An email has been sent to your address with instructions for changing your password.
There is no user registered with this email.
Sign Up
To create a free account, please fill out the form below.
Thank you for signing up!
A confirmation email has been sent to your email address. Please check your email and follow the instructions in the message to complete the registration process. If you do not receive the email, please check your spam folder or contact us for assistance.
Welcome to our platform!
Oops!
Something went wrong while trying to create your new account. Please try again and if the problem persist, Email Us to receive support.
Bicycle Therapeutics plc (NASDAQ: BCYC) has announced the publication of preclinical data for BT8009, a Nectin-4 targeting Bicycle Toxin Conjugate, in the Journal of Medicinal Chemistry. This study, alongside previous research, supports BT8009's development for treating Nectin-4 expressing tumors, which are prevalent in various solid cancers. The company is currently evaluating BT8009 in a Phase I/II clinical trial. Bicycle's innovative Bicycle technology aims to create effective therapies for underserved cancer indications.
Positive
Publication of BT8009 preclinical data in a reputable journal.
Ongoing Phase I/II clinical trial for BT8009 targeting a validated tumor antigen.
Potential for innovative treatment options for patients with solid tumors.
Negative
Reliance on the success of Phase I/II trials, with uncertainty regarding outcomes.
Possible delays and unsatisfactory results in ongoing clinical studies.
CAMBRIDGE, England & BOSTON--(BUSINESS WIRE)--
Bicycle Therapeutics plc (NASDAQ:BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle®) technology, today announced that an article highlighting preclinical data from BT8009, a Nectin-4 targeting Bicycle Toxin Conjugate, was published in the Journal of Medicinal Chemistry. The article, titled “Discovery of BT8009: a Nectin-4 Targeting Bicycle® Toxin Conjugate for the Treatment of Cancer” is available at the publications section of the Bicycle website at this link.
“The pre-clinical data published in the Journal of Medicinal Chemistry describe the discovery of our clinical-stage Bicycle Toxin Conjugate candidate targeting Nectin-4 expressing tumors,” said Nicholas Keen, Ph.D., Chief Scientific Officer of Bicycle Therapeutics. “Together with our study published recently in Molecular Cancer Therapeutics, these articles describe the preclinical work supporting the development of BT8009, which we are currently evaluating in a Phase I/II clinical trial across a number of solid tumor cancers. Nectin-4 is a validated tumor antigen target and we are excited to develop a novel approach to Nectin-4 expressing tumors.”
About Bicycle Therapeutics
Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycles, for diseases that are underserved by existing therapeutics. Bicycles are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycles attractive candidates for drug development. Bicycle is evaluating BT5528, a second-generation Bicycle Toxin Conjugate (BTC®) targeting EphA2; BT8009, a second-generation BTC targeting Nectin-4, a well-validated tumor antigen; and BT7480, a Bicycle TICA® targeting Nectin-4 and agonizing CD137, in company-sponsored Phase I/II trials. In addition, BT1718, a BTC that targets MT1-MMP, is being investigated in an ongoing Phase I/IIa clinical trial sponsored by the Cancer Research UK Centre for Drug Development. Bicycle is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, MA. For more information, visit bicycletherapeutics.com.
Forward-Looking Statements
This press release may contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as “aims,” “anticipates,” “believes,” “could,” “estimates,” “expects,” “forecasts,” “goal,” “intends,” “may,” “plans,” “possible,” “potential,” “seeks,” “will” and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements regarding the potential of BT8009 to target and kill cancer tumor cells. Bicycle may not actually achieve the intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: whether the outcomes of preclinical studies will be predictive of clinical trial results the risk that trials and studies may be delayed and may not have satisfactory outcomes; and other important factors, any of which could cause Bicycle’s actual results to differ from those contained in the forward-looking statements, are described in greater detail in the section entitled “Risk Factors” in Bicycle’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) on August 4, 2022, as well as in other filings Bicycle may make with the SEC in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and Bicycle expressly disclaims any obligation to update any forward-looking statements contained herein, whether because of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.
What is BT8009 and its purpose in cancer treatment?
BT8009 is a Nectin-4 targeting Bicycle Toxin Conjugate designed to treat cancer by targeting tumors that express Nectin-4.
What are the results of the preclinical studies for BT8009?
The preclinical studies published in the Journal of Medicinal Chemistry support the development of BT8009, indicating its potential effectiveness in targeting specific cancer cells.
What stage is BT8009 currently in?
BT8009 is currently being evaluated in a Phase I/II clinical trial across various solid tumor cancers.
How could the publication of the BT8009 data impact Bicycle Therapeutics investors?
The publication may enhance confidence among investors regarding the validity of Bicycle's approach and the potential success of its ongoing trials.
Bicycle Therapeutics plc American Depositary Shares
