Agenus to Present New BOT/BAL Data in Two Presentations at AACR 2025
Agenus (Nasdaq: AGEN) has announced two upcoming presentations at the American Association for Cancer Research (AACR) Annual Meeting in Chicago (April 25-30, 2025), highlighting their neoadjuvant immunotherapy program with botensilimab and balstilimab (BOT/BAL).
The presentations include:
- An oral presentation of initial results from the NEOASIS trial studying BOT/BAL in MMR proficient and deficient early-stage cancers, presented by Dr. Myriam Chalabi from Netherlands Cancer Institute on April 28, 2025
- A poster presentation featuring new data from the Phase 1 study of BOT/BAL in treatment-refractory hepatocellular carcinoma (HCC), presented by Dr. Anthony El-Khoueiry from USC Norris Comprehensive Cancer Center on April 29, 2025
These presentations build upon previous BOT/BAL data from two independent studies (UNICORN and NEST) in colorectal cancer presented earlier at ASCO-GI.
Agenus (Nasdaq: AGEN) ha annunciato due prossime presentazioni all'American Association for Cancer Research (AACR) Annual Meeting a Chicago (25-30 aprile 2025), evidenziando il loro programma di immunoterapia neoadiuvante con botensilimab e balstilimab (BOT/BAL).
Le presentazioni includono:
- Una presentazione orale dei risultati iniziali del trial NEOASIS che studia BOT/BAL in tumori precoci MMR proficient e deficient, presentata dalla Dr.ssa Myriam Chalabi dell'Istituto Nazionale dei Tumori dei Paesi Bassi il 28 aprile 2025
- Una presentazione poster con nuovi dati dallo studio di Fase 1 di BOT/BAL in carcinoma epatocellulare (HCC) refrattario al trattamento, presentata dal Dr. Anthony El-Khoueiry del USC Norris Comprehensive Cancer Center il 29 aprile 2025
Queste presentazioni si basano su dati precedenti di BOT/BAL provenienti da due studi indipendenti (UNICORN e NEST) nel carcinoma colorettale presentati in precedenza all'ASCO-GI.
Agenus (Nasdaq: AGEN) ha anunciado dos próximas presentaciones en la Reunión Anual de la Asociación Americana para la Investigación del Cáncer (AACR) en Chicago (25-30 de abril de 2025), destacando su programa de inmunoterapia neoadyuvante con botensilimab y balstilimab (BOT/BAL).
Las presentaciones incluyen:
- Una presentación oral de los resultados iniciales del ensayo NEOASIS que estudia BOT/BAL en cánceres en etapas tempranas con MMR competente y deficiente, presentada por la Dra. Myriam Chalabi del Instituto del Cáncer de los Países Bajos el 28 de abril de 2025
- Una presentación en poster con nuevos datos del estudio de Fase 1 de BOT/BAL en carcinoma hepatocelular (HCC) refractario al tratamiento, presentada por el Dr. Anthony El-Khoueiry del USC Norris Comprehensive Cancer Center el 29 de abril de 2025
Estas presentaciones se basan en datos previos de BOT/BAL de dos estudios independientes (UNICORN y NEST) en cáncer colorrectal presentados anteriormente en ASCO-GI.
Agenus (Nasdaq: AGEN)는 미국 암 연구 협회(AACR) 연례 회의에서 (2025년 4월 25-30일 시카고) botensilimab 및 balstilimab (BOT/BAL)을 사용한 신보조 면역요법 프로그램을 강조하는 두 가지 발표를 발표했습니다.
발표 내용은 다음과 같습니다:
- 2025년 4월 28일 네덜란드 암 연구소의 Dr. Myriam Chalabi가 발표하는 MMR 적합 및 결핍 초기 단계 암에서 BOT/BAL을 연구한 NEOASIS 시험의 초기 결과에 대한 구두 발표
- 2025년 4월 29일 USC 노리스 종합 암 센터의 Dr. Anthony El-Khoueiry가 발표하는 치료 불응성 간세포 암종(HCC)에서 BOT/BAL의 1상 연구의 새로운 데이터가 포함된 포스터 발표
이 발표는 ASCO-GI에서 이전에 발표된 대장암에 대한 두 개의 독립적인 연구(UNICORN 및 NEST)에서의 BOT/BAL 데이터에 기반하고 있습니다.
Agenus (Nasdaq: AGEN) a annoncé deux présentations à venir lors de la Réunion Annuelle de l'American Association for Cancer Research (AACR) à Chicago (du 25 au 30 avril 2025), mettant en avant leur programme d'immunothérapie néoadjuvante avec botensilimab et balstilimab (BOT/BAL).
Les présentations comprennent:
- Une présentation orale des résultats initiaux de l' étudiant BOT/BAL dans des cancers précoces MMR compétents et déficients, présentée par Dr. Myriam Chalabi de l'Institut National du Cancer des Pays-Bas le 28 avril 2025
- Une présentation par affiche présentant de nouvelles données de l' de BOT/BAL dans le carcinome hépatocellulaire (CHC) réfractaire au traitement, présentée par Dr. Anthony El-Khoueiry du USC Norris Comprehensive Cancer Center le 29 avril 2025
Ces présentations s'appuient sur des données antérieures de BOT/BAL provenant de deux études indépendantes (UNICORN et NEST) dans le cancer colorectal présentées précédemment à l'ASCO-GI.
Agenus (Nasdaq: AGEN) hat zwei bevorstehende Präsentationen auf dem Jahrestreffen der American Association for Cancer Research (AACR) in Chicago (25.-30. April 2025) angekündigt, die ihr neoadjuvantes Immuntherapieprogramm mit botensilimab und balstilimab (BOT/BAL) hervorheben.
Die Präsentationen umfassen:
- Eine mündliche Präsentation der ersten Ergebnisse der NEOASIS-Studie, die BOT/BAL bei MMR-proficienten und -defizienten frühen Krebsarten untersucht, präsentiert von Dr. Myriam Chalabi vom Niederländischen Krebsinstitut am 28. April 2025
- Eine Posterpräsentation mit neuen Daten aus der Phase-1-Studie zu BOT/BAL bei behandlungsresistentem hepatozellulärem Karzinom (HCC), präsentiert von Dr. Anthony El-Khoueiry vom USC Norris Comprehensive Cancer Center am 29. April 2025
Diese Präsentationen bauen auf früheren BOT/BAL-Daten aus zwei unabhängigen Studien (UNICORN und NEST) im kolorektalen Krebs auf, die zuvor auf der ASCO-GI präsentiert wurden.
- None.
- None.
- First oral presentation of BOT/BAL neoadjuvant results from the NEOASIS trial in MSI-H and MSS solid tumors
- New data from the treatment-refractory hepatocellular carcinoma (HCC) cohort of the BOT/BAL Phase 1 trial to be presented
Oral Presentation Details:
Presentation Title: Neoadjuvant botensilimab plus balstilimab in MMR proficient and deficient early-stage cancers: First results of the pan-cancer NEOASIS study (NCT06279130)
Presenting Author: Myriam Chalabi, MD, Netherlands Cancer Institute
Session Title: Aiming for Cure: Adjuvant and Neoadjuvant Approaches
Session Date and Time: 4/28/2025; 2:30:00 - 4:30:00 PM CT
Abstract Presentation Number: CT130
Poster Presentation Details:
Presentation Title: Results from a phase 1 study of botensilimab and balstilimab in treatment refractory hepatocellular carcinoma (NCT03860272)
Presenting Author: Anthony El-Khoueiry, MD, USC Norris Comprehensive Cancer Center
Session Title: Late-Breaking Research: Clinical Research 3
Session Date and Time: 4/29/2025; 2:00 - 5:00 PM CT
Location: Poster Section 53
Poster Board Number: 9
Abstract Presentation Number: LB365
About Botensilimab (BOT)
Botensilimab is a human Fc enhanced CTLA-4 blocking antibody designed to boost both innate and adaptive anti-tumor immune responses. Its novel design leverages mechanisms of action to extend immunotherapy benefits to “cold” tumors which generally respond poorly to standard of care or are refractory to conventional PD-1/CTLA-4 therapies and investigational therapies. Botensilimab augments immune responses across a wide range of tumor types by priming and activating T cells, downregulating intratumoral regulatory T cells, activating myeloid cells and inducing long-term memory responses.
Approximately 1,100 patients have been treated with botensilimab in phase 1 and phase 2 clinical trials. Botensilimab alone, or in combination with Agenus’ investigational PD-1 antibody, balstilimab, has shown clinical responses across nine metastatic, late-line cancers. For more information about botensilimab trials, visit www.clinicaltrials.gov with the identifiers NCT03860272, NCT05608044, NCT05630183, and NCT05529316.
About Balstilimab (BAL)
Balstilimab is a novel, fully human monoclonal immunoglobulin G4 (IgG4) designed to block PD-1 (programmed cell death protein 1) from interacting with its ligands PD-L1 and PD-L2. It has been evaluated in >900 patients to date and has demonstrated clinical activity and a favorable tolerability profile in several tumor types.
About Agenus
Agenus is a leading immuno-oncology company targeting cancer with a comprehensive pipeline of immunological agents. The company was founded in 1994 with a mission to expand patient populations benefiting from cancer immunotherapy through combination approaches, using a broad repertoire of antibody therapeutics, adoptive cell therapies (through MiNK Therapeutics) and adjuvants (through SaponiQx). Agenus has robust end-to-end development capabilities, across commercial and clinical cGMP manufacturing facilities, research and discovery, and a global clinical operations footprint. Agenus is headquartered in
Forward-Looking Statements
This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding its botensilimab and balstilimab programs, expected regulatory timelines and filings, and any other statements containing the words "may," "believes," "expects," "anticipates," "hopes," "intends," "plans," "forecasts," "estimates," "will," “establish,” “potential,” “superiority,” “best in class,” and similar expressions are intended to identify forward-looking statements. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Annual Report on Form 10-K for 2023, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.
View source version on businesswire.com: https://www.businesswire.com/news/home/20250325174550/en/
Investors
917-362-1370
investor@agenusbio.com
Media
510-323-5188
communications@agenusbio.com
Source: Agenus Inc.