Bicycle tumor-targeted immune cell agonists designed to improve cancer treatment outcomes.

When and where is the SITC 2022 meeting held?

The SITC 2022 meeting is taking place in Boston from November 8-12, 2022.

What type of data is presented about BT7480?

Preclinical data emphasizing novel approaches to engaging immune cells for targeted cancer therapy is being presented.

What implications do these presentations have for BCYC stock?

Successful presentations may increase investor confidence and interest in BCYC, potentially impacting stock performance positively.