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Aptose Biosciences, Inc. (NASDAQ: APTO, TSX: APS) is a clinical-stage biotechnology company dedicated to developing precision medicines for the treatment of life-threatening cancers. This science-driven organization is focused on advancing first-in-class agents targeting acute myeloid leukemia (AML), high-risk myelodysplastic syndromes (MDS), and other hematologic malignancies. Based on a deep understanding of the genetic and epigenetic profiles of specific cancers and patient demographics, Aptose is building a robust pipeline of novel oncology therapies aimed at dysregulated processes and signaling pathways.
One of Aptose's pioneering agents, tuspetinib (TUS), is a highly potent, first-in-class pan-FLT3/BTK inhibitor. Developed as a small molecule therapeutic, tuspetinib targets various key kinases such as SYK, FLT3, JAK1/2, and mutant forms of KIT, RSK2, and TAK1-TAB1. This mechanism of action not only combats the proliferation of AML cells but also minimizes the typical cytotoxic side effects associated with conventional cancer treatments, thus enhancing the quality of life for patients.
Tuspetinib has shown significant promise in ongoing clinical trials. In the APTIVATE Phase 1/2 study, tuspetinib, both as a monotherapy and in combination with venetoclax (VEN), has demonstrated favorable safety profiles and robust efficacy in relapsed/refractory AML patients. This includes patients with various genetic mutations and those who have failed prior therapies. Notably, tuspetinib has demonstrated a 48% overall response rate when used in combination with venetoclax, making it a potential candidate for accelerated approval in difficult-to-treat VEN-resistant AML cases.
Aptose is also developing luxeptinib (CG-806), an oral, dual lymphoid and myeloid kinase inhibitor currently in Phase 1 a/b development. Luxeptinib targets relapsed or refractory hematologic malignancies and is being positioned for future clinical trials using its new generation 3 (G3) formulation, which has shown improved pharmacokinetics and tolerability.
Recently, Aptose has entered strategic financial transactions, including a public offering and private placement, to support the further development of tuspetinib and general corporate activities. With strong clinical data and robust financial backing, Aptose continues to make strides in the oncology field, aiming to bring life-saving treatments to patients in need.
Aptose Biosciences Inc. (Nasdaq: APTO) is set to release its financial results for Q1 2023 on May 8, 2023, after market close, alongside a corporate update. The company is focused on developing innovative oral targeted therapies for hematologic malignancies. Key products under development include tuspetinib, a myeloid kinase inhibitor in Phase 1/2 trials for acute myeloid leukemia, and luxeptinib, a dual kinase inhibitor in Phase 1a/b trials. A dedicated conference call and webcast will occur at 5:00 PM ET on the same day, offering insights into the company's performance and future directions. Analysts can pre-register for a Q&A session to engage further.
Aptose Biosciences Inc. (NASDAQ: APTO, TSX: APS), a clinical-stage precision oncology company, announced that Dr. William G. Rice, Chairman and CEO, will participate in a panel at Canaccord Genuity’s 2023 Horizons in Oncology Virtual Conference on April 20, 2023. The panel discussion, titled New & Better Approaches for Oncology Targets, will take place from 2:00 PM to 2:45 PM and will be moderated by John Newman, Ph.D., a Biotechnology Analyst. In addition, the Aptose management team will host one-on-one meetings during the event. Aptose is focused on developing oral kinase inhibitors targeting hematologic malignancies with two candidates in clinical stages: tuspetinib and luxeptinib. For more information, visit www.aptose.com.
Aptose Biosciences Inc. (Nasdaq: APTO; TSX: APS) announced participation in Cantor Fitzgerald’s The Future of Oncology Virtual Symposium from April 3-5, 2023. The event will feature fireside chats and panel discussions, including one titled “Targeted Therapies in AML”, led by Aptose's Chief Medical Officer, Rafael Bejar, M.D., Ph.D., on April 5 from 12:00 to 12:45 PM Eastern Time. Aptose specializes in developing oral kinase inhibitors for hematologic malignancies, with key candidates being tuspetinib and luxeptinib, aimed at addressing unmet clinical needs in oncology.
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