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Altimmune, Inc. (Nasdaq: ALT) is a clinical-stage biopharmaceutical company dedicated to developing next-generation immunotherapeutics and vaccines addressing critical public health and biodefense needs. Leveraging the unique properties of its proprietary platform technologies, Altimmune is adept at swiftly designing product candidates targeting a range of diseases, including respiratory conditions, chronic infections, and cancer.
Altimmune's advanced Densigen™ T-cell platform technology is specifically designed to guide the immune system's response against complex disease targets by focusing on multiple antigens simultaneously. Another key platform, RespirVec™, uses needle-free intranasal delivery for faster and broader immunity against pathogens compared to traditional vaccines.
The company is also heavily involved in addressing obesity and liver diseases through its innovative peptide therapeutics. The lead product candidate, pemvidutide, is a GLP-1/glucagon dual receptor agonist under development for obesity and non-alcoholic steatohepatitis (NASH). Pemvidutide has shown promising results in clinical trials, achieving significant weight loss and liver fat reduction. It has received Fast Track designation from the U.S. FDA for treating NASH, highlighting its potential to meet significant unmet medical needs.
Altimmune's pipeline also includes HepTcell™, an immunotherapeutic designed to achieve a functional cure for chronic hepatitis B. However, the company has recently decided to cease further development on HepTcell based on Phase 2 trial findings.
Financially, Altimmune maintains a robust cash position, enabling it to advance its clinical programs. Recent financial results indicate a focused investment in research and development, ensuring continued progress in its pipeline.
Significant recent achievements include:
- Positive top-line results from the 48-week MOMENTUM Phase 2 obesity trial of pemvidutide.
- Ongoing Phase 2b IMPACT trial of pemvidutide in MASH with top-line results expected in Q1 2025.
- Strong financial position with substantial cash reserves to support ongoing and future research activities.
Altimmune is poised at the forefront of developing transformative therapies for serious health conditions, potentially delivering significant advancements in patient care.
Altimmune, a clinical-stage biopharmaceutical company, will present at the H.C. Wainwright 23rd Annual Global Investment Conference from September 13-15, 2021. The presentation will be led by CEO Vipin Garg and CMO Scott Harris, with a pre-recorded session available on September 13 at 7 a.m. EST. Altimmune focuses on developing treatments for obesity and liver diseases, including therapies like ALT-801 for NASH and HepTcell™ for chronic hepatitis B. For further details, visit Altimmune's website.
Altimmune, Inc. (Nasdaq: ALT) has announced its financial results for Q2 2021, reporting a cash position of approximately $218 million, enabling ongoing development of its obesity and liver disease pipeline. The interim results from the ALT-801 Phase 1 trial showed a placebo-adjusted weight loss of 6.3% over six weeks. The 12-week data readout for ALT-801 is expected in September 2021, alongside plans for IND applications in NASH and obesity. Revenue was $0.1 million, down from $0.7 million YoY, with a net loss of $24.8 million for the quarter.
Altimmune, Inc. (Nasdaq: ALT) will announce its second quarter 2021 financial results on August 11, 2021. Management will host a conference call at 8:30 am E.T. to discuss the results and provide further business updates. The conference can be accessed via dial-in or webcast. Altimmune is focused on developing treatments for obesity and liver diseases, with a pipeline that includes therapies for NASH and chronic hepatitis B.
Altimmune (Nasdaq: ALT) has announced the discontinuation of its AdCOVID vaccine development after a Phase 1 trial revealed it was well tolerated but failed to generate adequate immune responses compared to existing COVID-19 vaccines. The focus will shift to advancing its obesity and liver disease programs, notably ALT-801 and HepTcell. Encouraging interim data from the ALT-801 trial indicate significant weight loss in overweight participants. Meanwhile, enrollment challenges in the T-COVID Phase 1/2 trial have led to the decision to halt further enrollment while evaluating future development options.
Altimmune announced interim results from its Phase 1 trial of ALT-801, a dual GLP-1/glucagon receptor agonist, showing a significant 5.4% weight loss at 6 weeks with a 1.8 mg dose, exceeding the 2% target. The treatment was well-tolerated with low nausea rates. Further developments include plans to file an additional IND for an obesity program in 2021 and an anticipated 12-week data readout in Q3 2021. The trial aims to explore ALT-801's effects on liver fat and metabolic conditions, enhancing its therapeutic potential in tackling obesity and NASH.
Altimmune, Inc. (Nasdaq: ALT), a clinical-stage biopharmaceutical company, will participate in the 2021 Jefferies Virtual Healthcare Conference from June 1 to 4, 2021. The management team, including Vipin Garg, Scot Roberts, and Scott Harris, will present on June 2, 2021 at 11:30 am ET. Attendees can access the presentation through a webcast link on the Altimmune website. Altimmune focuses on developing intranasal vaccines and therapies for various diseases, including its COVID-19 vaccine, AdCOVID™.
Altimmune reported promising preclinical results for its AdCOVID vaccine against the South African variant B.1.351. The neutralizing titers against this variant were only 4.4-fold lower than those against the original SARS-CoV-2 strain after a single intranasal dose. A booster dose further narrowed this gap to 1.8-fold. The study also highlighted strong mucosal immunity, suggesting that AdCOVID could effectively combat variants while simplifying vaccination strategies. The company aims to report Phase 1 trial data in June 2021, with a focus on its potential to provide broad immune responses.
Altimmune, a clinical-stage biopharmaceutical company, reported financial results for Q1 2021, highlighting approximately $227 million in cash and short-term investments. Upcoming data readouts from the Phase 1 clinical trials of AdCOVID and ALT-801 are expected in June. The company anticipates a comprehensive Phase 2 trial for AdCOVID if results are favorable. ALT-801 also shows promise for treating non-alcoholic steatohepatitis (NASH) and obesity. However, Q1 revenue fell 64% year over year to $0.8 million, while net loss increased to $14.9 million, reflecting higher expenses.
Altimmune, Inc. (Nasdaq: ALT) will announce its first quarter 2021 financial results on May 17, 2021. The company, focused on developing intranasal vaccines and therapies, will hold a conference call at 8:30 am ET to discuss these results and provide updates on its business. The call can be accessed via a domestic dial-in at 877-423-9813 or internationally at 201-689-8573, using the conference ID 13719206. Investors can also join the webcast to get insights into Altimmune's pipeline, including its promising COVID-19 vaccine candidate, AdCOVID™.
Altimmune has reported promising preclinical results for its COVID-19 vaccine candidate, AdCOVID. A single intranasal dose of AdCOVID demonstrated sterilizing immunity in the lungs of vaccinated mice, showing no detectable levels of infectious virus after exposure to SARS-CoV-2. This study signifies a potential breakthrough in preventing viral transmission, crucial amid increasing vaccine hesitancy. The ongoing Phase 1 trial is set to deliver topline data in June 2021, assessing safety and immune response, while AdCOVID's features may enhance vaccine acceptance globally.
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