ProMIS Neurosciences Presents at 2022 Alzheimer’s Association International Conference
ProMIS Neurosciences presented at the Alzheimer's Association International Conference (AAIC) on July 31, 2022, showcasing its lead candidate, PMN310, an antibody targeting toxic amyloid-beta oligomers in Alzheimer’s Disease. The study demonstrated PMN310's enhanced selectivity and resilience against non-toxic monomers, suggesting greater therapeutic efficacy. Unlike other antibodies that failed in trials, PMN310 maintained binding to toxic oligomers without interference, potentially reducing risks like brain swelling associated with plaque-targeting antibodies. The presentation will be available online post-conference.
- PMN310 showed enhanced selectivity for toxic oligomers, potentially leading to greater efficacy in Alzheimer's treatment.
- Demonstrated less interaction with non-toxic monomers compared to competing antibodies, indicating stronger therapeutic potential.
- Potentially reduced risk of ARIA-E, linked to brain swelling, as PMN310 avoids binding to plaques.
- None.
Poster presentation of study highlighting oligomer selectivity of PMN310 compared to that of other amyloid-beta-directed antibodies
TORONTO, Ontario and CAMBRIDGE, Mass., Aug. 02, 2022 (GLOBE NEWSWIRE) -- ProMIS Neurosciences Inc. (Nasdaq: PMN) (TSX: PMN), a biotechnology company focused on the discovery and development of antibody therapeutics targeting misfolded proteins such as toxic oligomers implicated in the development of neurodegenerative diseases, today announced details of its poster presentation at the annual Alzheimer’s Association International Conference (AAIC®) being held from July 31-August 4, 2022 at the San Diego Convention Center, San Diego California and online.
Dr. Johanne Kaplan, ProMIS Chief Development Officer delivered a poster presentation on July 31st entitled: “Distinguishing between amyloid-beta-directed antibodies: ability of PMN310 to target toxic oligomers despite competing species.”
A large body of evidence indicates that the most pathogenic species of amyloid-beta (Aß) in Alzheimer’s disease (AD) consist of soluble toxic oligomers as opposed to insoluble fibrils (plaque) and monomers. The ability of a therapeutic antibody to target toxic Aß oligomers without being diverted by binding to competing non-toxic species is expected to result in greater efficacy.
The poster describes a study comparing ProMIS’ lead therapeutic candidate PMN310 to other Aß-directed antibodies for selectivity and ability to maintain interaction with toxic oligomers in the presence of competing Aß monomers. The binding of multiple Aß-directed antibodies to synthetic oligomers with and without pre-exposure to competing monomers, was evaluated by surface plasmon resonance (SPR). Binding of the antibodies to a toxic oligomer-enriched low molecular fraction of brain extract from Alzheimer’s disease (AD) patients was similarly evaluated by SPR, with and without monomer competition.
Results of this study showed that PMN310 displayed little or no interaction with monomers and was among the least impacted by excess monomer competition in binding to synthetic oligomers or to naturally occurring toxic oligomers in AD brain extract. This characteristic was shared by other Aß antibodies that have shown positive clinical outcomes, such as donanemab, lecanemab and aducanumab. In contrast, non-selective antibodies that failed in pivotal trials, such as crenezumab and solanezumab, were strongly inhibited by monomer competition.
In conclusion, PMN310 distinguished itself from other Aß-directed antibodies by its enhanced selectivity for toxic oligomers (negligible binding to monomers and plaque) along with its ability to withstand competition by abundant monomers. Additionally, the avoidance of interaction with plaque and vascular deposits by PMN310 could potentially reduce the risk of brain swelling associated with plaque-binding antibodies (amyloid-related imaging abnormality with edema, ARIA-E).
The narrated poster presentation will be available on the ProMIS website www.promisneurosciences.com after the AAIC® closes on August 4, 2022.
About PMN310
ProMIS Neurosciences’ lead therapeutic candidate, PMN310, is a monoclonal antibody for Alzheimer’s disease created with a novel, proprietary method for generating and developing antibodies that can uniquely and precisely target toxic forms of otherwise normal proteins. PMN310 selectively targets the toxic oligomeric species of amyloid-beta (Aß), a root cause of Alzheimer’s disease. Preclinical studies have shown that PMN310 demonstrates a high degree of selectivity and protective activity against toxic oligomers.
About ProMIS Neurosciences
ProMIS Neurosciences Inc. is a development stage biotechnology company focused on generating and developing antibody therapeutics selectively targeting toxic oligomers implicated in the development and progression of neurodegenerative diseases, in particular Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). The Company’s proprietary target discovery engine is based on the use of two complementary techniques. The Company applies its thermodynamic, computational discovery platforms - ProMIS™ and Collective Coordinates - to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this unique approach, the Company is developing novel antibody therapeutics for AD, ALS and PD. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on Nasdaq and the Toronto Stock Exchange under the symbol PMN.
To learn more, visit us at www.promisneurosciences.com, follow us on Twitter and LinkedIn
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