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Anixa Biosciences Enters Letter of Intent with VERDI Solutions to Develop Artificial Intelligence-Guided Personalized and Off-the-Shelf Cancer Vaccines

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Anixa Biosciences (NASDAQ: ANIX) has entered into a letter of intent with VERDI Solutions to develop AI-guided personalized and off-the-shelf peptide vaccines for cancer patients. VERDI's cloud-computing platform enables rapid development of personalized vaccines tailored to individual cancer patients.

The agreement grants Anixa a six-month exclusive right to negotiate the research, development, and commercialization of VERDI's cancer vaccines. VERDI has already demonstrated success in three patients with bone metastases under Europe's Individueller Heilversuch program, where patients experienced clinical benefits including significant pain relief and improved quality of life.

VERDI's proprietary algorithm predicts vaccine efficacy in recognizing and eliminating tumor cells at an individual level. While VERDI continues developing personalized vaccines in Europe, both companies plan to initiate clinical trials in the United States.

Anixa Biosciences (NASDAQ: ANIX) ha stipulato una lettera di intenti con VERDI Solutions per sviluppare vaccini peptidici personalizzati e pronti all'uso guidati dall'IA per pazienti oncologici. La piattaforma di cloud computing di VERDI consente lo sviluppo rapido di vaccini personalizzati su misura per i singoli pazienti affetti da cancro.

L'accordo concede ad Anixa un diritto esclusivo di sei mesi per negoziare la ricerca, lo sviluppo e la commercializzazione dei vaccini contro il cancro di VERDI. VERDI ha già dimostrato il successo in tre pazienti con metastasi ossee nel programma Individueller Heilversuch in Europa, dove i pazienti hanno sperimentato benefici clinici tra cui un significativo sollievo dal dolore e un miglioramento della qualità della vita.

L'algoritmo proprietario di VERDI prevede l'efficacia del vaccino nel riconoscere ed eliminare le cellule tumorali a livello individuale. Mentre VERDI continua a sviluppare vaccini personalizzati in Europa, entrambe le aziende pianificano di avviare studi clinici negli Stati Uniti.

Anixa Biosciences (NASDAQ: ANIX) ha firmado una carta de intenciones con VERDI Solutions para desarrollar vacunas peptídicas personalizadas y listas para usar guiadas por IA para pacientes con cáncer. La plataforma de computación en la nube de VERDI permite el desarrollo rápido de vacunas personalizadas adaptadas a pacientes oncológicos individuales.

El acuerdo otorga a Anixa un derecho exclusivo de seis meses para negociar la investigación, el desarrollo y la comercialización de las vacunas contra el cáncer de VERDI. VERDI ya ha demostrado éxito en tres pacientes con metástasis óseas bajo el programa Individueller Heilversuch en Europa, donde los pacientes experimentaron beneficios clínicos, incluyendo un alivio significativo del dolor y una mejora en la calidad de vida.

El algoritmo propietario de VERDI predice la eficacia de la vacuna en el reconocimiento y eliminación de células tumorales a nivel individual. Mientras VERDI continúa desarrollando vacunas personalizadas en Europa, ambas compañías planean iniciar ensayos clínicos en los Estados Unidos.

Anixa Biosciences (NASDAQ: ANIX)VERDI Solutions와 암 환자를 위한 AI 기반의 개인 맞춤형 및 기성 펩타이드 백신 개발을 위한 의향서에 서명했습니다. VERDI의 클라우드 컴퓨팅 플랫폼은 개별 암 환자에 맞춘 개인 맞춤형 백신의 신속한 개발을 가능하게 합니다.

이번 계약은 Anixa에게 VERDI의 암 백신 연구, 개발 및 상용화에 대한 6개월의 독점 협상 권한을 부여합니다. VERDI는 유럽의 Individueller Heilversuch 프로그램 하에서 뼈 전이 환자 3명에서 성공을 입증했으며, 환자들은 상당한 통증 완화와 삶의 질 향상 등 임상적 이점을 경험했습니다.

VERDI의 독점 알고리즘은 개별 수준에서 종양 세포를 인식하고 제거하는 백신의 효능을 예측합니다. VERDI가 유럽에서 개인 맞춤형 백신 개발을 계속하는 동안, 양사는 미국에서 임상 시험을 시작할 계획입니다.

Anixa Biosciences (NASDAQ: ANIX) a signé une lettre d'intention avec VERDI Solutions pour développer des vaccins peptidiques personnalisés et prêts à l'emploi guidés par l'IA pour les patients atteints de cancer. La plateforme de cloud computing de VERDI permet le développement rapide de vaccins personnalisés adaptés à des patients cancéreux individuels.

Le contrat accorde à Anixa un droit exclusif de six mois pour négocier la recherche, le développement et la commercialisation des vaccins contre le cancer de VERDI. VERDI a déjà démontré son succès chez trois patients atteints de métastases osseuses dans le cadre du programme Individueller Heilversuch en Europe, où les patients ont bénéficié d'avantages cliniques, notamment un soulagement significatif de la douleur et une amélioration de la qualité de vie.

L'algorithme propriétaire de VERDI prédit l'efficacité du vaccin dans la reconnaissance et l'élimination des cellules tumorales à un niveau individuel. Alors que VERDI continue de développer des vaccins personnalisés en Europe, les deux entreprises prévoient de lancer des essais cliniques aux États-Unis.

Anixa Biosciences (NASDAQ: ANIX) hat eine Absichtserklärung mit VERDI Solutions unterzeichnet, um KI-gesteuerte personalisierte und sofort verfügbare Peptidimpfstoffe für Krebspatienten zu entwickeln. Die Cloud-Computing-Plattform von VERDI ermöglicht die schnelle Entwicklung personalisierter Impfstoffe, die auf einzelne Krebspatienten zugeschnitten sind.

Die Vereinbarung gewährt Anixa ein sechsmonatiges exklusives Recht zur Verhandlung über die Forschung, Entwicklung und Vermarktung der Krebsimpfstoffe von VERDI. VERDI hat bereits bei drei Patienten mit Knochenmetastasen im Rahmen des Individueller Heilversuch-Programms in Europa Erfolge erzielt, wobei die Patienten klinische Vorteile wie signifikante Schmerzlinderung und verbesserte Lebensqualität erfahren haben.

Der proprietäre Algorithmus von VERDI sagt die Wirksamkeit des Impfstoffs bei der Erkennung und Eliminierung von Tumorzellen auf individueller Ebene voraus. Während VERDI weiterhin personalisierte Impfstoffe in Europa entwickelt, planen beide Unternehmen, klinische Studien in den Vereinigten Staaten zu beginnen.

Positive
  • Initial clinical benefits demonstrated in three patients with bone metastases
  • Six-month exclusive negotiation rights secured for research and commercialization
  • AI and cloud computing platform enables rapid personalized vaccine development
  • Existing regulatory pathway in Europe allows for real-world treatment data collection
Negative
  • Further clinical validation still required to prove efficacy
  • Only preliminary data from three patients available
  • Final agreement terms not yet established - only letter of intent signed

Insights

This letter of intent between Anixa Biosciences and VERDI Solutions marks a strategic expansion into the personalized cancer vaccine space. The deal provides Anixa a six-month exclusive negotiation window for VERDI's AI-driven platform, which uses cloud computing to develop tailored peptide vaccines based on individual tumor sequence data.

The partnership is bolstered by preliminary evidence from three cancer patients with bone metastases who received VERDI's personalized vaccines under Europe's Individueller Heilversuch provision. These patients reportedly experienced clinical benefits including significant pain relief from bone metastases and improved quality of life - though the article explicitly acknowledges that "further clinical validation is needed."

For a small-cap biotech like Anixa ($100M market cap), this deal aligns with their stated "capital-efficient business model" by adding pipeline optionality without immediate substantial financial commitments. The companies plan to initiate formal clinical trials in the United States, which would generate more robust efficacy data than the current patient experience.

While still early-stage, this partnership potentially positions Anixa in both personalized and off-the-shelf cancer vaccines, with the latter paired with companion diagnostics to identify likely responders. The AI-driven approach to cancer vaccine development represents an innovative technology addition to Anixa's oncology portfolio.

VERDI's personalized vaccines have demonstrated safety and efficacy in cancer patients

SAN JOSE, Calif., March 25, 2025 /PRNewswire/ -- Anixa Biosciences, Inc. ("Anixa" or the "Company") (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer, today announced that it has entered into a letter of intent with VERDI Solutions, GmbH to develop personalized and off-the-shelf peptide vaccines for cancer patients.

VERDI Solutions, headquartered in Vienna, Austria, is pioneering personalized cancer treatment by integrating artificial intelligence (AI) and advanced cloud computing to accelerate the development and implementation of personalized cancer vaccines. By combining computerized vaccine design with real-world data collection and clinical trials, VERDI is making personalized cancer vaccines accessible to more patients worldwide. At the core of VERDI's innovation is its cloud-computing platform, which enables the rapid development of personalized peptide vaccines tailored to individual cancer patients. Additionally, the company is developing off-the-shelf cancer vaccines, paired with companion diagnostics to identify likely responders and optimize treatment outcomes.

In some European countries, oncologists may administer personalized cancer vaccines under Individueller Heilversuch (Individual Healing Attempt), which allows physicians to prescribe individualized treatments for patients with life-threatening conditions who lack satisfactory therapeutic alternatives. Unlike clinical trials, where only a limited number of eligible patients can be enrolled, Heilversuch offers an innovative treatment option for any cancer patient, potentially providing valuable insights into the efficacy and safety of personalized vaccines in real-world settings. Moreover, Heilversuch aligns with the increasing recognition by global regulatory agencies of real-world evidence (RWE) as a critical component of drug development. VERDI is pioneering a data-driven approach to accelerating regulatory validation and commercialization of personalized cancer vaccines.

VERDI has successfully developed personalized vaccines using sequence data from the primary tumors for three patients with bone metastases, which were administered by their oncologists under Heilversuch. These patients experienced clinical benefits, including significant pain relief caused by bone metastases and improved quality of life. While these outcomes highlight the potential of VERDI's platform to scale personalized cancer care, further clinical validation is needed.

Under the letter of intent, VERDI has granted Anixa a six-month exclusive right to negotiate a transaction for the research, development, and commercialization of VERDI's cancer vaccines. While VERDI continues to develop personalized vaccines for individual treatment attempts in Europe, VERDI and Anixa plan to initiate clinical trials in the United States.

"We utilize advanced cloud computing to develop a set of personalized VERDI vaccines for each patient from their sequence data. Our proprietary algorithm predicts the efficacy of the vaccines to recognize and eliminate tumor cells in the individual patient. Our unique approach models the complex mechanisms of tumor-specific immune responses at an individual level, potentially enabling faster and more effective personalized vaccine development using state-of-the-art science compared to existing neoantigen-based cancer vaccines. Our initial results in three patients are highly encouraging, and we are eager to demonstrate broader clinical benefits in additional patients," stated Dr. Julianna Lisziewicz, Founder and CEO of VERDI.

Dr. Amit Kumar, Chairman and CEO of Anixa stated, "We are very pleased to be working with VERDI Solutions on this exciting technology that has already demonstrated benefit to terminally ill patients. The letter of intent with VERDI provides us with the optionality to collaborate on the further development of VERDI's technology, while preserving our ability to structure the relationship in a way that is mutually beneficial to both parties. Additionally, partnering with VERDI aligns with our strategy of implementing a capital-efficient business model for personalized cancer care."

About Anixa Biosciences, Inc.
Anixa is a clinical-stage biotechnology company focused on the treatment and prevention of cancer. Anixa's therapeutic portfolio consists of an ovarian cancer immunotherapy program being developed in collaboration with Moffitt Cancer Center, which uses a novel type of CAR-T, known as chimeric endocrine receptor-T cell (CER-T) technology. The Company's vaccine portfolio includes vaccines being developed in collaboration with Cleveland Clinic to treat and prevent breast cancer and ovarian cancer, as well as additional cancer vaccines to address many intractable cancers, including high incidence malignancies in lung, colon, and prostate. These vaccine technologies focus on immunizing against "retired" proteins that have been found to be expressed in certain forms of cancer. Anixa's unique business model of partnering with world-renowned research institutions on all stages of development allows the Company to continually examine emerging technologies in complementary fields for further development and commercialization. To learn more, visit www.anixa.com or follow Anixa on Twitter, LinkedIn, Facebook and YouTube.

Forward-Looking Statements
Statements that are not historical fact may be considered forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are not statements of historical facts, but rather reflect Anixa's current expectations concerning future events and results. We generally use the words "believes," "expects," "intends," "plans," "anticipates," "likely," "will" and similar expressions to identify forward-looking statements. Such forward-looking statements, including those concerning our expectations, involve risks, uncertainties and other factors, some of which are beyond our control, which may cause our actual results, performance or achievements, or industry results, to be materially different from any future results, performance, or achievements expressed or implied by such forward-looking statements. These risks, uncertainties and factors include, but are not limited to, those factors set forth in "Item 1A - Risk Factors" and other sections of our most recent Annual Report on Form 10-K as well as in our Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. We undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. You are cautioned not to unduly rely on such forward-looking statements when evaluating the information presented in this press release.

Contact:
Mike Catelani
President, COO & CFO
mcatelani@anixa.com
408-708-9808

Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/anixa-biosciences-enters-letter-of-intent-with-verdi-solutions-to-develop-artificial-intelligence-guided-personalized-and-off-the-shelf-cancer-vaccines-302409908.html

SOURCE Anixa Biosciences, Inc.

FAQ

What is the partnership between Anixa Biosciences (ANIX) and VERDI Solutions?

Anixa has secured a 6-month exclusive right to negotiate the research, development, and commercialization of VERDI's AI-guided cancer vaccines, both personalized and off-the-shelf versions.

What clinical results has VERDI Solutions shown for their cancer vaccines?

VERDI has treated three patients with bone metastases, who experienced clinical benefits including significant pain relief and improved quality of life.

How does VERDI's cancer vaccine technology work?

VERDI uses AI and cloud computing to develop personalized peptide vaccines based on individual patient tumor sequence data, with an algorithm predicting vaccine efficacy.

What are the next steps for Anixa (ANIX) and VERDI's cancer vaccine development?

While VERDI continues treatments in Europe, both companies plan to initiate clinical trials in the United States.

What is the significance of the Individueller Heilversuch program for VERDI's vaccine development?

This European program allows physicians to prescribe individualized treatments for life-threatening conditions, enabling VERDI to collect real-world evidence on their vaccines' efficacy.
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