180 Life Sciences Announces Positive Topline Results of a Clinical Pharmacology Study Testing a New Solid Formulation of CBD with Enhanced Oral Uptake
180 Life Sciences Corp. (NASDAQ: ATNF) announced positive topline results from a clinical pharmacology study comparing two solid formulations of cannabidiol (CBD) with the FDA-approved drug Epidiolex. The study, conducted with 12 volunteers, showed that one of the solid forms was absorbed faster and exhibited higher maximal levels compared to Epidiolex. Both solid formulations were well-tolerated.
The company developed 'ProNanoLipospheres' (PNL), a mixture of over-the-counter components that form droplets absorbed from the gastrointestinal tract into blood. This new formulation could potentially advance testing of CBD in other indications such as pain, PTSD, and head trauma. The solid formulation may provide medical professionals with expanded options to prescribe CBD in a precisely dosed, high uptake pill format.
180 Life Sciences Corp. (NASDAQ: ATNF) ha annunciato risultati positivi preliminari da uno studio di farmacologia clinica che confronta due formulazioni solide di cannabidiolo (CBD) con il farmaco approvato dalla FDA Epidiolex. Lo studio, condotto con 12 volontari, ha mostrato che una delle forme solide era assorbita più rapidamente e presentava livelli massimi più elevati rispetto a Epidiolex. Entrambe le formulazioni solide sono state ben tollerate.
L'azienda ha sviluppato 'ProNanoLipospheres' (PNL), una miscela di componenti da banco che formano gocce assorbite dal tratto gastrointestinale nel sangue. Questa nuova formulazione potrebbe potenzialmente favorire la sperimentazione del CBD in altre indicazioni come il dolore, il PTSD e i traumi cranici. La formulazione solida potrebbe fornire ai professionisti medici maggiori opzioni per prescrivere il CBD in un formato di pillola ad assorbimento elevato e dosato con precisione.
180 Life Sciences Corp. (NASDAQ: ATNF) anunció resultados positivos preliminares de un estudio de farmacología clínica que compara dos formulaciones sólidas de cannabidiol (CBD) con el medicamento aprobado por la FDA Epidiolex. El estudio, realizado con 12 voluntarios, mostró que una de las formas sólidas fue absorbida más rápidamente y alcanzó niveles máximos más altos en comparación con Epidiolex. Ambas formulaciones sólidas fueron bien toleradas.
La empresa desarrolló 'ProNanoLipospheres' (PNL), una mezcla de componentes de venta libre que forman gotitas absorbidas del tracto gastrointestinal al torrente sanguíneo. Esta nueva formulación podría avanzar la prueba del CBD en otras indicaciones como el dolor, el PTSD y el trauma craneal. La formulación sólida podría ofrecer a los profesionales médicos más opciones para prescribir CBD en un formato de píldora de alta absorción y dosificación precisa.
180 Life Sciences Corp. (NASDAQ: ATNF)는 FDA 승인 약물인 Epidiolex와 두 가지 고형 제형의 칸나비디올 (CBD)을 비교한 임상 약리학 연구에서 긍정적인 초기 결과를 발표했습니다. 12명의 자원자를 대상으로 진행된 이 연구에서는 한 고형 제형이 더 빠르게 흡수되고 Epidiolex보다 더 높은 최대 수준을 나타냈습니다. 두 가지 고형 제형 모두 잘 견디는 것으로 나타났습니다.
회사는 소화기 계통에서 혈액으로 흡수되는 방울을 형성하는 일반 의약품 성분의 혼합물인 'ProNanoLipospheres'(PNL)을 개발했습니다. 이 새로운 제형은 CBD의 다른 적응증에 대한 테스트를 발전시킬 수 있는 가능성이 있습니다 예를 들어 통증, PTSD 및 두부 외상 같은 것입니다. 고형 제형은 의료 전문가에게 정확한 용량으로 높은 흡수율을 가진 알약 형식으로 CBD를 처방할 수 있는 더 많은 옵션을 제공할 수 있습니다.
180 Life Sciences Corp. (NASDAQ: ATNF) a annoncé des résultats positifs préliminaires d'une étude de pharmacologie clinique comparant deux formulations solides de cannabidiol (CBD) avec le médicament approuvé par la FDA Epidiolex. L'étude, réalisée avec 12 volontaires, a montré que l'une des formulations solides était absorbée plus rapidement et présentait des niveaux maximaux plus élevés par rapport à Epidiolex. Les deux formulations solides ont été bien tolérées.
L'entreprise a développé des 'ProNanoLipospheres' (PNL), un mélange de composants en vente libre qui forment des gouttelettes absorbées du tractus gastro-intestinal dans le sang. Cette nouvelle formulation pourrait potentiellement favoriser l'essai du CBD pour d'autres indications telles que la douleur, le PTSD et les traumatismes crâniens. La formulation solide pourrait fournir aux professionnels de la santé des options élargies pour prescrire du CBD sous un format de pilule à absorption élevée et dosage précis.
180 Life Sciences Corp. (NASDAQ: ATNF) hat positive vorläufige Ergebnisse aus einer klinischen Pharmakologiestudie veröffentlicht, die zwei feste Formulierungen von Cannabidiol (CBD) mit dem von der FDA genehmigten Medikament Epidiolex vergleicht. Die Studie, die mit 12 Freiwilligen durchgeführt wurde, zeigte, dass eine der festen Formen schneller absorbiert wurde und höhere maximale Werte im Vergleich zu Epidiolex aufwies. Beide festen Formulierungen wurden gut vertragen.
Das Unternehmen entwickelte 'ProNanoLipospheres' (PNL), eine Mischung aus rezeptfreien Bestandteilen, die Tropfen bilden, die aus dem Magen-Darm-Trakt ins Blut aufgenommen werden. Diese neue Formulierung könnte die Prüfung von CBD bei anderen Indikationen wie Schmerzen, PTSD und Kopfverletzungen vorantreiben. Die feste Formulierung könnte medizinischen Fachkräften erweiterte Möglichkeiten bieten, CBD in einer genau dosierten, hochgradig aufnehmbaren Pillenform zu verschreiben.
- One solid CBD formulation showed faster absorption and higher maximal levels compared to Epidiolex
- Both solid formulations were well-tolerated by study participants
- New formulation could potentially advance testing of CBD for various indications
- Solid pill format may provide better dosing precision and potentially higher market acceptance
- Full study results are not yet available
- The trial results are not expected to affect financial results for the year ended December 31, 2024
Insights
The topline results from 180 Life Sciences' clinical pharmacology study on a new solid formulation of CBD are indeed significant. This study compared two solid formulations of CBD with the FDA-approved liquid CBD drug, Epidiolex, in a crossover randomized trial with 12 volunteers.
Key findings include:
- One of the solid formulations was absorbed faster and showed higher maximal levels compared to Epidiolex
- Both solid formulations were well-tolerated
- The solid formulation used "ProNanoLipospheres" (PNL) technology, which forms small droplets that can be absorbed from the gastrointestinal tract into the bloodstream
These results are promising for several reasons:
- Improved bioavailability: The faster absorption and higher maximal levels of the solid formulation could lead to more effective treatments
- Convenience: A solid pill form is generally more convenient for patients than liquid formulations
- Potential for precise dosing: Solid formulations typically allow for more accurate dosing compared to liquids
However, it's important to note that this was a small study with only 12 participants and full results are not yet available. Further research will be needed to confirm these findings and explore the potential applications of this new formulation.
The implications for 180 Life Sciences could be significant if this formulation proves successful in larger trials. It could potentially open up new markets for CBD-based treatments in areas such as pain management, PTSD and head trauma, where liquid formulations may be less desirable.
This development by 180 Life Sciences represents a potentially significant advancement in CBD drug delivery. The pharmaceutical implications of this study are noteworthy:
- Market Expansion: A solid, oral formulation of CBD could significantly broaden the market for CBD-based pharmaceuticals. Many patients and healthcare providers prefer pills over liquid formulations, potentially increasing adoption rates.
- Competitive Advantage: If further studies confirm these results, 180 Life Sciences could gain a competitive edge in the CBD pharmaceutical space. The company's proprietary ProNanoLipospheres technology could become a valuable asset.
- Regulatory Pathway: While this study is promising, it's important to note that extensive additional research will be required before any new formulation could gain FDA approval. The regulatory path for CBD products remains complex.
- Manufacturing Considerations: Solid formulations often have advantages in terms of stability, shelf life and ease of manufacturing at scale compared to liquid formulations. This could potentially lead to cost savings in production and distribution.
From an investment perspective, this news is positive for 180 Life Sciences, but it's important to temper enthusiasm with caution. The CBD pharmaceutical market is highly competitive and larger players with more resources could potentially develop similar technologies. Additionally, the company notes that this trial is not expected to impact their 2024 financial results, indicating that commercialization, if it occurs, is still some way off.
Investors should closely monitor future updates on this technology, particularly any announcements about larger clinical trials or potential partnerships with major pharmaceutical companies.
PALO ALTO, Calif., July 30, 2024 (GLOBE NEWSWIRE) -- PALO ALTO, Calif., July 30, 2024 (GLOBE NEWSWIRE) -- 180 Life Sciences Corp. (NASDAQ: ATNF) (“180 Life Sciences” or the “Company”), today announced topline results from a clinical pharmacology study (the “Study”), that evaluated the uptake of cannabidiol (CBD) in a solid formulation which can be delivered as a pill orally. The clinical trial in humans, performed with Prof. Avi Domb of the Hebrew University, School of Pharmacy, and with Prof. Elyad Davidson, of Hadassah Hospital, compared two solid formulations of CBD with a U.S. Food and Drug Administration (FDA) approved drug for epilepsy, Epidiolex. The purpose of the Study was to compare the pharmokinetic (PK) profile of a generic approved CBD product, Epidiolex®, with two solid formulations. We believe this type of trial has yet to be examined in a clinical setting. For the Company’s trial, twelve volunteers received all three formulations in a crossover randomized trial.
Epidiolex is a CBD dissolved in
CBD is a purified product that is not psychoactive, which we believe has potential benefits for treatment of inflammatory processes and pain. A major problem in working with CBD is its low, unpredictable and variable uptake following the most convenient delivery form, by mouth, as a liquid CBD in oil like the approved pharmaceutical Epidiolex, given for epilepsy.
To help try to solve this problem, Prof. Domb and colleagues developed “ProNanoLipospheres” (PNL), a mixture of components available over-the-counter, which form little droplets and have been shown to be absorbed from the gastrointestinal tract into blood. The results of the clinical trial performed on 12 adult males at the Hadassah Hospital, shows that capsules composed of one of the PNL formulations performed better statistically than Epidiolex in terms of the speed of absorption and achievement of maximal levels. The other PNL formulation, also given as a capsule, was statistically equivalent to Epidiolex in terms of speed of absorption and achievement of maximal levels.
We believe that a solid formulation for testing in clinical trials will advance testing CBD in other indications. CBD has shown promise in studies on treatment of pain, post-traumatic stress disorder (PTSD), head trauma, and other indications, yet an oral liquid formulation is undesirable.1 The new formulations tested by 180 Life Sciences and its collaborators open a potential path for testing solid CBD given by mouth in a capsule.
According to Prof. Avi Domb, “If shown via further clinical testing, 180 Life Sciences’ proprietary solid formulation for the delivery of CBD may provide medical professionals with greatly expanded options to prescribe and deliver CBD in a precisely dosed, high uptake pill format rather than the current liquid format. This may have potentially significant commercial market potential by avoiding the complexity associated with unpredictable liquid formulation delivery. Both physicians and patients may have broader acceptance of a solid oral pill format.”
Full study results are not yet available. The trial results are planned to be submitted for scientific publication at a later date. We do not anticipate the outcome of this trial to have any effect on our financial results for the year ended December 31, 2024.
About 180 Life Sciences Corp.
180 Life Sciences Corp. is a clinical stage biotechnology company focused on the development of therapeutics for unmet medical needs in chronic pain, inflammation and fibrosis by employing innovative research, and, where appropriate, combination therapy.
Forward-Looking Statements
This press release includes “forward-looking statements”, including information about management’s view of the Company’s future expectations, plans and prospects, within the safe harbor provisions provided under federal securities laws, including under The Private Securities Litigation Reform Act of 1995 (the “Act”). Words such as “expect,” “estimate,” “project,” “budget,” “forecast,” “anticipate,” “intend,” “plan,” “may,” “will,” “could,” “should,” “believes,” “predicts,” “potential,” “continue” and similar expressions are intended to identify such forward-looking statements. These forward-looking statements involve significant risks and uncertainties that could cause the actual results to differ materially from the expected results and, consequently, you should not rely on these forward-looking statements as predictions of future events. These forward-looking statements and factors that may cause such differences include, without limitation, statements expressed or implied relating to the properties or potential benefits of PNL; our ability to commercialize PNL and our other drug candidates, if proven successful for treatment in trials; risks regarding whether the administrative processes required for the issuance of patents will be completed in a timely manner or at all; the Company’s ability to meet Nasdaq’s conditions for continued listing on Nasdaq, and the timing relating thereto; the ability of the Company to maintain the continued listing of the Company’s securities on The Nasdaq Stock Market, including that the Company is not currently in compliance with Nasdaq’s continued listing standards; the review and evaluation of strategic transactions and their impact on shareholder value; the process by which the Company engages in evaluation of strategic transactions; the outcome of potential future strategic transactions and the terms thereof; the ability of the Company to raise funding, the terms of such funding, and dilution caused thereby; risks regarding the outcome of pharmaceutical studies, the timing and costs thereof, and the ability to obtain sufficient participants; the timing of, outcome of, and results of, clinical trials statements regarding the timing of marketing authorization application (MAA) submissions to the UK Medicines and Healthcare products Regulatory Agency (MHRA) and New Drug Application submissions (NDA) to the U.S. Food and Drug Administration (FDA), our ability to obtain approval and acceptance thereof, the willingness of MHRA to review such MAA and the FDA to review such NDA, and our ability to address outstanding comments and questions from the MHRA and FDA; statements about the ability of our clinical trials to demonstrate safety and efficacy of our product candidates, and other positive results; the uncertainties associated with the clinical development and regulatory approval of 180 Life Sciences’ drug candidates, including potential delays in the enrollment and completion of clinical trials, the costs thereof, closures of such trials prior to enrolling sufficient participants in connection therewith, issues raised by the FDA, the MHRA and the European Medicines Agency (EMA); the ability of the Company to persuade regulators that chosen endpoints do not require further validation; timing and costs to complete required studies and trials, and timing to obtain governmental approvals; the accuracy of simulations and the ability to reproduce the outcome of such simulations in real world trials; 180 Life Sciences’ reliance on third parties to conduct its clinical trials, enroll patients, and manufacture its preclinical and clinical drug supplies; the ability to come to mutually agreeable terms with such third parties and partners, and the terms of such agreements; estimates of patient populations for 180 Life Sciences planned products; 180 Life Sciences’ ability to fully comply with numerous federal, state and local laws and regulatory requirements, as well as rules and regulations outside the United States, that apply to its product development activities; current negative operating cash flows and a need for additional funding to finance our operating plans; the terms of any further financing, which may be highly dilutive and may include onerous terms, increases in interest rates which may make borrowing more expensive and increased inflation which may negatively affect costs, expenses and returns; statements relating to expectations regarding future agreements relating to the supply of materials and license and commercialization of products; the availability and cost of materials required for trials; the risk that initial drug trials and results are not predictive of future results or will not be able to be replicated in clinical trials or that such drugs selected for clinical development will not be successful; challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; the inherent risks in early stage drug development including demonstrating efficacy; development time/cost and the regulatory approval process; the progress of our clinical trials; our ability to find and enter into agreements with potential partners; our ability to attract and retain key personnel; changing market and economic conditions; competition, including technological advances, new products and patents attained by competitors; challenges to patents; changes to applicable laws and regulations, including global health care reforms; expectations with respect to future performance, growth and anticipated acquisitions; expectations regarding the capitalization, resources and ownership structure of the Company; the ability of the Company to execute its plans to develop and market new drug products and the timing and costs of these development programs; estimates of the size of the markets for the Company’s potential drug products; the outcome of current litigation involving the Company; potential future litigation involving the Company or the validity or enforceability of the intellectual property of the Company or lawsuits alleging that we have violated the intellectual property of others; global economic conditions; geopolitical events and regulatory changes; the expectations, development plans and anticipated timelines for the Company’s drug candidates, pipeline and programs, including collaborations with third parties; and the effect of changing interest rates and inflation, economic downturns and recessions, declines in economic activity or global conflicts. These risk factors and others are included from time to time in documents the Company files with the Securities and Exchange Commission, including, but not limited to, its Form 10-Ks, Form 10-Qs and Form 8-Ks, and including the Annual Report on Form 10-K for the year ended December 31, 2023, and Quarterly Report on Form 10-Q for the quarter ended March 31, 2024, and future SEC filings. These reports and filings are available at www.sec.gov and are available for download, free of charge, soon after such reports are filed with or furnished to the SEC, on the “Investors”, “SEC Filings”, “All SEC Filings” page of our website at www.180lifesciences.com. All subsequent written and oral forward-looking statements concerning the Company, the results of the Company’s clinical trial results and studies or other matters and attributable to the Company or any person acting on its behalf are expressly qualified in their entirety by the cautionary statements above. Readers are cautioned not to place undue reliance upon any forward-looking statements, which speak only as of the date made, including the forward-looking statements included in this press release, which are made only as of the date hereof. The Company cannot guarantee future results, levels of activity, performance or achievements. Accordingly, you should not place undue reliance on these forward-looking statements. The Company does not undertake or accept any obligation or undertaking to release publicly any updates or revisions to any forward-looking statement to reflect any change in its expectations or any change in events, conditions, or circumstances on which any such statement is based, except as otherwise provided by law.
Investors:
Please contact Blair Jordan, Interim CEO – bjordan@180lifesciences.com
1 See, for example:
- Izzo, A. A., Borrelli, F., Capasso, R., Di Marzo, V. & Mechoulam, R. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol. Sci. 30, 515–527 (2009).
- Hayakawa, K. et al. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism. Biol. Pharm. Bull. 32, 1538–44 (2009).
- Chagas, M. H. N. et al. Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients: a case series. J. Clin. Pharm. Ther. 39, 564–566 (2014).
- Giacoppo, S. et al. A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis. DARU J. Pharm. Sci. 23, 48 (2015).
- Pertwee, R. G. Cannabinoids and multiple sclerosis. Mol. Neurobiol. 36, 45–59 (2007).
- Parker, L. A., Mechoulam, R. & Schlievert, C. Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats. Neuroreport 13, 567–570 (2002).
- Ribeiro, A. et al. Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A2A receptor. Eur. J. Pharmacol. 678, 78–85 (2012).
- WHO, W. H. O. Cannabidiol (CBD): pre-review report. Expert Committee on Drug Dependence 39, (2017).
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