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Artelo Biosciences Announces Publication of Peer-Reviewed Article Highlighting FABP7 as a Promising Novel Target in Cancer Therapy

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Artelo Biosciences announces the publication of a peer-reviewed article highlighting FABP7 as a promising novel target in cancer therapy. The article discusses the role of FABP7 in various cancers, its potential as a validated target in cancer treatment, and the impact of FABP7 inhibition on tumor growth and patient prognosis. Artelo is focused on developing FABP inhibitors for cancer and other serious conditions, with the lead compound ART26.12 showing promising results in preclinical studies for conditions like cancer bone pain and chemotherapy-induced peripheral neuropathy.
Artelo Biosciences annuncia la pubblicazione di un articolo revisionato da esperti che evidenzia FABP7 come un nuovo bersaglio promettente nella terapia del cancro. L'articolo tratta il ruolo di FABP7 in vari tipi di cancro, il suo potenziale come bersaglio validato nel trattamento del cancro e l'impatto dell'inibizione di FABP7 sulla crescita tumorale e sulla prognosi dei pazienti. Artelo si sta concentrando sullo sviluppo di inibitori di FABP per il cancro e altre gravi condizioni, con il composto principale ART26.12 che mostra risultati promettenti in studi preclinici per condizioni come il dolore osseo da cancro e la neuropatia periferica indotta dalla chemioterapia.
Artelo Biosciences anuncia la publicación de un artículo revisado por pares que destaca a FABP7 como un objetivo novedoso y prometedor en la terapia del cáncer. El artículo discute el papel de FABP7 en varios cánceres, su potencial como un objetivo validado en el tratamiento del cáncer, y el impacto de la inhibición de FABP7 en el crecimiento del tumor y el pronóstico del paciente. Artelo está enfocado en desarrollar inhibidores de FABP para el cáncer y otras condiciones graves, con el compuesto líder ART26.12 mostrando resultados prometedores en estudios preclínicos para condiciones como el dolor óseo por cáncer y la neuropatía periférica inducida por la quimioterapia.
Artelo Biosciences가 암 치료에서 FABP7을 유망한 새로운 타겟으로 강조하는 동료 평가 논문 발표를 발표했습니다. 이 논문은 다양한 암에서 FABP7의 역할, 암 치료에서 검증된 타겟으로서의 잠재력, 그리고 FABP7 억제가 종양 성장과 환자의 예후에 미치는 영향에 대해 논의합니다. Artelo는 암 및 기타 심각한 질환을 위한 FABP 억제제 개발에 집중하고 있으며, 주요 화합물 ART26.12는 암성 뼈 통증 및 화학 요법 유발 말초 신경병증과 같은 조건에 대한 전임상 연구에서 유망한 결과를 보여주고 있습니다.
Artelo Biosciences annonce la publication d'un article évalué par des pairs mettant en lumière FABP7 comme nouvelle cible prometteuse dans la thérapie du cancer. L'article discute du rôle de FABP7 dans divers cancers, son potentiel en tant que cible validée dans le traitement du cancer, et l'impact de l'inhibition de FABP7 sur la croissance tumorale et le pronostic des patients. Artelo se concentre sur le développement d'inhibiteurs de FABP pour le cancer et d'autres conditions graves, avec le composé leader ART26.12 montrant des résultats prometteurs dans des études précliniques pour des conditions comme la douleur osseuse liée au cancer et la neuropathie périphérique induite par la chimiothérapie.
Artelo Biosciences kündigt die Veröffentlichung eines durch Peer-Review geprüften Artikels an, der FABP7 als ein vielversprechendes neues Ziel in der Krebstherapie hervorhebt. Der Artikel diskutiert die Rolle von FABP7 bei verschiedenen Krebsarten, sein Potenzial als validiertes Ziel in der Krebsbehandlung und die Auswirkungen der FABP7-Hemmung auf das Tumorwachstum und die Prognose der Patienten. Artelo konzentriert sich auf die Entwicklung von FABP-Hemmern für Krebs und andere ernsthafte Zustände, wobei die Leitsubstanz ART26.12 in präklinischen Studien für Bedingungen wie Krebsschmerzen im Knochen und durch Chemotherapie verursachte periphere Neuropathie vielversprechende Ergebnisse zeigt.
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Insights

An intriguing aspect of Artelo Biosciences' latest publication lies in the validation of FABP7 as a novel target in cancer therapies. The implications are significant, given that current treatments often have limitations in specificity and efficacy. By pinpointing a protein upregulated in multiple types of cancer, Artelo may be able to devise drugs with better outcomes, particularly in terms of patient prognosis.

When analyzing the preclinical success of ART26.12, the compound's potential benefits extend beyond cancer treatment alone to include alleviation of cancer bone pain and chemotherapy-induced peripheral neuropathy (CIPN), a condition lacking FDA-approved management options. The bid to file an IND for ART26.12 could mark a substantial step forward in pain management for cancer patients, addressing a substantial unmet medical need.

From a financial perspective, Artelo's progress in the drug development pipeline is of substantial interest to investors. The move to file an IND represents a transition from research into potential commercialization, which can offer investors insights into the company's trajectory. The market for neuropathic pain management, particularly in connection with cancer treatment, is notably underserved. Should ART26.12 advance through clinical trials, it provides a clear pathway towards market entry in a niche with limited competition and potentially high demand.

Understanding the market dynamics for FABP7 inhibitors gives context to Artelo's strategic positioning. Their broad FABP inhibitor library and the specific focus on CIPN tap into a growing demand for cancer supportive care treatments. The statistics mentioned – approximately 40% of patients developing neuropathic pain from certain chemotherapies – demonstrate the scale of the potential user base for ART26.12. Commercially, the company is moving towards fulfilling a significant gap, potentially positioning itself at the forefront of this therapeutic niche.

Provides Further Evidence of Multiple Opportunities for Development of the FABP Inhibitor Platform in Cancer & Other Serious Conditions

SOLANA BEACH, Calif., April 23, 2024 (GLOBE NEWSWIRE) -- Artelo Biosciences, Inc. (Nasdaq: ARTL), a clinical-stage pharmaceutical company focused on modulating lipid-signaling pathways to develop treatments for people living with cancer, pain, dermatological, and neurological conditions, today announced the publication of an article, “The emerging role of fatty acid binding protein 7 (FABP7) in cancers,” in Drug Discovery Today, a peer-reviewed journal. The article analyzes the results of various studies and presents a comprehensive analysis of FABP7’s role in a variety of cancers and its correlation with patient prognosis, as well as its potential utility as a validated target in cancer treatment.

The publication reveals that FABP7, an intracellular protein involved in the uptake, transportation, metabolism, and storage of fatty acids, is upregulated in several cancers including breast, brain, and kidney cancers and is generally associated with a poor patient prognosis. Additionally, the evidence shows that both genetic and pharmacological inhibition of FABP7 led to reduced tumor cell growth, migration, and invasion in multiple studies. Moreover, inhibition of FABP7 improved host survival rates, particularly in brain cancers, indicating its role as a novel target in cancer.

“Artelo is dedicated to furthering research on FABP inhibition including selective- and pan-FABP inhibition, with the aim of providing new therapeutic options for patients battling cancer and other serious conditions,” said Professor Saoirse Elizabeth O’Sullivan, Vice President of Translational Sciences at Artelo Biosciences. “The insights highlighted in this review continue to underscore the potential impact of our FABP inhibitor platform in several therapeutic areas.”

Artelo is currently evaluating multiple compounds for their therapeutic potential from the Company’s extensive FABP inhibitor library. The most advanced of these is ART26.12, a novel, potent and selective inhibitor of FABP5. In preclinical studies, ART26.12 demonstrated positive results in cancer, cancer bone pain, and painful neuropathies such as chemotherapy-induced peripheral neuropathy (CIPN). Artelo plans to file an investigational new drug (IND) application with the U.S. Food and Drug Administration (FDA) during the second quarter of 2024 for the development of ART26.12 in CIPN. Approximately 40% of cancer patients treated with certain chemotherapies will develop neuropathic pain which often requires dose reduction or cessation of anti-cancer treatment and there is currently no FDA-approved therapy to treat or prevent CIPN.

For more information about Artelo Biosciences and our commitment to innovative therapies, please visit our website at www.artelobio.com

About ART26.12
ART26.12, Artelo’s lead Fatty Acid Binding Protein (FABP) inhibitor, is a potent and selective inhibitor of FABP5 being developed as a novel, peripherally acting, non-opioid, non-steroidal analgesic, with an initial clinical study planned for chemotherapy-induced peripheral neuropathy (CIPN). FABPs are a family of intracellular proteins that chaperone lipids including endocannabinoids and fatty acids. FABP is overexpressed and associated with abnormal lipid signaling in a number of pathologies. Beyond ART26.12, Artelo’s extensive library of small molecule inhibitors of FABPs have shown therapeutic promise for the treatment of certain cancers, cancer bone pain, neuropathic and nociceptive pain, dermatological and anxiety disorders.

About Artelo Biosciences
Artelo Biosciences, Inc. is a clinical stage pharmaceutical company dedicated to the development and commercialization of proprietary therapeutics that modulate lipid-signaling pathways. Artelo is advancing a portfolio of broadly applicable product candidates designed to address significant unmet needs in multiple diseases and conditions, including anorexia, cancer, anxiety, pain, and inflammation. Led by proven biopharmaceutical executives collaborating with highly respected researchers and technology experts, the company applies leading edge scientific, regulatory, and commercial discipline to develop high-impact therapies. More information is available at www.artelobio.com and on X (formerly Twitter): @ArteloBio.

Forward Looking Statements
This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and Private Securities Litigation Reform Act, as amended, including those relating to the Company’s product development, market opportunity, competitive position, business strategies, potential growth opportunities and other statement that are predictive in nature. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management’s current beliefs and assumptions. These statements may be identified by the use of forward-looking expressions, including, but not limited to, “expect,” “anticipate,” “intend,” “plan,” “believe,” “estimate,” “potential,” “predict,” “project,” “should,” “would” and similar expressions and the negatives of those terms. These statements relate to future events and involve known and unknown risks, uncertainties, and other factors which may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Such factors include those set forth in the Company’s filings with the Securities and Exchange Commission, including our ability to raise additional capital in the future. Prospective investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this press release. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise, except to the extent required by applicable securities laws.

Investor Relations Contact:
Crescendo Communications, LLC
Tel: 212-671-1020
Email: ARTL@crescendo-ir.com


FAQ

What is the focus of the peer-reviewed article published by Artelo Biosciences?

The article highlights FABP7 as a promising novel target in cancer therapy.

Which journal published the article on FABP7?

The article was published in Drug Discovery Today, a peer-reviewed journal.

What are some cancers in which FABP7 is upregulated according to the publication?

FABP7 is upregulated in breast, brain, and kidney cancers.

What is the potential utility of FABP7 in cancer treatment?

FABP7 shows potential as a validated target in cancer treatment.

Which compound is the most advanced in Artelo's FABP inhibitor library?

ART26.12 is the most advanced compound, a novel and selective inhibitor of FABP5.

What is the therapeutic potential of ART26.12?

ART26.12 has shown positive results in cancer, cancer bone pain, and painful neuropathies like chemotherapy-induced peripheral neuropathy.

When does Artelo plan to file an IND application with the FDA for ART26.12 development?

Artelo plans to file an IND application during the second quarter of 2024 for the development of ART26.12 in chemotherapy-induced peripheral neuropathy.

What percentage of cancer patients treated with certain chemotherapies develop neuropathic pain?

Approximately 40% of cancer patients treated with certain chemotherapies will develop neuropathic pain.

Is there an FDA-approved therapy for chemotherapy-induced peripheral neuropathy?

Currently, there is no FDA-approved therapy to treat or prevent chemotherapy-induced peripheral neuropathy.

Artelo Biosciences, Inc.

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