Avalon GloboCare Advances AI-Enhanced Protein Design Technology for Cellular Therapy Development

Rhea-AI Summary

Avalon GloboCare Corp. (NASDAQ: AVCO) has partnered with the Massachusetts Institute of Technology (MIT) to combine its QTY Code protein design technology with Google's DeepMind AI program, AlphaFold2. This collaboration aims to enhance the development of novel cellular therapies by accurately predicting the 3D structures of protein receptors relevant to immuno-oncology and cellular medicine. A study published in the November 2021 issue of Life validated the effectiveness of this integration, showcasing its potential in addressing cytokine storms in conditions like COVID-19 and enhancing drug development.

Positive

• Collaboration with MIT enhances drug development capabilities.
• Innovative QTY Code technology shows potential in clinical applications.
• Study published in a peer-reviewed journal validates the technology's effectiveness.

Negative

• None.

• Avalon and research partner, Massachusetts Institute of Technology (MIT), combine their protein design “QTY Code” technology with Google’s DeepMind artificial intelligence (AI) program, AlphaFold2, to accurately predict the 3D structures of protein receptors that have potential use as cellular therapy targets
  
  
• A study of the application and capabilities of the dual technology was published in the November 2021 issue of Life, a peer-reviewed life sciences journal
  

FREEHOLD, N.J., Dec. 09, 2021 (GLOBE NEWSWIRE) -- Avalon GloboCare Corp. (NASDAQ: AVCO) (Avalon or The Company), a clinical-stage global developer of cell-based technologies and therapeutics, today announced further advancement of the Company’s sponsored research and licensing agreement with the Massachusetts Institute of Technology (MIT). Avalon and MIT have combined their artificial intelligence (AI)-enhanced protein design “QTY Code” technology with Google’s AlphaFold2, a DeepMind AI program developed to predict 3-dimensional (3D) protein structures of previously difficult to work with drug targets. This new system is designed to accelerate and advance Avalon’s capabilities in developing novel targets for immuno-oncology and cellular medicine.

The “QTY Code” breakthrough technology, developed by Avalon and the laboratory of Dr. Shuguang Zhang, Ph.D., of MIT’s Media lab in Boston, MA, is a protein-design platform that can turn water-insoluble transmembrane receptor proteins into water-soluble proteins, enabling their use in many clinical applications, including drug development.   This program has already successfully generated a series of decoy receptors, which function to soak up excess chemokines and cytokines produced in the body during a potentially fatal ‘cytokine storm.’ These cytokine storms can occur in patients with COVID-19 and in cancer patients being treated with CAR T-cell therapy.

The newly published study demonstrated the utility and efficiency of combining the two AI-based technologies. The researchers used the QTY code technology to design water-soluble versions of chemokine receptors—water-insoluble proteins involved in cytokine storms, cancer, autoimmune diseases and important drug targets—and then used AlphaFold to accurately predict the structures of these clinically important proteins.

Combining the “QTY code” with AlphaFold2, provides Avalon with a novel, accurate, and efficient in-silico tool to improve knowledge about important potential therapeutic targets such as transmembrane receptors and other proteins to better understand their biology and facilitate the development of novel cellular therapies.

“This new study with our collaborator, Dr. Shuguang Zhang from MIT, has validated the innovative application of the QTY code technology to transform important cellular therapy targets that have been previously difficult to work with in the laboratory,” said David Jin, M.D., Ph.D., President and Chief Executive Officer of Avalon. “This new approach is advancing our capabilities in designing novel immuno-oncology and cellular medicine therapies and we are excited to continue to work with Dr. Zhang to advance these drug development technologies,” added Dr. Jin.

The study of the new dual technology application was published in the November 2021 issue of Life, an international, peer-reviewed, open-access life sciences journal.

About Avalon GloboCare Corp.

Avalon GloboCare Corp. (NASDAQ: AVCO) is a clinical-stage, vertically integrated, leading CellTech bio-developer dedicated to advancing and empowering innovative, transformative immune effector cell therapy, exosome technology, as well as COVID-19 related diagnostics and therapeutics. Avalon also provides strategic advisory and outsourcing services to facilitate and enhance its clients' growth and development, as well as competitiveness in healthcare and CellTech industry markets. Through its subsidiary structure with unique integration of verticals from innovative R&D to automated bioproduction and accelerated clinical development, Avalon is establishing a leading role in the fields of cellular immunotherapy (including CAR-T/NK), exosome technology (ACTEX™), and regenerative therapeutics. For more information about Avalon GloboCare, please visit www.avalon-globocare.com.

For the latest updates on Avalon GloboCare's developments, please follow our twitter at @avalongc_avco

Forward-Looking Statements
Certain statements contained in this press release may constitute "forward-looking statements." Forward-looking statements provide current expectations of future events based on certain assumptions and include any statement that does not directly relate to any historical or current fact. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors as disclosed in our filings with the Securities and Exchange Commission located at their website (http://www.sec.gov). In addition to these factors, actual future performance, outcomes, and results may differ materially because of more general factors including (without limitation) general industry and market conditions and growth rates, economic conditions, and governmental and public policy changes. The forward-looking statements included in this press release represent the Company's views as of the date of this press release and these views could change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date of the press release.

Contact Information:
Avalon GloboCare Corp.
4400 Route 9, Suite 3100
Freehold, NJ 07728
PR@Avalon-GloboCare.com

Investor Relations:
Crescendo Communications, LLC
Tel: (212) 671-1020 Ext. 304
avco@crescendo-ir.com

 

FAQ

What is Avalon GloboCare's recent partnership with MIT about?

Avalon GloboCare has partnered with MIT to combine its QTY Code technology with Google's AlphaFold2 AI program to enhance protein design for cellular therapies.

How does the QTY Code technology benefit drug development?

The QTY Code technology transforms insoluble transmembrane receptor proteins into soluble forms, making them suitable for various clinical applications, including drug development.

What publication featured the study on Avalon GloboCare's technology?

The study demonstrating the combined technologies was published in the November 2021 issue of the journal Life.

How does Avalon GloboCare's collaboration with Google impact immuno-oncology research?

The collaboration enables Avalon to utilize advanced AI tools to better understand therapeutic targets in immuno-oncology, potentially leading to novel treatment options.