atai Life Sciences Reports Second Quarter 2021 Financial Results and Business Update
atai Life Sciences (Nasdaq: ATAI) successfully completed its IPO, raising $258.8 million in gross proceeds. The company received $20 million from Otsuka for a collaborative effort in developing R-ketamine. It has advanced 11 therapeutic programs, with notable trials such as Recognify's Phase 2 and GABA's Phase 1 commencing. The company's cash position stands at $453.6 million, positioning it well for upcoming milestones, including 18 catalysts anticipated over the next 18 months.
- Raised $258.8 million from IPO to support growth and therapeutic programs.
- Received $20 million from Otsuka, enhancing collaboration efforts.
- Initiated key therapeutic trials, advancing the pipeline significantly.
- Strong cash position of $453.6 million to fund future initiatives.
- Net loss of $48.5 million for Q2 2021, an increase from previous year.
-Successfully completed Initial Public Offering on Nasdaq raising
-Received
-Advancement of 11 therapeutic programs, including initiation of Recognify’s Phase 2 and GABA’s Phase 1 trials-
-18 significant catalysts across atai’s platform anticipated over next 18 months including two clinical trials to be completed and four clinical trials to be initiated in 2021-
-Solidified leadership position with strong cash position of
-Company to host a webcast and conference call today at 08:30am EDT-
BERLIN and NEW YORK, Aug. 16, 2021 (GLOBE NEWSWIRE) -- atai Life Sciences N.V. (Nasdaq: ATAI) (“atai”), a clinical-stage biopharmaceutical company aiming to transform the treatment of mental health disorders, today reported its financial results for the second quarter ended June 30, 2021 and provided a corporate update.
“In the second quarter of 2021, we made significant advancements to build our business and successfully completed an initial public offering on Nasdaq, raising approximately US
Q2 Corporate Updates
- Received
$20 million as part of Perception’s collaboration with Otsuka for the development of R-ketamine, the first major collaboration between a biopharmaceutical company developing psychedelics and large pharma. - Entered a strategic partnership with IntelGenx, a leader in pharmaceutical films. As part of the strategic partnership, IntelGenx will exclusively partner with atai to develop compounds for the prevention or treatment of mental health diseases or disorders.
- Announced InnarisBio in partnership with UniQuest, Australia’s leading university technology transfer company commercializing the research of The University of Queensland (UQ), to develop a novel sol-gel-based intranasal drug delivery technology to improve treatments for mental health disorders.
Recent Advancements and Upcoming Milestones for atai’s Core Value Drivers
Perception Neuroscience:
Program Details: PCN-101 is a parenteral formulation of R-ketamine, a glutamatergic modulator being developed as a rapid-acting antidepressant, with the potential to be an at-home non-dissociative alternative to S-ketamine (marketed as SPRAVATO).
Upcoming Milestones
- Phase 2 randomized, double blind, placebo-controlled trial in patients with treatment-resistant depression (TRD) to be initiated in the third quarter and expected to run through late 2022.
- The trial will assess efficacy and safety, dose response and duration of action in patients with TRD.
Recognify Life Sciences:
Program Details:
- RL-007, a cholinergic, glutamatergic and GABA-B receptor modulator, is an orally available compound that is thought to alter the excitatory/inhibitory balance in the brain to produce pro-cognitive effects.
- atai is developing this compound for the treatment of cognitive impairments associated with schizophrenia.
Q2 Advancements
- In April 2021, Recognify initiated a Phase 2a study for RL-007, after receiving IND clearance from the U.S. Food and Drug Administration to commence clinical trials for the treatment of Cognitive Impairment Associated with Schizophrenia (CIAS).
- The study is designed to evaluate the effects of RL-007 on safety, tolerability, electroencephalogram-based biomarkers, and cognition.
Upcoming Milestones: Topline results from the Phase 2a single-arm, multiple dose trial in patients with CIAS expected in late 2021.
GABA:
Program Details
- GRX-917 is an oral formulation of a deuterated version of etifoxine, a compound that has a long history of prescription use in France for treating anxiety disorders.
- GRX-917 is designed to provide rapid anxiolytic activity with improved tolerability compared to current treatments for anxiety in the United States.
Q2 Advancements
- In June 2021, GABA initiated a randomized, double blind, placebo-controlled Phase 1 trial.
- The study will evaluate safety, tolerability, pharmacokinetics, as well as pharmacodynamics using qEEG.
Upcoming Milestones: Topline results from the Phase 1 single ascending dose/multiple ascending dose program expected early in 2022.
DemeRx:
Program Details: DMX-1002 is an oral formulation of ibogaine, a cholinergic, glutamatergic and monoaminergic receptor modulator being developed for the treatment of opioid use disorder.
Q2 Advancements: DemeRx received approval from the UK Medicines and Healthcare products Regulatory Agency to commence subject enrollment in our proposed Phase 1/2 clinical trial.
Upcoming Milestones
- Phase 1 component of Phase 1/2 trial of DMX-1002 in recreational drug users and healthy volunteers to be initiated in Q3 2021 and is expected to read out safety data in early 2022.
- The trial is designed to assess safety, tolerability, pharmacokinetics, and efficacy, and the results will inform future studies in patients with opioid use disorder.
COMPASS Pathways:
Program Details: COMP360 is a proprietary formulation of synthetic psilocybin, a 5-HT2A-R agonist being developed as an oral, rapid-acting antidepressant.
Q2 Advancements
- In June 2021, COMPASS completed dosing in the Phase 2b clinical trial of COMP360 psilocybin therapy for treatment-resistant depression.
- The randomized, double-blind, dose-ranging study investigated the safety and efficacy of psilocybin therapy in 233 patients, making it the largest clinical trial with psilocybin to date.
Upcoming Milestones: Phase 2b trial results are expected in late 2021.
Second Quarter 2021 Financial Results
Cash and Cash Equivalents
Cash and cash equivalents totaled
Revenues
License revenue in the first half 2021 of
Operating Costs and Expenses
Research and development expenses were
We recorded acquisition of in-process research and development expense of
General and administrative expenses for the three and six months ended June 30, 2021 were
Total stock-based compensation expense for the three and six months ended June 30, 2021 was
Net loss attributable to atai stockholders for the three and six months ended June 30, 2021 was
Conference Call Information
atai will host a conference call and live audio webcast today at 08:30am ET to discuss its financial results and provide a corporate update. To access the live conference call, please dial 877-407-3982 from the United States, or +1 (201) 493-6780 internationally, using the conference ID: 13721888. The live and archived webcast of this call will be available in the “Events” section of the atai Life Sciences website at ir.atai.life. An archived copy of the webcast will be available on the atai website for at least 30 days after the conference call.
About atai Life Sciences
atai is a clinical-stage biopharmaceutical company aiming to transform the treatment of mental health disorders. atai was founded in 2018 as a response to the significant unmet need and lack of innovation in the mental health treatment landscape. atai is dedicated to acquiring, incubating and efficiently developing innovative therapeutics to treat depression, anxiety, addiction, and other mental health disorders. atai's business model combines funding, technology, scientific and regulatory expertise with a focus on psychedelic therapy and other drugs with differentiated safety profiles and therapeutic potential. By pooling resources and best practices, atai aims to responsibly accelerate the development of new medicines across its companies, seeking to effectively treat and ultimately heal mental health disorders. atai's mission is to bridge the gap between what the mental healthcare system currently provides and what patients need. atai is headquartered in Berlin, with offices in New York and London. For more information, please visit www.atai.life.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “anticipate,” “initiate,” “could,” “would,” “project,” “plan,” “potentially,” “preliminary,” “likely,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements include express or implied statements relating to, among other things, our future operating results and financial position; the success, cost and timing of development of our product candidates, including the progress of preclinical and clinical trials; the commercialization of our current product candidates and any other product candidates we may identify and pursue, if approved, including our ability to successfully build a specialty sales force and commercial infrastructure to market our current product candidates and any other product candidates we may identify and pursue; the timing of and our ability to obtain and maintain regulatory approvals; our business strategy and plans; potential acquisitions; and the plans and objectives of management for future operations and capital expenditures. The forward-looking statements in this press release are neither promises nor guarantees, and you should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties, and other factors, many of which are beyond our control and which could cause actual results, levels of activity, performance or achievements to differ materially from those expressed or implied by these forward-looking statements.
We have based these forward-looking statements largely on our current expectations and projections about future events and trends that we believe may affect our financial condition, results of operations, business strategy, short-term and long-term business operations and objectives, and financial needs. These forward-looking statements are subject to a number of risks, uncertainties, and assumptions, including without limitation: we are a clinical-stage biopharmaceutical company and have incurred significant losses since our inception, and we anticipate that we will continue to incur significant losses for the foreseeable future; we will require substantial additional funding to achieve our business goals, and if we are unable to obtain this funding when needed and on acceptable terms, we could be forced to delay, limit or terminate our product development efforts; our limited operating history may make it difficult to evaluate the success of our business and to assess our future viability; we have never generated revenue and may never be profitable; our product candidates contain controlled substances, the use of which may generate public controversy; clinical and preclinical development is uncertain, and our preclinical programs may experience delays or may never advance to clinical trials; we currently rely on qualified therapists working at third-party clinical trial sites to administer certain of our product candidates in our clinical trials and we expect this to continue upon approval, if any, of our current or future product candidates; if third-party sites fail to recruit and retain a sufficient number of therapists or effectively manage their therapists, our business, financial condition and results of operations would be materially harmed; we cannot give any assurance that any of our product candidates will receive regulatory approval, which is necessary before they can be commercialized; research and development of drugs targeting the central nervous system, or CNS, is particularly difficult, and it can be difficult to predict and understand why a drug has a positive effect on some patients but not others; we face significant competition in an environment of rapid technological and scientific change; third parties may claim that we are infringing, misappropriating or otherwise violating their intellectual property rights, the outcome of which would be uncertain and may prevent or delay our development and commercialization efforts; a change in our effective place of management may increase our aggregate tax burden; we identified material weaknesses in connection with our internal control over financial reporting; and a pandemic, epidemic, or outbreak of an infectious disease, such as the COVID-19 pandemic, may materially and adversely affect our business, including our preclinical studies, clinical trials, third parties on whom we rely, our supply chain, our ability to raise capital, our ability to conduct regular business and our financial results. Other risk factors include the important factors described in the section titled “Risk Factors” in our final prospectus, filed with the Securities and Exchange Commission (“SEC”) on June 21, 2021 pursuant to Rule 424(b) under the Securities Act, and in our other filings with the SEC, that may cause our actual results, performance or achievements to differ materially and adversely from those expressed or implied by the forward-looking statements.
Any forward-looking statements made herein speak only as of the date of this press release, and you should not rely on forward-looking statements as predictions of future events. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the future results, performance, or achievements reflected in the forward-looking statements will be achieved or will occur. Except as required by applicable law, we undertake no obligation to update any of these forward-looking statements for any reason after the date of this press release or to conform these statements to actual results or revised expectations.
Investor Contact:
Greg Weaver
atai – Chief Financial Officer
Email: greg.weaver@atai.life
Media Contact:
Anne Donohoe
KCSA Strategic Communications
Phone: +1 (212) 896-1265
Email: atai@kcsa.com
| ATAI LIFE SCIENCES N.V. | |||||||||||||||||||||||
| CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS | |||||||||||||||||||||||
| (Amounts in thousands, except share and per share amounts) | |||||||||||||||||||||||
| (unaudited) | |||||||||||||||||||||||
| Three Months Ended | Six Months Ended | ||||||||||||||||||||||
| June 30, | June 30, | ||||||||||||||||||||||
| 2021 | 2020 | 2021 | 2020 | ||||||||||||||||||||
| License revenue | $ | - | $ | - | $ | 19,880 | $ | - | |||||||||||||||
| Operating expenses: | |||||||||||||||||||||||
| Research and development | 16,026 | 2,854 | 21,611 | 4,998 | |||||||||||||||||||
| Acquisition of in-process research and development | 7,962 | 120 | 8,934 | 120 | |||||||||||||||||||
| General and administrative | 37,331 | 2,851 | 46,604 | 4,421 | |||||||||||||||||||
| Total operating expenses | 61,319 | 5,825 | 77,149 | 9,539 | |||||||||||||||||||
| Loss from operations | (61,319 | ) | (5,825 | ) | (57,269 | ) | (9,539 | ) | |||||||||||||||
| Other income (expense), net | (5,982 | ) | (1,321 | ) | (4,279 | ) | 20,294 | ||||||||||||||||
| Net loss before income taxes | (67,301 | ) | (7,146 | ) | (61,548 | ) | 10,755 | ||||||||||||||||
| Provision for income taxes | (58 | ) | - | (64 | ) | - | |||||||||||||||||
| Gain on investment dilution | 16,923 | - | 16,923 | - | |||||||||||||||||||
| Losses from investments in equity method investees, net of tax | (2,937 | ) | (9,811 | ) | (4,640 | ) | (11,831 | ) | |||||||||||||||
| Net loss | (53,373 | ) | (16,957 | ) | (49,329 | ) | (1,076 | ) | |||||||||||||||
| Net loss attributable to redeemable noncontrolling | |||||||||||||||||||||||
| interests and noncontrolling interests | (4,912 | ) | (600 | ) | (1,556 | ) | (1,022 | ) | |||||||||||||||
| Net loss attributable to ATAI Life Sciences N.V. stockholders | $ | (48,461 | ) | $ | (16,357 | ) | $ | (47,773 | ) | $ | (54 | ) | |||||||||||
| Net loss per share attributable to ATAI Life Sciences N.V. stockholders-- basic and diluted | $ | (0.37 | ) | $ | (0.18 | ) | $ | (0.38 | ) | $ | (0.00 | ) | |||||||||||
| Weighted average common shares outstanding attributable to ATAI Life Sciences N.V. stockholders — basic and diluted | |||||||||||||||||||||||
| 132,265,075 | 90,709,312 | 125,797,732 | 90,709,312 | ||||||||||||||||||||
| ATAI LIFE SCIENCES N.V. | ||||||||||
| CONDENSED CONSOLIDATED BALANCE SHEET | ||||||||||
| (Amounts in thousands) | ||||||||||
| June 30, | December 31, | |||||||||
| 2021 | 2020 | |||||||||
| (unaudited) | (1) | |||||||||
| Assets | ||||||||||
| Cash and cash equivalents | $ | 453,622 | $ | 97,246 | ||||||
| Prepaid expenses and other current assets | 3,964 | 2,076 | ||||||||
| Short term notes receivable - related party | - | 226 | ||||||||
| Property and equipment, net | 331 | 71 | ||||||||
| Deferred offering costs | - | 1,575 | ||||||||
| Equity method investments | 19,780 | - | ||||||||
| Other investments held at fair value | 6,886 | - | ||||||||
| Other investments | 16,107 | 8,044 | ||||||||
| Long term notes receivable | 1,388 | 911 | ||||||||
| Long term notes receivable - related parties | 3,194 | 1,060 | ||||||||
| Other assets | 689 | 339 | ||||||||
| Total assets | $ | 505,961 | $ | 111,548 | ||||||
| Liabilities and Stockholders' Equity | ||||||||||
| Accounts payable | $ | 6,202 | $ | 3,083 | ||||||
| Accrued liabilities | 7,824 | 9,215 | ||||||||
| Deferred revenue | 120 | - | ||||||||
| Short-term notes payable | 39 | - | ||||||||
| Contingent consideration liability - related parties | 2,466 | 1,705 | ||||||||
| Convertible promissory notes - related parties, net of discounts and deferred issuance costs | 1,176 | 1,199 | ||||||||
| Convertible promissory notes and derivative liability | - | 978 | ||||||||
| Other liabilities | 3,239 | - | ||||||||
| Total stockholders' equity attributable to ATAI Life Sciences N.V. stockholders | 474,850 | 90,822 | ||||||||
| Noncontrolling interests | 10,045 | 4,546 | ||||||||
| Total liabilities and stockholders' equity | $ | 505,961 | $ | 111,548 | ||||||
| (1)The condensed consolidated financial statements as of and for the year ended December 31, 2020 are derived from the audited consolidated financial statements as of that date. | ||||||||||
FAQ
What are the financial results of atai Life Sciences for Q2 2021?
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What significant collaborations has atai initiated recently?
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What upcoming milestones can investors expect from atai?
