Allogene Therapeutics Presents Data on Dagger™, a Next Generation AlloCAR T™ Platform Technology

Rhea-AI Summary

Allogene Therapeutics, Inc. (Nasdaq: ALLO) recently presented preclinical data on its innovative Dagger technology at the Keystone Symposia in Banff, Canada. This new platform aims to prevent immune rejection of AlloCAR T cells, allowing for enhanced persistence and efficacy against cancer. The Dagger technology is integral to ALLO-316, targeting CD70 in renal cell carcinoma within the ongoing Phase 1 TRAVERSE study. Preclinical findings indicate improved AlloCAR T cell survival and effectiveness in targeting tumors. The firm plans to leverage this technology across various hematologic malignancies and solid tumors, aiming to advance patient outcomes.

Positive

• Dagger technology demonstrated enhanced survival of AlloCAR T cells in preclinical models.
• Initial clinical data from ALLO-316 shows promise in advanced renal cell carcinoma patients.
• Potential to expand Dagger technology applications to a range of hematologic and solid tumors.

Negative

• None.

SOUTH SAN FRANCISCO, Calif., Feb. 01, 2023 (GLOBE NEWSWIRE) -- Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T™) products for cancer, presented preclinical data highlighting the Company’s next generation Dagger^TM platform technology at the Emerging Cellular Therapies at the Forefront of Cancer Immunotherapy Keystone Symposia in Banff, Alberta, Canada.

The Dagger technology, first unveiled at the Company’s R&D Showcase in November 2022, is designed to resist rejection of AlloCAR T cells by the host immune cells, enabling a prolonged window of persistence during which AlloCAR T cells can expand and actively target and destroy cancer cells. Dagger is a component of Allogene’s anti-CD70 product candidate ALLO-316, which is being evaluated in TRAVERSE, a Phase 1 study of patients with relapsed/refractory renal cell carcinoma (RCC).

“We are excited by the potential of this proprietary technology to enhance AlloCAR T cell function by preventing premature rejection of the cells while potentially reducing dependence on other lymphodepletion strategies,” said Barbra Sasu, Ph.D., Chief Scientific Officer at Allogene. “The early clinical experience with ALLO-316 in advanced renal cell carcinoma suggests Dagger can meaningfully enhance AlloCAR T cell expansion and persistence. We are keen to apply this technology to other product candidates targeting both hematologic and solid tumors.”

The Dagger platform arms AlloCAR T cells with a CD70-targeting receptor designed to recognize and deplete CD70 positive host cells while also masking the CD70 molecule expressed on the AlloCAR T cells themselves, preventing fratricide. CD70 is expressed on activated T cells and NK cells, and by selectively depleting alloreactive host cells, Dagger can potentially prevent the immune rejection of AlloCAR T cells. The results from these pre-clinical studies show that:

• A CD70 Dagger construct was optimized to selectively eliminate alloreactive T cells, enabling enhanced AlloCAR T cell survival in several in vitro models of rejection
• Allogeneic CAR T cells expressing dual CD19 CAR and CD70 Dagger receptors demonstrated the ability to simultaneously kill CD19-positive tumor cells and resist rejection and fratricide
• CD19 AlloCAR T cells armed with a CD70 Dagger were endowed with dual specificity and prevented CD19 antigen loss dependent escape by tumor cells in vitro and in vivo
  

The Company has pursued an integrated strategy within Research and Development aimed at matching technology with insights obtained from the clinic to improve patient outcomes. In addition to ALLO-316, the Company plans to deploy Dagger technology to enhance the persistence and activity of next generation AlloCAR T products.

About ALLO-316
ALLO-316, an AlloCAR T investigational product targets CD70, which is highly expressed in renal cell carcinoma (RCC). CD70 is also selectively expressed in several cancers, creating the potential for ALLO-316 to be developed across a variety of both hematologic malignancies and solid tumors. The ongoing Phase 1 TRAVERSE trial is designed to evaluate the safety, tolerability, and activity of ALLO-316 in patients with advanced or metastatic clear cell RCC. In March 2022, The U.S. Food and Drug Administration granted Fast Track Designation (FTD) based on the potential of ALLO-316 to address the unmet need for patients with difficult to treat RCC who have failed standard RCC therapies.

About Allogene Therapeutics
Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) products for cancer. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. For more information, please visit www.allogene.com and follow @AllogeneTx on Twitter and LinkedIn.

Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The press release may, in some cases, use terms such as "predicts," "believes," "potential," "proposed," "continue," "estimates," "anticipates," "expects," "plans," "intends," "may," "could," "might," "will," "should" or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: the ability to advance ALLO-316; the ability to deploy Dagger technology to enhance the persistence and activity of next generation AlloCAR T products; the potential benefits of Dagger Technology; and the potential benefits of AlloCAR T. Various factors may cause differences between Allogene’s expectations and actual results as discussed in greater detail in Allogene’s filings with the SEC, including without limitation in its Form 8-K filed on November 29, 2022 and under the “Risk Factors” heading of its Form 10-Q for the quarter ended September 30, 2022. Any forward-looking statements that are made in this press release speak only as of the date of this press release. Allogene assumes no obligation to update the forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.

AlloCAR T™ and Dagger™ are trademarks of Allogene Therapeutics, Inc.

Allogene’s AlloCAR T™ programs utilize Cellectis technologies. The anti-CD70 AlloCAR T programs are licensed exclusively from Cellectis by Allogene and Allogene holds global development and commercial rights to these AlloCAR T programs.

Allogene Media/Investor Contact:
Christine Cassiano
Chief Communications Officer
(714) 552-0326
Christine.Cassiano@allogene.com

FAQ

What is the Dagger technology developed by Allogene Therapeutics?

Dagger technology is a proprietary platform designed to prevent immune rejection of AlloCAR T cells, enhancing their persistence and efficacy in targeting cancer.

What is ALLO-316 and its significance?

ALLO-316 is an investigational AlloCAR T product targeting CD70, primarily aimed at treating advanced renal cell carcinoma, currently undergoing evaluation in the TRAVERSE Phase 1 trial.

When was the Dagger technology presented?

The Dagger technology was presented on February 1, 2023, at the Emerging Cellular Therapies conference in Banff, Alberta.

What are the potential benefits of ALLO-316?

ALLO-316 is expected to provide a new treatment option for patients with advanced renal cell carcinoma who have not responded to standard therapies.