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Overview of Artelo Biosciences Inc (ARTL)
Artelo Biosciences Inc is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapeutics. With a strong focus on lipid-signaling pathways and the endocannabinoid system, the company employs a disciplined approach to leverage decades of research and cutting‐edge science. Its innovative platform is designed to modulate complex biochemical networks, aiming to address significant unmet medical needs in conditions such as cancer, pain, anxiety, anorexia, and inflammation.
Core Business and Product Portfolio
At its core, Artelo Biosciences targets lipid-mediated signaling mechanisms to develop proprietary therapies that have the potential to transform patient care. The company’s research spans several therapeutic areas, including:
- Cannabinoid-based Therapeutics: Utilizing a proprietary cocrystal composition that combines cannabidiol (CBD) with tetramethylpyrazine (TMP), the company is innovating in the realm of cannabinoid pharmacology. Their flagship product candidate exhibits superior pharmacokinetic and pharmacodynamic properties compared to conventional CBD formulations.
- FABP Inhibitors: A highlight of the portfolio is the selective inhibition of Fatty Acid Binding Protein 5 (FABP5), an approach designed to provide non-opioid, non-steroidal pain management solutions. These inhibitors are being explored in various pain models including chemotherapy-induced peripheral neuropathy, cancer bone pain, and osteoarthritis-related discomfort.
- Appetite and Cachexia Management: Artelo is developing therapies aimed at supporting patients suffering from cancer-related anorexia. Their efforts focus on improving body weight, appetite, and overall quality of life by targeting specific G-Protein Coupled Receptors (GPCRs) linked to metabolic regulation.
Scientific Innovation and Research Excellence
Artelo Biosciences emphasizes scientific innovation and regulatory discipline. The company strategically leverages world-class research expertise in its collaborations across Europe and North America. This collaborative approach ensures that the preclinical and clinical development of their compounds is built on robust scientific findings. Utilizing advanced drug formulation techniques such as cocrystallization, the company addresses challenges related to solubility and bioavailability, thereby optimizing the delivery and efficacy of their compounds.
Operational Footprint and Global Presence
Headquartered in San Diego, California, and with a significant presence in Dublin, Ireland, Artelo Biosciences has strategically positioned itself at the nexus of global biopharmaceutical innovation. This dual presence facilitates access to premier research institutions and allows the company to foster partnerships with leading academic and commercial entities across both the North American and European markets.
Competitive Position and Industry Significance
In the competitive landscape of clinical-stage biopharmaceutical companies, Artelo Biosciences distinguishes itself through its specialized focus on lipid-signaling and endocannabinoid modulation. By capitalizing on novel mechanisms of action and proprietary technologies, the company aims to fill clinical gaps where existing therapies are inadequate. Its methodical approach to product candidate development, emphasizing improved pharmacological profiles and optimized formulations, positions it as a credible player in the market. In a world where precision medicine and targeted therapies are increasingly important, Artelo’s platform presents a relevant and enduring solution for diverse therapeutic challenges.
Expertise, Experience, and Collaborative Strength
The leadership at Artelo Biosciences is composed of experienced biopharmaceutical executives and renowned researchers with deep domain expertise. This seasoned team guides the company’s multi-disciplinary projects, ensuring that every phase of development integrates regulatory excellence and scientific rigor. Strategic collaborations with academic institutions and industry partners enhance the company’s pipeline by providing access to innovative methodologies and specialized research tools, thus reinforcing its commitment to high-impact therapeutic discoveries.
Research and Development Strategy
Artelo’s R&D strategy is driven by an integrated approach that spans early discovery to clinical development. Each product candidate is supported by extensive preclinical validation, demonstrating efficacy in well-established laboratory models of disease. The company’s emphasis on establishing patent-protected products further underscores its commitment to long-term innovation. Through an agile development process, Artelo continuously refines its drug candidates to enhance safety, dosing precision, and clinical applicability. This systematic approach highlights the company’s regulatory discipline and forward-thinking in addressing complex pathologies.
Addressing Unmet Medical Needs
The challenges in treating conditions such as chemotherapeutic pain, chronic neuropathies, and cancer-associated cachexia underscore a significant need for innovative therapeutic options. Artelo Biosciences’ approach, which modulates upstream lipid-signaling pathways, offers the potential to achieve clinical benefits not attainable with traditional therapies. By focusing on molecular targets that regulate bioactive lipids, the company promises solutions that are less reliant on conventional mechanisms, thereby reducing adverse effects while improving efficacy.
Scientific Integrity and Transparency
In its commitment to scientific integrity and transparency, Artelo Biosciences provides comprehensive disclosure on its research methods and collaborative engagements. The company’s numerous presentations at global scientific symposia demonstrate its dedication to contributing to the broader body of knowledge in cannabinoid research and lipid signaling. This openness reinforces its reputation for expertise and builds trust among stakeholders, including investors, researchers, and clinical practitioners.
Conclusion
Artelo Biosciences Inc is a dynamic and forward-thinking biopharmaceutical company that has built a niche in the development of novel therapies targeting lipid-signaling pathways. With a robust and diversified drug pipeline, a strong scientific foundation, and a global operational footprint, the company continues to contribute valuable insights and therapeutic solutions in areas where patient needs are greatest. By maintaining a clear focus on rigorous research and strategic collaborations, Artelo is well-equipped to sustain its relevance and impact in the evolving landscape of biopharmaceutical innovation.
Artelo Biosciences, a clinical-stage pharmaceutical company focusing on lipid-signaling pathways for various medical conditions, announced its participation in the Maxim Group 2024 Virtual Healthcare Summit. The event is scheduled for October 15-17, 2024.
CEO Gregory D. Gorgas will engage in a fireside chat with Jason McCarthy, Maxim's Senior MD and Head of Biotechnology Research analyst, on Wednesday, October 16, 2024, at 4:00 p.m. ET. Interested parties can access the webcast by registering at the provided link.
Artelo Biosciences (Nasdaq: ARTL) focuses on developing treatments for people living with cancer, pain, dermatologic and neurological conditions. This participation offers an opportunity for investors and interested parties to gain insights into the company's progress and future plans.
Artelo Biosciences (Nasdaq: ARTL), a clinical-stage pharmaceutical company, announced its participation in the H.C. Wainwright 26th Annual Global Investment Conference from September 9-11, 2024, in New York City. CEO Gregory D. Gorgas will represent the company, with an on-demand presentation available to registered attendees starting September 9 at 7:00 AM Eastern Time.
The presentation will be accessible via webcast on the conference platform and Artelo's investor relations website. Management will also engage in one-on-one meetings with qualified investors throughout the conference. Artelo focuses on modulating lipid-signaling pathways to develop treatments for cancer, pain, and dermatologic and neurological conditions.
Artelo Biosciences (Nasdaq: ARTL) reported its Q2 2024 financial results and provided a business update. The company is entering a productive phase in clinical development, with multiple readouts expected over the next 18 months. Key highlights include:
- FDA clearance to initiate clinical trials for ART26.12 for chemotherapy-induced peripheral neuropathy
- Anticipated full enrollment in Phase 2a of the CAReS trial for ART27.13 by early 2025
- ART12.11 in final stages of product formulation, potential clinical study entry in early 2025
Financially, Artelo reported $5.6 million in cash and cash equivalents as of June 30, 2024, with an additional $1.3 million received from UK R&D tax credits in July. Q2 2024 net loss was $2.4 million, or $0.75 per share, compared to $1.6 million, or $0.56 per share, in Q2 2023.
Artelo Biosciences (Nasdaq: ARTL) has received FDA clearance for its Investigational New Drug (IND) application for ART26.12, a selective Fatty Acid Binding Protein 5 (FABP5) inhibitor. This clearance allows Artelo to initiate a Phase 1 single ascending dose study for chemotherapy-induced peripheral neuropathy (CIPN), a condition with no FDA-approved treatment. ART26.12 is being developed as a non-opioid approach to manage painful neuropathies. The company expects Phase 1 trial results in the first half of 2025. Artelo's FABP inhibitor platform has attracted interest from potential partners due to its preclinical efficacy, novel mechanism, and strong patent estate.
Artelo Biosciences presented comparative preclinical data on ART12.11 at the 34th Annual International Cannabinoid Research Society Symposium. Findings revealed ART12.11, a novel cannabidiol: tetramethylpyrazine cocrystal, has a unique pharmacokinetic profile, potentially superior to existing treatments for anxiety-related disorders. Research showed ART12.11 increased plasma levels of CBD in rodents and displayed efficacy in reducing anxiety and depressive symptoms. The drug demonstrated similar plasma levels of CBD as Epidiolex, suggesting its potential as an effective treatment. Artelo is currently optimizing ART12.11's oral delivery formulation.
Artelo Biosciences (Nasdaq: ARTL) announced promising data from several research studies on its Fatty Acid Binding Protein 5 (FABP5) inhibitors at the ICRS Symposium, held June 30 – July 5, 2024, in Salamanca, Spain. The studies demonstrated the potential of FABP5 inhibitors in treating cancer, psoriasis, and anxiety disorders. ART26.12, one of Artelo’s lead inhibitors, showed anti-tumor effects in colon cancer models and potential for treating chemotherapy-induced peripheral neuropathy and psoriasis. Another inhibitor, SBFI103, improved depressive-like behaviors in preclinical studies. These findings support further development of FABP5 inhibitors, with first-in-human trials expected next year.
Artelo Biosciences (Nasdaq: ARTL) presented preclinical data on ART26.12, a fatty acid-binding protein 5 (FABP5) inhibitor, at the 34th Annual International Cannabinoid Research Society Symposium. The data demonstrated ART26.12's effectiveness in reducing pain behaviors caused by breast cancer in preclinical studies. This study is the fourth in a series showing consistent efficacy in various pain models, including oxaliplatin-induced peripheral neuropathy. Artelo aims to initiate human trials following FDA approval of their Investigational New Drug application. Breast cancer often leads to bone metastasis, causing severe pain. ART26.12 offers a novel, non-opioid, non-steroidal treatment option for such pain.
Artelo Biosciences (Nasdaq: ARTL), a clinical-stage pharmaceutical company, presented new preclinical data on ART26.12 at the 57th Annual Scientific Meeting of the British Pain Society. The conference took place from June 4-6, 2024, in Nottingham, UK. ART26.12, a Fatty Acid Binding Protein 5 (FABP5) inhibitor, showed efficacy in reducing breast cancer-induced bone pain and diabetic neuropathy in preclinical models. Effective doses and plasma exposures were consistent with previous data. Artelo plans to submit an Investigational New Drug application to the U.S. FDA this month. This non-opioid, non-steroidal treatment is seen as a promising alternative for pain management.
Artelo Biosciences (Nasdaq: ARTL) presented new pre-clinical data on ART12.11 at the CT-CANN24 conference, demonstrating that ART12.11, a patented cocrystal of CBD and TMP, has comparable pharmacokinetics to Epidiolex in rats. Epidiolex, an FDA-approved oral CBD solution, saw over $845 million in net sales in 2023. ART12.11, in an unoptimized formulation, showed similar CBD levels in plasma to Epidiolex, suggesting potential for a solid dosage form that is preferred for adolescents and adults due to better dosing precision, storage, and transport. Previous animal studies indicated ART12.11 outperformed CBD in stress-induced anxiety and depression with a lower CBD amount. Artelo is developing an optimized tablet form of ART12.11 for clinical studies, aiming to broaden CBD research in larger populations.
Artelo Biosciences, Inc. (Nasdaq: ARTL) reported financial results for Q1 2024, highlighting progress in developing treatments for cancer, pain, dermatologic, and neurological conditions. The company's lead inhibitor, ART26.12, shows promise in treating neuropathic pain. Artelo's cash and investments stood at $7.6 million, with R&D expenses at $1.5 million and a net loss of $2.5 million.
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