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Anavex Life Sciences Corp. (Nasdaq: AVXL) is a clinical-stage biopharmaceutical company dedicated to the development of novel therapeutics for neurodegenerative and neurodevelopmental disorders. Headquartered in New York, Anavex focuses on precision medicine to treat diseases with high unmet medical needs, such as Alzheimer's disease, Parkinson's disease, Rett syndrome, and schizophrenia.
Anavex's lead compound, ANAVEX 2-73 (blarcamesine), is an orally available small molecule targeting sigma-1 and muscarinic receptors. It aims to restore cellular homeostasis, showing promise in multiple CNS disorders. Blarcamesine has successfully completed Phase 2a and Phase 2b/3 trials for Alzheimer's disease and various studies in Rett syndrome, including a recent Phase 2/3 EXCELLENCE pediatric trial demonstrating significant improvements in Rett Syndrome Behaviour Questionnaire (RSBQ) scores.
The company also has other promising drug candidates, such as ANAVEX 3-71, targeting sigma-1 and M1 muscarinic receptors. This candidate has exhibited disease-modifying activity in Alzheimer's disease models and is currently in a Phase 2 trial for schizophrenia.
Anavex actively engages in partnerships and collaborations, including support from the Michael J. Fox Foundation for Parkinson's Research. With a robust intellectual property portfolio, Anavex is committed to advancing its pipeline through rigorous clinical trials to bring effective treatments to market.
Recent highlights include presenting at key industry conferences and filing a Marketing Authorisation application with the European Medicines Agency (EMA) for blarcamesine in Alzheimer's disease. Anavex also recently bolstered its executive team with seasoned professionals to drive its R&D and clinical strategies forward.
For more information, visit www.anavex.com or follow the company on Twitter, Facebook, Instagram, and LinkedIn.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced the publication of preclinical data on ANAVEX®2-73 (blarcamesine) for treating Fragile X Syndrome in Scientific Reports. The study demonstrated the drug's ability to reverse hyperactivity, restore associative learning, and reduce anxiety in Fmr1 knockout mice. Positron emission tomography confirmed dose-dependent receptor occupancy. These findings pave the way for a Phase 2/3 clinical trial, potentially expanding treatment options for the 62,500 Fragile X patients in the US.
Anavex Life Sciences Corp. (Nasdaq: AVXL) reported promising developments in its late-stage clinical trials for ANAVEX®2-73 (blarcamesine). A total of 509 patients have been enrolled in the Phase 2b/3 trial for Alzheimer’s disease, exceeding enrollment targets. The company holds a strong cash position of $157.6 million. However, the net loss for the quarter totaled $10.2 million, or $0.14 per share, which is an increase from $6.5 million in the same quarter last year. Upcoming topline data releases in 2H 2021 for Rett syndrome and 2H 2022 for Alzheimer’s disease are anticipated.
Anavex Life Sciences Corp. (Nasdaq: AVXL) will announce its financial results for the fiscal quarter ending June 30, 2021, on August 12, 2021, at 4:30 PM EDT. A conference call will follow, allowing management to discuss financial results and strategies for growth. Anavex specializes in developing therapeutics for neurodegenerative and neurodevelopmental disorders, including Alzheimer's and Parkinson's diseases. The company's lead drug, ANAVEX®2-73, has shown promise in clinical trials.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced participation by CEO Christopher U. Missling, PhD, in the BTIG Virtual Biotechnology Conference 2021 on August 10, 2021, at 9:30 a.m. EDT. The conference will focus on the company's development of therapeutics for neurodegenerative disorders like Alzheimer's and Parkinson's diseases. Anavex's lead drug, ANAVEX®2-73, showed promise in clinical trials and targets sigma-1 and muscarinic receptors to restore cellular balance. A webcast of the event will be available on Anavex's website under the Investors section.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced promising data indicating that ANAVEX®2-73 can prevent cognitive decline associated with Alzheimer's disease. In preclinical studies, the drug showed significant protection against Aβ25-35-induced cognitive impairments. The company plans to initiate a Phase 3 trial focusing on prevention in at-risk patients. Previously, clinical studies demonstrated cognitive improvements in Alzheimer's patients after treatment with ANAVEX®2-73 over 57 weeks. These advancements highlight the drug's potential in addressing significant unmet needs in neurodegenerative therapies.
Anavex Life Sciences Corp. (AVXL) announced promising results from its Phase 2 trial of ANAVEX®2-73 for treating Parkinson’s disease dementia. The treatment significantly increased the expression of the SIGMAR1 mRNA biomarker, correlating with improvements in cognitive and clinical efficacy endpoints, including a 14.51-point reduction in the MDS-UPDRS Total score (p = 0.034) compared to placebo. The study supports the regulatory pathway for ANAVEX®2-73 as a potential therapeutic option for Parkinson's disease. The findings will be submitted to the FDA to seek further regulatory guidance.
Anavex Life Sciences Corp. (Nasdaq: AVXL) has successfully closed a registered direct offering with Deep Track Capital, issuing 2,380,953 shares at $21.00 per share, raising approximately $50 million before fees. The funds are earmarked for advancing its drug pipeline and general corporate purposes. The offering is made under the effective shelf registration statement with the SEC. Anavex is focused on developing therapeutics for neurodegenerative disorders, including its lead candidate, ANAVEX®2-73, which has shown promise in clinical trials for Alzheimer’s and Parkinson’s diseases.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced a definitive purchase agreement with Deep Track Capital for a registered direct offering of 2,380,953 shares at $21.00 each, totaling approximately $50 million in gross proceeds. The offering is set to close around June 24, 2021, pending customary conditions. Funds from this offering will support advancing Anavex's clinical pipeline and general corporate needs. H.C. Wainwright & Co. serves as the exclusive placement agent for the offering.
Anavex Life Sciences Corp. (Nasdaq: AVXL) reported promising results from a Phase 2 trial of ANAVEX®2-73 in adult patients with Rett syndrome. The treatment significantly increased the expression of SIGMAR1 mRNA, correlating with improvements in primary efficacy endpoints, RSBQ (p = 0.035) and CGI-I (p = 0.029). Participants with WT SIGMAR1 showed a notable 14.5-point improvement in RSBQ (p = 0.009) over placebo. The study's results support the treatment's safety and efficacy, leading Anavex to pursue regulatory approval with the FDA.
Anavex Life Sciences Corp. (Nasdaq: AVXL) announced that its compounds, ANAVEX®2-73 (blarcamesine) and ANAVEX®3-71 (AF710B), are highlighted in a peer-reviewed journal publication focusing on the sigma-1 receptor's role in Alzheimer’s disease treatment. The paper indicates that sigma-1 receptor expression decreases in Alzheimer's, linking it to autophagy reduction. It suggests that ANAVEX compounds activate this receptor, which may improve neuroprotection and cognitive function. The company is currently conducting advanced clinical studies for Alzheimer’s and Parkinson’s disease, emphasizing the potential of its drug candidates.
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