Aileron Therapeutics and Advancium Health Network Announce an Exclusive Option Agreement for the Acquisition of ALRN-6924 for Retinoblastoma
Aileron Therapeutics (NASDAQ: ALRN) and Advancium Health Network have entered into an exclusive option agreement for ALRN-6924, targeting retinoblastoma, a rare pediatric eye cancer. Advancium paid a non-refundable fee for the option to acquire ALRN-6924, with potential additional payments upon exercise. The drug selectively targets MDM2 and MDMX proteins to activate p53-mediated tumor suppression in cancer cells. Retinoblastoma affects approximately 300 cases in the US and 9,000 worldwide annually, primarily in children. ALRN-6924 has shown promising results in preclinical models, demonstrating anti-proliferative activity in RB cell lines and compatibility with intraocular injection.
Aileron Therapeutics (NASDAQ: ALRN) e Advancium Health Network hanno stipulato un accordo di opzione esclusiva per ALRN-6924, mirato al retinoblastoma, un raro cancro oculare pediatrico. Advancium ha pagato una tassa non rimborsabile per l'opzione di acquisire ALRN-6924, con potenziali pagamenti aggiuntivi al momento dell'esercizio. Il farmaco colpisce selettivamente le proteine MDM2 e MDMX per attivare la soppressione tumorale mediata da p53 nelle cellule cancerose. Il retinoblastoma colpisce circa 300 casi negli Stati Uniti e 9.000 a livello mondiale ogni anno, principalmente nei bambini. ALRN-6924 ha mostrato risultati promettenti nei modelli preclinici, dimostrando attività anti-proliferativa nelle linee cellulari di RB e compatibilità con l'iniezione intraoculare.
Aileron Therapeutics (NASDAQ: ALRN) y Advancium Health Network han firmado un acuerdo de opción exclusiva para ALRN-6924, enfocado en el retinoblastoma, un raro cáncer ocular pediátrico. Advancium pagó una tarifa no reembolsable por la opción de adquirir ALRN-6924, con posibles pagos adicionales al momento de ejercerla. El fármaco ataca selectivamente las proteínas MDM2 y MDMX para activar la supresión tumoral mediada por p53 en las células cancerosas. El retinoblastoma afecta aproximadamente 300 casos en EE. UU. y 9,000 en todo el mundo anualmente, principalmente en niños. ALRN-6924 ha mostrado resultados prometedores en modelos preclínicos, demostrando actividad antiproliferativa en líneas celulares de RB y compatibilidad con la inyección intraocular.
Aileron Therapeutics (NASDAQ: ALRN)와 Advancium Health Network가 소아 희귀 안암인 망막모세포종에 대한 ALRN-6924에 대한 독점 옵션 계약을 체결했습니다. Advancium은 ALRN-6924를 인수할 수 있는 옵션에 대한 비환불 수수료를 지급했으며, 권리를 행사할 경우 추가 지급도 있을 수 있습니다. 이 약물은 MDM2 및 MDMX 단백질을 선택적으로 표적하여 암세포에서 p53 매개 종양 억제를 활성화합니다. 망막모세포종은 매년 미국에서 약 300건, 전 세계에서 9,000건에 영향을 미치며, 주로 어린이를 대상으로 합니다. ALRN-6924는 전임상 모델에서 유망한 결과를 보였으며, RB 세포주에서 항증식 활성을 나타내고 안구 내 주사와의 호환성을 입증하였습니다.
Aileron Therapeutics (NASDAQ: ALRN) et Advancium Health Network ont conclu un accord d'option exclusif pour ALRN-6924, visant le rétinoblastome, un rare cancer pédiatrique des yeux. Advancium a payé des frais non remboursables pour l'option d'acquérir ALRN-6924, avec des paiements supplémentaires possibles lors de l'exercice. Le médicament cible sélectivement les protéines MDM2 et MDMX pour activer la suppression tumorale médiée par p53 dans les cellules cancéreuses. Le rétinoblastome affecte environ 300 cas aux États-Unis et 9 000 dans le monde chaque année, principalement chez les enfants. ALRN-6924 a montré des résultats prometteurs dans des modèles précliniques, démontrant une activité antiproliférative dans des lignées cellulaires de RB et une compatibilité avec l'injection intraoculaire.
Aileron Therapeutics (NASDAQ: ALRN) und Advancium Health Network haben eine exklusive Optionsvereinbarung für ALRN-6924 abgeschlossen, das auf Retinoblastom abzielt, ein seltenes pädiatrisches Augenkarzinom. Advancium zahlte eine nicht erstattungsfähige Gebühr für die Option, ALRN-6924 zu erwerben, mit möglichen zusätzlichen Zahlungen bei Ausübung. Das Medikament zielt selektiv auf die Proteine MDM2 und MDMX ab, um die p53-vermittelte Tumorsuppressionsaktivität in Krebszellen zu aktivieren. Retinoblastom betrifft jährlich etwa 300 Fälle in den USA und 9.000 weltweit, hauptsächlich bei Kindern. ALRN-6924 hat in präklinischen Modellen vielversprechende Ergebnisse gezeigt und weist in RB-Zelllinien anti-proliferative Aktivität sowie eine Kompatibilität mit intraokularer Injektion auf.
- Received non-refundable option fee from Advancium
- Potential for additional development, regulatory and commercial milestone payments
- Possible future sales royalties if option is exercised
- Drug showed positive preclinical results in retinoblastoma models
- Asset divestment of a clinical-stage drug candidate from pipeline
Insights
This exclusive option agreement marks a strategic pivot for ALRN-6924, targeting retinoblastoma - a rare pediatric eye cancer with significant unmet needs. The deal structure includes an upfront non-refundable fee, potential exercise payment and milestone/royalty payments, providing multiple value-creation opportunities.
The scientific rationale is compelling: ALRN-6924's unique dual-inhibition of MDM2/MDMX addresses a key driver of retinoblastoma pathogenesis. As the only clinical-stage drug targeting MDMX, it offers a potentially selective treatment approach compared to current non-selective chemotherapy options. Preclinical data showing potent activity and intraocular compatibility strengthens its therapeutic potential.
While this represents a positive development for monetizing a non-core asset, investors should note that Aileron's primary focus remains on pulmonary and fibrosis indications. The partnership with Advancium, backed by Deerfield Management, provides a credible development path for ALRN-6924 in pediatric oncology.
The retinoblastoma market, though small with ~300 US cases and ~9,000 global cases annually, represents a compelling opportunity due to several factors:
- High unmet need in current treatment landscape
- Potential for premium pricing as an orphan drug
- competition in targeted therapies
- Strong market access potential for pediatric cancer treatments
Partnering with Advancium, a Deerfield-backed public charity, provides unique advantages including potential accelerated development pathways and enhanced stakeholder goodwill. The deal structure allows Aileron to benefit from upside while minimizing development costs and risks.
Agreement marks first of its kind for Advancium, a public charity launched by Deerfield Management and the Deerfield Foundation
Advancium will evaluate ALRN-6924 as a potential therapy for retinoblastoma, a rare but devastating pediatric cancer of the eye
During the option period, Advancium intends to evaluate ALRN-6924 as a potential therapy for retinoblastoma (RB), a rare but devastating cancer of the eye, with around 300 cases diagnosed in
Under the terms of the option agreement, Advancium paid Aileron a non-refundable fee for the exclusive option to acquire ALRN-6924 and related assets. If Advancium exercises its option, Aileron will receive an exercise payment with potential for additional development, regulatory and commercial milestone payments and sales royalties.
"This agreement is a significant landmark for our work at Advancium, as it is the first drug opportunity we are pursuing in our mission as a public charity to develop much-needed therapies for children with cancer," said Mark Veich, Chief Executive Officer of Advancium and Vice President of Philanthropy and Executive Director of the Deerfield Foundation. "We look forward to evaluating ALRN-6924 as a potential treatment for children with retinoblastoma who currently have limited care options."
"Aileron is a strong supporter of Advancium's cause," said Brian Windsor, Ph.D., President and Chief Executive Officer of Aileron. "Although we remain focused on developing novel therapies for the treatment of orphan pulmonary and fibrosis indications, we are honored that they have chosen to partner with us in this important step towards their goal of delivering therapies to pediatric patients with high unmet need."
References
[1] Cobrinik, D. "Retinoblastoma Origins and Destinations" N Engl J Med. 2024 Apr 18;390(15):1408-1419
[2] Guerlavais, V. et al, "Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development" J Med Chem, 2023; 66:9401–9417
[3] Laurie, N. A. et al, "Inactivation of the p53 pathway in retinoblastoma" Nature. 2006 Nov 2;444(7115):61-6
[4] Wilson, M. W. et al, "Intraocular MDMX Inhibition by ALRN-6924: A Targeted Strategy to Reactivate p53 in Retinoblastoma." Investigative Ophthalmology & Visual Science, 2023 June;64(8): 1272
About Aileron Therapeutics
Aileron Therapeutics is a biopharmaceutical company advancing a novel pipeline of first-in-class medicines to address significant unmet medical needs in orphan pulmonary and fibrosis indications. Aileron's lead product candidate, LTI-03, is a novel, synthetic peptide with a dual mechanism targeting alveolar epithelial cell survival as well as inhibition of profibrotic signaling. Currently, LTI-03 is being evaluated in a Phase 1b clinical trial for the treatment of idiopathic pulmonary fibrosis. Aileron's second product candidate, LTI-01, is a proenzyme that has completed Phase 1b and Phase 2a clinical trials for the treatment of loculated pleural effusions. LTI-01 has received Orphan Drug Designation in the US and EU and Fast Track Designation in the US.
About Advancium Health Network
Advancium Health Network is a mission-driven public charity pioneering ways to overcome barriers in healthcare through a unique model that combines for-profit infrastructure with non-profit ideals. Advancium forges bonds between a diverse body of industry partners, experts, and philanthropic support to leverage its collective expertise and resources. From early-stage innovation to pediatric MedTech and rare diseases, we are confronting healthcare's most daunting hurdles for underserved patients and catalyzing a positive impact on human health.
Forward-Looking Statements
This press release may contain forward-looking statements of Aileron Therapeutics, Inc. ("Aileron", the "Company", "we", "our" or "us") within the meaning of the Private Securities Litigation Reform Act of 1995, including statements with respect to: the terms of the option agreement between Advancium and the Company; the exercise of the option to acquire ALRN-6924 pursuant to the option agreement; and the potential of the Company to receive a future option exercise payment, milestone payments and royalties pursuant to the option agreement with Advancium. We use words such as "anticipate," "believe," "estimate," "expect," "hope," "intend," "may," "plan," "predict," "project," "target," "potential," "would," "can," "could," "should," "continue," and other words and terms of similar meaning to help identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including risks and uncertainties related to, changes in applicable laws or regulations, the possibility that the Company may be adversely affected by other economic, business, and/or competitive factors, including risks inherent in pharmaceutical research and development, such as: adverse results in the Company's drug discovery, preclinical and clinical development activities, the risk that the results of preclinical studies and early clinical trials may not be replicated in later clinical trials or that partial results of a trial such as the Cohort 1 results from the Company's ongoing Phase 1b clinical trial will be indicative of the full results of the trial, the Company's ability to enroll patients in its clinical trials, and the risk that any of its clinical trials may not commence, continue or be completed on time, or at all; decisions made by the
Aileron Investor Relations & Media Contact:
Argot Partners
aileron@argotpartners.com
212-600-1902
Advancium Investor Relations & Media Contact:
Jyoti Patel
media@advanciumhealth.org
646-771-0699
View original content to download multimedia:https://www.prnewswire.com/news-releases/aileron-therapeutics-and-advancium-health-network-announce-an-exclusive-option-agreement-for-the-acquisition-of-alrn-6924-for-retinoblastoma-302292196.html
SOURCE Aileron Therapeutics, Inc.; Advancium Health Network
FAQ
What is the purpose of the option agreement between Aileron Therapeutics (ALRN) and Advancium?
How does ALRN-6924 work in treating retinoblastoma?
What are the financial terms of the ALRN option agreement with Advancium?