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BridgeBio Pharma, Inc. (Nasdaq: BBIO) is a pioneering commercial-stage biopharmaceutical company that specializes in the discovery, creation, and delivery of transformative medicines for patients suffering from genetic diseases and cancers with clear genetic drivers. Established in 2015, the company is headquartered in Palo Alto, California. BridgeBio's mission is to address significant unmet medical needs through genetic medicine by leveraging a comprehensive pipeline of development programs that span from early-stage scientific research to late-stage clinical trials.
The company's core focus areas include Mendelian diseases, Genetic Dermatology, Oncology, and Gene Therapy. BridgeBio’s innovative approach involves systematically mapping the genetic disease landscape to identify promising therapeutic assets. Their proprietary platform and management expertise are harnessed to accelerate the development of these early-stage assets into clinically impactful treatments.
BridgeBio’s robust pipeline boasts several notable programs:
- Acoramidis (AG10): Aiming to treat transthyretin amyloid cardiomyopathy (ATTR-CM), this next-generation, orally-administered TTR stabilizer has shown positive results in the Phase 3 ATTRibute-CM trial. The New Drug Application (NDA) for acoramidis has been accepted by the FDA, with a target decision date set for November 29, 2024.
- Infigratinib: Targeting achondroplasia and hypochondroplasia, this FGFR1-3 inhibitor aims to address skeletal dysplasias. The PROPEL 2 Phase 2 trial has demonstrated significant and sustained increases in growth velocity.
- BBP-418: Designed for limb-girdle muscular dystrophy type 2I/R9 (LGMD2I/R9), this glycosylation substrate is under Phase 3 trials, with the potential for accelerated approval based on recent interactions with the FDA.
BridgeBio's track record includes successful capital raises, strategic partnerships, and a series of public offerings that have strengthened its financial positioning. The company recently completed a $200 million private financing for its oncology subsidiary, BridgeBio Oncology Therapeutics, to accelerate the development of its precision oncology pipeline.
Key recent developments include:
- The initiation of a comprehensive equity grants program to attract top talent in the biopharmaceutical industry.
- Positive results from multiple clinical trials, including significant improvements in health-related quality of life measures for patients with ATTR-CM treated with acoramidis.
- Ongoing collaborations with global pharmaceutical leaders like Bayer for the commercial development and distribution of key assets in international markets.
BridgeBio remains committed to advancing genetic medicine and delivering groundbreaking therapies to improve patient lives. For more information, visit bridgebio.com and follow them on LinkedIn and Twitter.
BridgeBio Pharma's affiliate, QED Therapeutics, has initiated the PROPEL 2 Phase 2 clinical trial, dosing the first child with achondroplasia using infigratinib, an oral medicine targeting FGFR3. This trial aims to assess safety and measure height growth impact. Preclinical data show potential for significant growth improvement. CEO Michael Henderson emphasized the trial's significance, highlighting the extensive preparatory work. Infigratinib operates as a selective tyrosine kinase inhibitor, and the trial follows previous assessments demonstrating its efficacy at lower doses.
BridgeBio Pharma's affiliate, Phoenix Tissue Repair, announced the presentation of interim safety and tolerability data from a Phase 1/2 trial for PTR-01, a recombinant collagen 7 therapy aimed at treating recessive dystrophic epidermolysis bullosa (RDEB). The results will be shared virtually during the Society for Pediatric Dermatology’s Annual Meeting from July 10-12, 2020. PTR-01 has previously shown promising preclinical results, with Orphan Drug Designation granted by the FDA and EMA. Currently, no approved therapies exist for DEB, and the standard care is limited to wound management.
BridgeBio Pharma, Inc. (Nasdaq: BBIO) announced on July 1, 2020, that it granted stock options for 7,120 shares and restricted stock units for 15,134 shares to eight employees. The exercise price for the stock options is set at $30.34. These awards are part of BridgeBio's 2019 Inducement Equity Plan and were granted to incentivize employees joining the company, complying with Nasdaq Listing Rule 5635(c)(4). Founded in 2015, BridgeBio focuses on developing medicines for genetic diseases and has over 20 programs in its pipeline.
BridgeBio Pharma (NASDAQ: BBIO) announced the appointment of three new independent directors: Brent Saunders, Randy Scott, Ph.D., and Andrew Lo, Ph.D. Saunders, former CEO of Allergan, brings expertise in scaling businesses, having driven significant product launches and revenue growth. Scott, a leader in genomics, aims to revolutionize genetic medicine application, while Lo will leverage his financial engineering background to enhance funding strategies. This leadership expansion aims to accelerate the development of innovative therapies for genetic diseases.
BridgeBio Pharma (NASDAQ: BBIO) has announced a strategic collaboration with the University of Florida to advance research in genetically driven diseases into clinical development. This partnership aims to leverage the University’s expertise in gene therapy alongside BridgeBio's capabilities in therapeutics. The collaboration focuses on providing sponsorship for select research programs, including strategies for optimizing small-molecule therapies and conducting proof-of-concept studies. BridgeBio aims to establish long-term partnerships to facilitate the advancement of groundbreaking research into viable therapies.
BridgeBio Pharma (NASDAQ: BBIO) has announced a collaboration with Johns Hopkins University to advance the clinical development of therapies targeting genetically driven diseases. The partnership aims to apply academic innovations into viable treatments, focusing on gene therapy and small molecules. CEO Neil Kumar expressed excitement over leveraging Johns Hopkins' research for potential patient benefits. BridgeBio intends to establish long-term partnerships in biomedical research, reinforcing its commitment to addressing Mendelian diseases, with over 20 programs in its pipeline.
Phoenix Tissue Repair, an affiliate of BridgeBio Pharma (Nasdaq: BBIO), provided updates on its Phase 1/2 study of PTR-01 for recessive dystrophic epidermolysis bullosa (RDEB). The initial cohorts showed that PTR-01 was well tolerated across nine patients, with no serious adverse events reported. Furthermore, a dose-dependent increase in collagen 7 skin deposition was observed. The trial is progressing with a fourth cohort, and results may lead to a six-month open-label study. Dr. Sanuj K. Ravindran has been appointed as the executive chairman, focusing on creating a systemic treatment for RDEB.
BridgeBio Pharma (Nasdaq: BBIO) announced its Q1 2020 financial results, reporting a net loss of $91.9 million, up from $61.2 million in Q1 2019. The company holds $928.4 million in cash and equivalents, ensuring operational stability amid COVID-19 challenges. Clinical trials are ongoing but slowed in enrollment due to the pandemic. BridgeBio aims to file multiple NDAs and INDs later this year. Despite operational hurdles, recent financing raised $550 million, positioning them to progress their pipeline of 20+ drug programs through 2022.
BridgeBio Pharma (Nasdaq: BBIO) will present at the Bank of America Securities 2020 Health Care Conference on May 14, 2020, at 11 AM ET. The presentation will be accessible via a live webcast on the company’s investor page, with a replay available until August 12, 2020. Founded in 2015, BridgeBio focuses on developing transformative medicines for genetic diseases and cancers with genetic drivers. The company boasts a robust pipeline of over 20 development programs, ranging from early discovery to late-stage development.
BridgeBio Pharma (Nasdaq: BBIO) announced the granting of stock options and restricted stock units on May 1, 2020. The compensation committee approved awards for five employees, totaling 39,600 stock options with an exercise price of $28.97 and 18,230 restricted stock units. These awards comply with Nasdaq Listing Rule 5635(c)(4) and are part of the 2019 Inducement Equity Plan established in November 2019. BridgeBio focuses on developing treatments for genetic diseases and has a pipeline of over 20 programs.
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