BioCryst Reports Second Quarter 2023 Financial Results and Provides Business Update
- Q2 2023 net revenue increased by 24% YoY
- On track to achieve ≥ $320 million in full year 2023 ORLADEYO revenue
- Company to introduce additional pipeline assets and programs at R&D day in November
- Q2 2023 GAAP EPS of ($0.40), non-GAAP EPS of ($0.24)
— Q2 2023 ORLADEYO net revenue of
— On-track to achieve ≥
— Q2 2023 GAAP EPS of (
— BCX10013, once-daily, oral Factor D inhibitor, clinical trial in patients expected to begin enrollment by end of year—
—Company to host R&D day on Friday, November 3rd to introduce additional pipeline assets and programs—
RESEARCH TRIANGLE PARK, N.C., Aug. 03, 2023 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq:BCRX) today reported financial results for the second quarter ended June 30, 2023, and provided a corporate update.
“Our strong second quarter keeps us firmly on track to achieve no less than
Program Updates
ORLADEYO® (berotralstat): Oral, Once-daily Treatment for Prevention of Hereditary Angioedema (HAE) Attacks
“The significant step-up in revenue we expected and achieved in the second quarter reflects the continued strong growth in patients taking ORLADEYO, the normal seasonality in revenue that follows first quarter prescription reauthorizations, and our steady improvement in helping patients get to reimbursed therapy. We recently attended the HAEA summit, attended by 1,200 patients and family members. Their strong interest and enthusiasm gave us even more confidence in our expectations for sustained long-term demand for ORLADEYO in the U.S. and globally,” said Charlie Gayer, chief commercial officer of BioCryst.
- ORLADEYO net revenue in the second quarter of 2023 was
$81.0 million (+24.2 percent year-over-year (y-o-y)). - Total growth in patients taking ORLADEYO continued on a strong, linear trajectory.
- The percentage of U.S. ORLADEYO patients receiving paid drug improved in the second quarter as the company made progress converting commercially-insured patients who had been receiving long-term free product, and as patients who received temporary free product during the first quarter prescription re-authorization process returned to reimbursed product in the second quarter.
- Sales from outside the U.S. contributed 10.1 percent of global ORLADEYO net revenues in the second quarter.
- The ongoing APeX-P trial in pediatric HAE patients who are 2 to <12 years of age continues to enroll as expected.
BCX10013—Oral Factor D Inhibitor
“Our goal with BCX10013 is to bring a best-in-class molecule to physicians and patients. That means a safe, highly effective, once-daily oral therapy, and we are now focused on preparing for enrollment in our dose-ranging trial in patients,” said Dr. Helen Thackray, chief research and development officer.
- The company has begun opening clinical trial sites for a dose-ranging trial in patients with paroxysmal nocturnal hemoglobinuria (PNH) and expects to begin patient enrollment (in countries without other approved therapies) by the end of the year. The trial is designed to identify a safe, effective, once-daily dose that BioCryst can advance into a pivotal program in renal complement-mediated diseases.
- The company also plans to complete an additional cohort of its multiple ascending dose trial (MAD) of BCX10013, at a higher dose (160 mg QD), in healthy volunteers to provide further information to the pharmacokinetic model.
Upcoming R&D Day—November 3, 2023
BioCryst will host a Research and Development (R&D) day at 1:00p ET on Friday, November 3 at its Research Center of Excellence in Birmingham, AL (the event also will be webcast live). At the R&D day, the company plans to introduce additional assets from its pipeline targeting rare diseases.
Second Quarter 2023 Financial Results
For the three months ended June 30, 2023, total revenues were
R&D expenses for the second quarter of 2023 decreased to
Selling, general and administrative expenses for the second quarter of 2023 increased to
Interest expense was
Net loss for the second quarter of 2023 was
Cash, cash equivalents, restricted cash and investments totaled
Non-GAAP Pro forma Financial Measures
The information furnished in this release includes non-GAAP pro forma financial measures that differ from measures calculated in accordance with generally accepted accounting principles in the United States of America (GAAP), including financial measures labeled as “non-GAAP” or “adjusted.”
We believe providing these non-GAAP measures, which show our pro forma results with these items adjusted, is valuable and useful since they allow the company and investors to better understand the company’s financial performance in the absence of these one-time events and allow investors to more accurately understand our second quarter 2023 results and more easily compare them to future results. These non-GAAP pro forma measures also correspond with the way we expected Wall Street analysts to compare our results. Our non-GAAP pro forma measures should be considered only as supplements to, and not as substitutes for or in isolation from, our other measures of financial information prepared in accordance with GAAP, such as GAAP revenue, operating income, net income, and earnings per share.
Our references to our second quarter 2023 and first six months 2023 “non-GAAP pro forma” financial measures of adjusted net loss and adjusted earnings per share constitute non-GAAP financial measures. They refer to our GAAP results, adjusted to show the results without the one-time loss on the extinguishment of the Athyrium term loans.
Financial Outlook for 2023
The company expects full year 2023 global net ORLADEYO revenue to be no less than
Conference Call and Webcast
BioCryst management will host a conference call and webcast at 8:30 a.m. ET today to discuss the financial results and provide a corporate update. The live call may be accessed by dialing 1-866-777-2509 for domestic callers and 1-412-317-5413 for international callers. A live webcast and replay of the call will be available online in the investors section of the company website at www.biocryst.com.
About BioCryst Pharmaceuticals
BioCryst Pharmaceuticals discovers novel, oral, small-molecule medicines that treat rare diseases in which significant unmet medical needs exist and an enzyme plays a key role in the biological pathway of the disease. Oral, once-daily ORLADEYO® (berotralstat) is approved in the United States and many global markets. BioCryst has active programs to develop oral medicines for multiple targets across the complement system, including BCX10013, an oral Factor D inhibitor in clinical development. RAPIVAB® (peramivir injection) is approved in the U.S. and multiple global markets, with post-marketing commitments ongoing. For more information, please visit the company’s website at www.biocryst.com.
Forward-Looking Statements
This press release contains forward-looking statements, including statements regarding future results, performance or achievements. These statements involve known and unknown risks, uncertainties and other factors which may cause BioCryst’s actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These statements reflect our current views with respect to future events and are based on assumptions and are subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Some of the factors that could affect the forward-looking statements contained herein include: the ongoing COVID-19 pandemic, which could create challenges in all aspects of BioCryst’s business, including without limitation delays, stoppages, difficulties and increased expenses with respect to BioCryst’s and its partners’ development, regulatory processes and supply chains, negatively impact BioCryst’s ability to access the capital or credit markets to finance its operations, or have the effect of heightening many of the risks described below or in the documents BioCryst files periodically with the Securities and Exchange Commission; BioCryst’s ability to successfully implement its commercialization plans for, and to commercialize, ORLADEYO, which could take longer or be more expensive than planned; the results of BioCryst’s partnerships with third parties may not meet BioCryst’s current expectations; risks related to government actions, including that decisions and other actions, including as they relate to pricing, may not be taken when expected or at all, or that the outcomes of such decisions and other actions may not be in line with BioCryst’s current expectations; the commercial viability of ORLADEYO, including its ability to achieve market acceptance; ongoing and future preclinical and clinical development of BCX10013 and other product candidates may take longer than expected and may not have positive results; BioCryst may not be able to enroll the required number of subjects in planned clinical trials of product candidates; BioCryst may not advance human clinical trials with product candidates as expected; the FDA or other applicable regulatory agency may require additional studies beyond the studies planned for products and product candidates, may not provide regulatory clearances which may result in delay of planned clinical trials, may impose certain restrictions, warnings, or other requirements on products and product candidates, may impose a clinical hold with respect to product candidates, or may withhold, delay or withdraw market approval for products and product candidates; product candidates, if approved, may not achieve market acceptance; BioCryst’s ability to successfully commercialize its products and product candidates, manage its growth and compete effectively; risks related to the international expansion of BioCryst’s business; and actual financial results may not be consistent with expectations, including that revenue, operating expenses and cash usage may not be within management's expected ranges. Please refer to the documents BioCryst files periodically with the Securities and Exchange Commission, specifically BioCryst’s most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K, which identify important factors that could cause actual results to differ materially from those contained in BioCryst’s projections and forward-looking statements.
BCRXW
Contact:
John Bluth
+1 919 859 7910
jbluth@biocryst.com
| BIOCRYST PHARMACEUTICALS, INC. | |||||||||||||||
| CONSOLIDATED FINANCIAL SUMMARY | |||||||||||||||
| (in thousands, except per share) | |||||||||||||||
| Statements of Operations (Unaudited) | |||||||||||||||
| Three Months Ended | Six Months Ended | ||||||||||||||
| June 30, | June 30, | ||||||||||||||
| 2023 | 2022 | 2023 | 2022 | ||||||||||||
| Revenues: | |||||||||||||||
| ORLADEYO | $ | 81,009 | $ | 65,223 | $ | 149,423 | $ | 114,927 | |||||||
| Other | 1,482 | 309 | 1,846 | 528 | |||||||||||
| Total revenues | 82,491 | 65,532 | 151,269 | 115,455 | |||||||||||
| Expenses: | |||||||||||||||
| Cost of product sales | 894 | 246 | 1,825 | 482 | |||||||||||
| Research and development | 51,247 | 61,990 | 99,635 | 127,350 | |||||||||||
| Selling, general and administrative | 50,997 | 38,017 | 98,864 | 72,299 | |||||||||||
| Royalty | 56 | 1 | 63 | 3 | |||||||||||
| Total operating expenses | 103,194 | 100,254 | 200,387 | 200,134 | |||||||||||
| Loss from operations | (20,703 | ) | (34,722 | ) | (49,118 | ) | (84,679 | ) | |||||||
| Interest and other income | 3,750 | 609 | 7,128 | 663 | |||||||||||
| Interest expense | (28,915 | ) | (24,022 | ) | (56,311 | ) | (47,859 | ) | |||||||
| Foreign currency gains (losses), net | 301 | 132 | 72 | (45 | ) | ||||||||||
| Loss on extinguishment of debt | (29,019 | ) | - | (29,019 | ) | - | |||||||||
| Loss before income taxes | (74,586 | ) | (58,003 | ) | (127,248 | ) | (131,920 | ) | |||||||
| Income tax expense | 740 | 856 | 1,411 | 1,135 | |||||||||||
| Net loss | $ | (75,326 | ) | $ | (58,859 | ) | $ | (128,659 | ) | $ | (133,055 | ) | |||
| Basic and diluted net loss per common share | $ | (0.40 | ) | $ | (0.32 | ) | $ | (0.68 | ) | $ | (0.72 | ) | |||
| Weighted average shares outstanding | 189,118 | 185,605 | 188,815 | 185,253 | |||||||||||
| Balance Sheet Data (in thousands) | |||||||||||||||
| June 30, 2023 | December 31, 2022 | ||||||||||||||
| (Unaudited) | (Note 1) | ||||||||||||||
| Cash, cash equivalents and investments | $ | 414,115 | $ | 442,387 | |||||||||||
| Restricted cash | 1,574 | 1,472 | |||||||||||||
| Receivables | 57,667 | 50,599 | |||||||||||||
| Total assets | 529,885 | 550,000 | |||||||||||||
| Secured term loan | 293,176 | 231,624 | |||||||||||||
| Royalty financing obligation | 526,121 | 501,655 | |||||||||||||
| Accumulated deficit | (1,583,279 | ) | (1,454,620 | ) | |||||||||||
| Stockholders’ deficit | (388,713 | ) | (294,597 | ) | |||||||||||
| Shares of common stock outstanding | 189,491 | 187,906 | |||||||||||||
| Note 1: Derived from audited financial statements. | |||||||||||||||
| Reconciliation of Adjusted Net Income and Adjusted Diluted Earnings Per Share (in thousands) | |||||||||||||||
| Three Months Ended | Six Months Ended | ||||||||||||||
| June 30, | June 30, | ||||||||||||||
| 2023 | 2022 | 2023 | 2022 | ||||||||||||
| GAAP net loss | $ | (75,326 | ) | $ | (58,859 | ) | $ | (128,659 | ) | $ | (133,055 | ) | |||
| Less : One-time loss on extinguishment of Athyrium term loans | (29,019 | ) | - | (29,019 | ) | - | |||||||||
| Adjusted net loss | $ | (46,307 | ) | $ | (58,859 | ) | $ | (99,640 | ) | $ | (133,055 | ) | |||
| GAAP basic and diluted net loss per common share | $ | (0.40 | ) | $ | (0.32 | ) | $ | (0.68 | ) | $ | (0.72 | ) | |||
| Adjusted basic and diluted net loss per common share | $ | (0.24 | ) | $ | (0.32 | ) | $ | (0.53 | ) | $ | (0.72 | ) | |||
FAQ
What was BioCryst Pharmaceuticals' Q2 2023 net revenue?
What are BioCryst Pharmaceuticals' revenue goals for 2023?
What will BioCryst Pharmaceuticals introduce at their R&D day in November?
