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ARIDIS PHARMACEUTICAL INC - ARDS STOCK NEWS

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Aridis Pharmaceuticals, Inc. (NASDAQ: ARDS) is a biopharmaceutical company based in Los Gatos, California, focused on developing innovative anti-infective therapies for life-threatening infections. The company leverages its proprietary ʎPEX™ and MabIgX® technology platforms to identify potent B-cells from patients who have successfully overcome infections and rapidly manufacture monoclonal antibodies (mAbs) for therapeutic use. These mAbs are already of human origin and do not require further engineering optimization to achieve full functionality.

Aridis is advancing multiple clinical-stage mAbs targeting bacteria and viruses that cause severe infections such as ventilator-associated pneumonia (VAP) and hospital-acquired pneumonia (HAP). The company’s novel approach addresses the limitations of current broad-spectrum antibiotics, such as increasing drug resistance, short duration of efficacy, and disruption of the human microbiome.

Highlighted in Aridis' pipeline are seven key products:

  • AR-301 (VAP/HAP/CAP): A fully human IgG1 mAb targeting Staphylococcus aureus alpha-toxin, currently in Phase 3 clinical development.
  • AR-320 (VAP): A fully human mAb for the prevention of VAP caused by S. aureus, in Phase 3 clinical development.
  • AR-501 (Cystic Fibrosis): An inhaled formulation of gallium citrate to treat chronic lung infections in cystic fibrosis patients, in Phase 2a clinical study.
  • AR-701 (COVID-19): A cocktail of fully human mAbs targeting SARS-CoV-2 spike proteins.
  • AR-101 (HAP): A fully human IgM mAb in Phase 2 clinical development targeting Pseudomonas aeruginosa liposaccharides serotype O11.
  • AR-201 (RSV Infection): A fully human IgG1 mAb directed against the F-protein of respiratory syncytial virus (RSV), licensed to the Serum Institute of India.
  • AR-401 (Blood Stream Infections): A preclinical mAb program targeting gram-negative Acinetobacter baumannii.

Aridis has recently achieved significant milestones including positive Phase 2a results for AR-501, FDA and EMA agreement on AR-301 Phase 3 study design, and multiple grants from the National Institute of Allergy and Infectious Diseases (NIAID). The company continues to explore strategic partnerships to advance its clinical programs and maximize value for shareholders.

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Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) received a notice from Nasdaq on April 19, 2023, regarding its non-compliance with Listing Rules due to the late filing of its Form 10-K for the year ended December 31, 2022. The Due Date for this filing was April 17, 2023. While this notice doesn't immediately affect ARDS's securities listing, the company must appeal to a Hearings Panel within seven days to avoid suspension. Aridis is already under review for failing to meet the $35 million minimum market value requirement. The company is working diligently to complete and submit the Form 10-K as soon as possible, emphasizing its commitment to compliance.

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Aridis Pharmaceuticals (Nasdaq: ARDS) announced a corporate update, highlighting a significant development regarding its candidate AR-320. MedImmune Limited has terminated their license for AR-320 due to payment issues, placing its Phase 3 study on hold. The company seeks resolution while emphasizing commitment to its pipeline, including AR-301 and AR-501, which show positive clinical data. Operating expenses have decreased due to the trial pause, and employee headcount is now at 26. Feedback from FDA and EMA on AR-301’s study design is expected by the end of April 2023.

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Aridis Pharmaceuticals (Nasdaq: ARDS) has announced a registered direct offering of 6 million shares of common stock at $0.38 per share, expected to close around March 16, 2023. The offering aims to raise approximately $2.28 million before expenses, with proceeds designated for working capital and general corporate purposes. H.C. Wainwright & Co. is the exclusive placement agent. This transaction utilizes a previously filed shelf registration statement with the SEC. The company develops innovative anti-infectives and has multiple monoclonal antibody candidates in various stages of clinical development.

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Aridis Pharmaceuticals (Nasdaq: ARDS) announced promising preliminary results from its Phase 2a study of AR-501, aimed at treating cystic fibrosis patients with Pseudomonas aeruginosa infections. Key findings include that AR-501 demonstrated safety and met pharmacokinetic endpoints, with no serious adverse events reported. Patients received three inhaled doses, achieving over 50-fold higher sputum concentrations than needed to inhibit the bacteria. The study showed better respiratory uptake compared to previous intravenous formulations, setting a foundation for further efficacy studies. Aridis plans to engage regulatory bodies to discuss next steps.

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RedChip Companies announced that interviews featuring Rail Vision Ltd. (RVSN), Aridis Pharmaceuticals, Inc. (ARDS), and Digital Ally, Inc. (DGLY) will be aired on The RedChip Money Report on Bloomberg TV on February 18, 2023, at 7 p.m. ET. This program reaches approximately 73 million homes across the U.S., offering significant exposure for the companies involved. Rail Vision aims to enhance railway safety and efficiency through AI technology, while Aridis focuses on developing innovative anti-infectives. Digital Ally engages in video solutions and health protection products, expanding its business through strategic acquisitions.

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Aridis Pharmaceuticals (Nasdaq: ARDS) announced top-line results from the AR-301-002 Phase 3 study, assessing the efficacy of the monoclonal antibody AR-301 in treating ventilator-associated pneumonia (VAP) caused by S. aureus. The study enrolled 174 ICU patients but fell short of its target of 240 due to pandemic-related disruptions. Results showed a clinical cure rate of 68.9% for AR-301 plus standard care, compared to 57.6% for standard care alone, although statistical significance was not achieved (p=0.23). Notably, older patients showed a 34% improvement in clinical cure at Day 21 (p=0.057). Plans for a second Phase 3 study are underway to further investigate AR-301's potential.

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FAQ

What is the current stock price of ARIDIS PHARMACEUTICAL (ARDS)?

The current stock price of ARIDIS PHARMACEUTICAL (ARDS) is $0.0001 as of December 23, 2024.

What is the market cap of ARIDIS PHARMACEUTICAL (ARDS)?

The market cap of ARIDIS PHARMACEUTICAL (ARDS) is approximately 8.9K.

What is Aridis Pharmaceuticals, Inc. known for?

Aridis Pharmaceuticals, Inc. is known for discovering and developing anti-infective therapies to combat life-threatening infections, focusing on innovative monoclonal antibodies (mAbs).

What are the key products in Aridis' pipeline?

Key products include AR-301 for VAP/HAP/CAP, AR-320 for VAP prevention, AR-501 for cystic fibrosis, AR-701 for COVID-19, AR-101 for HAP, AR-201 for RSV infection, and AR-401 for blood stream infections.

What technology platforms does Aridis use?

Aridis utilizes its proprietary ʎPEX™ and MabIgX® technology platforms to rapidly identify and manufacture potent antibody-producing B-cells for therapeutic use.

What recent achievements has Aridis Pharmaceuticals accomplished?

Recent achievements include positive Phase 2a results for AR-501, FDA and EMA agreement on AR-301 Phase 3 study design, and receiving multiple NIH grants for developing new mAbs.

What is the focus of Aridis' clinical programs?

Aridis focuses on developing monoclonal antibodies to treat severe bacterial and viral infections, targeting drug-resistant strains and overcoming the limitations of broad-spectrum antibiotics.

Where is Aridis Pharmaceuticals located?

Aridis Pharmaceuticals is headquartered in Los Gatos, California, USA.

How does Aridis Pharmaceuticals address antimicrobial resistance?

Aridis targets drug-resistant bacteria and viruses with innovative mAbs that harness the human immune system, offering a therapeutic approach distinct from broad-spectrum antibiotics.

What are the strategic goals of Aridis Pharmaceuticals?

Aridis aims to advance its clinical programs through partnerships, optimize therapeutic efficacy, and address unmet medical needs in infections with high mortality rates.

Who are the collaborators and partners of Aridis Pharmaceuticals?

Aridis collaborates with organizations like the Cystic Fibrosis Foundation and has licensing agreements with entities like the Serum Institute of India.

What is AR-301 and what infections does it target?

AR-301 is a fully human IgG1 mAb targeting S. aureus alpha-toxin, developed as an adjunctive therapy for ventilator-associated pneumonia (VAP), hospital-acquired pneumonia (HAP), and community-acquired pneumonia (CAP).

ARIDIS PHARMACEUTICAL INC

Nasdaq:ARDS

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8.91k
36.53M
18.05%
11.43%
5.55%
Biotechnology
Healthcare
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United States of America
Los Gatos