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Adaptimmune Therapeutics plc (NASDAQ: ADAP) is a clinical-stage biopharmaceutical company focused on the design, development, and delivery of T-cell therapies to treat cancer. Established in 2008, Adaptimmune has grown from a private entity to one of the top biopharmaceutical IPOs in 2015, and its U.S. operations are headquartered in Philadelphia, PA. Using its proprietary T-cell receptor (TCR) platform, Adaptimmune engineers T-cells to target and destroy cancer cells. This innovative approach has led to the development of a robust pipeline of immuno-oncology product candidates primarily aimed at solid tumors.
The company’s leading programs include afami-cel and lete-cel, both engineered T-cell therapies targeting specific cancer antigens. Afami-cel, targeting MAGE-A4, has shown promising results in treating advanced synovial sarcoma, with the U.S. FDA accepting its Biologics License Application (BLA) for priority review. The anticipated approval and commercial launch of afami-cel in 2024 will mark a significant milestone for Adaptimmune, potentially making it the first engineered T-cell therapy for solid tumors available to patients. Lete-cel, targeting NY-ESO-1, is being evaluated for synovial sarcoma and myxoid round cell liposarcoma (MRCLS) in the pivotal IGNYTE-ESO trial. Preliminary results indicate a 40% response rate, meeting the primary efficacy endpoint.
Adaptimmune has formed strategic partnerships to advance its pipeline and enhance its manufacturing capabilities. Recent collaborations include agreements with Galapagos to develop next-generation TCR therapies and a $125 million debt financing deal with Hercules Capital, strengthening its financial position.
In addition to its lead programs, Adaptimmune is advancing a broad clinical and preclinical pipeline, including ADP-A2M4CD8 (uza-cel), targeting a range of solid tumors, and several other next-generation and allogeneic T-cell therapies. The company continues to invest in research and development, with plans to expand its platform and address additional cancer indications.
The company’s commitment to transforming cancer treatment is underpinned by a strategy of bringing novel therapies to market efficiently. With over $300 million in funding and strategic plans extending into 2026, Adaptimmune is well-positioned to achieve significant milestones and make substantial impacts in the field of oncology.
Adaptimmune Therapeutics (Nasdaq:ADAP) announced promising initial data from its Phase 2 SPEARHEAD-1 trial of afamitresgene autoleucel (afami-cel) in treating synovial sarcoma and myxoid/round cell liposarcoma (MRCLS). Presented at ASCO, the trial reported a 39.3% overall response rate with an encouraging disease control rate of 86.2% in synovial sarcoma patients. Initial safety results indicate a favorable profile, mostly low-grade cytokine release syndrome. The company aims for a Biologics License Application (BLA) submission next year, bolstering hopes for a new treatment option in an unmet medical need.
Adaptimmune Therapeutics (Nasdaq: ADAP) announced preclinical data on its HiT targeting mesothelin at the ASGCT meeting. The HLA-independent TCR technology showed promising results, inducing complete tumor regression in a mouse model and outperforming a TRuC comparator. Notably, human T-cells expressing the HiT effectively killed mesothelin-expressing tumor cells, independent of CD8. Unlike the TRuC construct, the HiT was not neutralized by soluble mesothelin, highlighting its potential advantages for future cancer therapies.
Adaptimmune Therapeutics plc (Nasdaq: ADAP) announced updates on May 6, 2021, highlighting progress in its clinical trials and financial performance for Q1 2021. Key developments include the initial data presentation from the SPEARHEAD-1 trial at ASCO, increased enrollment in the SURPASS and ADP-A2AFP trials, and a financial report showing $0.4 million in revenue. R&D expenses rose to $24.5 million. The company confirmed it has sufficient liquidity to fund operations into early 2023. The second target has been nominated under the co-development agreement with Astellas.
Adaptimmune Therapeutics (Nasdaq:ADAP) announced the upcoming presentation of initial preclinical data on its HLA Independent TCR (HiT) targeting mesothelin, co-developed with Astellas, at the ASGCT meeting. This will occur on May 11, 2021, during the Cancer - Immunotherapy session, with abstract #641 published online. Adaptimmune focuses on cell therapies for cancer, utilizing its SPEAR T-cell platform to combat various solid tumors. The release contains forward-looking statements, indicating potential risks related to product development and regulatory processes.
Adaptimmune Therapeutics (Nasdaq:ADAP) will report its Q1 financial results and business update on May 6, 2021, before market opening. The company specializes in cancer immunotherapy using its SPEAR T-cell platform. Following the results announcement, a live teleconference will take place at 9:00 a.m. EDT. Investors can access the webcast on Adaptimmune's corporate site. The release highlights the company’s focus on advancing TCR therapeutic candidates while noting potential risks and uncertainties inherent in product development and regulatory processes.
Adaptimmune Therapeutics (ADAP) has reported significant advancements in its cell therapy strategies, aiming for a market presence by 2025 through its '2-2-5-2' plan. In 2020, the company achieved compelling results in treating synovial sarcoma and completed enrollment in the SPEARHEAD-1 trial, with plans for a Biologics License Application in 2022 for ADP-A2M4. Additionally, the company will initiate a Phase 2 trial (SURPASS-2) for esophageal and esophagogastric junction cancers. Financially, Adaptimmune ended 2020 with $368.2 million in total liquidity, supporting operations into early 2023.
Adaptimmune Therapeutics (Nasdaq:ADAP) is set to announce its financial results and provide business updates for Q4 and the year ending December 31, 2020, before market open on February 25, 2021. A live teleconference and webcast will follow at 8:00 a.m. EST. Adaptimmune specializes in developing cancer immunotherapy using its unique SPEAR® T-cell platform designed to target various solid tumors. The press release includes forward-looking statements, highlighting risks associated with product development and clinical trials.
Adaptimmune Therapeutics (ADAP) announced its ongoing enrollment in the SPEARHEAD-1 trial, targeting ADP-A2M4 for synovial sarcoma. The company is set to initiate a trial for ADP-A2M4CD8 in gastroesophageal cancers in the first half of 2021. The MAGE-A4 target shows strong efficacy potential across multiple solid tumors. Adaptimmune aims to introduce five new autologous products and two allogeneic products by 2024. Financial guidance is updated, indicating funding through early 2023. A Virtual Investor Day is scheduled, showcasing strategic visions and growth plans.
Adaptimmune Therapeutics (Nasdaq: ADAP) presented positive data from the Phase 1 ADP-A2M4 trial for synovial sarcoma at the CTOS annual meeting. The trial showed a 28-week median duration of response and a 94% disease control rate among 16 patients. The company aims to complete recruitment for the pivotal SPEARHEAD-1 trial by Q1 2021, with a goal to commercialize ADP-A2M4 in 2022. Additional trials for gastroesophageal cancers are planned for H1 2021.
Adaptimmune Therapeutics, a leader in cancer cell therapy, will host a virtual Investor Day on November 20, 2020. The event, set for 8 AM EST / 1 PM GMT, aims to highlight the market potential of its SPEAR T-cell portfolio and discuss its early-stage pipeline beyond current autologous TCR T-cell products. Presentations will be made by the Senior Leadership Team and Dr. Dejka Araujo from MD Anderson Cancer Center. Interested parties can register here.
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