Welcome to our dedicated page for Aptevo Therapeutics news (Ticker: APVO), a resource for investors and traders seeking the latest updates and insights on Aptevo Therapeutics stock.
Aptevo Therapeutics Inc. (NASDAQ:APVO) is a clinical-stage biotechnology company based in Seattle, Washington, renowned for pioneering oncology and hematology therapeutics. The company leverages its proprietary ADAPTIR™ and ADAPTIR-FLEX™ platform technologies to develop novel immunotherapeutic candidates aimed at enhancing cancer treatment outcomes.
Aptevo's robust pipeline includes APVO436, a clinical candidate targeting acute myeloid leukemia (AML), as well as preclinical candidates ALG.APV-527 and APVO603. These candidates utilize the company's versatile technology platforms to generate bispecific and multi-specific antibody candidates that harness the human immune system to target cancer cells.
Recently, Aptevo announced a reverse stock split aimed at regaining compliance with NASDAQ's minimum bid price requirement. The split is part of a strategic plan approved by the shareholders and aims to reduce the number of outstanding shares, thereby increasing the share price.
Among its promising projects, APVO436 has shown significant clinical benefits in combination with venetoclax and azacitidine for frontline AML treatment. The company is preparing to initiate a Phase 1b/2 dose optimization study, further exploring its efficacy. Additionally, ALG.APV-527 is in a Phase 1 trial for multiple solid tumor types, showing early signs of clinical activity and biological effectiveness.
Aptevo's culture of innovation and collaboration has attracted leading minds from pioneering biotech firms, fostering an environment conducive to groundbreaking research and development. The company's latest news highlights ongoing initiatives, such as presenting new data at major conferences and securing strategic partnerships to advance its clinical programs.
Financially, Aptevo remains focused on clinical development and operational efficiency. In recent quarters, the company has reported decreases in research and development expenses due to the transition between phases of its clinical studies. General and administrative expenses have also seen reductions, primarily attributed to lower employee and consulting costs.
Looking ahead, Aptevo continues to advance its pipeline with the aim of transforming cancer treatment paradigms. This commitment is underscored by their participation in major industry conferences and ongoing collaborations with leading CROs and biopharmaceutical firms.
Aptevo Therapeutics announced promising results from a Phase 1 clinical study of its lead drug candidate, APVO436, for patients with relapsed acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The study involved 46 adult patients, with 27.5% achieving favorable responses, including complete remissions. APVO436 demonstrated a favorable safety profile, with manageable adverse events primarily involving infusion reactions. The median survival for responding patients exceeded 300 days, compared to 100 days for others. These findings support further clinical development of APVO436 as a potential new treatment option.
Aptevo Therapeutics (APVO) reported financial results for Q2 2021, highlighting a net loss of $7.9 million or $1.75 per share, compared to a loss of $6.8 million or $2.10 per share in Q2 2020. Cash and cash equivalents totaled $61.7 million, with a runway through Q3 2022. The company advanced its Phase 1 trial for APVO436 in treating acute myeloid leukemia, showing promising safety and preliminary efficacy. Aptevo was also added to the Russell Microcap Index, reflecting growth and increased visibility in the market.
Aptevo Therapeutics (NASDAQ:APVO), a clinical-stage biotechnology company, announced that Dr. Jane Gross will speak at the Cambridge Health Institute PEGS Virtual Conference from July 19-22, 2021. Her presentation, titled Generating Immuno-Modulatory Bispecific Therapeutic Candidates for the Treatment of Hematologic and Solid Tumors, is scheduled for July 19 at 11:25 AM ET. Dr. Gross will also participate in a panel discussion on bispecific antibodies versus CAR T therapies at noon on the same day. Aptevo aims to leverage its ADAPTIR technologies for novel cancer treatments.
Aptevo Therapeutics (NASDAQ:APVO) has been added to the Russell Microcap Index, effective June 28, 2021. This membership, determined by market capitalization, enhances share valuation and presents opportunities for potential investors. The company recently completed a phase 1b clinical trial of its lead drug candidate, APVO436, for acute myeloid leukemia, achieving the primary endpoint of identifying a recommended phase 2 dose. Aptevo's proprietary ADAPTIR platforms enable the development of advanced immunotherapies targeting challenging cancers.
Aptevo Therapeutics has initiated the expansion phase of its clinical trial for APVO436, aimed at treating adult patients with acute myeloid leukemia (AML). Following a successful dose escalation phase, the new multi-center trial will enroll 90 patients across five cohorts, evaluating the drug's safety and efficacy when combined with standard treatments. Positive results from the initial phase highlighted a manageable side effect profile and no severe neutropenia, promising potential for APVO436's integration into standard AML treatments.
Aptevo Therapeutics (NASDAQ:APVO) announced results from a Phase 1 dose escalation trial of APVO436, its lead candidate for acute myeloid leukemia (AML) and myelodysplastic syndromes. The study enrolled 46 patients, demonstrating a favorable safety profile with no severe neutropenia, a common issue with CD123-targeting therapies. The trial identified an active dose for advanced studies and reported encouraging signs of clinical activity, including stabilization and complete remissions in several patients. Aptevo plans to submit the data for publication later this year.
Aptevo Therapeutics reported Q1 2021 financial results, highlighting ongoing progress in the Phase 1 trial of APVO436 for Acute Myeloid Leukemia and High-Grade Myelodysplastic Syndrome. As of March 31, 2021, the company had cash and cash equivalents of $58.8 million. They received $35 million from a royalty purchase agreement with HCR and recorded $2.4 million in royalty revenue from Pfizer's RUXIENCE. However, Aptevo reported a net loss of $7.3 million, or $1.64 per share, compared to a net income of $2.9 million in Q1 2020.
Aptevo Therapeutics (NASDAQ:APVO) announced its participation at the American Association for Cancer Research Virtual Annual Meeting, showcasing two key posters from April 10-15 and May 17-21, 2021. The posters cover preclinical updates on APVO603 and APVO442. APVO603 targets both 4-1BB and OX40, demonstrating significant anti-tumor response and safety in murine studies. APVO442, a bispecific candidate, shows strong efficacy and a favorable safety profile against PSMA+ tumors. Detailed abstracts will be available in the Virtual Poster Hall, allowing for presenter interactions.
Aptevo Therapeutics (NASDAQ:APVO) announced a significant advancement in its Phase 1/1b study of APVO436 for treating acute myeloid leukemia, with ongoing enrollment in cohort 10. The 2020 financial results showed a net loss of $17.75 million, an improvement from $40.45 million in 2019. Aptevo sold the RUXIENCE royalty payment stream for $35 million, with an additional $32.5 million possible based on sales milestones. The company maintains a strong balance sheet, allowing for continued clinical development. CEO Marvin White expressed optimism regarding the company's growth prospects.
Aptevo Therapeutics Inc. (NASDAQ:APVO) announced on February 9, 2021, that it received a notice from Tang Capital Partners, LP (TCP) intending to nominate two candidates for election to the Board of Directors and to submit an advisory stockholder proposal for the upcoming 2021 Annual Meeting. The Company’s Board and management are committed to maximizing long-term stockholder value and will review the nominations and present their recommendations in a proxy statement. Stockholders are not required to take any action at this time.
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