Bicycle Therapeutics Announces Publication of Article in Bioconjugate Chemistry, Describing an Extension of its Proprietary Technology Platform Based on Bicyclic Peptides

Rhea-AI Summary

Bicycle Therapeutics plc (NASDAQ: BCYC) announced the publication of an article in Bioconjugate Chemistry regarding the use of tris-Gold complexes to enhance the chemical diversity of its proprietary Bicycle peptides. The research showcases a method for constructing constrained Bicycle peptides, which may be beneficial for future targets. CEO Kevin Lee highlighted this publication as a sign of the company's robust research capabilities. Bicycle continues clinical trials for several candidates, including BT5528 and BT8009, targeting important tumor antigens.

Positive

• Publication of significant research in Bioconjugate Chemistry demonstrating innovative use of tris-Gold complexes.
• Potential for new Bicycle targets with the novel construction method showcased.
• Ongoing clinical trials for multiple promising candidates like BT5528 and BT8009.

Negative

• None.

CAMBRIDGE, England & BOSTON--(BUSINESS WIRE)-- Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle^®) technology, today announced that an article highlighting data using tris-Gold complexes to increase the chemical diversity of Bicycles, was published in Bioconjugate Chemistry. The article, titled “Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides” is available at the publications section of the Bicycle website at this link.

“The research published in Bioconjugate Chemistry demonstrates that Gold-mediated cysteine arylation can be used as an approach for construction of novel, highly constrained Bicycles under conditions previously shown to be compatible with reactions on biological systems such as bacteriophage, highlighting the potential to be utilized for new Bicycle targets moving forward. Assessment of the suitability of this methodology to Bicycle phage screening is underway,” said Kevin Lee, Ph.D., Chief Executive Officer of Bicycle Therapeutics. “The article adds to the wealth of scientific papers coming from our Company, and the acceleration in output is a testament to the robustness of our platform as well as the hard work and quality of the Bicycle team.”

Bicycles are formed through the reaction of three cysteine residues within a linear sequence with a trivalent, symmetrical small molecule scaffold. Bicycles with high binding affinities to therapeutically important targets are discovered using a proprietary phage display technology. Tris-Gold complexes have recently been described as a method for the efficient bioconjugation of cysteine residues under conditions we believe to be compatible with phage display. The article exemplifies an approach for the construction of novel, highly constrained Bicycles.

About Bicycle Therapeutics

Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycles, for diseases that are underserved by existing therapeutics. Bicycles are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycles attractive candidates for drug development. Bicycle is evaluating BT5528, a second-generation Bicycle Toxin Conjugate (BTC™) targeting EphA2; BT8009, a second-generation BTC targeting Nectin-4, a well-validated tumor antigen; and BT7480, a Bicycle TICA™ targeting Nectin-4 and agonizing CD137, in company-sponsored Phase I/II trials. In addition, BT1718, a BTC that targets MT1-MMP, is being investigated in an ongoing Phase I/IIa clinical trial sponsored by the Cancer Research UK Centre for Drug Development. Bicycle is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts. For more information, visit bicycletherapeutics.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220802006012/en/

Investors:

David Borah, CFA

VP, Capital Markets & Investor Relations

david.borah@bicycletx.com

617 203-8300

Media:

Argot Partners

Sarah Sutton

bicycle@argotpartners.com

212-600-1902

Source: Bicycle Therapeutics plc

FAQ

What does the recent article published by Bicycle Therapeutics in <i>Bioconjugate Chemistry</i> discuss?

The article discusses using tris-Gold complexes to enhance the chemical diversity of Bicycle peptides and the construction of novel constrained Bicycle peptides.

How might the research in the article impact Bicycle Therapeutics' future targets?

The research highlights an innovative approach that could enable the development of new Bicycle targets for therapeutic applications.

What clinical trials is Bicycle Therapeutics currently conducting?

Bicycle is conducting clinical trials for several candidates, including BT5528 targeting EphA2 and BT8009 targeting Nectin-4.

Who is the CEO of Bicycle Therapeutics?

The CEO of Bicycle Therapeutics is Kevin Lee, Ph.D.

What is the significance of tris-Gold complexes in Bicycle Therapeutics' research?

Tris-Gold complexes provide a method for efficient bioconjugation of cysteine residues, which may improve the development of Bicycle peptides.