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Aptevo Therapeutics Inc - APVO STOCK NEWS

Welcome to our dedicated page for Aptevo Therapeutics news (Ticker: APVO), a resource for investors and traders seeking the latest updates and insights on Aptevo Therapeutics stock.

Aptevo Therapeutics Inc. (NASDAQ:APVO) is a clinical-stage biotechnology company based in Seattle, Washington, renowned for pioneering oncology and hematology therapeutics. The company leverages its proprietary ADAPTIR™ and ADAPTIR-FLEX™ platform technologies to develop novel immunotherapeutic candidates aimed at enhancing cancer treatment outcomes.

Aptevo's robust pipeline includes APVO436, a clinical candidate targeting acute myeloid leukemia (AML), as well as preclinical candidates ALG.APV-527 and APVO603. These candidates utilize the company's versatile technology platforms to generate bispecific and multi-specific antibody candidates that harness the human immune system to target cancer cells.

Recently, Aptevo announced a reverse stock split aimed at regaining compliance with NASDAQ's minimum bid price requirement. The split is part of a strategic plan approved by the shareholders and aims to reduce the number of outstanding shares, thereby increasing the share price.

Among its promising projects, APVO436 has shown significant clinical benefits in combination with venetoclax and azacitidine for frontline AML treatment. The company is preparing to initiate a Phase 1b/2 dose optimization study, further exploring its efficacy. Additionally, ALG.APV-527 is in a Phase 1 trial for multiple solid tumor types, showing early signs of clinical activity and biological effectiveness.

Aptevo's culture of innovation and collaboration has attracted leading minds from pioneering biotech firms, fostering an environment conducive to groundbreaking research and development. The company's latest news highlights ongoing initiatives, such as presenting new data at major conferences and securing strategic partnerships to advance its clinical programs.

Financially, Aptevo remains focused on clinical development and operational efficiency. In recent quarters, the company has reported decreases in research and development expenses due to the transition between phases of its clinical studies. General and administrative expenses have also seen reductions, primarily attributed to lower employee and consulting costs.

Looking ahead, Aptevo continues to advance its pipeline with the aim of transforming cancer treatment paradigms. This commitment is underscored by their participation in major industry conferences and ongoing collaborations with leading CROs and biopharmaceutical firms.

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Aptevo Therapeutics (Nasdaq: APVO) has closed a $3.0 million offering priced at-the-market under Nasdaq rules. The offering included 9,090,910 shares of common stock or pre-funded warrants, along with warrants to purchase up to 18,181,820 additional shares. The purchase price was $0.33 per share and associated warrant. Each share came with two Common Warrants, exercisable at $0.33 per share upon stockholder approval, expiring in five years.

Roth Capital Partners acted as the placement agent. Aptevo plans to use the net proceeds for clinical development of product candidates, working capital, and general corporate purposes. The company also amended previously issued warrants from July 2024, April 2024, and November 2023, reducing their exercise price to $0.33 per share, subject to stockholder approval.

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Aptevo Therapeutics Inc. (NASDAQ:APVO) has announced a $3.0 million registered direct offering priced at-the-market under Nasdaq rules. The offering includes 9,090,910 shares of common stock or pre-funded warrants, along with warrants to purchase up to 18,181,820 additional shares. The purchase price is set at $0.33 per share and associated Common Warrant. Each share comes with two Common Warrants, exercisable at $0.33 per share upon stockholder approval, expiring in five years. The offering is expected to close around September 18, 2024. Roth Capital Partners is acting as the placement agent. Aptevo plans to use the net proceeds for clinical development of product candidates, working capital, and general corporate purposes. Additionally, the company will amend certain existing warrants from previous issuances, reducing their exercise price to $0.33 per share.

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Aptevo Therapeutics (NASDAQ: APVO) and Alligator Bioscience (ATORX) announced positive interim data from their Phase 1 trial of ALG.APV-527, a bispecific antibody targeting 4-1BB and 5T4 for solid tumors. Key findings include:

- 60% of evaluable patients (9/15) achieved stable disease
- A breast cancer patient maintained stable disease for over 11 months
- Favorable safety, tolerability, and pharmacokinetics observed
- No maximum tolerated dose identified yet
- Biomarker analyses confirm biological activity

The trial is nearing full enrollment, with 18 patients included in the safety analysis. Results were presented at the ESMO Annual Congress on September 14, 2024.

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Aptevo Therapeutics (NASDAQ:APVO) and Alligator Bioscience (ATORX) announced positive interim data from the Phase 1 dose escalation trial of ALG.APV-527 in multiple solid tumor types. The results will be presented at the ESMO Congress 2024 in Barcelona, Spain. The poster presentation, titled 'First-in-Human Phase I Dose Escalation Study of ALG.APV-527, a 5T4 Tumor Antigen-Conditional 4-1BB Bispecific Antibody, in Patients with Advanced Solid Tumors,' demonstrates positive safety profiles, signals of biological activity, and patients with lasting stable disease. This marks a significant milestone in the development of ALG.APV-527, a novel bispecific antibody targeting 5T4 tumor antigen and 4-1BB, potentially offering a new treatment option for advanced solid tumors.

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Aptevo Therapeutics (NASDAQ:APVO) has initiated the Phase 1b/2 'RAINIER' trial for its lead candidate mipletamig (formerly APVO436) in combination with venetoclax and azacitidine for frontline acute myeloid leukemia (AML) patients. The study aims to identify the recommended Phase 2 dose and evaluate safety, tolerability, and efficacy. Previous trials showed promising results, including a 75% complete response rate among frontline patients and efficacy outcomes more than double the benchmarks. The multi-center, open-label dose-finding study will enroll up to 39 patients across five dose levels. Primary endpoints include safety assessment, determining the maximum tolerated dose, and evaluating cytokine release syndrome incidence.

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Aptevo Therapeutics (NASDAQ:APVO) reported its Q2 2024 financial results and provided a business update. Key highlights include:

  • Successful completion of APVO436 dose expansion trial with a 91% clinical benefit rate
  • Plans to initiate Phase 1b/2 dose optimization study for APVO436 in AML treatment
  • Ongoing Phase 1 trial for ALG.APV-527 in solid tumors with promising preliminary data
  • $2.75 million registered direct offering extending cash runway into 2025
  • Q2 2024 net loss of $5.9 million or $1.67 per share, compared to $7.9 million or $53.95 per share in Q2 2023
  • Cash position of $8.1 million as of June 30, 2024, with proforma $10.4 million including recent equity raise
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Aptevo Therapeutics, a clinical-stage biotech firm, announced the closing of a $2.75 million offering. This includes the issuance of 5,339,806 shares of common stock or pre-funded warrants and 10,679,612 common warrants, priced at $0.515 per share. The warrants have an exercise price of $0.515 per share, becoming exercisable upon stockholder approval and expiring in five years. Roth Capital Partners acted as the placement agent. The net proceeds will fund clinical development, working capital, and general corporate purposes. Additionally, certain existing warrants have been amended to a reduced exercise price of $0.515 per share.

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Aptevo Therapeutics (Nasdaq: APVO) announced a $2.75 million securities offering priced at-the-market under Nasdaq rules. The offering includes 5,339,806 shares of common stock or pre-funded warrants and warrants to purchase 10,679,612 shares at $0.515 per share. The offering is expected to close around July 1, 2024, with gross proceeds estimated at $2.3 million. The net proceeds will be used for clinical development, working capital, and general corporate purposes. Additionally, existing warrants issued in August 2023, November 2023, and April 2024 will be amended to have a reduced exercise price of $0.515 per share.

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Aptevo Therapeutics (Nasdaq: APVO), a clinical-stage biotech firm, is attending the BIO International Convention in San Diego from June 3-6, 2024. The conference, the largest in the biotechnology sector, is projected to draw over 18,000 attendees globally. Representing Aptevo are Dr. Michelle N. Nelson, Director of Immunobiology, and SoYoung Kwon, SVP, General Counsel, and Head of Business Development. Aptevo specializes in immuno-oncology therapeutics using its proprietary ADAPTIR™ and ADAPTIR-FLEX™ platforms.

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Aptevo Therapeutics (NASDAQ: APVO) announced its participation in The Protein & Antibody Engineering Summit (PEGS) in Boston, MA, where they will present their strategies for designing bispecific drug candidates. Dr. Peter Pavlik, Senior Director of Protein Engineering, will lead the session, focusing on early functional screening and multiple screening formats to predict outcomes. The company has developed a portfolio of candidates, including clinical-stage APVO436 and ALG.APV-527 and preclinical APVO603, APVO711, and APVO442. Recent clinical updates include a breast cancer patient in the ALG.APV-527 trial showing stable disease for over eleven months and plans to start a dose optimization trial for APVO436 in AML patients in Q2 2024.

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FAQ

What is the current stock price of Aptevo Therapeutics (APVO)?

The current stock price of Aptevo Therapeutics (APVO) is $4.71 as of December 23, 2024.

What is the market cap of Aptevo Therapeutics (APVO)?

The market cap of Aptevo Therapeutics (APVO) is approximately 2.2M.

What is Aptevo Therapeutics Inc.?

Aptevo Therapeutics Inc. is a clinical-stage biotechnology company focused on developing novel immuno-oncology therapies for cancer treatment.

What technologies does Aptevo Therapeutics use?

Aptevo Therapeutics uses proprietary ADAPTIR™ and ADAPTIR-FLEX™ platform technologies to develop its immunotherapeutic candidates.

What are the key clinical candidates of Aptevo Therapeutics?

The key clinical candidates include APVO436 for acute myeloid leukemia (AML), ALG.APV-527 for multiple solid tumors, and APVO603.

Where is Aptevo Therapeutics headquartered?

Aptevo Therapeutics is headquartered in Seattle, Washington.

What recent financial measures has Aptevo taken?

Recently, Aptevo announced a reverse stock split to regain NASDAQ compliance and reduce the number of outstanding shares.

What is ADAPTIR™ technology?

ADAPTIR™ technology is a versatile platform designed to create bispecific and multi-specific antibodies that enhance the immune system's ability to target cancer cells.

What recent achievements has APVO436 made?

APVO436 has shown a 91% clinical benefit rate in combination with venetoclax and azacitidine for treating AML and is moving into a Phase 1b/2 dose optimization study.

What is ALG.APV-527?

ALG.APV-527 is a clinical candidate being evaluated for multiple solid tumors, currently in a Phase 1 dose escalation trial.

How is Aptevo's financial health regarding R&D expenses?

Aptevo has reported a decrease in research and development expenses, primarily due to transitioning between clinical study phases.

What is Aptevo's approach to innovation?

Aptevo fosters an environment of innovation and collaboration, attracting leading experts from pioneering biotech firms and focusing on groundbreaking research in cancer treatment.

Aptevo Therapeutics Inc

Nasdaq:APVO

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APVO Stock Data

2.24M
500.19k
0.03%
11.36%
3.97%
Biotechnology
Pharmaceutical Preparations
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