Apollomics Reports Full Year 2024 Financial Results and Highlights Clinical Updates and Business Progress
Apollomics (NASDAQ: APLM) reported its full year 2024 financial results and clinical updates. The company secured a strategic collaboration with LaunXP for vebreltinib development, bringing in a $10 million upfront payment. Key clinical highlights include a 43% objective response rate in non-CNS MET fusion solid tumors and 30% response rate in high MET gene copy number patients.
Financial results show cash position of $9.8 million as of December 31, 2024, compared to $37.8 million in 2023. R&D expenses decreased to $24.6 million from $34.2 million, while administrative expenses reduced to $17.8 million from $20.6 million. Net loss for 2024 was $(53.9) million or $(52.80) per share, improved from $(172.6) million loss in 2023.
The company implemented strategic expense reductions and expects current cash, combined with the LaunXP payment, to fund operations into Q1 2026.
Apollomics (NASDAQ: APLM) ha riportato i risultati finanziari e gli aggiornamenti clinici per l'intero anno 2024. L'azienda ha siglato una collaborazione strategica con LaunXP per lo sviluppo di vebreltinib, ricevendo un pagamento iniziale di 10 milioni di dollari. I principali risultati clinici includono un tasso di risposta obiettivo del 43% nei tumori solidi con fusione MET non CNS e un tasso di risposta del 30% nei pazienti con elevato numero di copie del gene MET.
I risultati finanziari mostrano una posizione di liquidità di 9,8 milioni di dollari al 31 dicembre 2024, rispetto ai 37,8 milioni del 2023. Le spese per R&S sono diminuite a 24,6 milioni di dollari rispetto ai 34,2 milioni, mentre le spese amministrative si sono ridotte a 17,8 milioni di dollari dai 20,6 milioni. La perdita netta per il 2024 è stata di $(53,9) milioni o $(52,80) per azione, in miglioramento rispetto alla perdita di $(172,6) milioni nel 2023.
L'azienda ha attuato riduzioni strategiche delle spese e si aspetta che la liquidità attuale, insieme al pagamento di LaunXP, finanzi le operazioni fino al primo trimestre del 2026.
Apollomics (NASDAQ: APLM) informó sus resultados financieros y actualizaciones clínicas para todo el año 2024. La compañía aseguró una colaboración estratégica con LaunXP para el desarrollo de vebreltinib, recibiendo un pago inicial de 10 millones de dólares. Los aspectos destacados clínicos incluyen una tasa de respuesta objetiva del 43% en tumores sólidos con fusión MET no CNS y una tasa de respuesta del 30% en pacientes con un alto número de copias del gen MET.
Los resultados financieros muestran una posición de efectivo de 9,8 millones de dólares al 31 de diciembre de 2024, en comparación con 37,8 millones en 2023. Los gastos de I+D disminuyeron a 24,6 millones de dólares desde 34,2 millones, mientras que los gastos administrativos se redujeron a 17,8 millones de dólares desde 20,6 millones. La pérdida neta para 2024 fue de $(53,9) millones o $(52,80) por acción, mejorando desde una pérdida de $(172,6) millones en 2023.
La compañía implementó reducciones estratégicas de gastos y espera que el efectivo actual, combinado con el pago de LaunXP, financie las operaciones hasta el primer trimestre de 2026.
Apollomics (NASDAQ: APLM)는 2024년 전체 재무 결과 및 임상 업데이트를 보고했습니다. 이 회사는 vebreltinib 개발을 위해 LaunXP와 전략적 협력을 확보하였으며, 1천만 달러의 선불 지급을 받았습니다. 주요 임상 하이라이트에는 비 CNS MET 융합 고형 종양에서 43%의 객관적 반응률과 높은 MET 유전자 복제 수 환자에서 30%의 반응률이 포함됩니다.
재무 결과는 2024년 12월 31일 기준 980만 달러의 현금 보유액을 보여주며, 이는 2023년의 3,780만 달러에 비해 감소한 수치입니다. 연구개발 비용은 3,420만 달러에서 2,460만 달러로 줄어들었고, 관리 비용은 2,060만 달러에서 1,780만 달러로 감소했습니다. 2024년 순손실은 $(5390)만 달러 또는 주당 $(52.80)로, 2023년의 $(1억7260)만 달러 손실에서 개선되었습니다.
회사는 전략적 비용 절감을 시행하였으며, 현재의 현금과 LaunXP의 지급금이 2026년 1분기까지 운영을 지원할 것으로 예상하고 있습니다.
Apollomics (NASDAQ: APLM) a publié ses résultats financiers et ses mises à jour cliniques pour l'année entière 2024. L'entreprise a sécurisé une collaboration stratégique avec LaunXP pour le développement de vebreltinib, recevant un paiement initial de 10 millions de dollars. Les points forts cliniques incluent un taux de réponse objectif de 43 % dans les tumeurs solides à fusion MET non CNS et un taux de réponse de 30 % chez les patients avec un nombre élevé de copies du gène MET.
Les résultats financiers montrent une position de trésorerie de 9,8 millions de dollars au 31 décembre 2024, contre 37,8 millions en 2023. Les dépenses de R&D ont diminué à 24,6 millions de dollars contre 34,2 millions, tandis que les dépenses administratives ont été réduites à 17,8 millions de dollars contre 20,6 millions. La perte nette pour 2024 s'élevait à $(53,9) millions ou $(52,80) par action, s'améliorant par rapport à une perte de $(172,6) millions en 2023.
L'entreprise a mis en œuvre des réductions stratégiques des dépenses et s'attend à ce que la trésorerie actuelle, combinée au paiement de LaunXP, finance ses opérations jusqu'au premier trimestre 2026.
Apollomics (NASDAQ: APLM) hat seine Finanzzahlen und klinischen Updates für das gesamte Jahr 2024 veröffentlicht. Das Unternehmen sicherte sich eine strategische Zusammenarbeit mit LaunXP zur Entwicklung von vebreltinib und erhielt eine Vorauszahlung von 10 Millionen Dollar. Zu den wichtigsten klinischen Höhepunkten gehören eine objektive Ansprechrate von 43% bei nicht-CNS MET-Fusionssolidtumoren und eine Ansprechrate von 30% bei Patienten mit hoher MET-Genenkopienzahl.
Die finanziellen Ergebnisse zeigen eine Liquiditätsposition von 9,8 Millionen Dollar zum 31. Dezember 2024, verglichen mit 37,8 Millionen Dollar im Jahr 2023. Die F&E-Ausgaben sanken auf 24,6 Millionen Dollar von 34,2 Millionen Dollar, während die Verwaltungsausgaben auf 17,8 Millionen Dollar von 20,6 Millionen Dollar reduziert wurden. Der Nettoverlust für 2024 betrug $(53,9) Millionen oder $(52,80) pro Aktie, eine Verbesserung gegenüber einem Verlust von $(172,6) Millionen im Jahr 2023.
Das Unternehmen hat strategische Kostensenkungen umgesetzt und erwartet, dass das aktuelle Bargeld, zusammen mit der Zahlung von LaunXP, die Betriebe bis zum ersten Quartal 2026 finanzieren wird.
- Strategic collaboration with LaunXP bringing $10 million upfront payment plus potential $50 million in milestones
- Strong 43% objective response rate in non-CNS MET fusion solid tumors
- Reduced net loss by 69% year-over-year
- Extended cash runway into Q1 2026 through cost reductions and partnership
- Cash position declined 74% to $9.8 million from $37.8 million year-over-year
- $53.9 million net loss in 2024
- $13.0 million impairment losses of intangible assets
- Terminated collaborations with Glycomimetics and TYG Oncology
Insights
Apollomics' strategic shift and financial results reveal a company making tough choices to extend runway. The
The clinical data shows promise with a
Financially, cash decreased precipitously to
The strategic narrowing to focus on vebreltinib in MET amplification NSCLC makes sense given resource constraints but increases concentration risk. Testing method standardization remains a significant hurdle that could limit both trial enrollment and commercial opportunity.
Apollomics presents a classic biotech case study of promising assets versus financial constraints. The LaunXP collaboration validates vebreltinib's potential value but the
The pipeline prioritization represents a necessary but risky concentration strategy. By focusing on vebreltinib for MET amplification NSCLC and terminating other collaborations, management is making a calculated bet on their lead asset. The diagnostic challenges in MET amplification—requiring standardized FISH testing with GCN ≥6—create a bottleneck for both trial enrollment and eventual commercialization.
The clinical data shows vebreltinib has activity across multiple tumor types with MET dysregulation, with particularly strong signals in non-CNS MET fusion tumors (
With market capitalization of approximately
- Strategic collaboration with LaunXP for the development of vebreltinib in combination with an EGFR inhibitor (“EGFRi”) to bring in
$10 million upfront payment and expand dataset to combination therapy - New interim data for the vebreltinib development program, including in non-CNS MET fusion tumors and non-small cell lung cancer (NSCLC) with MET amplification
$9.8 million in cash and cash equivalents as of December 31, 2024, in conjunction with LaunXP upfront payment, pipeline focus and expense reductions expected to provide cash runway into the first quarter of 2026
FOSTER CITY, Calif., April 03, 2025 (GLOBE NEWSWIRE) -- Apollomics Inc. (Nasdaq: APLM) (“Apollomics”), a late-stage clinical biopharmaceutical company developing multiple oncology drug candidates to address difficult-to-treat and treatment-resistant cancers, today announced financial results for the fiscal year ended December 31, 2024, and highlighted clinical updates and business progress.
“Our new partnership with LaunXP provides an opportunity to expand the clinical dataset for vebreltinib to include combination therapy with an EGFRi. This class is currently the frontline treatment for many patients with NSCLC, and combination therapy with vebreltinib may delay the emergence of resistance to this foundational therapeutic class,” said Dr. Guo-Liang Yu, CEO of Apollomics. “We will continue to seek collaborative opportunities to maximize the global opportunity for vebreltinib, both as a single agent and in combination approaches for the treatment of cancers.”
“In addition, preliminary results we announced in 2024 for various SPARTA cohorts highlight the opportunity for vebreltinib in the treatment of various tumors with c-Met dysregulation. This includes new interim data for the treatment of NSCLC with MET Amplification, new interim data for the treatment of non-CNS solid tumors with MET fusions, and an incremental update for NSCLC with Met Exon 14 skipping,” continued Dr. Yu.
Pipeline Update
- Vebreltinib (APL-101) – a highly specific c-Met inhibitor for the treatment of NSCLC and other solid tumors with MET dysregulation
- In August 2024, Apollomics announced interim data from its SPARTA Phase 2 clinical trial for 14 patients with non-CNS MET fusion solid tumors, where a
43% objective response rate (ORR) was achieved by RECIST v1.1 criteria. This includes six confirmed responses out of 14 evaluable patients: one complete response in second-line metastatic NSCLC and five partial responses (three patients with NSCLC, one patient with pancreatic cancer, and one patient with intrahepatic bile duct cancer). Alongside the Avistone data for vebreltinib in the treatment of glioblastoma with PTPRZ1 MET fusions, vebreltinib has now demonstrated activity in a variety of tumors with MET fusions. - Also in August 2024, Apollomics announced an interim analysis of 38 patients in the SPARTA MET amplification cohorts. Testing method discordance (determination of MET amplification by status sequencing of blood, sequencing of tumor biopsies, and/or fluorescent in-situ hybridization (FISH), as well as the use of local versus central laboratory testing), has complicated the analysis. Of the patients with the highest MET gene copy number (GCN) as determined by central sequencing, an ORR of
30% (3/10) was achieved, as compared to13% (5/38) in the overall dataset. Going forward, Apollomics will only enroll NSCLC patients with MET amplification confirmed by central FISH testing. Apollomics believes that MET GCN ≥10 by sequencing may be comparable to GCN ≥6 by central FISH testing, which is the criteria to define MET amplification used in previous clinical trials of other MET inhibitors. However, challenges associated with this diagnostic test limit the enrollment rate as well as the commercial opportunity for this patient population, and Apollomics is evaluating alternatives for development of vebreltinib in this indication. - In March 2024, Apollomics announced an updated efficacy analysis by GCN subgroup in the treatment of NSCLC patients with Met Exon 14 skipping mutations. The data show vebreltinib activity similar to previously announced. In the absence of overlapping c-Met amplification (GCN<4), in a pooled analysis of patients from SPARTA and KUNPENG an ORR of
67% was achieved (n=86).
- In August 2024, Apollomics announced interim data from its SPARTA Phase 2 clinical trial for 14 patients with non-CNS MET fusion solid tumors, where a
- Other pipeline programs
- APL-122: Apollomics licensed rights to this ErbB1/2/4 inhibitor from Edison Oncology Holding Corporation (“Edison”) in 2021. Edison has completed six dose escalation cohorts in the Phase 1 trial, including two within the expected therapeutic window, and expects to provide a data update in 2025.
- APL-102: APL-102 is an oral, small molecule MTKi targeting the VEGFR and MAPK pathways via B-RAF and C-RAF, and colony stimulating factor 1 receptor. The Phase 1 clinical trial in China has been closed and Apollomics expects to provide topline results in 2025.
Business Highlights
- Collaboration with LaunXP: In March 2025, Apollomics and LaunXP announced a collaboration agreement for the exclusive development and commercialization rights for vebreltinib in combination with an EGFRi in Asia (excluding mainland China, Hong Kong and Macau) for the treatment of NSCLC. Under the terms of the agreement, Apollomics is to receive upfront payments totaling
$10 million within 60 days of the date of the agreement. Apollomics is also eligible for regulatory and other pre-commercial milestone payments of up to$50 million , and royalties on net product sales. - Focus on vebreltinib MET Amplification: In July 2024, Apollomics announced a strategic prioritization for the treatment of NSCLC patients with MET Amplification. By focusing on the patient population with the greatest unmet medical need that can be addressed by c-Met inhibition with vebreltinib, Apollomics intends to apply its resources in the most efficient manner to generate additional clinical data for support of regulatory submissions.
- Raised
$5.8 million : In May 2024, Apollomics raised$5.8 million in a private placement in public equity (PIPE) financing, before transaction expenses. - Expense reductions: In line with the strategic focus on vebreltinib MET Amplification, Apollomics has terminated collaborations with Glycomimetics and TYG Oncology. Along with the vebreltinib focus and previously announced headcount reductions, Apollomics expects current cash and equivalents, and the LaunXP upfront payment, will be sufficient to fund planned operations into the first quarter of 2026.
Full Year 2024 Financial Results
- Cash, cash equivalents, bank deposits and money market funds as of December 31, 2024 were
$9.8 million , compared to$37.8 million as of December 31, 2023. - Research and development expenses were
$24.6 million , including share-based compensation of$4.3 million , for 2024, compared to$34.2 million , including share-based compensation of$5.9 million , for 2023. - Administrative expenses were
$17.8 million , including share-based compensation of$6.7 million , for 2024, compared to$20.6 million , including share-based compensation of$6.8 million , for 2023. - Net loss for 2024 was
$(53.9) million , or$(52.80) per basic and diluted share, compared with a net loss of$(172.6) million , or$(231.99) per basic and diluted share, for 2023. Net loss for 2024 includes impairment losses of intangible assets of$13.0 million . Net loss for 2023 includes a non-cash expense for change in fair value of convertible preferred shares of$76.4 million and expenses related to capital markets activities of$45.5 million .
About Apollomics Inc.
Apollomics Inc. is an innovative clinical-stage biopharmaceutical company focused on the discovery and development of oncology therapies with the potential to be combined with other treatment options to harness the immune system and target specific molecular pathways to inhibit cancer. Apollomics’ lead program is vebreltinib (APL-101), a potent, selective c-Met inhibitor for the treatment of non-small cell lung cancer and other advanced tumors with c-Met alterations, which is currently in a Phase 2 multicohort clinical trial in the United States and over 10 other countries. For more information, please visit www.apollomicsinc.com.
Cautionary Statement Regarding Forward-Looking Statements
This press release includes statements that constitute “forward-looking statements” within the meaning of the federal securities laws, including Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). All statements, other than statements of present or historical fact included in this press release, regarding Apollomics’ strategy, prospects, plans, objectives including with respect to the expected payments under its agreement with LaunXP, anticipated outcomes from the development and commercialization of vebreltinib with an EGFR inhibitor and with respect to updates for other programs in the pipeline, are forward-looking statements. When used in this press release, the words “could,” “should,” “will,” “may,” “believe,” “anticipate,” “intend,” “estimate,” “expect,” “seek,” “project,” the negative of such terms and other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain such identifying words. These forward-looking statements are based on management’s current expectations and assumptions about future events and are based on currently available information as to the outcome and timing of future events. Apollomics cautions you that these forward-looking statements are subject to numerous risks and uncertainties, most of which are difficult to predict and many of which are beyond the control of Apollomics. In addition, Apollomics cautions you that the forward-looking statements contained in this press release are subject to unknown risks, uncertainties and other factors, including: (i) the impact of any current or new government regulations in the United States and China affecting Apollomics’ operations and the continued listing of Apollomics’ securities; (ii) the inability to achieve successful clinical results or to obtain licensing of third-party intellectual property rights for future discovery and development of Apollomics’ oncology projects; (iii) the failure to commercialize product candidates and achieve market acceptance of such product candidates; (iv) the failure to protect Apollomics’ intellectual property; (v) breaches in data security; (vi) the risk that Apollomics may not be able to develop and maintain effective internal controls; (vii) unfavorable changes to the regulatory environment; and (viii) those risks and uncertainties discussed in the Annual Report on Form 20-F for the year ended December 31, 2024, filed by Apollomics Inc. with the U.S. Securities and Exchange Commission (“SEC”) under the heading “Risk Factors” and the other documents filed, or to be filed, by Apollomics with the SEC. Additional information concerning these and other factors that may impact the operations and projections discussed herein can be found in the reports that Apollomics has filed and will file from time to time with the SEC. These SEC filings are available publicly on the SEC’s website at www.sec.gov. Forward-looking statements speak only as of the date made by Apollomics. Apollomics undertakes no obligation to update publicly any of its forward-looking statements to reflect actual results, new information or future events, changes in assumptions or changes in other factors affecting forward-looking statements, except to the extent required by applicable law.
Investor Contact:
Eric Ribner
LifeSci Advisors, LLC
(646) 751-4363
eric@lifesciadvisors.com
| APOLLOMICS INC. CONSOLIDATED STATEMENTS OF FINANCIAL POSITION (UNAUDITED) (All amounts in thousands of $) | ||||||||
| As of December 31, | ||||||||
| 2023 | 2024 | |||||||
| $ | $ | |||||||
| Non-current assets | ||||||||
| Plant and equipment, net | $ | 161 | $ | 92 | ||||
| Right-of-use assets | 425 | 927 | ||||||
| Intangible assets, net | 14,757 | 1,737 | ||||||
| Rental deposits | 119 | 75 | ||||||
| Total non-current assets | 15,462 | 2,831 | ||||||
| Current assets | ||||||||
| Deposits, prepayments and deferred expenses | 2,108 | 501 | ||||||
| Financial assets at FVTPL | 5,761 | — | ||||||
| Cash and cash equivalents | 32,056 | 9,766 | ||||||
| Total current assets | 39,925 | 10,267 | ||||||
| Total assets | 55,387 | 13,098 | ||||||
| Current liabilities | ||||||||
| Other payables and accruals | 9,162 | 7,166 | ||||||
| Short term bank loans | 4,236 | — | ||||||
| Lease liabilities, current portion | 158 | 233 | ||||||
| Total current liabilities | 13,556 | 7,399 | ||||||
| Net current assets | 26,369 | 2,868 | ||||||
| Total assets less current liabilities | 41,831 | 5,699 | ||||||
| Non-current liabilities | ||||||||
| Lease liabilities, noncurrent portion | 267 | 733 | ||||||
| Warrant liabilities at FVTPL | 330 | 102 | ||||||
| Total non-current liabilities | 597 | 835 | ||||||
| Net assets | $ | 41,234 | $ | 4,864 | ||||
| Equity | ||||||||
| Share capital | 9 | 11 | ||||||
| Share premium | 661,474 | 666,528 | ||||||
| Reserves | 26,716 | 39,148 | ||||||
| Accumulated losses | (646,965 | ) | (700,823 | ) | ||||
| Total equity | $ | 41,234 | $ | 4,864 | ||||
| APOLLOMICS INC. CONSOLIDATED STATEMENTS OF LOSS AND OTHER COMPREHENSIVE LOSS (UNAUDITED) (All amounts in thousands of $, except for per share data) | ||||||||||||
| Years ended December 31, | ||||||||||||
| 2022 | 2023 | 2024 | ||||||||||
| Other income | $ | 1,447 | $ | 1,217 | $ | 1,489 | ||||||
| Foreign exchange gains (losses) | (829 | ) | 1,191 | 145 | ||||||||
| Fair value change of financial assets at fair value through profit and loss (“FVTPL”) | 323 | 821 | 198 | |||||||||
| Fair value change of financial liabilities at FVTPL | — | 1,597 | 222 | |||||||||
| Fair value change of convertible preferred shares | (189,646 | ) | (76,430 | ) | — | |||||||
| Research and development expenses | (35,457 | ) | (34,193 | ) | (24,566 | ) | ||||||
| Administrative expenses | (9,947 | ) | (20,641 | ) | (17,768 | ) | ||||||
| Impairment of intangible assets | — | — | (13,000 | ) | ||||||||
| Finance costs | (93 | ) | (150 | ) | (179 | ) | ||||||
| Other expense | (6,608 | ) | (46,003 | ) | (140 | ) | ||||||
| Loss before taxation | (240,810 | ) | (172,591 | ) | (53,599 | ) | ||||||
| Income tax expenses | (1 | ) | (10 | ) | (259 | ) | ||||||
| Loss and total comprehensive loss for the period, net of taxation, attributable to owners of the Company | (240,811 | ) | (172,601 | ) | (53,858 | ) | ||||||
| Loss per share – Basic and diluted | $ | (844.95 | ) | $ | (231.99 | ) | $ | (52.80 | ) | |||
FAQ
What are the key results from Apollomics' (APLM) vebreltinib SPARTA trial in 2024?
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