Arrowhead Announces JNJ-75220795 in Development for NASH

Rhea-AI Summary

Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced a collaboration with Janssen Pharmaceuticals on the investigational compound JNJ-75220795, currently in a Phase 1 clinical study. This siRNA therapeutic targets the reduction of PNPLA3 expression in the liver, aimed at treating non-alcoholic steatohepatitis (NASH). The collaboration began in October 2018 and leverages Arrowhead's TRIM platform, demonstrating the potential to address significant liver disease by targeting genetic factors associated with fat accumulation.

Positive

• Collaboration with Janssen Pharmaceuticals on JNJ-75220795 enhances research capability.
• JNJ-75220795 targets a validated genetic factor (PNPLA3) linked to NASH.

Negative

• Dependence on the success of ongoing Phase 1 study for future developments.
• -

PASADENA, Calif.--(BUSINESS WIRE)-- Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) today announced that its collaborator, Janssen Pharmaceuticals, Inc., (Janssen) one of the Janssen Pharmaceutical Companies of Johnson & Johnson, has disclosed its collaboration with Arrowhead on investigational compound JNJ-75220795, which is in a Phase 1 clinical study.

JNJ-75220795 is an investigational siRNA therapeutic developed using Arrowhead’s proprietary TRIM^TM platform and designed to reduce expression in the liver of patatin like phospholipase domain containing 3 (PNPLA3) as a potential treatment for patients with non-alcoholic steatohepatitis (NASH). PNPLA3 has strong genetic and preclinical validation as a driver of fat accumulation and damage in the livers of patients who carry the common I148M mutation.

Arrowhead entered into a research collaboration and option agreement with Janssen in October 2018, which resulted in collaboration on JNJ-75220795.

About Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

For more information, please visit www.arrowheadpharma.com, or follow us on Twitter @ArrowheadPharma. To be added to the Company's email list and receive news directly, please visit http://ir.arrowheadpharma.com/email-alerts.

Safe Harbor Statement under the Private Securities Litigation Reform Act:

This news release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Any statements contained in this release except for historical information may be deemed to be forward-looking statements. Without limiting the generality of the foregoing, words such as “may,” “will,” “expect,” “believe,” “anticipate,” “hope,” “intend,” “plan,” “project,” “could,” “estimate,” or “continue” are intended to identify such forward-looking statements. In addition, any statements that refer to projections of our future financial performance, trends in our business, expectations for our product pipeline or product candidates, including anticipated regulatory submissions and clinical program results, prospects or benefits of our collaborations with other companies, or other characterizations of future events or circumstances are forward-looking statements. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of numerous factors and uncertainties, including the impact of the ongoing COVID-19 pandemic on our business, the safety and efficacy of our product candidates, decisions of regulatory authorities and the timing thereof, the duration and impact of regulatory delays in our clinical programs, our ability to finance our operations, the likelihood and timing of the receipt of future milestone and licensing fees, the future success of our scientific studies, our ability to successfully develop and commercialize drug candidates, the timing for starting and completing clinical trials, rapid technological change in our markets, the enforcement of our intellectual property rights, and the other risks and uncertainties described in our most recent Annual Report on Form 10-K, subsequent Quarterly Reports on Form 10-Q and other documents filed with the Securities and Exchange Commission from time to time. We assume no obligation to update or revise forward-looking statements to reflect new events or circumstances.

Source: Arrowhead Pharmaceuticals, Inc.

View source version on businesswire.com: https://www.businesswire.com/news/home/20211117005898/en/

Arrowhead Pharmaceuticals, Inc.

Vince Anzalone, CFA

626-304-3400

ir@arrowheadpharma.com

Investors:

LifeSci Advisors, LLC

Brian Ritchie

212-915-2578

britchie@lifesciadvisors.com

www.lifesciadvisors.com

Media:

LifeSci Communications, LLC

Josephine Belluardo, Ph.D.

646-751-4361

jo@lifescicomms.com

www.lifescicommunications.com

Source: Arrowhead Pharmaceuticals, Inc.

FAQ

What is the significance of Arrowhead Pharmaceuticals' collaboration with Janssen Pharmaceuticals?

The collaboration focuses on JNJ-75220795, a drug targeting PNPLA3 to treat NASH, enhancing Arrowhead's research and development capabilities.

What is JNJ-75220795 and its intended use?

JNJ-75220795 is an investigational siRNA therapeutic aimed at reducing liver expression of PNPLA3, which is linked to non-alcoholic steatohepatitis (NASH).

When did Arrowhead Pharmaceuticals start collaborating with Janssen Pharmaceuticals?

The collaboration between Arrowhead Pharmaceuticals and Janssen Pharmaceuticals began in October 2018.

What clinical phase is JNJ-75220795 currently in?

JNJ-75220795 is currently undergoing a Phase 1 clinical study.