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Arcturus Therape - ARCT STOCK NEWS

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Company Overview

Arcturus Therapeutics Holdings Inc. is a globally recognized RNA medicines and vaccines company, founded in 2013 and based in San Diego, California. The company is distinguished by its focus on the application of advanced RNA technologies to develop innovative therapeutic solutions, with a strong emphasis on addressing rare diseases and enhancing public health outcomes. Through its pioneering work in RNA therapeutics, particularly in the development of self-amplifying messenger RNA (sa-mRNA) vaccines, Arcturus has established itself as a critical player in the biopharmaceutical research and development arena.

Core Technologies and Platforms

At the heart of Arcturus Therapeutics is a suite of enabling technologies that underscore its scientific expertise and research capabilities. The company leverages its proprietary LUNAR® lipid-mediated delivery system and STARR® mRNA Technology to facilitate the efficient delivery of nucleic acid medicines. These platforms enable the creation of a versatile range of products, including:

  • Self-amplifying mRNA (sa-mRNA) vaccines – designed to elicit robust and durable immune responses using lower doses compared to conventional mRNA vaccines.
  • RNA therapeutic candidates – targeting rare diseases such as liver and respiratory conditions, including therapeutic interventions for disorders like ornithine transcarbamylase deficiency and cystic fibrosis.
  • Nucleic acid medicines – encompassing a broad array of modalities including small interfering RNA, circular RNA, antisense RNA, and gene editing therapeutics.

Research and Development Focus

Arcturus is deeply committed to expansive research and innovation. It actively pursues advanced nucleic acid technologies supported by an extensive patent portfolio that spans multiple regions including the U.S., Europe, Japan, and China. This intellectual property foundation not only safeguards its innovative work but also reinforces its competitive stance within the industry. The company’s R&D framework is built on a robust pipeline of clinical and preclinical projects, reflecting years of accumulated expertise in drug discovery and development of novel therapeutic modalities.

Strategic Collaborations and Market Position

Understanding the multifaceted challenges of the biotechnology sector, Arcturus has maintained a disciplined approach towards strategic collaborations. Its partnerships with prominent global biotechnology firms have enhanced its capability to develop and commercialize novel mRNA vaccines and therapeutics. A notable collaboration includes its joint venture in Japan, through which it has successfully advanced the world's first approved sa-mRNA COVID-19 vaccine. By combining its technical expertise with the commercial and regulatory strengths of its partners, Arcturus is positioned well within an increasingly competitive market segment that values innovation, scientific rigor, and timely execution.

Competitive Landscape and Value Proposition

Arcturus operates within a highly competitive field of biotechnology and RNA-based therapeutics, competing with firms that also invest heavily in novel medical technologies. What sets Arcturus apart is its concentrated focus on rare diseases and its ability to harness advanced mRNA delivery systems that maximize the therapeutic potential of low-dose formulations. Its differentiated approach is underpinned by a deep understanding of molecular biology and nanotechnology, enabling the development of safe and efficacious treatments that can be rapidly adapted to meet evolving healthcare challenges.

Business Model and Revenue Generation

The company generates revenue primarily through licensing its proprietary RNA technologies, strategic collaborations, and co-development agreements with industry partners. By concentrating on breakthrough products in special niche markets such as rare diseases, Arcturus maintains a focused business model that emphasizes quality, innovation, and operational efficiency rather than high-volume sales. This model has allowed it to allocate significant resources towards further research and regulatory advancement, ensuring a continuous stream of innovation and value creation for its stakeholders.

Expertise, Authoritativeness, and Industry Engagement

Arcturus Therapeutics reflects deep industry expertise through its scientific publications, active participation in global regulatory discussions, and a management team with extensive experience in drug discovery and therapeutic development. The company remains actively engaged in academic and clinical dialogues, ensuring that its approaches to RNA therapeutic development remain at the cutting edge of biomedical science. Such engagement fosters trust and validates the company’s methodologies among peers, investors, and public health experts alike.

Summary

In summary, Arcturus Therapeutics Holdings Inc. represents a paradigm shift in the field of RNA medicines and nucleic acid therapeutics. Its integration of innovative technology platforms, commitment to scientific excellence, and strategic market positioning have collectively defined it as a compelling entity in the biotech landscape. The company’s robust portfolio of patented technologies and its collaborative approach to overcoming healthcare challenges underscore its lasting impact on the development of next-generation medicines.

Rhea-AI Summary
CSL and Arcturus Therapeutics announce positive results of a Phase 3 study evaluating a booster dose of ARCT-154, the world's first approved self-amplifying messenger RNA (sa-mRNA) COVID-19 vaccine, compared to a conventional mRNA COVID-19 vaccine. The study conducted in Japan demonstrates Immunological Non-Inferiority to Wuhan Strain and Superior Immunogenicity to Omicron BA.4/5 Variant. The new analysis at 6 months post-vaccination shows that ARCT-154 induces a longer immune response compared to Comirnaty for both the original Wuhan strain and Omicron BA.4/5 variant, and an advantage in antibody persistence. The results follow the approval of the world's first sa-mRNA COVID-19 vaccine for adults by Japan Ministry of Health, Labor and Welfare in November 2023.
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PassPort Technologies, Inc. (PPTI) collaborates with Arcturus Therapeutics (ARCT) to evaluate innovative mRNA formulations and transdermal delivery mechanisms for vaccines and therapeutics.
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CSL (ASX:CSL; USOTC:CSLLY) and Arcturus Therapeutics (Nasdaq: ARCT) announced the publication in Lancet Infectious Diseases of a Phase 3 study showing that a booster dose of ARCT-154, a novel, self-amplifying messenger RNA (sa-mRNA) vaccine, elicited a numerically higher immune response against the original Wuhan-Hu-1 virus strain and a superior immune response against Omicron BA.4/5 subvariant of SARS-CoV-2 virus compared to a booster dose of the conventional mRNA vaccine Comirnaty®. ARCT-154 results were achieved with one sixth the dose of Comirnaty® (5 μg vs 30 μg). The study included healthy adults initially immunized with two doses of an mRNA vaccine (Comirnaty® or Spikevax™) and then a third dose of Comirnaty® at least three months prior to the booster dose of either ARCT-154 or Comirnaty® in the study. Both vaccines were well-tolerated, with no causally associated severe or serious adverse events.
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CSL and Arcturus Therapeutics Announce Positive Phase 3 Results for ARCT-154 Sa-mRNA COVID-19 Vaccine
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Arcturus Therapeutics Holdings Inc. (ARCT) to present at the 42nd Annual J.P. Morgan Healthcare Conference. The President & CEO will discuss the company's focus on mRNA medicines for infectious diseases and rare liver and respiratory conditions.
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CSL (ASX:CSL; USOTC:CSLLY) and Arcturus Therapeutics receive historic approval for ARCT-154, the world's first Self-Amplifying messenger RNA (sa-mRNA) COVID-19 Vaccine in Japan. This marks a significant milestone in CSL's promise to develop and deliver innovative vaccines to combat respiratory viral diseases, expanding their comprehensive portfolio.
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CSL (CSL; CSLLY) and Arcturus Therapeutics announced that Japan's Ministry of Health, Labor and Welfare granted approval for ARCT-154, a self-amplifying mRNA COVID-19 vaccine. This marks the first sa-mRNA vaccine in the world to be registered, highlighting CSL's commitment to global public health. The vaccine is approved for initial vaccination and booster for adults 18 years and older, based on positive clinical data from several studies. CSL Seqirus, in partnership with Meiji Seika Pharma, will distribute the vaccine in Japan.
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Arcturus Therapeutics Holdings Inc. (Arcturus, Nasdaq: ARCT) has received Orphan Drug Designation from the FDA for ARCT-032 to treat cystic fibrosis. The company remains on track to share interim Phase 1b data in H1 2024, with the first patient in the study successfully completing two administrations of the product.
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Arcturus Therapeutics Holdings Inc. (ARCT) extends expected cash runway to 2026, achieves $35 million milestone under CSL collaboration, and provides corporate updates. The company reports financial results for Q3 2023 and highlights progress in expanding its next-generation STARR vaccine platform, COVID vaccine development, and mRNA therapeutic pipeline.
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Arcturus Therapeutics will release its financial results for the quarter ended September 30, 2023 on November 14. They will also host a conference call and webcast on the same day.
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FAQ

What is the current stock price of Arcturus Therape (ARCT)?

The current stock price of Arcturus Therape (ARCT) is $10.57 as of April 15, 2025.

What is the market cap of Arcturus Therape (ARCT)?

The market cap of Arcturus Therape (ARCT) is approximately 289.6M.

What is the primary focus of Arcturus Therapeutics?

Arcturus Therapeutics is focused on the development of RNA medicines, particularly utilizing mRNA and self-amplifying mRNA technologies to create vaccines and therapeutics for rare diseases and public health challenges.

What technologies underpin Arcturus Therapeutics' product development?

The company leverages proprietary platforms such as the LUNAR® lipid-mediated delivery system and STARR® mRNA Technology to ensure efficient delivery and enhanced efficacy of its RNA-based therapeutics.

How does Arcturus generate revenue?

Arcturus primarily generates revenue through strategic collaborations, licensing of its proprietary RNA technologies, and co-development agreements with leading global biotechnology partners.

What types of diseases does Arcturus Therapeutics target?

Arcturus primarily targets rare diseases, with current research and development efforts focused on conditions related to liver and respiratory systems, as well as other therapeutic areas such as ornithine transcarbamylase deficiency and cystic fibrosis.

What distinguishes Arcturus’ approach in the competitive biotech sector?

The company distinguishes itself by concentrating on advanced RNA delivery systems, low-dose formulations for enhanced immunogenicity, and robust R&D supported by a strong patent portfolio.

What role do collaborations play in Arcturus’ business strategy?

Collaborations are critical to Arcturus’ strategy, enabling the company to leverage external expertise and regulatory strengths, particularly in markets such as Japan and Europe, to enhance the development and commercialization of its RNA therapeutics.

How does Arcturus demonstrate its expertise in RNA therapeutics?

The company showcases its expertise through its advanced technology platforms, extensive patent portfolio, consistent research and development efforts, and active participation in global regulatory and scientific discussions.

How are Arcturus' products positioned within the current market landscape?

Arcturus' products are positioned as novel and scientifically advanced solutions in the field of RNA medicines, with a distinctive focus on rare and underserved therapeutic areas. This positioning is bolstered by its strategic partnerships and robust technological framework.
Arcturus Therape

OTC:ARCT

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289.59M
24.83M
8.45%
92.53%
15.52%
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