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Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) is a leading clinical-stage biotechnology company dedicated to developing innovative medicines that address intractable diseases through gene silencing. The company utilizes an extensive array of RNA chemistries and efficient delivery systems to harness the power of RNA interference (RNAi) mechanisms. This approach allows for the rapid, deep, and durable knockdown of target genes, thereby reducing the production of specific proteins that cause diseases.
Arrowhead's groundbreaking therapies are at the forefront of genetic-based treatments, presenting potential life-changing solutions for patients. Notable among their technologies is the Targeted RNAi Molecule (TRiMTM) platform. This platform employs ligand-mediated delivery for tissue-specific targeting while maintaining structural simplicity. The TRiMTM platform is built upon over a decade of research in actively targeted drug delivery, offering advantages such as simplified manufacturing processes and enhanced specificity.
The company's diverse portfolio includes promising treatments for conditions such as Hepatitis B, Alpha-1 Antitrypsin Deficiency, thrombosis and angioedema, clear-cell and renal cell carcinoma, and cardiovascular diseases. Arrowhead is continuously engaged in advancing its clinical programs and forging strategic partnerships to bring its novel therapies to market.
With headquarters in Pasadena, California, Arrowhead Pharmaceuticals remains committed to transforming the landscape of genetic medicine and improving patient outcomes worldwide. Their dedication to scientific innovation and patient care positions them as a pivotal player in the biotechnology sector.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced on
Horizon Therapeutics plc (Nasdaq: HZNP) announced the dosing of the first subject in a Phase 1 clinical trial for HZN-457, a small interfering RNA designed to treat gout by silencing liver xanthine dehydrogenase. This trial aims to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics in up to 56 healthy volunteers. Gout affects over 9 million patients in the U.S., with many inadequately treated by current therapies. HZN-457 aims to lower uric acid levels effectively, potentially improving patient outcomes. The development is part of a collaboration with Arrowhead Pharmaceuticals (Nasdaq: ARWR).
Arrowhead Pharmaceuticals (NASDAQ: ARWR) has received a $15 million milestone payment from Horizon Therapeutics (NASDAQ: HZNP) following the enrollment of the first subject in a Phase 1 clinical trial for HZN-457, aimed at treating gout. This candidate, previously known as ARO-XDH, targets liver xanthine dehydrogenase to lower uric acid levels. The study will enroll 56 healthy volunteers to assess safety, tolerability, and pharmacokinetics. The collaboration with Horizon is pivotal in advancing innovative treatments for the over 9 million gout patients in the U.S.
Arrowhead Pharmaceuticals reported fiscal year 2022 results, achieving $243.2 million in revenue, up from $138.3 million in 2021. The company incurred a net loss of $172.7 million or $1.67 per diluted share. Operating expenses rose to $421.7 million compared to $287.3 million the prior year. Despite financial challenges, significant progress was made in clinical trials, with promising interim data on ARO-APOC3 and ARO-ANG3. The balance sheet was bolstered by a $250 million royalty sale and potential future earnings from Amgen.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) will hold a webcast and conference call on November 28, 2022, at 4:30 p.m. ET to discuss its financial results for the fiscal year ending September 30, 2022. Investors can access the live audio via the company’s website, with a replay available two hours post-call. Arrowhead focuses on developing RNA interference therapies targeting intractable diseases.
Arrowhead Pharmaceuticals has announced that Royalty Pharma has acquired a royalty interest in Amgen's olpasiran for $250 million upfront, plus up to $160 million in additional payments based on milestones. Olpasiran, developed for cardiovascular disease treatment, is approaching Phase 3 trials. Arrowhead retains rights to $400 million in milestone payments related to Amgen's development of olpasiran. This agreement reinforces the potential of olpasiran and supports Arrowhead's investment in its RNAi therapeutic pipeline.
Arrowhead Pharmaceuticals presented new clinical data on RNAi-based therapies ARO-APOC3, ARO-ANG3, and olpasiran at the AHA Scientific Sessions 2022. ARO-APOC3 showed significant decreases in triglycerides by 86% and increases in HDL-C by 99%. ARO-ANG3 reduced triglycerides by 59% and LDL-C by 32%, while olpasiran decreased lipoprotein(a) levels by over 95% in ASCVD patients. The company plans to discuss these findings and its future plans in a virtual event on November 9, 2022.
Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) announced on October 4, 2022, the approval of inducement grants for 39 new employees, totaling up to 117,500 restricted stock units. This includes 30,000 restricted stock units awarded to Peter Carignan, the new vice president of clinical operations. The grants, which fall under NASDAQ Listing Rules, are outside existing shareholder-approved equity incentive plans and will vest over four years.
Arrowhead Pharmaceuticals (NASDAQ: ARWR) will present interim clinical data on ARO-APOC3 and ARO-ANG3 at the American Heart Association Scientific Sessions 2022 in Chicago, from
Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) will participate in several upcoming events in September 2022. Key presentations include:
- ERS International Congress: September 4-6, 2022, by Erik Bush on MMP7 gene silencing.
- Wells Fargo Healthcare Conference: September 7-9, 2022, investor meetings with Vincent Anzalone.
- H.C. Wainwright Global Investment Conference: September 12-14, 2022, fireside chat by Christopher Anzalone.
- Baird Global Healthcare Conference: September 13-14, 2022, also featuring Christopher Anzalone.
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