Algernon Pharmaceuticals Establishes 6 hours as Optimum Treatment Period for DMT in Neuron Study

Rhea-AI Summary

Algernon Pharmaceuticals Inc. (CSE: AGN) (OTCQB: AGNPF) announced the successful results of a preclinical study on DMT, demonstrating a 40% increase in neuron outgrowth at a sub-hallucinogenic dose over a 6-hour treatment period. Conducted by Charles River Laboratories, the study confirmed that DMT outperformed ketamine at similar doses. The final analysis on the mechanisms of DMT's effects is expected by the end of November 2021. Algernon is progressing towards a Phase 1 clinical study for stroke treatment using DMT.

Positive

• DMT treatment showed over 40% increase in neuron outgrowth at 30 nM concentration during a 6-hour exposure.
• Results indicated DMT's effectiveness exceeded that of ketamine in the study.
• Algernon plans to move towards Phase 1 clinical trials for DMT in stroke treatment.

Negative

• None.

VANCOUVER, British Columbia, Nov. 01, 2021 (GLOBE NEWSWIRE) -- Algernon Pharmaceuticals Inc. (CSE: AGN) (FRANKFURT: AGW) (OTCQB: AGNPF) (the “Company” or “Algernon”) a clinical stage pharmaceutical development company, is pleased to announce that it has established the optimum peak stimulation period of 6 hours for neuron outgrowth by AP-188 (“N,N-Dimethyltryptamine” or “DMT”) in its pre-clinical in vitro study conducted by Charles River Laboratories. Algernon also confirms that the increased growth was achieved with a sub-hallucinogenic dose.

This current data set is from the second part of the Company’s in vitro experiment designed to focus on duration of infusion needed to achieve maximal cortical neuron outgrowth. The data showed that an increase in growth of over 40% was observed in the group treated for 6 hours with 30 nM DMT, with statistical significance, when compared to control. The results from the 6-hour period were superior to other treatment time periods and doses.

The final data set from the study will focus on investigating the mechanisms related to DMT which may be causing the growth of the neurons and is expected to be completed by the end of November 2021.

Study Data Summary

In the study, rat primary cortical neurons were treated with DMT or vehicle for timepoints of 1, 6, 12, 24 and 72 hours at varying concentrations, and then allowed to grow until 72 hours total growth time had elapsed, at which point the cells were fixed, stained, and examined for neuron outgrowth. Ketamine (10 nM) was used as a positive control.

• An increase of over 40% in the mean total length of processes and branches per cell was observed in the group treated for 6 hours with 30 nM DMT compared to vehicle (p < 0.05 two-way ANOVA, Dunnett’s multiple comparison test).
  
  
• The growth achieved with 30 nM DMT was also significantly higher than an optimized dose of ketamine.
  
  
• Significant increases in the number of processes were also observed after treatment of one hour at concentrations as low as 3 nM.
  

“This is Algernon’s second preclinical study confirming that DMT stimulates brain cell growth at sub-psychedelic doses,” said Christopher J. Moreau, CEO of Algernon Pharmaceuticals. “In addition, the data is showing that a maximum effect is seen at 6 hours exposure which would translate well for clinical use. We look forward to moving the research program on to a Phase 1 study.”

About DMT

Algernon has established a clinical research program for the treatment of stroke focused on DMT, a known psychedelic compound that is part of the tryptamine family (other drugs in the tryptamine family include psilocybin and psilocin).

Algernon has also filed new provisional patents for new forms of DMT, in addition to formulation, dosage and method of use claims for ischemic stroke. The Company has also filed claims for combination therapy of DMT and Constraint Induced Movement Therapy (“CIMT”).

About Algernon Pharmaceuticals Inc. 

Algernon is a drug re-purposing company that investigates safe, already approved drugs, and naturally occurring compounds, for new disease applications, moving them efficiently and safely into new human trials, developing new formulations and seeking new regulatory approvals in global markets. Algernon specifically investigates compounds that have never been approved in the U.S. or Europe to avoid off label prescription writing.

CONTACT INFORMATION

Christopher J. Moreau
CEO
Algernon Pharmaceuticals Inc.
604.398.4175 ext 701

info@algernonpharmaceuticals.com
investors@algernonpharmaceuticals.com
www.algernonpharmaceuticals.com.

Neither the Canadian Securities Exchange nor its Market Regulator (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release.

CAUTIONARY DISCLAIMER STATEMENT: No Securities Exchange has reviewed nor accepts responsibility for the adequacy or accuracy of the content of this news release. This news release contains forward-looking statements relating to product development, licensing, commercialization and regulatory compliance issues and other statements that are not historical facts. Forward-looking statements are often identified by terms such as “will”, “may”, “should”, “anticipate”, “expects” and similar expressions. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include the failure to satisfy the conditions of the relevant securities exchange(s) and other risks detailed from time to time in the filings made by the Company with securities regulations. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements as expressly required by applicable law.

FAQ

What were the results of Algernon Pharmaceuticals' DMT study for neuron outgrowth?

Algernon Pharmaceuticals' study showed a 40% increase in neuron outgrowth with DMT at a 30 nM concentration during a 6-hour treatment.

When can we expect the final results of Algernon's DMT study?

The final results from Algernon's DMT study are expected to be completed by the end of November 2021.

What is the significance of the 6-hour treatment period for DMT?

The 6-hour treatment period maximized neuron outgrowth, making it significant for potential clinical applications.

How does DMT compare to ketamine in this study?

The study found that DMT at the optimized dose had superior effects on neuron growth compared to ketamine.

What are the next steps for Algernon Pharmaceuticals regarding DMT?

Algernon Pharmaceuticals plans to advance their research program to a Phase 1 study for DMT's use in stroke treatment.